Noble Life Sciences
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Gaithersburg, Maryland, US
Noble Life Sciences is a woman owned preclinical contract research organization offering GLP and non-GLP services, in both large and small animals, for the development of drugs, vaccines, and medical devices. Preclinical development services include PK and PD studies; biodistribution studies;... Show more »
Noble Life Sciences is a woman owned preclinical contract research organization offering GLP and non-GLP services, in both large and small animals, for the development of drugs, vaccines, and medical devices. Preclinical development services include PK and PD studies; biodistribution studies; immunization and immunogenicity testing; early safety assessments; reproductive and developmental toxicity testing; surgical services; medical device protocol development and testing; analytical and imaging services; and preclinical formulation development. Our services also include the derivation and maintenance of animal breeding colonies, animal housing and husbandry, the development of disease and animal models, and the production of custom antibodies and are backed by AAALAC accreditation, OLAW assurance, a USDA license and over 50 years of experience. Facility certifications: - AAALAC Accredited - OLAW Assurance - USDA Licensed - FDA Inspected -Woman owned small business Standard shipment requests: Contact Shipping Coordinator prior to any arranged scheduling
Medical Device testing services in Orthopedics, Spinal Fusion, Cardiovascular, Trauma, Wound Healing, Imaging
Medical Device testing services in Orthopedics, Spinal Fusion, Cardiovascular, Trauma, Wound Healing, Imaging
Broad range of rodent in vivo efficacy PK/PD models
Broad range of rodent in vivo efficacy PK/PD models
Standard and fast protocols, multiple adjuvant, antigen and immunization options; sample processing, purification and ELISA
Standard and fast protocols, multiple adjuvant, antigen and immunization options; sample processing, purification and ELISA
Animal blood, serum and tissue from various species; aseptic collection
Animal blood, serum and tissue from various species; aseptic collection
Xenograft tumors are usually established via subcutaneous inoculation of a predetermined number of tumor cells into the flank of nude mice. Xenograft models are commonly used to determine ideal drug dosing, treatment schedules, and routes of drug administration that maximize anti-tumor efficacy and therapeutic window.
Pricing:... Show more »
Xenograft tumors are usually established via subcutaneous inoculation of a predetermined number of tumor cells into the flank of nude mice. Xenograft models are commonly used to determine ideal drug dosing, treatment schedules, and routes of drug administration that maximize anti-tumor efficacy and therapeutic window.
Pricing: per animal
Average turnaround time: 30 days
METHODOLOGY:
OPTIONS:
(See storefront attachment for more info.)
Mouse, Guinea Pig, Ferret, Rat, Rabbit, Sheep and Goat
Standard or FAST Protocol
Mouse, Guinea Pig, Ferret, Rat, Rabbit, Sheep and Goat
Standard or FAST Protocol
Immunogenicity and repeat dose toxicity, biosdistribution, reproductive and developmental toxicity testing as well as product release testing
GLP
Immunogenicity and repeat dose toxicity, biosdistribution, reproductive and developmental toxicity testing as well as product release testing
GLP
Infectious disease models
Complicated skin and soft tissue infections are frequently encountered in clinical practice and are a significant cause of morbidity and mortality in hospitalized patients. The neutropenic mouse thigh model of infection has been used extensively to test and benchmark antimicrobial drugs leading to a... Show more »
Infectious disease models
Complicated skin and soft tissue infections are frequently encountered in clinical practice and are a significant cause of morbidity and mortality in hospitalized patients. The neutropenic mouse thigh model of infection has been used extensively to test and benchmark antimicrobial drugs leading to a significant impact on our current knowledge of antimicrobial pharmacology. This model allows the quantitative comparison of different agents and different dosing regimes and the determination of the time-course of antimicrobial activity under conditions optimal for efficacy, i.e., neutropenia. Because the pharmacology of antimicrobial agents is affected by the presence of neutrophils, animals are commonly rendered neutropenic with cytotoxic agents like cyclophosphamide, the most frequently used immunosuppressive agent in animal infection models.
Turnaround time: Average 30 days
Implantable continuous infusion osmotic pumps have several applications in preclinical drug development. The pumps enable continuous, controlled dosing and thereby allow the achievement of steady state conditions and accurate compound delivery.
Turnaround time: Average 45 days
Implantable continuous infusion osmotic pumps have several applications in preclinical drug development. The pumps enable continuous, controlled dosing and thereby allow the achievement of steady state conditions and accurate compound delivery.
Turnaround time: Average 45 days
Vaccine Models including RSV and Influenza
Other Mouse Models for In Vivo Study Challenges
Expert Cotton Rat Model
Turnaround time: Average 30 days
Vaccine Models including RSV and Influenza
Other Mouse Models for In Vivo Study Challenges
Expert Cotton Rat Model
Turnaround time: Average 30 days
Vaccine Models including RSV and Influenza
Other Mouse Models for In Vivo Study Challenges
Expert Cotton Rat Model
Turnaround time: Average 30 days
Vaccine Models including RSV and Influenza
Other Mouse Models for In Vivo Study Challenges
Expert Cotton Rat Model
Turnaround time: Average 30 days
Services included customized contract breeding of your genetically altered mouse and rat research models, genotyping, and delivery of the exact quantity, sex, age and genotype of study animal groups to free your vivarium capacity. Client receives rapid feedback, turnaround time, and regular updates on colony development, customized to meet their immediate needs
Services included customized contract breeding of your genetically altered mouse and rat research models, genotyping, and delivery of the exact quantity, sex, age and genotype of study animal groups to free your vivarium capacity. Client receives rapid feedback, turnaround time, and regular updates on colony development, customized to meet their immediate needs
In vivo xenograft studies
Mouse models of cancer have consistently been used to determine the in vivo activity of new anti-cancer therapeutics prior to clinical development and testing in humans.
The most common models are xenografts of human tumors and cell lines grown subcutaneously in
immunodeficient mice such as athymic... Show more »
In vivo xenograft studies
Mouse models of cancer have consistently been used to determine the in vivo activity of new anti-cancer therapeutics prior to clinical development and testing in humans.
The most common models are xenografts of human tumors and cell lines grown subcutaneously in
immunodeficient mice such as athymic (nude) or severe combined immune deficient (SCID) mice. These mouse strains exhibit very high take rates for xenografts, making them ideal hosts for in vivo propagation of human tumor cells.
Xenograft tumors are usually established via subcutaneous inoculation of a predetermined number of tumor cells into the flank of nude mice. Xenograft models are commonly used to determine ideal drug dosing, treatment schedules, and routes of drug administration that maximize anti-tumor efficacy and therapeutic window.
Pricing: per animal
Average turnaround time: 30 days
METHODOLOGY:
OPTIONS:
(See storefront attachment for more info.)
Formulation & Manufacturing Services
Formulation & Manufacturing Services
Pharmacology Services
Pharmacology Services
Drug Discovery & Development Services
Drug Discovery & Development Services
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