Noble Life Sciences

Medical Device testing services in Orthopedics, Spinal Fusion, Cardiovascular, Trauma, Wound Healing, Imaging

Broad range of rodent in vivo efficacy PK/PD models

Standard and fast protocols, multiple adjuvant, antigen and immunization options; sample processing, purification and ELISA

Animal blood, serum and tissue from various species; aseptic collection

Xenograft tumors are usually established via subcutaneous inoculation of a predetermined number of tumor cells into the flank of nude mice. Xenograft models are commonly used to determine ideal drug dosing, treatment schedules, and routes of drug administration that maximize anti-tumor efficacy and therapeutic window.

Pricing: per animal
Average turnaround time: 30 days

METHODOLOGY:
- Human cancer cells are injected into 6-week old female NU NU mice.
- Tumor size measurements are initiated 8 days post inoculation and monitored two times per week.
- Tumor measurements are evaluated using calipers; tumor size is calculated as: MIN (L:W)2x MAX(L:W)/2.

OPTIONS:
- Animals: Mice or Rats
- Cell Line: Client-specified strain
- Route of Drug Administration: Intraperitoneal, intramuscular, intratumoral, intravenous, subcutaneous
- Reference Substance & Control: Client-specified reference drug; vehicle
- Length/Endpoint: Death or protocol-specified endpoint
- Assays & Measurements: Tumor growth rate, tumor growth delay, tumor growth inhibition, PK/PD analyses, molecular analyses

(See storefront attachment for more info.)

Mouse, Guinea Pig, Ferret, Rat, Rabbit, Sheep and Goat
Standard or FAST Protocol

Immunogenicity and repeat dose toxicity, biosdistribution, reproductive and developmental toxicity testing as well as product release testing

GLP

Infectious disease models

Complicated skin and soft tissue infections are frequently encountered in clinical practice and are a significant cause of morbidity and mortality in hospitalized patients. The neutropenic mouse thigh model of infection has been used extensively to test and benchmark antimicrobial drugs leading to a significant impact on our current knowledge of antimicrobial pharmacology. This model allows the quantitative comparison of different agents and different dosing regimes and the determination of the time-course of antimicrobial activity under conditions optimal for efficacy, i.e., neutropenia. Because the pharmacology of antimicrobial agents is affected by the presence of neutrophils, animals are commonly rendered neutropenic with cytotoxic agents like cyclophosphamide, the most frequently used immunosuppressive agent in animal infection models.

Turnaround time: Average 30 days

Implantable continuous infusion osmotic pumps have several applications in preclinical drug development. The pumps enable continuous, controlled dosing and thereby allow the achievement of steady state conditions and accurate compound delivery.

Turnaround time: Average 45 days

Vaccine Models including RSV and Influenza
Other Mouse Models for In Vivo Study Challenges
Expert Cotton Rat Model

Turnaround time: Average 30 days

Vaccine Models including RSV and Influenza
Other Mouse Models for In Vivo Study Challenges
Expert Cotton Rat Model

Turnaround time: Average 30 days

Services included customized contract breeding of your genetically altered mouse and rat research models, genotyping, and delivery of the exact quantity, sex, age and genotype of study animal groups to free your vivarium capacity. Client receives rapid feedback, turnaround time, and regular updates on colony development, customized to meet their immediate needs

In vivo xenograft studies

Mouse models of cancer have consistently been used to determine the in vivo activity of new anti-cancer therapeutics prior to clinical development and testing in humans.

The most common models are xenografts of human tumors and cell lines grown subcutaneously in
immunodeficient mice such as athymic (nude) or severe combined immune deficient (SCID) mice. These mouse strains exhibit very high take rates for xenografts, making them ideal hosts for in vivo propagation of human tumor cells.

Xenograft tumors are usually established via subcutaneous inoculation of a predetermined number of tumor cells into the flank of nude mice. Xenograft models are commonly used to determine ideal drug dosing, treatment schedules, and routes of drug administration that maximize anti-tumor efficacy and therapeutic window.

Pricing: per animal
Average turnaround time: 30 days

METHODOLOGY:
- Human cancer cells are injected into 6-week old female NU NU mice.
- Tumor size measurements are initiated 8 days post inoculation and monitored two times per week.
- Tumor measurements are evaluated using calipers; tumor size is calculated as: MIN (L:W)2x MAX(L:W)/2.

OPTIONS:
- Animals: Mice or Rats
- Cell Line: Client-specified strain
- Route of Drug Administration: Intraperitoneal, intramuscular, intratumoral, intravenous, subcutaneous
- Reference Substance & Control: Client-specified reference drug; vehicle
- Length/Endpoint: Death or protocol-specified endpoint
- Assays & Measurements: Tumor growth rate, tumor growth delay, tumor growth inhibition, PK/PD analyses, molecular analyses

(See storefront attachment for more info.)

Formulation & Manufacturing Services

Pharmacology Services

Drug Discovery & Development Services