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NSrepair

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MARSEILLE CEDEX 05, FR

About NSrepair

We are a Preclinical Contract Research Organization highly specialized in Acute Neurological Injuries and Associated Syptoms.

We offer our unique biopharmaceutical... Show more »

We are a Preclinical Contract Research Organization highly specialized in Acute Neurological Injuries and Associated Syptoms.

We offer our unique biopharmaceutical know-how in a range of tailored services:

  • design of preclinical plans
  • in vivo pharmacology
  • training programs

Our experts are dedicated towards establishing close relationships with our partners in order to ensure that specific milestones are reached according to specific timelines.

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Our Services (1)


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Spinal Cord Injury Models

Price on request

More than 2.5 million of patients around the world.
Depending on their location and severity, Spinal Cord Injury results in paralysis, loss of sensation, respiratory or urogenital disorders, and chronic pain. Patients demonstrate lower rates of school enrollment and economic participation and are two to... Show more »

More than 2.5 million of patients around the world.
Depending on their location and severity, Spinal Cord Injury results in paralysis, loss of sensation, respiratory or urogenital disorders, and chronic pain. Patients demonstrate lower rates of school enrollment and economic participation and are two to five times more likely to die prematurely

Models

  • Contusion: NYU weight-drop device
  • Transection: complete, hemisection, T shape lesion

SCI models - Validation data & References

Functional recovery study

  • Locomotion, coordination, balance, strength
    The BBB (BMS for mice) locomotor rating scale is the most widely used open field test and has been accepted as a valid way to assess locomotor function after spinal cord injury in rat.
  • Open arena test: spontaneous locomotion and rearing
  • Grid walk and Horizontal ladder
  • Incline plane
  • Rotarod
  • Narrow beam

Spasticity

  • Monosynaptic reflex: Rate-Dependent Depression (RDD) of the Hoffmann's reflex (H-reflex)
  • Polysynaptic reflex: hindlimb muscle spasms evoked with stimulation of the tibial nerve, in awake chronic adult SCI rat

Spasticity models - Validation data & References

Touch sensitivity

  • Von Frey hair sensory testing
  • Plantar Analgesia test

Autonomic bladder control

  • Bladder scale

 

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NYU weight-drop device Spinal cord injury Spasticity Spinal cord contusion Transection Hemisection T shape lesion NYU weight-drop device Neuroscience Show 9 more tags Show less

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Philippe Marino

CEO-CSO

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