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Nova Research Labs LLC.

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New Orleans, Louisiana, US

About Nova Research Labs LLC.

The NOVA team has been involved in ion channel research since the 1980’s. They have a long history of providing data for regulatory guidelines. For instance, we conducted the hERG screening for the original ILSI/HESI safety study which became the groundwork for the current S7B guidelines, and members of our team have been contracted by the FDA to provide ion channel screening in support of the new CiPA safety assessment guidelines. NOVA has worked with 100’s of companies along with multiple government agencies to help de-risk compounds.

The NOVA Difference

  • Experience in CRO business since 1996
  • We offer full CiPA ion channel panel
  • We offer screening with native adult human cardiac myocytes
  • Provided the hERG screening for the ILSI-HESI study which became foundation for S7B guidelines
  • Contracted by FDA since 2014 to provide manual ion channel screening in support of the CiPA initiative
  • Our data is being used by the FDA to parameterize their in silico AP model
  • Our data is also used as the standard against which automated patch clamp data is compared

Diversity Certificates

Small business

Our Services (14)


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hERG Channel Inhibition Assay

Price on request
Request a quote for more information about this service.

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Ion Channel Screening Assays

Price on request

GLP hERG (IKr)

  • Required for IND submission
  • Physiologic temperature
  • Dose-response assessment
  • Dose formulation analysis

Other GLP ion channels:

  • Cav1.2 (L-type Ca)
  • Nav1.5 (cardiac INa)
  • KvLQT1/minK (IKs)
  • Kv4.3 (Ito)
  • Kir2.1 (IK1)


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Cardiac Channel Assays

Price on request

Cardiac Action Potential

Cardiac action potentials allow an integrated look at the effects of a drug on ion channels important in cardiac conduction and repolarization.

  • Assays can be performed using atrial or ventricular myocytes or Purkinje fibers
  • Cells can be from guinea pig, rabbit, canine
  • Acutely isolated adult human cells available
  • Normal or diseased human cells available

Advantages:

  • Indicator of multi-channel effects
  • Can detect proarrhythmic markers
  • Adult human cardiac insight when human myocytes are used
  • Avoids issues of embryonic phenotype observed with iPS-CMs


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Comprehensive in vitro Proarrhythmia Assay (CiPA)

Price on request

The Comprehensive in vitro Proarrhythmic Assay (CiPA) is a series of assays designed to predict arrhythmias and not simply QT prolongation.

Nova staff have provided the manual ion channel data for the FDA which has been used to parameterize the in silico action potential model and provide a benchmark for the ILSI/HESI automated patch clamp study.

With our experienced staff, we can fulfill all of the CiPA recommendations.


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In vitro Protein Binding Assays

Price on request

Our protein binding assays allow for the characterization of serum proteins onion channel block. Only the free (unbound) form of the drug can interact with ion channels. If the protein binding of your drug is not known or if there is a species-dependent difference in protein binding, this assay can provide valuable insight.

Using the manual patch clamp technique, the potency of your drug can be examined in the presence and absence of human serum albumin. This will allow for a more relevant comparison with in vivo concentrations.

This assay can be performed on any of the following:

  • hERG (IKr)
  • Cav1.2 (L-type Ca)
  • Nav1.5 (cardiac INa)
  • KvLQT1/minK (IKs)
  • Kv4.3 (Ito)
  • Kir2.1 (IK1)


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In vitro Ion Channel Assays

Price on request

Cellular Ion Channel Assays Services


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In vitro Cardiotoxicity Screening

Price on request

Cardiovascular Toxicology Services


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Cell-Based Assays

Price on request

Cell-Based Assays Services


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Biology

Price on request

Biology Services


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Toxicology

Price on request

Toxicology Services


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Pharmacology & Toxicology

Price on request

Pharmacology & Toxicology Services


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Drug Discovery & Development

Price on request

Drug Discovery & Development Services


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Biomolecular Interaction Analysis

Price on request

Biomolecular Interaction Analysis Services


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Biochemistry & Molecular Biology

Price on request

Biochemistry & Molecular Biology Services


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Benjamin Butterfield

Business Development

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