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PB Genomics

Carlsbad, California, US

PB Genomics is enabling next-generation drug development screens using high-throughput screening, cerebral organoids and single-cell transcriptomics.

We use our proprietary in vitro genetics platform in collaboration with drug industry partners to identify novel drug targets and elucidate molecular mechanisms of action. We also collaborate with government partners to determine pathways of toxicity for thousands of environmental toxicants.

The power of this technology will provide you a competitive advantage over those using traditional cell culture methods and bulk RNA-sequencing by saving you time and money.

PB Genomics has not listed any services.

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Organoids
Price on request

We specialize in the development of Cerebral Oranoids and the analysis of such organoids via single-cell RNA sequencing. We can:

  • Develop cerebral organoids derived from our proprietary genetically diverse mouse embryonic stem cell lines
  • Develop cerebral organoids from user supplied human iPSC lines.
  • Treat cerebral... Show more »

We specialize in the development of Cerebral Oranoids and the analysis of such organoids via single-cell RNA sequencing. We can:

  • Develop cerebral organoids derived from our proprietary genetically diverse mouse embryonic stem cell lines
  • Develop cerebral organoids from user supplied human iPSC lines.
  • Treat cerebral organoids with compound
  • Dissociate organoids and analyze their transcriptome at the single cell level
  • Identify cell types being affected by compound
  • Identify upregulated and downregulated genes/pathways to elucidate mechanism of action
  • Use pharmacogenomics to predict a response a population level

We will work with you to design the most appropriate experiment to fit your needs. Our screens can be scaled to thousands of organoids.

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Human
Mouse
Stress & Behavior
Development
CNS/Neurology
Neuroscience
Neuropathic Pain
Alzheimers
Behavior
toxicology
neurotoxcity
Neurodegenerative
Drug development
Single Cell Transcriptome Sequencing
Price on request

Single-cell RNA sequencing of cerebral organoids is enabling scientist to test their compound of interest cheaply and effectively. By day 21, a vast diversity of cell types have been found within mouse cerebral organoids such as:

-neural progenitors
-oligodendrocytes
-astrocytes
-layered forebrain
-choroid... Show more »

Single-cell RNA sequencing of cerebral organoids is enabling scientist to test their compound of interest cheaply and effectively. By day 21, a vast diversity of cell types have been found within mouse cerebral organoids such as:

-neural progenitors
-oligodendrocytes
-astrocytes
-layered forebrain
-choroid plexus
-Cajal-retzius
-somatostatin-expressing neurons
-dopaminergic neurons
-retinal
-neuroepithelial cells.
-plus many more, depending on how granular you want to look

This complexity of cell types brings together an environment of cell networks that image that of a functioning brain, and thus allowing scientist to better understand their compounds mode and mechanism of action.

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10x Genomics Chromium System
Transcriptomics Data Analysis
Price on request

We offer tailored bioinformatic analysis of your single-cell transcriptomic data, which includes:

-Fastq demultiplexing
-read alignments
-UMI counting
-data normalization
-dimensionality reduction
-clustering
-data visualization
-gene/barcode matrix generation
-identification of affected cell types
-identification of... Show more »

We offer tailored bioinformatic analysis of your single-cell transcriptomic data, which includes:

-Fastq demultiplexing
-read alignments
-UMI counting
-data normalization
-dimensionality reduction
-clustering
-data visualization
-gene/barcode matrix generation
-identification of affected cell types
-identification of up-regulated and down-regulated genes/pathways
-identification of master regulators and causal networks that explain your data's phenotype
-identification of other potential drug targets

« Show less
Bioinformatics
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Assay Development
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Stem Cell Differentiation
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High Throughput Screening (HTS)
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3D Cell Culture Models
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Toxicology
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Experimental Design
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Project Management, Consulting, & Support Services
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Data Services
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Computational Modeling
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Biology
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Biostatistics & Bioinformatics
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Cells and Tissues
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Mammalian Cell Culture
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RNA Sequencing
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RNA
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Pharmacology & Toxicology
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Hit Identification
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Drug Discovery & Development
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Biochemistry & Molecular Biology
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Drug Discovery
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Nucleic Acid Services
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2018-05-17 10:46:00 -0700

Net Promoter Score of 10 received for RNA Sequencing.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2018-04-04 14:51:08 -0700

Net Promoter Score of 10 received for Transcriptomics Data Analysis.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2018-04-03 05:51:39 -0700

Net Promoter Score of 10 received for Single Cell Transcriptome Sequencing.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 9.

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