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Nilogen Oncosystems, LLC

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Tampa, Florida, US

About Nilogen Oncosystems, LLC

Nilogen Oncosystems is a contract research organization offering cancer drug development services for pharmaceutical and biotechnology companies.

In our CLIA-certified lab, Nilogen performs correlative studies between ex vivo drug responses and multiple aspects of the tumor microenvironment to develop companion diagnostics that can be applied to clinical trials and patient care.

Using fresh patient tissue sample is where it all begins. Our proprietary drug testing platform utilizes fresh patient tumor tissue with intact tumor immune microenvironment to accurately assess the therapeutic potential of drug treatments.

From there, we use complementary platforms with cutting-edge technologies in next-generation sequencing, Nanostring gene expression profiling, flow cytometry, multiplex cytokine assays, confocal microscopy, mass spectrometry, immunohistochemistry and many more to help our research partners take their most promising therapies from preclinical data to clinical results.

Our expert PhD scientists can assist drug developers throughout every phase of the project, from the design and execution of the study to the preparation of the final report, including interpretation of the data.

Diversity Certificates

Small business

Our Services (10)


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Organoids

Price on request

Nilogen’s 3D tumor organoids prepared from fresh patient tumor tissue without any propagation step allow for the evaluation of tumor immune microenvironment, cytotoxic efficacy of immuno-oncology drugs and tumor-drug interaction. 

Immuno-Oncology Oncology Drug Discovery Human tissue Human Oncology Show 6 more tags Show less

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Ex Vivo Models and Assays

Price on request

Nilogen’s proprietary, patient-derived 3D-EX℠ platform rapidly and accurately analyzes the tumor response to oncology and immuno-oncology drugs. The screening system uses microspheroids created from fresh patient tumor tissue without any propagation step to allow for the evaluation of tumor immune microenvironment, cytotoxic efficacy of immuno-oncology drugs and tumor-drug interaction. 3D-EX℠ can also be used in the clinical setting on fresh tumor biopsy samples to guide treatment options in clinical decision-making.


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3D Tumor Models

Price on request
Request a quote for more information about this service.

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Drug Discovery

Price on request

Due to cancer’s complexity, researchers are finding that a combination of drugs will be the most likely solution for a desired immune response. In order to develop effective treatments, researchers need a reliable model that allows them to analyze the drug response profile, including drug-mediated changes on tumor-infiltrating lymphocyte subpopulations and expression of immune checkpoint proteins.

Utilizing our integrated immuno-oncology platforms, Nilogen’s team of experts can provide a comprehensive analysis of drug effects on the tumor microenvironment, and interpret results in a way that informs cancer drug development.

Our platforms enable you to:

  • Test the immunostimulatory activity of rational combination treatments at single or multiple drug concentrations
  • Test the efficacy of immune checkpoint inhibitors, both antibody-based and small molecule
  • Perform ex vivo co-culture experiments with 3D tumor spheroids and matching peripheral blood mononuclear cells obtained from the same patient
  • Test the pharmacodynamic activity of small molecule inhibitors
  • Analyze drug effects on all components of the tumor microenvironment, including cancer-associated fibroblasts
  • Test the effect of a drug on tumor cell viability
  • Develop and optimize genetically modified T-cells in solid tumors


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Pharmacology & Toxicology

Price on request

Pharmacology & Toxicology Services


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3D Tumor Spheroid Invasion Assays

Price on request

3D Microspheroids

The screening system uses microspheroids created from fresh patient tumor tissue without any propagation step to allow for the evaluation of tumor immune microenvironment, cytotoxic efficacy of immuno-oncology drugs and tumor-drug interaction.


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Cell-Based Assays

Price on request

Cell-Based Assays Services


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Cell Invasion & Migration Assays

Price on request

Cell Invasion & Migration Assays Services


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Cell Viability & Proliferation Assays

Price on request
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Cell Death Assays

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SA
JK

Jenny Kreahling

Director of Operations
CL

Colter Lena

Marketing Assoc.
SV

Sigrid Volko

CEO & President

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