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PB Genomics

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Carlsbad, California, US

About PB Genomics

PB Genomics is enabling next-generation drug development screens using high-throughput screening, cerebral organoids and single-cell transcriptomics.

We use our proprietary in vitro genetics platform in collaboration with drug industry partners to identify novel drug targets and elucidate molecular... Show more »

PB Genomics is enabling next-generation drug development screens using high-throughput screening, cerebral organoids and single-cell transcriptomics.

We use our proprietary in vitro genetics platform in collaboration with drug industry partners to identify novel drug targets and elucidate molecular mechanisms of action. We also collaborate with government partners to determine pathways of toxicity for thousands of environmental toxicants.

The power of this technology will provide you a competitive advantage over those using traditional cell culture methods and bulk RNA-sequencing by saving you time and money.

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Our Services (25)


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Organoids

Price on request

We specialize in the development of Cerebral Oranoids and the analysis of such organoids via single-cell RNA sequencing. We can:

  • Develop cerebral organoids from human iPSC lines
  • Develop cerebral organoids from mouse embryonic stem cell lines in a rapid assay
  • Treat cerebral organoids with compound
  • Dissociate... Show more »

We specialize in the development of Cerebral Oranoids and the analysis of such organoids via single-cell RNA sequencing. We can:

  • Develop cerebral organoids from human iPSC lines
  • Develop cerebral organoids from mouse embryonic stem cell lines in a rapid assay
  • Treat cerebral organoids with compound
  • Dissociate organoids and analyze their transcriptome at the single cell level
  • Identify cell types being affected by compound
  • Identify upregulated and downregulated genes/pathways to elucidate mechanism of action
  • Use pharmacogenomics to predict a response a population level

We will work with you to design the most appropriate experiment to fit your needs. Our screens can be scaled to thousands of organoids.

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Human Mouse Mental Health CNS/Neurology Pain Alzheimers Disease Drug Discovery Toxicology Show 8 more tags Show less

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Single Cell RNA-Seq

Price on request

Single-cell RNA sequencing of cerebral organoids is enabling scientist to test their compound of interest cheaply and effectively. By day 21, a vast diversity of cell types have been found within mouse cerebral organoids such as:

-neural progenitors
-oligodendrocytes
-astrocytes
-layered forebrain
-choroid... Show more »

Single-cell RNA sequencing of cerebral organoids is enabling scientist to test their compound of interest cheaply and effectively. By day 21, a vast diversity of cell types have been found within mouse cerebral organoids such as:

-neural progenitors
-oligodendrocytes
-astrocytes
-layered forebrain
-choroid plexus
-Cajal-retzius
-somatostatin-expressing neurons
-dopaminergic neurons
-retinal
-neuroepithelial cells.
-plus many more, depending on how granular you want to look

This complexity of cell types brings together an environment of cell networks that image that of a functioning brain, and thus allowing scientist to better understand their compounds mode and mechanism of action.

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10x Genomics Chromium System

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Transcriptomics Data Analysis

Price on request

We offer tailored bioinformatic analysis of your single-cell transcriptomic data, which includes:

-Fastq demultiplexing
-read alignments
-UMI counting
-data normalization
-dimensionality reduction
-clustering
-data visualization
-gene/barcode matrix generation
-identification of affected cell types
-identification of... Show more »

We offer tailored bioinformatic analysis of your single-cell transcriptomic data, which includes:

-Fastq demultiplexing
-read alignments
-UMI counting
-data normalization
-dimensionality reduction
-clustering
-data visualization
-gene/barcode matrix generation
-identification of affected cell types
-identification of up-regulated and down-regulated genes/pathways
-identification of master regulators and causal networks that explain your data's phenotype
-identification of other potential drug targets

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Bioinformatics

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Assay Development

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Stem Cell Differentiation

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High Throughput Screening (HTS)

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3D Cell Culture Models

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Toxicology

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Mammalian Cell Culture

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Cell and Tissue Culture

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Cell and Tissue Culture Services

Cell and Tissue Culture Services

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Drug Discovery & Development

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Drug Discovery

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Pharmacology & Toxicology

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RNA Services

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Data Services

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Biochemistry & Molecular Biology

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Nucleic Acid Services

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RNA Sequencing

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Project Management

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Cells and Tissues

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Hit Identification

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Biostatistics & Bioinformatics

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Computational Modeling

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Biology

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Ted Choi

President and Chief Scientific Officer

PB Genomics has not received any reviews.

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