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NTS Ventures LLC

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Cleveland, Ohio, US

About NTS Ventures LLC

NTS provides preclinical, clinical and translational services designed to bring antifungal and antibacterial agents from discovery to market. We have the ability to support drug development in preclinical and clinical testing phases in order to satisfy FDA Investigational New Drug (IND) and New Drug Application... Show more »

NTS provides preclinical, clinical and translational services designed to bring antifungal and antibacterial agents from discovery to market. We have the ability to support drug development in preclinical and clinical testing phases in order to satisfy FDA Investigational New Drug (IND) and New Drug Application (NDA) submissions.

The NTS team has worked with a large range of entities including global Big Pharma, start up and growth stage biotech companies, full-spectrum CRO's as well as academic institutions.

Recent Publications

  • Christensen L, Turner R, Weaver S, Caserta F, Long L, Ghannoum M, Brown M. Evaluation of the Ability of a Novel Miconazole Formulation to Penetrate Nail Using Three Nail In Vitro Models. Antimicrob Agents Chemother. 2017 Apr 24. pii: AAC.02554-16. doi: 10.1128/AAC.02554-16.
  • Larkin E, Hager C, Chandra J, Mukherjee PK, Retuerto M, Salem I, Long L, Isham N, Kovanda L, Borroto-Esoda K, Wring S, Angulo D, Ghannoum M. The Emerging Pathogen Candida auris: Growth Phenotype, Virulence Factors, Activity of Antifungals, and Effect of SCY-078, a Novel Glucan Synthesis Inhibitor, on Growth Morphology and Biofilm Formation. Antimicrob Agents Chemother. 2017 Apr 24;61(5). pii: e02396-16. doi: 10.1128/AAC.02396-16.
  • Lockhart SR, Ghannoum MA, Alexander BD. Establishment and Use of Epidemiological Cutoff Values for Molds and Yeasts by Use of the Clinical and Laboratory Standards Institute M57 Standard. J Clin Microbiol. 2017 May;55(5):1262-1268. doi: 10.1128/JCM.02416-16.
  • Mukherjee PK, Esper F, Buchheit K, Arters K, Adkins I, Ghannoum MA, Salata RA. Randomized, double-blind, placebo-controlled clinical trial to assess the safety and effectiveness of a novel dual-action oral topical formulation against upper respiratory infections. BMC Infect Dis. 2017 Jan 14;17(1):74. doi: 10.1186/s12879-016-2177-8.
  • Scorneaux B, Angulo D, Borroto-Esoda K, Ghannoum M, Peel M, Wring S. SCY-078 Is Fungicidal against Candida Species in Time-Kill Studies. Antimicrob Agents Chemother. 2017 Feb 23;61(3). pii: e01961-16. doi: 10.1128/AAC.01961-16.
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Our Services (36)


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Fungal Identification

Price on request
  • Culture and identification of fungi
    • Specimen-collection kits provided, Shipping material provided compliant with the International Air Transport Association (IATA)
  • Culture and identification of fungi
    • Specimen-collection kits provided, Shipping material provided compliant with the International Air Transport Association (IATA)
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Antimicrobial Susceptibility Testing

Price on request

Antimicrobial activity in vitro

  • Antifungal susceptibility testing (AST) CLSI and EUCAST based:

    • Minimum inhibitory concentration (MIC)
    • Minimum fungicidal concentration (MFC)
    • Minimum effective concentration (MEC)
  • Antifungal susceptibility testing

    • Baseline and end-of-study isolates that allows monitoring of resistance development

Antimicrobial activity in vitro

  • Antifungal susceptibility testing (AST) CLSI and EUCAST based:

    • Minimum inhibitory concentration (MIC)
    • Minimum fungicidal concentration (MFC)
    • Minimum effective concentration (MEC)
  • Antifungal susceptibility testing

    • Baseline and end-of-study isolates that allows monitoring of resistance development
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Antimicrobial Activity Testing

Price on request

Antimicrobial activity in vitro

  • Testing of drug combinations
  • Time-kill assay (microbial kill curves)
  • Post-antimicrobial effect (PAE)
  • Nail penetration assay including lacquer effect on drug penetration
  • Keratin binding assay
  • Biofilms prevention and treatment assays

Antimicrobial activity in vitro

  • Testing of drug combinations
  • Time-kill assay (microbial kill curves)
  • Post-antimicrobial effect (PAE)
  • Nail penetration assay including lacquer effect on drug penetration
  • Keratin binding assay
  • Biofilms prevention and treatment assays
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Clinical Development Strategy

Price on request

Antifungal clinical trial support

  • Central lab for single and multi-site clinical trials both national and international
  • Assist in selection of optimal clinical sites
  • Implementation of clinical protocols
    • Protocol-related training, Fungal isolate storage, Close interactions with site Principle Investigators (PI)... Show more »

Antifungal clinical trial support

  • Central lab for single and multi-site clinical trials both national and international
  • Assist in selection of optimal clinical sites
  • Implementation of clinical protocols
    • Protocol-related training, Fungal isolate storage, Close interactions with site Principle Investigators (PI) and staff, Data integrity maintained in collaboration with other CROs

Dermatology clinical trial support in the following areas:

  • Atopic Dermatitis
  • Autoimmune Responses
  • Cutaneous Lupus
  • Cutaneous Oncology
  • Hidradenitis
  • Laser Dermatology
  • Lymphoma
  • Melanoma and Skin Cancer
  • Psoriasis
  • Psoriatic Arthritis
  • Pyoderma Gangrenosum
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In vivo Skin Irritation/Sensitization Testing

Price on request

Skin, skin products and skin disease services

  • Sunscreens
  • Antioxidants
  • Probiotics
  • Hair Regrowth Agents
  • Allergy/Immune Response
  • Other interventions aimed at protecting or improving the condition of human skin, hair and nails

Skin, skin products and skin disease services

  • Sunscreens
  • Antioxidants
  • Probiotics
  • Hair Regrowth Agents
  • Allergy/Immune Response
  • Other interventions aimed at protecting or improving the condition of human skin, hair and nails
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Rabbit Guinea pig Mouse

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Clinical Laboratory Services

Price on request

Clinical photography, utilization of skin scoring systems such as PASI, SCORAD and Scinexa

Clinical photography, utilization of skin scoring systems such as PASI, SCORAD and Scinexa

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Human Allergy Testing

Price on request

Allergen sensitization/elicitation (patch testing), Transepidermal water loss measurements and chromametry

Allergen sensitization/elicitation (patch testing), Transepidermal water loss measurements and chromametry

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Human Tissue Procurement

Price on request

Specifically skin biopsies in the form of punch, keratome, epidermal blister, stratum corneum stripping, as well as collection of blood, saliva and other specimens

Specifically skin biopsies in the form of punch, keratome, epidermal blister, stratum corneum stripping, as well as collection of blood, saliva and other specimens

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Fungal Infection Animal Models

Price on request
  • Immunocompetent and immunosuppressed models:
    • Mice
      • Invasive candidiasis, Invasive mould infections (aspergillosis, fusariosis, mucormycosis), Mucosal (oral and vaginal) candidiasis, Wound infection model, Subcutaneous device-associated microbial biofilms, Keratitis (Fusarium, Candida, bacterial)
    • Guinea pig
      ... Show more »
  • Immunocompetent and immunosuppressed models:
    • Mice
      • Invasive candidiasis, Invasive mould infections (aspergillosis, fusariosis, mucormycosis), Mucosal (oral and vaginal) candidiasis, Wound infection model, Subcutaneous device-associated microbial biofilms, Keratitis (Fusarium, Candida, bacterial)
    • Guinea pig
      • Onychomycosis (topical and oral dosing), Invasive and cutaneous candidiasis
    • Rabbit
      • Invasive candidiasis, Biofilms-associated infections
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Regulatory Affairs Services

Price on request

Provides assistance with research design and regulatory compliance in accordance with IRB and Federal requirements

Provides assistance with research design and regulatory compliance in accordance with IRB and Federal requirements

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Data Management

Price on request
  • Comply with information technology rules/regulations
  • All data are firewall and password protected
  • Data stored in 21 CFR part 11-compliant database
  • Redundant data backup procedures in place
  • Comply with information technology rules/regulations
  • All data are firewall and password protected
  • Data stored in 21 CFR part 11-compliant database
  • Redundant data backup procedures in place
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Drug Mechanism of Action Studies

Mechanism of Action Studies
Price on request
  • Effect on microbial ultrastructure/morphology/architecture
  • Inhibition of cell wall synthesis/cell wall damange
  • Lysis of cell membrane
  • Protein synthesis
  • Inhibition of DNA or RNA replication
  • Assessment of potential to develop resistance
  • Effect on microbial ultrastructure/morphology/architecture
  • Inhibition of cell wall synthesis/cell wall damange
  • Lysis of cell membrane
  • Protein synthesis
  • Inhibition of DNA or RNA replication
  • Assessment of potential to develop resistance
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In vivo Phototoxicity Testing

Price on request

Specializes in phototesting with simulated solar radiation and erythema/pigmentation assessment using colorimetry

Specializes in phototesting with simulated solar radiation and erythema/pigmentation assessment using colorimetry

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Rabbit Guinea pig Mouse

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Fungal Infection Testing

Price on request
  • KOH/Fluorescent (Calcoflour) direct smear
    • Results sent within 24 hours
  • KOH/Fluorescent (Calcoflour) direct smear
    • Results sent within 24 hours
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Toxicology

Price on request
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Biospecimens

Price on request
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Clinical Trials, Consulting, and Management

Price on request
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Computational Modeling

Price on request
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Infectious Disease Animal Models

Price on request
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Project Management

Price on request
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In vivo Toxicity Testing

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Pharmacology & Toxicology

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Clinical Immunology Tests

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Medicinal Chemistry

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Microbiology

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Animal Models and Studies

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Animal Models of Disease

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Clinical Microbiology, Virology and Parasitology

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Drug Discovery

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Data Services

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Clinical Research

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Biospecimen Management and Storage

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Biology

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Cells and Tissues

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Drug Discovery & Development

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Microbiology Assays

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Danielle Foote

VP of Testing Services
  • Positive review for Antimicrobial Susceptibility Testing:

    July 2017

    "Very happy with the work performed by NTS Ventures. Exhibit true expertise with an ability to deliver on time to high quality."

NTS Ventures LLC has not received any endorsements.