1339457798000

Organic Synthesis Core Facility (OSCF)

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New York, New York, US

About Organic Synthesis Core Facility (OSCF)

The GMP compliant Organic Synthesis Core Facility (OSCF) mission is to provide chemical synthesis work.

Our Services (21)


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Compound Purification

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Activity-based purification of active intermediates from extracts, and scale up purification of active intermediates.

Activity-based purification of active intermediates from extracts, and scale up purification of active intermediates.

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Structure Determination

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Chemical Synthesis

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The synthesis of modified and unmodified compounds in amounts that permit their availability for in vitro and in vivo assays and for secondary assays.

Some of the modifications that could be introduced will address such properties of molecules to render them more versatile. More precisely, we could introduce alterations that... Show more »

The synthesis of modified and unmodified compounds in amounts that permit their availability for in vitro and in vivo assays and for secondary assays.

Some of the modifications that could be introduced will address such properties of molecules to render them more versatile. More precisely, we could introduce alterations that improve solubility, affinity, and specificity.

Large-scale chemical synthesis of compounds with demonstrated activity in primary bioassays in order to provide sufficient quantities for continued testing.

Fluorescent Labeling
The synthesis of assay development tools and reagents:
-Fluorescently labeled compounds
-Affinity labeled intermediates
-Cross linker-tethered molecules

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Radiolabeling/Radiosynthesis

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DNA Synthesis and Probe Development

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Synthesis of modified nucleosides, nucleotides, as well as modified oligonucleotides (modified siRNAs, miRNAs, and damaged synthetic DNA).

Synthesis of modified nucleosides, nucleotides, as well as modified oligonucleotides (modified siRNAs, miRNAs, and damaged synthetic DNA).

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Molecular Dynamics Simulations

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Molecular modeling, homology modeling, and “in-silico” screening of virtual chemical libraries. This is backed by follow up organic synthesis of hits.

Molecular modeling, homology modeling, and “in-silico” screening of virtual chemical libraries. This is backed by follow up organic synthesis of hits.

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QSAR Studies

Quantitative Structure-Activity Relationship Studies
Price on request

Perform structure-activity relationship (SAR) studies on validated pharmacophores to optimize targeting, specificity, bioavailability, while minimizing toxicity.

Perform structure-activity relationship (SAR) studies on validated pharmacophores to optimize targeting, specificity, bioavailability, while minimizing toxicity.

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Radiotracers and Radiopharmaceuticals

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Precursors for radio-labeling experiments, as well as radio-labeled (11C, 3H, 125I, 32P …etc.) compounds for preclinical and clinical pharmacological evaluations.

Precursors for radio-labeling experiments, as well as radio-labeled (11C, 3H, 125I, 32P …etc.) compounds for preclinical and clinical pharmacological evaluations.

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MicroRNA (miRNA) Synthesis

Price on request

Synthesis of modified nucleosides, nucleotides, as well as modified oligonucleotides (modified siRNAs, miRNAs, and damaged synthetic DNA).

Synthesis of modified nucleosides, nucleotides, as well as modified oligonucleotides (modified siRNAs, miRNAs, and damaged synthetic DNA).

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Computational Modeling

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Synthetic Chemistry

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Radiochemistry

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Analytical Chemistry Services

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Computational Chemistry

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Chemistry and Materials

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Biology

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RNA Services

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Separation/Purification Services

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Biochemistry & Molecular Biology

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DNA Services

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Nucleic Acid Services

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Ouathek Ouerfelli

Director, Organic Synthesis Core Facility

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