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OXM BIO

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Salt Lake City, Utah, US

About OXM BIO

OXM BIO is a pre-clinical CRO focusing exclusively on xenograft studies, both allogeneic (human cell models) and syngeneic (immunotherapy models).

The staff at OXM BIO have performed hundreds of xenografts for pharmaceutical organizations across the United States, both in industry and in academia.... Show more »

OXM BIO is a pre-clinical CRO focusing exclusively on xenograft studies, both allogeneic (human cell models) and syngeneic (immunotherapy models).

The staff at OXM BIO have performed hundreds of xenografts for pharmaceutical organizations across the United States, both in industry and in academia. We've worked in the world of small, agile, start-up pharma, which gives us a unique perspective as a CRO. We appreciate that your priorities change quickly, and you need a partner that can adapt along with you.

We understand the importance of transparency and communication: at OXM BIO, our clients are assigned a single point-of-contact, who is responsible for managing their study from conception to completion. When you call with questions, updates, or just to “check in”, you will speak to a scientist who owns all aspects of your project. No transfers, no runaround, no frustration.

OXM BIO is a US-based organization, born from a desire to simplify the process of running xenograft studies and to provide domestic quality at overseas prices. We are The Xenograft Company - we believe in doing one thing, and doing it well.

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Small business

Our Services (14)


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Human Tumor Xenograft Models

Starting at $5,000.00 per study

Allogeneic xenografts entail the implantation of human cancer cells into a host animal, typically an immunocompromised mouse or rat. Xenograft tumor models are effective tools for assessing in vivo efficacy of candidate cancer drugs.

With syngeneic models, the tumor cell line is derived from the same species as the host... Show more »

Allogeneic xenografts entail the implantation of human cancer cells into a host animal, typically an immunocompromised mouse or rat. Xenograft tumor models are effective tools for assessing in vivo efficacy of candidate cancer drugs.

With syngeneic models, the tumor cell line is derived from the same species as the host animal. Syngeneic xenografts can thus test the efficacy of immuno-oncology agents as single therapies, or in combination with other anti-cancer drugs.

A standard allogeneic xenograft study design is performed as follows:
Species: Mouse
Strain: Athymic nude
Treatment arms: 6 + 1 vehicle
Vehicle: 5% dextrose in sterile water
Tumor cell line: A549 (or other well-characterized cell line), 10 million cells / mouse
Implantation site: Sub-cutaneous, left hind flank
Dosing to begin at 200mm3 average tumor size, sacrifice at 2500 mm3
Mice per arm: 10
Total mice required: 70
Dosing route: IP or PO
Dose schedule: Daily x 7, for 3 weeks
Observation: 7 days post-dosing (tumor size, body weight, mortality / morbidity)

The charge for a generic study such as this one starts at $2000 USD (setup) plus $3000 per arm (Total: $23,000 USD for a 7-arm study). Additional routes of administration or implantation, extended study length, tissue / blood collection, et cetera are available at client's request

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Mouse Immunology Oncology

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In vivo Acute Toxicity Studies

Starting at $1,200.00 per test

Acute toxicity studies provide broad dose-range information for use in short xenografts, or to set starting doses for repeat-dose toxicity studies

A common acute toxicity model is run as follows:
Species: Mouse
Strain: CD-1 female
Dose levels: 3 (to be determined by client) + 1 vehicle
Mice per dose level: 3
Total mice... Show more »

Acute toxicity studies provide broad dose-range information for use in short xenografts, or to set starting doses for repeat-dose toxicity studies

A common acute toxicity model is run as follows:
Species: Mouse
Strain: CD-1 female
Dose levels: 3 (to be determined by client) + 1 vehicle
Mice per dose level: 3
Total mice required: 12
Dosing route: IP or PO
Number of doses: 1
Observation: 5 days (mortality, morbidity, body weight)
Pricing for this generic dose-finding study starts at $1200 USD

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Mouse Immunology Oncology

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Repeat-Dose Toxicity Studies

Starting at $3,150.00 per test

Repeat-dose studies provide useful information for selection of dose(s) for efficacy studies

A common repeat-dose toxicity study is carried out as follows:
Species: Mouse
Strain: CD-1 female
Dose levels: 1 (to be determined by client) + 1 vehicle
Mice per dose level: 8
Total mice required: 16
Dosing route: IP or... Show more »

Repeat-dose studies provide useful information for selection of dose(s) for efficacy studies

A common repeat-dose toxicity study is carried out as follows:
Species: Mouse
Strain: CD-1 female
Dose levels: 1 (to be determined by client) + 1 vehicle
Mice per dose level: 8
Total mice required: 16
Dosing route: IP or PO
Number of doses: 5
Observation: 5 days post-dosing (mortality, morbidity, body weight)
Pricing for this generic repeat-dose toxicity study begins at $3150 USD

Additional models, routes, study lengths, post-dosing tissue / blood collection, et cetera are available upon request

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Mouse Immunology Oncology

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Small Animal in vivo Fluorescence Imaging

Price on request

Luminescent or fluorescent imaging is a non-invasive way to monitor tumor size, progression, and location. Fluorescent imaging is performed using the IVIS Spectrum in vivo imaging system from Caliper Life Sciences.

Luminescent or fluorescent imaging is a non-invasive way to monitor tumor size, progression, and location. Fluorescent imaging is performed using the IVIS Spectrum in vivo imaging system from Caliper Life Sciences.

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IVIS Mouse Immunology Oncology

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Safety Pharmacology

Price on request
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Animal in vivo Imaging

Price on request
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Toxicology

Price on request
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Xenograft Models

Price on request
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Animal Models of Disease

Price on request
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Pharmacology & Toxicology

Price on request
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Animal Models and Studies

Price on request
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Animal Model in vivo Analyses

Price on request
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Oncology Animal Models

Price on request
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In vivo Toxicity Testing

Price on request
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Cory Grand

VP, Research Services

OXM BIO has not received any reviews.

OXM BIO has not received any endorsements.