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Northern Biomedical Research, Inc.

Spring Lake, Michigan, US

For over twenty years, Northern Biomedical Research has collaborated with clients in the basic science, pharmaceutical and biomedical device communities to provide in vivo support in the development of treatments for diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis (Lou Gehrig’s disease), multiple sclerosis, epilepsy, CNS oncology, lysosomal storage disorders and spinal muscular atrophy. The extensive experience, meticulous research and constant innovation of our scientists, surgeons and technicians put NBR in the forefront of CNS-targeted delivery and device research. We specialize in characterizing the pharmacology, toxicology, distribution (in CSF and parenchyma) and pharmacokinetic profiles of potential neuropharmaceuticals, evaluating delivery systems and devices, and testing novel surgical and therapeutic protocols. Techniques used provide... Show more »

For over twenty years, Northern Biomedical Research has collaborated with clients in the basic science, pharmaceutical and biomedical device communities to provide in vivo support in the development of treatments for diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis (Lou Gehrig’s disease), multiple sclerosis, epilepsy, CNS oncology, lysosomal storage disorders and spinal muscular atrophy. The extensive experience, meticulous research and constant innovation of our scientists, surgeons and technicians put NBR in the forefront of CNS-targeted delivery and device research. We specialize in characterizing the pharmacology, toxicology, distribution (in CSF and parenchyma) and pharmacokinetic profiles of potential neuropharmaceuticals, evaluating delivery systems and devices, and testing novel surgical and therapeutic protocols. Techniques used provide unprecedented access to the CNS with minimal anatomical or physiological compromise. The results provide quality, precise and repeatable data on an assured basis, while working within a GLP environment. We look forward to discussing and implementing your research objectives.

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Northern Biomedical Research, Inc. has not listed any services.

In vivo Gene Delivery Studies
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Evaluation of rAAV Mediated Gene Delivery and Transduction Pattern in the Non Human Primate Brain

Evaluation of rAAV Mediated Gene Delivery and Transduction Pattern in the Non Human Primate Brain

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Drug Development
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The extensive experience, meticulous research and constant innovation of our scientists, surgeons and technicians put NBR in the forefront of CNS-targeted delivery and device research. We specialize in characterizing the pharmacology, toxicology, distribution (in CSF and parenchyma) and pharmacokinetic profiles of potential... Show more »

The extensive experience, meticulous research and constant innovation of our scientists, surgeons and technicians put NBR in the forefront of CNS-targeted delivery and device research. We specialize in characterizing the pharmacology, toxicology, distribution (in CSF and parenchyma) and pharmacokinetic profiles of potential neuropharmaceuticals, evaluating delivery systems and devices, and testing novel surgical and therapeutic protocols. Techniques used provide unprecedented access to the CNS with minimal anatomical or physiological compromise. The results provide quality, precise and repeatable data on an assured basis, while working within a GLP environment.

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CNS/Neurology
Animal Surgery
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For over twenty years, NBR has been the leader in nonclinical surgical implants and targeted delivery of large and small molecules to the CNS, utilizing intracerebroventricular, intraparenchymal, intrathecal and epidural routes of administration. A catheter is implanted in the region of interest and terminates in a subcutaneous... Show more »

For over twenty years, NBR has been the leader in nonclinical surgical implants and targeted delivery of large and small molecules to the CNS, utilizing intracerebroventricular, intraparenchymal, intrathecal and epidural routes of administration. A catheter is implanted in the region of interest and terminates in a subcutaneous access port (for single bolus injections or sample collections), implantable osmotic or mechanical infusion pump, or exteriorized for attachment to an ambulatory infusion pump. The experienced and capable surgical staff also performs specialty surgical procedures and microsurgical applications. In addition to our current expertise, NBR is also developing a platform that will provide real time, MRI-guided intraparenchymal or intracebroventricular drug delivery.

Surgical procedures completed at NBR comply with all applicable sections of the current version of the Animal Welfare Act, the Guide for the Care and Use of Laboratory Animals, the Institute of Laboratory Animal Resources, the Commission on Life Sciences, the National Research Council and must be approved by the Institutional Animal Care and Use Committee. All surgeries are completed in a sterile surgical suite under aseptic conditions.

Neurosurgical procedures are completed by a highly trained staff with superior technical ability and extensive neurosurgical experience. Surgery at NBR utilizes state of the art equipment, quality medical products and novel techniques for precision targeting of minute structures. Surgical recovery is closely monitored with strict adherence to established post-surgical care guidelines and protocols. All procedures are performed according to specific study protocols and in accordance with the Standard Operating Procedures of NBR.

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CNS/Neurology Animal Models
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Epilepsy & Seizure Animal Models
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Multiple Sclerosis Animal Models
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ALS Animal Models
Amyotrophic Lateral Sclerosis Animal Models
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Huntington's Disease Animal Models
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Parkinsons Disease Animal Models
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Alzheimer's Disease Animal Models
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Clinical Magnetic Resonance Imaging (MRI)
Clinical Magnetic Resonance Imaging
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NBR is equipped with an on-site MRI unit to meet all imaging needs. Located in its own bay with dedicated electrical and environmental controls, the Philips 3.0T Achieva X series unit combines a user friendly interface and decreased scanning time with superb image quality. Whether it is immediate access for acute imaging or the... Show more »

NBR is equipped with an on-site MRI unit to meet all imaging needs. Located in its own bay with dedicated electrical and environmental controls, the Philips 3.0T Achieva X series unit combines a user friendly interface and decreased scanning time with superb image quality. Whether it is immediate access for acute imaging or the collection of longitudinal study data, the state of the art scanner offers a wide range of applications designed to meet study specific goals. A variety of interchangeable imaging coils and various imaging modalities allow the experienced technical staff to tailor a specific scanning protocol to meet individual research needs.

MRI cartography guides NBR’s intraparenchymal and intracebroventricular stereotaxic surgical procedures. Study specific imaging protocols are developed to collect and characterize longitudinal study data. NBR is currently working to develop a real time, MRI guided intraparenchymal or intracerebroventricular drug delivery platform. Specialty imaging modalities are also available including whole body imaging (MobiView), diffusion tensor imaging (DTI – Fiber Tracking) and spectroscopy. The 3.0T clinical scanner is also capable of performing fMRI, angiography, DWIBS (diffusion-weighted whole-body imaging with background body signal suppression) and has a complete cardiac package installed. Studies have been performed in multiple species utilizing the MRI to track test article distribution following bolus or continuous administration via ICV or IT-L administration.

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rAAV Genome Editing
Recombinant Adeno-Associated Virus Mediated Genome Editing
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rAAV-mediated Gene Delivery in the Brain by Systemic Administration

rAAV-mediated Gene Delivery in the Brain by Systemic Administration

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Animal Models and Studies
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Animal Model in vivo Analyses
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Animal Physiology Analyses
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In vivo Assays
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Animal Models of Disease
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Clinical Research
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Medical Imaging Services
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Biology
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Cells and Tissues
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Discovery Pathology
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Genetic Engineering
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Drug Discovery & Development
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