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Otava Research Institute

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Kyiv, UA

About Otava Research Institute

Otava Research Institute, cooperating with leading Ukrainian research institutions, carries out research work in the format of outsourcing. The research team includes chemists, biologists, physicists whose combined efforts contribute to the complex contract research projects for customers from Western Europe, North America and Japan. We work as a preferred partner to many of the world’s top 10 pharma firms, and hundreds of other companies, providing support with creative solutions for complex technical compound issues. Our scientific knowledge, combined with our research and manufacturing capability, enables us to support chemical processing and production without ever compromising on quality.

Diversity Certificates

Small business

Our Services (54)


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Molecular Modeling

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Otava RDC develops molecular probes to discover and validate therapeutic drug targets, enzyme inhibitors, biological receptor antagonists and agonists, performs pharmacophore modeling, molecular docking, molecular dynamics simulations, SAR studies.


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Compound Library Design

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DNA Sequencing Data Analysis

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Chemoinformatics

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Cell-Based Compound Screening

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Hit to Lead and Lead Optimization

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Compound Library Synthesis

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Targeted-focused libraries comprise compounds with in silico predicted affinity to different molecular targets (G-protein coupled receptors, protein kinases, proteases, ion channels, epigenetic targets, nuclear receptors and others). In order to design targeted libraries Otava RDC applies various computational structure-based and ligand-based methods.


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Cell Line Generation

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Cytotoxicity Assays

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qPCR

Quantitative PCR
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Immunoprecipitation

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PCR Primer Design

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Transfection

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Recombinant Protein Expression

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Retrosynthetic Analysis and Synthetic Route Design

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Chemical Synthesis

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OtavaRD offers custom synthesis of organic molecules for pharmaceutical and biotech projects:

  • Chemical building blocks;
  • Starting materials, intermediates, and/or final products;
  • Combinatorial chemistry templates;
  • Advanced intermediates in drug synthesis;
  • Reference compounds, literature and non-literature compounds.

milligram gram kilogram

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PBPK Modeling

In silico absorption, distribution, metabolism, and excretion
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In silico Protein Modification Analysis

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Homology Modeling

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Template selection, sequence alignment and model generation.


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QSAR Studies

Quantitative Structure-Activity Relationship Studies
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Molecular Dynamics Simulations

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Microarray Data Analysis

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Phylogenetic Analysis

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NGS Data Analysis

Next generation sequencing data analysis
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Pharmacology & Toxicology

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Hit Identification

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Mammalian Cell Culture

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Nucleic Acid Analysis

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Computational Modeling

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Cell and Tissue Culture

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Biostatistics & Bioinformatics

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Protein Services

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PCR

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Toxicology

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Protein Production

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Nucleic Acid Services

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Biochemistry & Molecular Biology

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Chemistry and Materials

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DNA Services

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Protein Expression Visualization

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Synthetic Chemistry

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Lead Identification and Validation

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Nucleic Acid Data Analysis

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Computational Chemistry

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DNA Library Services

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Immunostaining

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Drug Discovery

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Biology

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Biomolecular Interaction Analysis

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Compound Libraries

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Compound Libraries Services


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ADME/DMPK Studies

Drug Metabolism and Pharmacokinetics
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Cells and Tissues

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Sequencing Data Analysis and Management

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Drug Discovery & Development

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Sergiy Starosila

Junior Research Scientist

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