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Lab Members:

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Executive Director, Project Management and Operations
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President and CEO
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Sr. Director, Business Development
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Sr. Director, Assay Services
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Director, Assay and Product Development
Nm6mnv6lsimovsjuquom optivia

Optivia Biotechnology Inc.

Santa Clara, California, US

Optivia Biotechnology, Inc. is an award-winning and innovative contract research organization (CRO), offering drug transporter research services and solutions to biotechnology, pharmaceutical and academic organizations.

Expertise: Optivia offers a suite of transporter assay services and products to assist your organization to discover and design better drugs with improved therapeutic responses and safety profiles.

Goal: At Optivia we are dedicated to assisting you in improving drug safety and efficacy by providing the most comprehensive, predictive, best-in-class transporter related assay services, informatics products and customized solutions.

Headquartered in the San Francisco Bay Area, Optivia Biotechnology was established by a team of seasoned entrepreneurs and industry veterans who have led successful biotechnology and biopharmaceutical companies. Our Client Services Groups are comprised of industry... Show more »

Optivia Biotechnology, Inc. is an award-winning and innovative contract research organization (CRO), offering drug transporter research services and solutions to biotechnology, pharmaceutical and academic organizations.

Expertise: Optivia offers a suite of transporter assay services and products to assist your organization to discover and design better drugs with improved therapeutic responses and safety profiles.

Goal: At Optivia we are dedicated to assisting you in improving drug safety and efficacy by providing the most comprehensive, predictive, best-in-class transporter related assay services, informatics products and customized solutions.

Headquartered in the San Francisco Bay Area, Optivia Biotechnology was established by a team of seasoned entrepreneurs and industry veterans who have led successful biotechnology and biopharmaceutical companies. Our Client Services Groups are comprised of industry professionals that have worked in drug discovery and development groups within the biotechnology and pharmaceutical industries. We fully understand the issues and challenges of drug development. Optivia is strongly committed to continually advancing services and products in transporter biology enabling cost-effective and efficient drug development for your organization.

We look forward to discussing how we can support your drug discovery and development programs.

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Optivia Biotechnology Inc. has not listed any services.

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In vitro Drug-Drug Interaction Models
Price on request

Validated DDI transporter assays with submission quality reports and agency approved substrates and inhibitors.

Optivia’s Opti-DDI™ Transporter Services Panel provides you with FDA, EMA & PMDA compliant services to help you meet your regulatory requirements. We provide unprecedented transporter assay capability and... Show more »

Validated DDI transporter assays with submission quality reports and agency approved substrates and inhibitors.

Optivia’s Opti-DDI™ Transporter Services Panel provides you with FDA, EMA & PMDA compliant services to help you meet your regulatory requirements. We provide unprecedented transporter assay capability and expertise in transporter DDIs and FDA/EMA/PMDA compliant transporter studies. Our award-winning transporter DDI services include robust validated assays with agency approved substrates and inhibitors, expert advice on study design, and regulatory submission quality reports, as well as guidance on additional transporters the agencies often request.

For more information, please visit www.optiviabio.com/ddi-transporters/

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ALL
Drug discovery
Small Molecules
Cell-based assays
Drug Safety and Toxicology
FDA
EMA
Regulatory compliance
PMDA
IND filing
NDA filing
Drug-drug interaction
DDI
DMPK
ADME
Clinical pharmacology
uptake assays
vesicle assays
bi-directional efflux assays
substrate test
inhibition test
all therapeutic areas
Drug Transporter Assays
Price on request

As the industry's leading drug transporter research solution provider, Optivia offers more than 80 transporter assay services and specialized transporter panels to help you select drug candidates with desirable transporter-interaction profiles, elucidate MOA of off-target clinical responses, and enhance the commercial... Show more »

As the industry's leading drug transporter research solution provider, Optivia offers more than 80 transporter assay services and specialized transporter panels to help you select drug candidates with desirable transporter-interaction profiles, elucidate MOA of off-target clinical responses, and enhance the commercial potential of your drugs through identifying potential new therapeutic indications.

Key Features of Optivia's assay services:

  • Turn-key solution with fast turnaround time
  • Both inhibitor and substrate tests are provided
  • Available for a large panel of clinically-relevant DDI, ADME, Toxicity and therapeutic target transporters
  • Reliable and biologically relevant data from robust functional assays designed to meet stringent regulatory standards
  • All assay models overexpress recombinant transporters, providing clean and definitive results
  • Free technical consultation from experienced, customer-oriented scientists

For a complete list of our transporter assays, please visit www.optiviabio.com/transporter-assays-a-z/

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ALL
Drug discovery
Small Molecules
Cell-based assays
Drug Safety and Toxicology
FDA
EMA
Regulatory compliance
PMDA
DDI
DMPK
ADME
vesicle assays
bi-directional efflux assays
substrate test
inhibition test
drug resistance
cellular uptake assays
LCMS
radiometric
Monoamine Transporter Assays
Price on request

Optivia provides definitive functional substrate and inhibition assays for the following monoamine transporters:

SERT: Serotonin transporter (SLC6A4)
NET: Norepinephrine transporter (SLC6A2)
DAT: Dopamine transporter (SLC6A3)
PMAT: Plasma membrane monoamine transporter (ENT4, SLC29A4)
OCT3: Organic cation transporter 3... Show more »

Optivia provides definitive functional substrate and inhibition assays for the following monoamine transporters:

SERT: Serotonin transporter (SLC6A4)
NET: Norepinephrine transporter (SLC6A2)
DAT: Dopamine transporter (SLC6A3)
PMAT: Plasma membrane monoamine transporter (ENT4, SLC29A4)
OCT3: Organic cation transporter 3 (SLC22A3)

Typical turnaround time: 2-4 weeks
Types of studies: IND/NDA enabling, discovery screening, mechanistic profiling

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Central Nervous System
Central Nervous System
Central Nervous System pathologies
Nucleoside Transporter Assays
Price on request

Optivia provides definitive functional substrate and inhibition assays for the following major nucleoside transporters:

CNT1 (human and rat): Concentrative nucleoside transporter 1 (SLC28A1)
CNT2 (human and rat): Concentrative nucleoside transporter 1 (SLC28A2)
CNT3 (human and rat): Concentrative nucleoside transporter 1... Show more »

Optivia provides definitive functional substrate and inhibition assays for the following major nucleoside transporters:

CNT1 (human and rat): Concentrative nucleoside transporter 1 (SLC28A1)
CNT2 (human and rat): Concentrative nucleoside transporter 1 (SLC28A2)
CNT3 (human and rat): Concentrative nucleoside transporter 1 (SLC28A3)
ENT1: Equilibrative nucleoside transporter 1 (SLC29A1)
ENT2: Equilibrative nucleoside transporter 1 (SLC29A2)
ENT4: Equilibrative nucleoside transporter 1 (SLC29A4)

Typical turnaround time: 2-4 weeks
Types of studies: IND/NDA enabling, discovery screening and mechanistic profiling

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Cancer
Drug discovery
Cell-based assays
Infectious Disease
Drug Safety and Toxicology
functional assays
substrate assessment
inhibition assessment
uptake assays
anti-viral
anti-cancer
Amino Acid Transporter Assays
Price on request

As the industry's leading transporter research solution provider, Optivia provides definitive, validated functional assays for a variety of amino acid transporters:

Asc-1: Alanine, serine, cysteine transporter 1 (SLC7A10)
ASCT2: Alanine, serine, cysteine transporter 2 (SLC1A5)
ATB0+: Sodium- and chloride-dependent neutral... Show more »

As the industry's leading transporter research solution provider, Optivia provides definitive, validated functional assays for a variety of amino acid transporters:

Asc-1: Alanine, serine, cysteine transporter 1 (SLC7A10)
ASCT2: Alanine, serine, cysteine transporter 2 (SLC1A5)
ATB0+: Sodium- and chloride-dependent neutral and basic amino acid transporter B (0+) (SLC6A14)
CAT3: Cationic amino acid transporter 3 (SLC7A3)
EAAT1 (GLAST-1): Excitatory amino acid transporter 1 (SLC1A3)
EAAT2 (GLT-1): Excitatory amino acid transporter 2 (SLC1A2)
EAAT3 (EAAC1): Excitatory amino acid transporter 3 (SLC1A1)
GAT1: y-aminobutyric acid (GABA) transporter 1 (SLC6A1)
GAT2: y-aminobutyric acid (GABA) transporter 2 (SLC6A13)
GAT3: y-aminobutyric acid (GABA) transporter 1 (SLC6A11)
GLYT1: Glycine transporter 1 (SLC6A9)
LAT1: L-type amino acid transporter 1 (SLC7A5)
SNAT1: Sodium-coupled neutral amino acid transporter1 (SLC38A1)
SNAT2: Sodium-coupled neutral amino acid transporter1 (SLC38A2)
xCT: cystine/glutamate exchanger (SLC7A11)

Typical turnaround time: 2-4 weeks
Types of studies: IND/NDA enabling, discovery screening, mechanistic profiling

The following functional amino acid transporters can be validated within 2-3 weeks upon request:
CAT1: Cationic amino acid transporter 1 (SLC7A1)
CAT2: Cationic amino acid transporter 1 (SLC7A2)
CHT: Choline transporter (SLC5A7)
GLYT2: Glycine transporter 2 (SLC6A5).
SBAT1: Sodium-dependent neutral amino acid transporter B(0)AT2 (SLC6A15)

For other amino acid transporters not on the lists above, please inquire on our expedited assay development service, which typically takes 4-6 weeks to have a new transporter assay fully characterized and validated.

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Cancer
Biology
Drug discovery
Cancer
Diagnostic
Central Nervous System
Central Nervous System
Central Nervous System pathologies
Drug Safety and Toxicology
MDR1-MDCK Permeability Assay
Price on request

Typical turnaround time: 1-2 weeks
Minimal number of compounds per batch: 2

Typical turnaround time: 1-2 weeks
Minimal number of compounds per batch: 2

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Cell Permeability Assay
Price on request
Request a quote for more information about this service.
Drug Absorption Studies
Price on request
Request a quote for more information about this service.
Transporter & Cell Uptake Assays
Price on request

As the industry's leading drug transporter research solution provider, Optivia offers more than 80 transporter assay services and specialized transporter panels to help you select drug candidates with desirable transporter-interaction profiles, elucidate MOA of off-target clinical responses, and enhance the commercial... Show more »

As the industry's leading drug transporter research solution provider, Optivia offers more than 80 transporter assay services and specialized transporter panels to help you select drug candidates with desirable transporter-interaction profiles, elucidate MOA of off-target clinical responses, and enhance the commercial potential of your drugs through identifying potential new therapeutic indications.

  • Opti-DDI™ Panel: Select and optimize preclinical candidates with less DDI liability
  • Opti-Target™ Panel: Profile of therapeutic transporter targets for studying the MOA of off-target clinical outcomes and for identifying new therapeutic indications for approved or experimental drugs
  • Opti-Safety ™ Panel: Identify safety liabilities of preclinical candidates by avoiding undesirable interactions with toxicity related transporters
  • Opti-ADME™ Panel: Elucidate key ADME pathways and determinants for predicting the pharmacological attributes of preclinical candidatesd tissue targeting

Key Features of Optivia's assay services:

  • Turn-key solution with fast turnaround time
  • Both inhibitor and substrate tests are provided
  • Available for a large panel of clinically-relevant DDI, ADME, Toxicity and therapeutic target transporters
  • Reliable and biologically relevant data from robust functional assays designed to meet stringent regulatory standards
  • All assay models overexpress recombinant transporters, providing clean and definitive results
  • Free technical consultation from experienced, customer-oriented scientists
« Show less
Cancer
Drug discovery
Central Nervous System
Infectious Disease
Drug Safety and Toxicology
Metabolic disorders
all therapeutic areas
FDA
EMA
IND enabling
Drug-drug interaction
DDI
DMPK
ADME
Clinical pharmacology
Membrane Protein Expression
Price on request

As the industry's leading drug transporter research solution provider, Optivia offers more than 80 transporter assay services and specialized transporter panels to help you select drug candidates with desirable transporter-interaction profiles, elucidate MOA of off-target clinical responses, and enhance the commercial... Show more »

As the industry's leading drug transporter research solution provider, Optivia offers more than 80 transporter assay services and specialized transporter panels to help you select drug candidates with desirable transporter-interaction profiles, elucidate MOA of off-target clinical responses, and enhance the commercial potential of your drugs through identifying potential new therapeutic indications.

Opti-DDI™ Panel: Select and optimize preclinical candidates with less DDI liability
Opti-Target™ Panel: Profile of therapeutic transporter targets for studying the MOA of off-target clinical outcomes and for identifying new therapeutic indications for approved or experimental drugs
Opti-Safety ™ Panel: Identify safety liabilities of preclinical candidates by avoiding undesirable interactions with toxicity related transporters
Opti-ADME™ Panel: Elucidate key ADME pathways and determinants for predicting the pharmacological attributes of preclinical candidatesd tissue targeting
Key Features of Optivia's assay services:

Turn-key solution with fast turnaround time
Both inhibitor and substrate tests are provided
Available for a large panel of clinically-relevant DDI, ADME, Toxicity and therapeutic target transporters
Reliable and biologically relevant data from robust functional assays designed to meet stringent regulatory standards
All assay models overexpress recombinant transporters, providing clean and definitive results
Free technical consultation from experienced, customer-oriented scientists

« Show less
Cancer
ALL
Biology
Drug discovery
Small Molecules
Drug Safety and Toxicology
FDA
EMA
PMDA
Drug-drug interaction
DDI
DMPK
ADME
Pharmacology
Toxicity
Cell-Based Assays
Price on request
Request a quote for more information about this service.
Pharmacology & Toxicology
Price on request
Request a quote for more information about this service.
Cell Death Assays
Price on request
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Biology
Price on request
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In vitro ADME
Price on request
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ADME/DMPK Studies
Drug Metabolism and Pharmacokinetics
Price on request
Request a quote for more information about this service.
Peptide Transporter Assays
Price on request
Request a quote for more information about this service.
Organic Ion Transporter Assays
Price on request
Request a quote for more information about this service.
Glucose Transporter Assays
Price on request
Request a quote for more information about this service.
2018-05-01 12:34:37 -0400

Net Promoter Score of 10 received for In vitro Drug-Drug Interaction Models.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2018-01-30 19:03:48 -0500

Net Promoter Score of 8 received for Amino Acid Transporter Assays.

Additional Ratings: satisfaction with deliverable: 8, satisfaction with timeliness: 10.
2018-01-08 13:17:12 -0500

Net Promoter Score of 10 received for Drug Transporter Assays.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.

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