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PAIRimmune

Montréal, Quebec, CA

PAIRimmune is a Contract Research Organization (CRO) specialized in immunology evaluation for vaccine research and immunotherapy proof of principle.

We offer to our clients key-in-hand solutions (in vivo, in vitro, readouts, reporting, etc). We have state-of-the-art scientific methods combined with an extensive preclinical biopharma and CRO expertise to move forward early biological products. PAIRimmune is a key-in-hand solution for the benefit of industry, academic and small biotech sponsors.

PAIRimmune has not listed any services.

Animal Immunization for Antibody Production
Price on request
Request a quote for more information about this service.
Rabbit
Ferret
Sheep
Goat
Mouse
Rat
Viral Infection Animal Models
Price on request

Lymphocytic Choriomeningitis

PAIRimmune has got a strong experience in the manipulation of this murine model of chronic infections. We are familiar with different strains of this virus, whether it is Clone 13, Armstrong of WE.

Different outcomes can occur depending of the parameters of infection:
- Strain used
- Route... Show more »

Lymphocytic Choriomeningitis

PAIRimmune has got a strong experience in the manipulation of this murine model of chronic infections. We are familiar with different strains of this virus, whether it is Clone 13, Armstrong of WE.

Different outcomes can occur depending of the parameters of infection:
- Strain used
- Route of infection
- Dose injected
- Age of the mice
Ask us what would fit the best for your application !

We can do many procedures like:
- Viral production, titrations and challenges
- ELISA for antibody responses
- Neutralization assays
- Flow cytometry to analyze the immune response triggered
- Other procedures on demand

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Mouse
Lymphocytic Choriomeningitis (LCMV)
Vaccinia
Cytotoxicity Assays
Price on request

PAIRimmune offers in vitro cell-mediated (T cells, NK, ADCC) cytotoxicity measurements in 96-well plates notably for cancer and antiviral immunotherapy testing.

Available using GAPDH measurement technology or flow cytometry approach.

Possibility to monitor cytotoxicity and viability in the same assay.

PAIRimmune offers in vitro cell-mediated (T cells, NK, ADCC) cytotoxicity measurements in 96-well plates notably for cancer and antiviral immunotherapy testing.

Available using GAPDH measurement technology or flow cytometry approach.

Possibility to monitor cytotoxicity and viability in the same assay.

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Preclinical Study Design
Price on request

PAIRimmune takes advantage of its long experience in the pharma industry to help you design pre-clinical studies perfectly fitting your research goals. Our communicative approach allows us to identify exactly your needs and lower the costs as much as possible.

Consulting in study design includes the optimization of the... Show more »

PAIRimmune takes advantage of its long experience in the pharma industry to help you design pre-clinical studies perfectly fitting your research goals. Our communicative approach allows us to identify exactly your needs and lower the costs as much as possible.

Consulting in study design includes the optimization of the different steps of a study: identification of the best animal model, ideal experimental in vivo parameters, animal protocol writing, relevant analysis depending of your goals, legal paperwork, etc.

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Therapeutic Monoclonal Antibody (mAb) Development
Price on request

PAIRimmune offers monoclonal and polyclonal antibody production fitting to the needs of your projects.

Polyclonal anti-sera production in mice, rats, rabbits, ferrets, sheep and goats.
Development of hybridoma lines for monoclonal antibody production.

Antibody characterization and titration for WB, ELISA, Dot Blot, IHC, IF, etc.).

PAIRimmune offers monoclonal and polyclonal antibody production fitting to the needs of your projects.

Polyclonal anti-sera production in mice, rats, rabbits, ferrets, sheep and goats.
Development of hybridoma lines for monoclonal antibody production.

Antibody characterization and titration for WB, ELISA, Dot Blot, IHC, IF, etc.).

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Rabbit
Ferret
Sheep
Goat
Mouse
Rat
ELISpot Assays
Enzyme-Linked ImmunoSpot Assays
Price on request

Kit-based recognized technology to quantify cells able to secrete:
- Cytokines: Granzyme B, IFNg, ILs, TNFa, etc.
- Antibodies: Total IgG, IgM, IgA, antigen-specific antibodies

Can be used to verify Th1/Th2/Th17 or B cell responses.
Available for mice, primate, rat, pigs, monkeys, depending of the target to screen.

Deliverables: raw data or full reports.

Kit-based recognized technology to quantify cells able to secrete:
- Cytokines: Granzyme B, IFNg, ILs, TNFa, etc.
- Antibodies: Total IgG, IgM, IgA, antigen-specific antibodies

Can be used to verify Th1/Th2/Th17 or B cell responses.
Available for mice, primate, rat, pigs, monkeys, depending of the target to screen.

Deliverables: raw data or full reports.

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Mouse
Pig
Rat
Primates
Flow Cytometry
Price on request

PAIRimmune has a sustained expertise in flow cytometry analysis (FACS).

Phenotyping: Identification and counting of specific cell populations
Intracellular staining (ICS): Identification of cytokines and transcription factors.
Proliferation: Quantification of cellular proliferation levels.
Survival: Identification of... Show more »

PAIRimmune has a sustained expertise in flow cytometry analysis (FACS).

Phenotyping: Identification and counting of specific cell populations
Intracellular staining (ICS): Identification of cytokines and transcription factors.
Proliferation: Quantification of cellular proliferation levels.
Survival: Identification of apoptotic/necrotic cells, quantification of viability.

Consulting for antibody cocktails design, gating strategies, troubleshooting.
Acquisition up to 10 colors at the same time.
Available for human, mouse, rats, pigs, and other species on demand.

Equipment:
BD LSR II

Deliverables: samples, raw data or full reports

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Human
Mouse
Pig
Rat
BD FacsCantoII/LSRII
Flow cytometry
organ
Immunofluorescence
Price on request

PAIRimmune offers whole or separate IF packages including: organ collection, embedding, preparation of slides, staining, acquisition and analysis.

Tissues can be Formalin Fixed Paraffin Embedded (FFPE) or frozen (OCT).

Immunofluorescence and counterstains available.

Consulting for protocol development and antibody... Show more »

PAIRimmune offers whole or separate IF packages including: organ collection, embedding, preparation of slides, staining, acquisition and analysis.

Tissues can be Formalin Fixed Paraffin Embedded (FFPE) or frozen (OCT).

Immunofluorescence and counterstains available.

Consulting for protocol development and antibody selection whether commercial or custom (separate procedure), depending of your needs.

Optimization of new antibodies.

Deliverables: samples, cut sections, stained slides, acquired images or full reports.

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organ
Diabetes Animal Models
Price on request

We propose services adapted to the needs of your research for type 1 and type 2 diabetes study.

  • Type 1 models:
    Can be used to study different aspects: new formulations of insulin, transplantation models, prevention of beta cell death, mechanistic of genetic understanding, etc.
    Chemicaly induced diabetes: Streptozocin... Show more »

We propose services adapted to the needs of your research for type 1 and type 2 diabetes study.

  • Type 1 models:
    Can be used to study different aspects: new formulations of insulin, transplantation models, prevention of beta cell death, mechanistic of genetic understanding, etc.
    Chemicaly induced diabetes: Streptozocin (STZ) or allocan injections.
    Spontaneous autoimmune models

  • Type 2 models:
    Can be used to study treatments to improve insulin resistance, beta cell function or to prevent diet-induced obesity.
    Chemicaly induced obesity: High fat fed mice or rats.
    Spontaneous obesity models

  • Available procedures:
    Fasting glucose and insulin measurements.
    Glucose (GTT) and insulin (ITT) tolerance tests.
    Specific procedures could also be discussed depending of the needs.

Deliverables: samples, raw data or full reports.

Pricing can vary depending of the model chosen, the procedures and the subsequent analysis selected.

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Mouse
Diabetes Type 1
Diabetes Type 2
Whole blood
serum
plasma
Metabolism and Endocrinology
Immunohistochemistry (IHC)
Price on request

PAIRimmune offers whole or separate IHC/IF packages including: organ collection, embedding, preparation of slides, staining, acquisition and analysis.

Tissues can be Formalin Fixed Paraffin Embedded (FFPE) or frozen (OCT).

Immunochemistry, immunofluorescence and counterstains available.

Consulting for protocol development... Show more »

PAIRimmune offers whole or separate IHC/IF packages including: organ collection, embedding, preparation of slides, staining, acquisition and analysis.

Tissues can be Formalin Fixed Paraffin Embedded (FFPE) or frozen (OCT).

Immunochemistry, immunofluorescence and counterstains available.

Consulting for protocol development and antibody selection whether commercial or custom (separate procedure), depending of your needs.

Optimization of new antibodies.

Deliverables: samples, cut sections, stained slides, acquired images or full reports.

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Histology and Pathology Services
Starting at $20.00 per slide

PAIRimmune offers whole or separate histology packages including: organ collection, embedding, preparation of slides and analysis.

Tissues can be Formalin Fixed Paraffin Embedded (FFPE) or frozen (OCT).
Standard (H&E or HPS) and special (Prussian blue, β-amyloid, Periodic Acid Shiff (PAS)) colorations available.

Slides... Show more »

PAIRimmune offers whole or separate histology packages including: organ collection, embedding, preparation of slides and analysis.

Tissues can be Formalin Fixed Paraffin Embedded (FFPE) or frozen (OCT).
Standard (H&E or HPS) and special (Prussian blue, β-amyloid, Periodic Acid Shiff (PAS)) colorations available.

Slides can be sent to our collaborator certified pathologist.

Deliverables: samples, cut sections, acquired images or full reports.

See also our IHC and IF services.

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IACUC Review Consutling
Starting at $1.00 per word

IACUC review and writing services available

IACUC review and writing services available

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ELISA
Enzyme-linked immunosorbent assay
Starting at $17.00 per sample

PAIRimmune provides kit or custom ELISA analysis depending of the needs of our client.
Direct, indirect, sandwich or competitive analysis available.

Analysis of serum, plasma, supernatants, tissue homogenates/lysates.
Available for cytokines, hormones or antigen-specific detection.

Equipment:
Automatic multi-channel... Show more »

PAIRimmune provides kit or custom ELISA analysis depending of the needs of our client.
Direct, indirect, sandwich or competitive analysis available.

Analysis of serum, plasma, supernatants, tissue homogenates/lysates.
Available for cytokines, hormones or antigen-specific detection.

Equipment:
Automatic multi-channel pipets – Automatic plate washer – Fluorescence and visible light plate reader – Softmax Pro Acquisition Software

Deliverables: sample, raw data or full reports.

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Softmax Pro
serum
plasma
Automatic Plate Washer
Automatic multi-channel pipets
ELISA
tissu homogenate
supernatant
In vivo Immunogenicity Assays
Price on request

Pre-clinical testing against a great variety of pathogens and pathologies.

Consulting for determining the best approach for you study.

Multiple models for immunization: mouse, rat, hamster, guinea pig, ferret, pig, etc.
Various routes of administration: intravenous, intramuscular, intranasal, intradermal, oral, sublingual,... Show more »

Pre-clinical testing against a great variety of pathogens and pathologies.

Consulting for determining the best approach for you study.

Multiple models for immunization: mouse, rat, hamster, guinea pig, ferret, pig, etc.
Various routes of administration: intravenous, intramuscular, intranasal, intradermal, oral, sublingual, intraperitoneal, etc.

Mini pigs and farm pigs (relevant model for skin administration) including adapted readouts (humoral, DC, T cell analysis)
Ferret Flu challenge model and mouse challenge model
Cancer models (xenograft)

Analysis technologies: ELISA, ELISPOT, FACS, IHC, IF, neutralization assays, ADCC, etc.

Antibody production in mice, rats, ferrets, rabbits, sheep and goats,

AAALAC and CALAS accreditation.

Deliverables: samples, raw data or full reports.

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Hamster
Guinea pig
Ferret
Mouse
Pig
Rat
Cotton Rat
In vitro Immunogenicity Assays
Price on request

Immunogenicity testing in animal for various compounds testing:

  • Vaccines (antigen specific antibody)
  • Anti mAb immunogenicity
  • Anti drug immunogenicity
  • Anti conjugate immuno
  • Adjuvants testing

Deliverables: samples, raw data or full reports

Immunogenicity testing in animal for various compounds testing:

  • Vaccines (antigen specific antibody)
  • Anti mAb immunogenicity
  • Anti drug immunogenicity
  • Anti conjugate immuno
  • Adjuvants testing

Deliverables: samples, raw data or full reports

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Bio Tek Microplate Washer EL404
GraphPad Prism
DIVA
Molecular Devices Softmax Pro
Molecular device microplate reader versamax
BD FacsCantoII/LSRII
Vaccine Development
Price on request

Consultation in vaccine and immunotherapy product development (early discovery PoC to pre-IND)

We possess 30 years of total experience in large biopharma vaccine organization as well as in biotech startups. We could help you to build a pre-clinical package attractive to large biopharma.

Consultation in vaccine and immunotherapy product development (early discovery PoC to pre-IND)

We possess 30 years of total experience in large biopharma vaccine organization as well as in biotech startups. We could help you to build a pre-clinical package attractive to large biopharma.

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In vivo Drug Efficacy Testing
Price on request

PAIRimmune proposes evaluation of vaccine candidates in different models adapted to your project. We guaranty high-quality screening to identify value candidates.

Flu Vaccine testing in relevant animal models (mouse, ferret challenge model, farm pig).
Efficacy challenge for BSL2 pathogen vaccine candidates.

Available... Show more »

PAIRimmune proposes evaluation of vaccine candidates in different models adapted to your project. We guaranty high-quality screening to identify value candidates.

Flu Vaccine testing in relevant animal models (mouse, ferret challenge model, farm pig).
Efficacy challenge for BSL2 pathogen vaccine candidates.

Available procedures: Viral load, clinical signs, biofilm measurement, quorum-sensing monitoring, pathogen-specific procedure, etc.

Deliverables: samples, raw data or full reports.

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Ferret
Mouse
Pig
Cytometry
Price on request
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Protein Services
Price on request
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Immunostaining
Price on request
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Protein Expression Visualization
Price on request
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Immunoassays
Price on request
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Protein Quantification
Price on request
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Formulation Services
Price on request
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Infectious Disease Animal Models
Price on request
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Toxicology
Price on request
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Hamster
Rabbit
Sheep
Goat
Mouse
Rat
Dog
In vivo Toxicity Testing
Price on request
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Ferret
Sheep
Goat
Mouse
Rat
Dog
Animal Models of Disease
Price on request

We're AAALAC and CALAS accredited

Small animals (mice, rats, hamsters, rabbits, etc.)
Large animals (dog, sheep, goats)
Pigs, notably for transdermal studies
Ferrets, notably for flu challenges
Non-human primates

We're AAALAC and CALAS accredited

Small animals (mice, rats, hamsters, rabbits, etc.)
Large animals (dog, sheep, goats)
Pigs, notably for transdermal studies
Ferrets, notably for flu challenges
Non-human primates

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Ferret
Sheep
Goat
Mouse
Pig
Rat
Dog
Nonhuman Primate
Biochemistry & Molecular Biology
Price on request
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Biology
Price on request
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Pharmacology & Toxicology
Price on request
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Regulatory Affairs Services
Price on request
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Antibody Services
Price on request
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Animal Models and Studies
Price on request
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Project and Process Management
Price on request
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Cells and Tissues
Price on request
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Metabolic Animal Models
Price on request
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Protein Purification
Price on request

Protein Purification and Quantification Services

Protein Purification and Quantification Services

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Drug Discovery & Development
Price on request

Drug Discovery & Development Services

Drug Discovery & Development Services

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Pharmacology
Price on request

Pharmacology Services

Pharmacology Services

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Safety Pharmacology
Price on request

Safety Pharmacology & Efficacy Testing Services

Safety Pharmacology & Efficacy Testing Services

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2017-06-29 16:32:09 -0700

Net Promoter Score of 10 received for ELISA.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 10.
2017-06-26 11:32:56 -0700

Net Promoter Score of 8 received for Viral Infection Animal Models.

Additional Ratings: satisfaction with deliverable: 8, satisfaction with timeliness: 6.
2017-06-02 10:58:34 -0700

Net Promoter Score of 10 received for ELISA.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 10.
Missing Avatar
2016-04-15 05:56:06 -0700

Biodextris has known the PairImmune team for many years, and recognises their customer-focused dedication to providing high-quality scientific support in an efficient and timely manner. Their expertise and capabilities are ideal for clients who need reliable and robust in vitro and in vivo immunology evaluation data, and we would not hesitate to recommend them as a valued partner.

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