1386200410850 b2971481cd01f53638d43b3fb2d4b66e

Noble Life Sciences

Gaithersburg, Maryland, US

Noble Life Sciences is a woman owned preclinical contract research organization offering GLP and non-GLP services, in both large and small animals, for the development of drugs, vaccines, and medical devices. Preclinical development services include PK and PD studies; biodistribution studies; immunization and immunogenicity testing; early safety assessments; reproductive and developmental toxicity testing; surgical services; medical device protocol development and testing; analytical and imaging services; and preclinical formulation development. Our services also include the derivation and maintenance of animal breeding colonies, animal housing and husbandry, the development of disease and animal models, and the production of custom antibodies and are backed by AAALAC accreditation, OLAW assurance, a USDA license and over 50 years of experience.

Facility certifications:
- AAALAC Accredited
- OLAW Assurance
-... Show more »

Noble Life Sciences is a woman owned preclinical contract research organization offering GLP and non-GLP services, in both large and small animals, for the development of drugs, vaccines, and medical devices. Preclinical development services include PK and PD studies; biodistribution studies; immunization and immunogenicity testing; early safety assessments; reproductive and developmental toxicity testing; surgical services; medical device protocol development and testing; analytical and imaging services; and preclinical formulation development. Our services also include the derivation and maintenance of animal breeding colonies, animal housing and husbandry, the development of disease and animal models, and the production of custom antibodies and are backed by AAALAC accreditation, OLAW assurance, a USDA license and over 50 years of experience.

Facility certifications:
- AAALAC Accredited
- OLAW Assurance
- USDA Licensed
- FDA Inspected
-Woman owned small business

Standard shipment requests:
Contact Shipping Coordinator prior to any arranged scheduling

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Medical Device Testing
Price on request

Medical Device testing services in Orthopedics, Spinal Fusion, Cardiovascular, Trauma, Wound Healing, Imaging

Medical Device testing services in Orthopedics, Spinal Fusion, Cardiovascular, Trauma, Wound Healing, Imaging

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In vivo Drug Efficacy Testing
Price on request

Broad range of rodent in vivo efficacy PK/PD models

Broad range of rodent in vivo efficacy PK/PD models

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Rabbit
Ferret
Mouse
Rat
Cotton Rat
Animal Immunization for Antibody Production
Price on request
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Hamster
Rabbit
Guinea pig
Ferret
Sheep
Goat
Mouse
Rat
Polyclonal Antibody Production
Price on request

Standard and fast protocols, multiple adjuvant, antigen and immunization options; sample processing, purification and ELISA

Standard and fast protocols, multiple adjuvant, antigen and immunization options; sample processing, purification and ELISA

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Animal Plasma and Serum
Price on request
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Animal Tissue Procurement
Price on request

Animal blood, serum and tissue from various species; aseptic collection

Animal blood, serum and tissue from various species; aseptic collection

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In vivo Immunogenicity Assays
Price on request
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Hamster
Rabbit
Guinea pig
Ferret
Sheep
Goat
Mouse
Pig
Rat
Cotton Rat
Mini Pig
swine
Drug Release Studies/In Vitro Release Testing (IVRT)
Price on request
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Cell Line Derived Xenograft (CDX) Models
Cell Line Derived Xenograft Models
Price on request

Xenograft tumors are usually established via subcutaneous inoculation of a predetermined number of tumor cells into the flank of nude mice. Xenograft models are commonly used to determine ideal drug dosing, treatment schedules, and routes of drug administration that maximize anti-tumor efficacy and therapeutic window.

Pricing:... Show more »

Xenograft tumors are usually established via subcutaneous inoculation of a predetermined number of tumor cells into the flank of nude mice. Xenograft models are commonly used to determine ideal drug dosing, treatment schedules, and routes of drug administration that maximize anti-tumor efficacy and therapeutic window.

Pricing: per animal
Average turnaround time: 30 days

METHODOLOGY:
- Human cancer cells are injected into 6-week old female NU NU mice.
- Tumor size measurements are initiated 8 days post inoculation and monitored two times per week.
- Tumor measurements are evaluated using calipers; tumor size is calculated as: MIN (L:W)2x MAX(L:W)/2.

OPTIONS:
- Animals: Mice or Rats
- Cell Line: Client-specified strain
- Route of Drug Administration: Intraperitoneal, intramuscular, intratumoral, intravenous, subcutaneous
- Reference Substance & Control: Client-specified reference drug; vehicle
- Length/Endpoint: Death or protocol-specified endpoint
- Assays & Measurements: Tumor growth rate, tumor growth delay, tumor growth inhibition, PK/PD analyses, molecular analyses

(See storefront attachment for more info.)

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Mouse
Monoclonal Antibody (mAb) Production
Price on request

Mouse, Guinea Pig, Ferret, Rat, Rabbit, Sheep and Goat
Standard or FAST Protocol

Mouse, Guinea Pig, Ferret, Rat, Rabbit, Sheep and Goat
Standard or FAST Protocol

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Hamster
Rabbit
Guinea pig
Ferret
Sheep
Goat
Mouse
Rat
In vivo Toxicity Testing
Price on request

Immunogenicity and repeat dose toxicity, biosdistribution, reproductive and developmental toxicity testing as well as product release testing

GLP

Immunogenicity and repeat dose toxicity, biosdistribution, reproductive and developmental toxicity testing as well as product release testing

GLP

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Hamster
Rabbit
Guinea pig
Ferret
Sheep
Mouse
Pig
Rat
Cotton Rat
Bacterial Infection Animal Models
Price on request

Infectious disease models

Complicated skin and soft tissue infections are frequently encountered in clinical practice and are a significant cause of morbidity and mortality in hospitalized patients. The neutropenic mouse thigh model of infection has been used extensively to test and benchmark antimicrobial drugs leading to a... Show more »

Infectious disease models

Complicated skin and soft tissue infections are frequently encountered in clinical practice and are a significant cause of morbidity and mortality in hospitalized patients. The neutropenic mouse thigh model of infection has been used extensively to test and benchmark antimicrobial drugs leading to a significant impact on our current knowledge of antimicrobial pharmacology. This model allows the quantitative comparison of different agents and different dosing regimes and the determination of the time-course of antimicrobial activity under conditions optimal for efficacy, i.e., neutropenia. Because the pharmacology of antimicrobial agents is affected by the presence of neutrophils, animals are commonly rendered neutropenic with cytotoxic agents like cyclophosphamide, the most frequently used immunosuppressive agent in animal infection models.

Turnaround time: Average 30 days

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IBS/IBD Animal Models
Irritable Bowel Syndrome/Disease Animal Models
Price on request
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Assay Development
Price on request
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Infusion Pump Implantation in Animals
Price on request

Implantable continuous infusion osmotic pumps have several applications in preclinical drug development. The pumps enable continuous, controlled dosing and thereby allow the achievement of steady state conditions and accurate compound delivery.

Turnaround time: Average 45 days

Implantable continuous infusion osmotic pumps have several applications in preclinical drug development. The pumps enable continuous, controlled dosing and thereby allow the achievement of steady state conditions and accurate compound delivery.

Turnaround time: Average 45 days

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Influenza Animal Models
Price on request

Vaccine Models including RSV and Influenza
Other Mouse Models for In Vivo Study Challenges
Expert Cotton Rat Model

Turnaround time: Average 30 days

Vaccine Models including RSV and Influenza
Other Mouse Models for In Vivo Study Challenges
Expert Cotton Rat Model

Turnaround time: Average 30 days

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Mouse
Rat
Influenza
RSV
RSV Animal Models
Respiratory Syncytial Virus Animal Models
Price on request

Vaccine Models including RSV and Influenza
Other Mouse Models for In Vivo Study Challenges
Expert Cotton Rat Model

Turnaround time: Average 30 days

Vaccine Models including RSV and Influenza
Other Mouse Models for In Vivo Study Challenges
Expert Cotton Rat Model

Turnaround time: Average 30 days

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Rodent Breeding
Price on request

Services included customized contract breeding of your genetically altered mouse and rat research models, genotyping, and delivery of the exact quantity, sex, age and genotype of study animal groups to free your vivarium capacity. Client receives rapid feedback, turnaround time, and regular updates on colony development, customized to meet their immediate needs

Services included customized contract breeding of your genetically altered mouse and rat research models, genotyping, and delivery of the exact quantity, sex, age and genotype of study animal groups to free your vivarium capacity. Client receives rapid feedback, turnaround time, and regular updates on colony development, customized to meet their immediate needs

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Human Tumor Xenograft Models
Price on request

In vivo xenograft studies

Mouse models of cancer have consistently been used to determine the in vivo activity of new anti-cancer therapeutics prior to clinical development and testing in humans.

The most common models are xenografts of human tumors and cell lines grown subcutaneously in
immunodeficient mice such as athymic... Show more »

In vivo xenograft studies

Mouse models of cancer have consistently been used to determine the in vivo activity of new anti-cancer therapeutics prior to clinical development and testing in humans.

The most common models are xenografts of human tumors and cell lines grown subcutaneously in
immunodeficient mice such as athymic (nude) or severe combined immune deficient (SCID) mice. These mouse strains exhibit very high take rates for xenografts, making them ideal hosts for in vivo propagation of human tumor cells.

Xenograft tumors are usually established via subcutaneous inoculation of a predetermined number of tumor cells into the flank of nude mice. Xenograft models are commonly used to determine ideal drug dosing, treatment schedules, and routes of drug administration that maximize anti-tumor efficacy and therapeutic window.

Pricing: per animal
Average turnaround time: 30 days

METHODOLOGY:
- Human cancer cells are injected into 6-week old female NU NU mice.
- Tumor size measurements are initiated 8 days post inoculation and monitored two times per week.
- Tumor measurements are evaluated using calipers; tumor size is calculated as: MIN (L:W)2x MAX(L:W)/2.

OPTIONS:
- Animals: Mice or Rats
- Cell Line: Client-specified strain
- Route of Drug Administration: Intraperitoneal, intramuscular, intratumoral, intravenous, subcutaneous
- Reference Substance & Control: Client-specified reference drug; vehicle
- Length/Endpoint: Death or protocol-specified endpoint
- Assays & Measurements: Tumor growth rate, tumor growth delay, tumor growth inhibition, PK/PD analyses, molecular analyses

(See storefront attachment for more info.)

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In vitro Diagnostic Development
Price on request
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Medical Device Development
Price on request
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Gastroenterology Animal Models
Price on request
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Animal Model in vivo Analyses
Price on request
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Safety Pharmacology & Efficacy Testing
Price on request
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Biochemistry & Molecular Biology
Price on request
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Toxicology
Price on request
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Rabbit
Guinea pig
Ferret
Sheep
Mouse
Pig
Rat
Cotton Rat
Oncology Animal Models
Price on request
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Infectious Disease Animal Models
Price on request
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Cells and Tissues
Price on request
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Animal Models and Studies
Price on request
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Formulation Services
Price on request

Formulation & Manufacturing Services

Formulation & Manufacturing Services

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Biology
Price on request
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Therapeutic Monoclonal Antibody (mAb) Development
Price on request
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Animal Model Housing and Maintenance
Price on request
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Experimental Design
Price on request
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Project and Process Management
Price on request
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Animal Biospecimens
Price on request
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Rabbit
Guinea pig
Ferret
Sheep
Mouse
Pig
Rat
Cotton Rat
Animal Models of Disease
Price on request
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Animal Physiology Analyses
Price on request
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Medical Devices & Diagnostics
Price on request
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Pharmacology & Toxicology
Price on request
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Xenograft Models
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Antibody Services
Price on request
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Biospecimens
Price on request
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Animal Surgery
Price on request
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Animal Husbandry
Price on request
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Drug Potency and Efficacy Testing
Price on request

Drug Potency and Efficacy Testing Services

Drug Potency and Efficacy Testing Services

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Drug Discovery & Development
Price on request

Drug Discovery & Development Services

Drug Discovery & Development Services

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Pharmacology
Price on request

Pharmacology Services

Pharmacology Services

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2018-07-15 18:48:11 -0400

Net Promoter Score of 9 received for Animal Plasma and Serum.

Additional Ratings: satisfaction with deliverable: 9, satisfaction with timeliness: 9.
2018-05-22 09:21:07 -0400

Net Promoter Score of 10 received for Bacterial Infection Animal Models.

Additional Ratings: satisfaction with deliverable: 10, satisfaction with timeliness: 10.
2018-05-18 19:22:44 -0400

Net Promoter Score of 8 received for Animal Biospecimens.

Additional Ratings: satisfaction with deliverable: 8, satisfaction with timeliness: 8.
2018-01-19 15:15:37 -0500

Net Promoter Score of 9 received for In vivo Toxicity Testing.

Additional Ratings: satisfaction with deliverable: 8, satisfaction with timeliness: 7.
2017-07-18 16:46:21 -0400

Net Promoter Score of 4 received for In vivo Immunogenicity Assays.

Additional Ratings: satisfaction with deliverable: 4, satisfaction with timeliness: 5.

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