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NJ Biopharmaceuticals LLC

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N BRUNSWICK, New Jersey, US

About NJ Biopharmaceuticals LLC

NJ Biopharmaceuticals LLC is a Contract Research Organization geared towards providing comprehensive chemistry and biology services to biopharmaceutical- and chemical-based technology companies. The company is located in the Commercialization Center for Innovative Technologies (CCIT), a significant biotech... Show more »

NJ Biopharmaceuticals LLC is a Contract Research Organization geared towards providing comprehensive chemistry and biology services to biopharmaceutical- and chemical-based technology companies. The company is located in the Commercialization Center for Innovative Technologies (CCIT), a significant biotech incubator in in North Brunswick in the heart of New Jersey’s “Research Corridor” with easy access to New Jersey and New York airports.

While the company has a strong background in synthetic organic chemistry and protein based biopharmaceuticals, it is a “differentiated” service provider with a niche in several areas:

  • Expertise in antibody-drug conjugates (ADCs), bioconjugation to proteins and biomaterials, linker chemistry design for conjugations, ADC constructs, and process development for small molecules and ADCs
  • Expertise in multi-step customized flow chemistry synthetic routes for drug intermediates and APIs along with a unique offering to design custom flow chemistry equipment in collaboration with experts at Amar Equipment Pvt. Ltd.
  • Services to manufacture research-grade protein and antibodies
  • Ability to develop plate-based assays to evaluate the ability of compounds to promote or inhibit cell proliferation
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Our Services (15)


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Antibody-Drug Conjugate (ADC) Development

Antibody Drug Conjugate Development
Price on request

Antibody-Drug Conjugates and Payloads: NJ Biopharmaceuticals also has a variety of highly potent warheads/payloads in stock for advancing its clients ADC programs. A selection of cleavable and non-cleavable linkers and spacer molecules is also available. The following is a list of several classes of payloads in the toolbox for... Show more »

Antibody-Drug Conjugates and Payloads: NJ Biopharmaceuticals also has a variety of highly potent warheads/payloads in stock for advancing its clients ADC programs. A selection of cleavable and non-cleavable linkers and spacer molecules is also available. The following is a list of several classes of payloads in the toolbox for preparing ADCs or PDCs:

  • PBD dimer analogs
  • Duocarmycin analogs
  • Auristatin analogs
  • Maytansine analogs
  • Additional payloads (details available on request)
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Protein PEGylation

Price on request

NJ Biopharmaceuticals can offer PEGylation services for proteins and small molecules to significantly improve the physicochemical properties of a drug, increase the solubility of poorly soluble molecules, and reduce the immunogenicity of biopharmaceuticals. The following is a list of the offered services:

NJ Biopharmaceuticals can offer PEGylation services for proteins and small molecules to significantly improve the physicochemical properties of a drug, increase the solubility of poorly soluble molecules, and reduce the immunogenicity of biopharmaceuticals. The following is a list of the offered services:

  • Protein PEGylation
  • Peptide PEGylation
  • Antibody PEGylation
  • Small molecule PEGylation
  • Purification of PEGylated products
  • Process development of PEGylated products
  • Custom synthesis of PEGs
  • Development of PEGylated biosimilars
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Chemical Synthesis

Price on request

NJ Biopharmaceuticals’ team of experienced organic chemists can tackle the synthesis of complex molecules, including chemical intermediates, drug metabolites, process impurities, degradants, reference compounds, preclinical drug candidates, and other organic molecules from diverse industries.

Our custom synthesis expertise... Show more »

NJ Biopharmaceuticals’ team of experienced organic chemists can tackle the synthesis of complex molecules, including chemical intermediates, drug metabolites, process impurities, degradants, reference compounds, preclinical drug candidates, and other organic molecules from diverse industries.

Our custom synthesis expertise includes:

  • Antibody-drug conjugates (ADCs)
  • Bioconjugate chemistry
  • Linker Chemistry
  • Carbohydrate chemistry (Including glucuronides)
  • Catalytic hydrogenation
  • Chiral synthesis and separations
  • General organic and small molecules synthesis.
  • Macrolides
  • Metabolites/ Impurities
  • Organometallic chemistry
  • Suzuki, Stille, Buchwald-Hartwig and other coupling reactions
  • Oxidations
  • Peptide/amino acid synthesis
  • Polycyclic aromatic hydrocarbons
  • Photochemistry
  • Pressure reactions.
  • Stable isotopes including deuterium, 13C, 15N
  • Steroids
  • Sulfonylations
  • Toxic/potent compounds
  • Ugi reactions
  • Wittig reactions
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Cell Line Generation

Price on request

We will establish a stable mammalian cell line for protein and antibody production, normally a time and cost consuming process. We possess extensive experience in cell culture and construct preparation to ensure success of the project. Transient transfection will be used ensure selection of a stable clone.

We will establish a stable mammalian cell line for protein and antibody production, normally a time and cost consuming process. We possess extensive experience in cell culture and construct preparation to ensure success of the project. Transient transfection will be used ensure selection of a stable clone.

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Cytotoxicity Assays

Price on request
Request a quote for more information about this service.

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Cell-Based Assays

Price on request

NJ Biopharmaceuticals will use plate-based assays to characterize the ability of the compounds to promote or inhibit cell proliferation, establish the cytotoxicity of compounds by measuring live/dead cells. Assay optimization would include a time course of incubation and compound concentration analysis. Client will supply proteins for analysis. Functional assays include binding assays.

NJ Biopharmaceuticals will use plate-based assays to characterize the ability of the compounds to promote or inhibit cell proliferation, establish the cytotoxicity of compounds by measuring live/dead cells. Assay optimization would include a time course of incubation and compound concentration analysis. Client will supply proteins for analysis. Functional assays include binding assays.

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Protein Manufacturing

Price on request

NJ Biopharmaceuticals can support the production of research-grade recombinant proteins, mammalian and bacterial. Our experts will promptly identify and evaluate the best expression conditions for your protein, rapid expression of functional protein or antibody. Our preparation includes FPLC and HPLC analysis, QC detection using... Show more »

NJ Biopharmaceuticals can support the production of research-grade recombinant proteins, mammalian and bacterial. Our experts will promptly identify and evaluate the best expression conditions for your protein, rapid expression of functional protein or antibody. Our preparation includes FPLC and HPLC analysis, QC detection using SDS-PAGE and Western blot. Other services, such as MS, are optional. We also provide service of expression and production of biosimilars in HEK293 and CHO cells

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Antibody Manufacturing

Price on request

NJ Biopharmaceuticals can support the production of research-grade recombinant proteins, mammalian and bacterial. Our experts will promptly identify and evaluate the best expression conditions for your protein, rapid expression of functional protein or antibody. Our preparation includes FPLC and HPLC analysis, QC detection using... Show more »

NJ Biopharmaceuticals can support the production of research-grade recombinant proteins, mammalian and bacterial. Our experts will promptly identify and evaluate the best expression conditions for your protein, rapid expression of functional protein or antibody. Our preparation includes FPLC and HPLC analysis, QC detection using SDS-PAGE and Western blot. Other services, such as MS, are optional. We also provide service of expression and production of biosimilars in HEK293 and CHO cells

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Protein Production

Price on request
Request a quote for more information about this service.

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Protein Purification

Price on request

Our state-of-the-art purifications lab is equipped with an army of analytical and preparative HPLC and FPLC instruments and columns, which allows us to handle the most difficult separations for small and large molecules, including antibodies and other proteins. In addition, our LC-MS and Q-TOF mass spectrometers and 300MHz NMR... Show more »

Our state-of-the-art purifications lab is equipped with an army of analytical and preparative HPLC and FPLC instruments and columns, which allows us to handle the most difficult separations for small and large molecules, including antibodies and other proteins. In addition, our LC-MS and Q-TOF mass spectrometers and 300MHz NMR spectrometer give us the capability to offer our clients valuable and reliable analytical data and along with these services. We are continually adding additional instrumentation in order to provide a seamless, uninterrupted operation.

Our Analytical capabilities include:

  • Analytical and preparatory HPLC method development
  • NMR analysis (300 MHz, 1H, 13C, 31P, 19F, multidimensional)
  • Size-exclusion/gel-filtration chromatography
  • LC-MS analysis
  • Chiral separations
  • Stability studies at variable temperature and humidity
  • Purity determinations by HPLC
  • Ion-exchange chromatography
  • Intact mass for protein and protein conjugates using mass spectrometer.
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Protein Characterization

Price on request
Request a quote for more information about this service.

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Biopharmaceutical Process Development

Price on request

NJ Biopharmaceuticals offers process development services for small molecules and protein manufacturing. In addition to traditional batch chemistry, NJ Biopharmaceuticals’ flow chemists have ample experience designing multi-step custom flow chemistry routes to drug intermediates and APIs. They can help you design chemical... Show more »

NJ Biopharmaceuticals offers process development services for small molecules and protein manufacturing. In addition to traditional batch chemistry, NJ Biopharmaceuticals’ flow chemists have ample experience designing multi-step custom flow chemistry routes to drug intermediates and APIs. They can help you design chemical reactions in continuous flow rather than batch, which offers many advantages, including: improved safety, better process control, and better heat transfer. In flow, it is possible to perform highly exothermic reactions in a safe and efficient manner.

Additionally, in collaboration with the flow chemistry experts at Amar Equipments Pvt. Ltd., we are able to design customized equipment for all your flow chemistry challenges.

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Flow Chemistry

Price on request

NJ Biopharmaceuticals offers process development services for small molecules and protein manufacturing. In addition to traditional batch chemistry, NJ Biopharmaceuticals’ flow chemists have ample experience designing multi-step custom flow chemistry routes to drug intermediates and APIs. They can help you design chemical... Show more »

NJ Biopharmaceuticals offers process development services for small molecules and protein manufacturing. In addition to traditional batch chemistry, NJ Biopharmaceuticals’ flow chemists have ample experience designing multi-step custom flow chemistry routes to drug intermediates and APIs. They can help you design chemical reactions in continuous flow rather than batch, which offers many advantages, including: improved safety, better process control, and better heat transfer. In flow, it is possible to perform highly exothermic reactions in a safe and efficient manner.

Additionally, in collaboration with the flow chemistry experts at Amar Equipments Pvt. Ltd., we are able to design customized equipment for all your flow chemistry challenges.

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Equipment Design

Price on request

Design of Flow Chemistry Equipment

Design of Flow Chemistry Equipment

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Bioconjugation/Chemical Crosslinking

Price on request

Antibody-drug conjugates (ADC) are comprised of an antibody to which is attached a cytotoxic agent through a linker. The type of linker chemistry used play significantly affects the potency, selectivity, and the pharmacokinetics of the resulting ADC product. NJ Biopharmaceuticals can offer a variety of linkers tailored for... Show more »

Antibody-drug conjugates (ADC) are comprised of an antibody to which is attached a cytotoxic agent through a linker. The type of linker chemistry used play significantly affects the potency, selectivity, and the pharmacokinetics of the resulting ADC product. NJ Biopharmaceuticals can offer a variety of linkers tailored for specific proteins and targets to affect potency, selectivity, and pharmacokinetics of resultant ADCs. These linkers will be selected based on the type of protein, antibody and desired release mechanism for drug molecules keeping long term stability of the protein as one of the priorities.

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Nareshumar Jain

Managing Director

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