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NovaBioAssays LLC

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Woburn, Massachusetts, US

About NovaBioAssays LLC

Founded in 2012, NovaBioAssays LLC is a Greater Boston-based contract research organization (CRO) specialized in providing innovative analytical and bioanalytical solutions to facilitate drug discovery and development. NovaBioAssays LLC occupies the two-story building with 12,000 SF space, and 10,000 SF for... Show more »

Founded in 2012, NovaBioAssays LLC is a Greater Boston-based contract research organization (CRO) specialized in providing innovative analytical and bioanalytical solutions to facilitate drug discovery and development. NovaBioAssays LLC occupies the two-story building with 12,000 SF space, and 10,000 SF for future expansion. We offer a full suite of analytical and bioanalytical services for quantitative and qualitative analysis of small molecules, oligonucleotides, peptides, and proteins.

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Our Services (21)


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Small Molecule Bioanalysis

Price on request
  • Small Molecule Quantification
  • Drug & Metabolites Quantification
  • Small Molecule Biomarker Assays
  • Drug Metabolite Identification and Profiling
  • ADME
  • Small Molecule Quantification
  • Drug & Metabolites Quantification
  • Small Molecule Biomarker Assays
  • Drug Metabolite Identification and Profiling
  • ADME
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Protein Quantification

Price on request

Historically, immunoassays and other ligand-binding assays (LBA) have been the golden standard for quantifying proteins in biological fluids to support preclinical and clinical studies due to their high sensitivity and throughput. However, the resource and time consuming process for reagent production and selection routinely... Show more »

Historically, immunoassays and other ligand-binding assays (LBA) have been the golden standard for quantifying proteins in biological fluids to support preclinical and clinical studies due to their high sensitivity and throughput. However, the resource and time consuming process for reagent production and selection routinely results in lengthy assay development period (>6 months). In addition, the selectivity of LBA is prone to be compromised by presence of endogenous interfering molecules in different matrices, especially in tissue samples. With recent development on mass spectrometry instrumentation and methodology, approaches for protein quantitation based on liquid chromatography mass spectrometry (LC-MS) have matured lately. LC-MS/MS assays have been increasingly used as the alternative for the absolute quantification of the endogenous biomarker proteins, and the therapeutic recombinant proteins or mAbs. LC-MS/MS assays are especially useful for situations when quantifying therapeutic proteins in human serum in the presence of pre-existing anti-drug antibodies; when required to quantify the therapeutic protein and its metabolites simultaneously; or when the reagents for LBA are not available. At NovaBioAssays, we provide a variety of LC-MS/MS-based platforms as well as traditional LBA methods to meet our clients’ bioanalytical needs.

  • Direct UPLC-MRM or UPLC-PRM/SIM
  • 2D UPLC UPLC-MRM or UPLC-HRMS
  • Immunoaffinity UPLC-MRM or UPLC-HRMS
  • Dual immunoaffinity nano UHPLC-MRM or nano UPLC-HRMS
  • Ligand Binding Assays
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Protein Characterization

Price on request
  • Intact Molecular Weight Determination
  • Peptide Mapping
  • Post Translational Modification(PTM) Analysis
  • Disulfide Bridge Mapping
  • De Novo Sequencing
  • Glycosylation Analysis and Glycosylation Site Mapping/Occupancy Determination
  • Protein Identification
  • Intact Molecular Weight Determination
  • Peptide Mapping
  • Post Translational Modification(PTM) Analysis
  • Disulfide Bridge Mapping
  • De Novo Sequencing
  • Glycosylation Analysis and Glycosylation Site Mapping/Occupancy Determination
  • Protein Identification
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Epitope Mapping

Price on request

Hydrogen Deuterium eXchange Mass Spectrometry (HDX-MS) is a powerful technique to study protein dynamics, protein folding, protein-protein interactions, protein small molecule interactions, as well as protein-RNA interactions. Novabioassays has built its reputation in providing HDX MS service for epitope mapping, biosimilarity... Show more »

Hydrogen Deuterium eXchange Mass Spectrometry (HDX-MS) is a powerful technique to study protein dynamics, protein folding, protein-protein interactions, protein small molecule interactions, as well as protein-RNA interactions. Novabioassays has built its reputation in providing HDX MS service for epitope mapping, biosimilarity comparison, studying small molecule-protein interactions, peptide-protein interactions, protein-protein interactions, and RNA-protein interactions for many small and large pharmaceutical companies globally in the past five years.

At Novabioassays, we have achieved almost 100% successful rate in performing epitope mapping for more than 200 antibodies targeting more than 40 different antigens (from ~10 kDa to ~200 kDa) to support our clients’ patent applications and/or IND filings.

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Metabolite Profiling

Price on request

NovaBioAssays uses advanced liquid chromatographic assays and ultrasensitive ELISA to quantify oligonucleotide therapeutics in biological matrices. While some ELISA assays are more sensitive, the chromatographic based methods are more specific and able to quantify multiple analytes in one assay. The chromatographic based assays... Show more »

NovaBioAssays uses advanced liquid chromatographic assays and ultrasensitive ELISA to quantify oligonucleotide therapeutics in biological matrices. While some ELISA assays are more sensitive, the chromatographic based methods are more specific and able to quantify multiple analytes in one assay. The chromatographic based assays can also conduct metabolite identification and/or quantification simultaneously.

  • Quantitative bioanalysis using UPLC-MS/MS assays on triple quadrupole mass spectrometer (Sciex API5000 or Thermo Quantiva) or UPLC-HRAM (Thermo Q Exactive-Plus)
  • Quantitative bioanalysis using ultrasensitive fluorescence ELISA
  • Quantitation and metabolite identification using LC-HRAM on Q Exactive or Q-Tof
  • Quantitation and metabolite profiling using hybridization based UPLC-fluorescence assays
  • Quantitation and metabolite profiling using UPLC-UV(PDA)-MS
  • Structure characterization and purity assessment of CRISPR sgRNA using LC-HRAM on Q Exactive or Q-Tof
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Biomarker Analysis

Price on request
  • Small molecule biomarker
    • Neurotransmitters (dopamine, nephrine, serotonin etc.)
    • Lipids
    • Polyamine
    • Amino acids
    • Hormones
  • Protein biomarkers
  • Oligomannose
  • Small molecule biomarker
    • Neurotransmitters (dopamine, nephrine, serotonin etc.)
    • Lipids
    • Polyamine
    • Amino acids
    • Hormones
  • Protein biomarkers
  • Oligomannose
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Antibody-Drug Conjugate Analysis

Price on request

NovaBioAssays provides the LC-MS or LC-MS/MS based analysis for Antibody-Drug Conjugates (ADCs) and other conjugates, such as bispecific antibodies, Fc fusion proteins, antibody fragments (Fab, Fc, and Nanobodies), etc.

Services for ADCs and other conjugated products include:

  • Drug-to-Antibody Ratio (DAR) Determination
    -... Show more »

NovaBioAssays provides the LC-MS or LC-MS/MS based analysis for Antibody-Drug Conjugates (ADCs) and other conjugates, such as bispecific antibodies, Fc fusion proteins, antibody fragments (Fab, Fc, and Nanobodies), etc.

Services for ADCs and other conjugated products include:

  • Drug-to-Antibody Ratio (DAR) Determination
  • Site Occupancy
  • Linkage site identification
  • Analysis of Free Drug (Payload) and Naked Carrier Protein/Antibody
  • Quantification of Drug-Conjugate Components
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Biopharmaceutical Characterization

Price on request

NovaBioAssays emphasizes the Reference Standard and Biosimilarity Characterization via LC-MS and LC-MS/MS technology, including:

  • nIntact Mass measurement
  • Peptide Mapping
  • Glycan Profiling
  • Post-translational Modification Analysis
  • Biosimilarity with HDX MS

NovaBioAssays emphasizes the Reference Standard and Biosimilarity Characterization via LC-MS and LC-MS/MS technology, including:

  • nIntact Mass measurement
  • Peptide Mapping
  • Glycan Profiling
  • Post-translational Modification Analysis
  • Biosimilarity with HDX MS
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ADME/DMPK Studies

Drug Metabolism and Pharmacokinetics
Price on request
  • Whole blood or plasma stability test
  • Microsomal and hepatocyte stability evaluation
  • Metabolite identification/profiling
  • Enzymatic reaction phenotyping
  • Protein binding evaluation using ultracentrifugation or RED (rapid equilibrium dialysis)
  • Whole blood or plasma stability test
  • Microsomal and hepatocyte stability evaluation
  • Metabolite identification/profiling
  • Enzymatic reaction phenotyping
  • Protein binding evaluation using ultracentrifugation or RED (rapid equilibrium dialysis)
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Bioanalysis

Price on request
  • Independent Quality Assurance
  • Validated and calibrated equipment
  • Method development and validation
  • Validated Watson LIMS 7.5 software
  • Validated AB Sciex Analyst 1.6.2 software
  • Validated Rees Scientific Environment Temperature and Moisture Monitoring
  • Independent Quality Assurance
  • Validated and calibrated equipment
  • Method development and validation
  • Validated Watson LIMS 7.5 software
  • Validated AB Sciex Analyst 1.6.2 software
  • Validated Rees Scientific Environment Temperature and Moisture Monitoring
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Drug Discovery & Development

Price on request

Drug Discovery & Development Services

Drug Discovery & Development Services

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Pharmacology & Toxicology

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Pharmacology & Toxicology Services

Pharmacology & Toxicology Services

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Pharmacology

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Pharmacology Services

Pharmacology Services

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Biology

Price on request

Biology Services

Biology Services

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Biochemistry & Molecular Biology

Price on request

Biochemistry & Molecular Biology Services

Biochemistry & Molecular Biology Services

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Protein Services

Price on request

Protein Services

Protein Services

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Antibody Services

Price on request

Antibody Services

Antibody Services

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Biomarkers

Price on request

Biomarkers Services

Biomarkers Services

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Omics

Price on request

Omics Services

Omics Services

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Metabolomics

Price on request

Metabolomics Services

Metabolomics Services

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Protein Purification

Price on request

Protein Purification and Quantification Services

Protein Purification and Quantification Services

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Chengjie Ji

President

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