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Ohan Cardiovascular Innovations Corp

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Rootstown, Ohio, US

About Ohan Cardiovascular Innovations Corp

Ohan Cardiovascular Innovations (OHCVI) focuses on providing preclinical studies while implementing the highest standard of quality services. Streamlined protocols, established techniques, and targeted efficiency allows us to conduct preclinical research for clients around the world.


OHCVI was founded by Dr. Vahagn Ohanyan, MD, PhD. With over 20 years of experience in cardiovascular research, as well as the academic understanding and professional skills of their team, OHCVI has the unique potential to address their clients’ needs.

Our Services (5)


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Ischemia Animal Models

Price on request

The murine hindlimb ischemia is a model of Peripheral Artery Disease (PAD) and is useful for testing new therapies. 

For this model, we will do permanent ligation of the femoral artery. 

For the Ischemia/reperfusion model, we will occlude the femoral artery for a certain time and do reperfusion. 

For this experiment, we are using a vascular hook designed by Ohan cardiovascular innovations team. 


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Myocardial Infarction Animal Models

Price on request

One of the important steps of the open chest, surgery is intubation.  

Ohan cardiovascular lab designed and invented rodent intubation system, which allows scientists to intubate mice in less than 1 minutes and 100 % accurate, 

For Myocardial infarction, Ischemia /reperfusion, for any open chest surgeries we use this intubation system, which increases the survival rate significantly9 https://www.youtube.com/watch?v=k5y7XbtneM0&t=68s)

https://www.youtube.com/watch?v=k5y7XbtneM0&t=68s


 



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Cardiovascular Animal Models

Price on request

We are using surgical and chemically induced cardiovascular disease models( mice and rats).


Surgical models:


- Myocardial ischemia and ischemia/reperfusion

- Transaortic Constriction (TAC)

- Abdominal aortic constriction

- Pulmonary artery constriction

- Renal artery stenosis


Drug-induced:


- Doxorubicin

- Streptozoticin

- Angiotensin

- Any drug of interest


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Surgical Animal Models

Price on request

- Myocardial ischemia and ischemia/reperfusion

- Transaortic Constriction (TAC)

- Abdominal aortic constriction

- Pulmonary artery constriction

- Renal artery stenosis


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Animal Echocardiography

Price on request

Ohan cardiovascular innovations lab is equipped with modern ultrasound systems. Our lab has Vevo 2100 and vevo770 high-frequency ultrasound systems, Siemens Sequia 512, 

By using we can get different parameters for cardiac performance. We are measuring cardiac systolic, diastolic functions.  We also monitor cardiac function after inducing myocardial infarction, transaortic constriction, or during the course of the drug treatment. 

By using the Siemens system we are measuring tissue perfusion. 

Ultrasound is a noninvasive method and we can monitor cardiac function for a long period of time, 

See one of our papers for the myocardial perfusion measurements,

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4843795/

 







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Vahgan Ohanyan

President

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