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Next Interactions, Inc

Richmond, California, US

At Next Interactions, Inc., we apply the unique expertise of our team and our class-leading platform technologies to your biotech research and development problems.

We offer a suite of services comprising protein-protein interaction (PPI) screens, protein engineering and functional assays. Our clients are in pharma, biotech and academic research.

We use Next-Generation Sequencing (NGS) as the readout, resulting in more complete datasets. Our thoroughly redesigned Y2H system components provide more quantitative and precise measurements of binding partner interactions than conventional Y2H assays. Our platform technology enables us to decipher the full coverage of protein-protein interactions (PPIs). These discoveries have been applied to problems in human health, energy, food security and sustainability.

Our team consists of scientists and entrepreneurs with extensive experience in protein interaction... Show more »

At Next Interactions, Inc., we apply the unique expertise of our team and our class-leading platform technologies to your biotech research and development problems.

We offer a suite of services comprising protein-protein interaction (PPI) screens, protein engineering and functional assays. Our clients are in pharma, biotech and academic research.

We use Next-Generation Sequencing (NGS) as the readout, resulting in more complete datasets. Our thoroughly redesigned Y2H system components provide more quantitative and precise measurements of binding partner interactions than conventional Y2H assays. Our platform technology enables us to decipher the full coverage of protein-protein interactions (PPIs). These discoveries have been applied to problems in human health, energy, food security and sustainability.

Our team consists of scientists and entrepreneurs with extensive experience in protein interaction technologies, cell signaling and systems biology. We use our platform technology and expertise to decipher more complete and accurate protein-protein interactomes to accelerate your research and product development.

Publications

  • Next-Generation Sequencing for Binary Protein-Protein Interactions. Suter B, Zhang X, Pesce CG, Mendelsohn AR, Dinesh-Kumar SP, Mao JH. Front Genet. 2015 Dec 17;6:346. doi: 10.3389/fgene.2015.00346. PMID: 26734059
  • Development and application of a DNA microarray-based yeast two-hybrid system. Suter B, Fontaine JF, Yildirimman R, Raskó T, Schaefer MH, Rasche A, Porras P, Vázquez-Álvarez BM, Russ J, Rau K, Foulle R, Zenkner M, Saar K, Herwig R, Andrade-Navarro MA, Wanker EE. Nucleic Acids Res. 2013 Feb 1;41(3):1496-507. PMID: 23275563
  • The Cross-and-Capture system: a versatile tool in yeast proteomics. Suter B. Methods. 2012 Dec;58(4):360-6. PMID: 22836129
  • Examining protein protein interactions using endogenously tagged yeast arrays: the cross-and-capture system. Suter B, Fetchko MJ, Imhof R, Graham CI, Stoffel-Studer I, Zbinden C, Raghavan M, Lopez L, Beneti L, Hort J, Fillingham J, Greenblatt JF, Giaever G, Nislow C, Stagljar I. Genome Res. 2007 Dec;17(12):1774-82. PMID: 17989249
  • Negative feedback confers mutational robustness in yeast transcription factor regulation. Denby CM, Im JH, Yu RC, Pesce CG, Brem RB. Proc Natl Acad Sci U S A. 2012 Mar 6;109(10):3874-8. PMID: 22355134
  • QiSampler: evaluation of scoring schemes for high-throughput datasets using a repetitive sampling strategy on gold standards. Fontaine JF, Suter B, Andrade-Navarro MA. BMC Res Notes. 2011 Mar 9;4:57. PMID: 21388526
  • Two-hybrid technologies in proteomics research. Suter B, Kittanakom S, Stagljar I. Curr Opin Biotechnol. 2008 Aug;19(4):316-23. Review. PMID: 18619540
  • The Alpha Project: a model system for systems biology research. Yu RC, Resnekov O, Abola AP, Andrews SS, Benjamin KR, Bruck J, Burbulis IE, Colman-Lerner A, Endy D, Gordon A, Holl M, Lok L, Pesce CG, Serra E, Smith RD, Thomson TM, Tsong AE, Brent R. IET Syst Biol. 2008 Sep;2(5):222-33. Review. PMID: 19045818
  • Negative feedback that improves information transmission in yeast signalling. Yu RC, Pesce CG, Colman-Lerner A, Lok L, Pincus D, Serra E, Holl M, Benjamin K, Gordon A, Brent R. Nature. 2008 Dec 11;456(7223):755-61. PMID: 19079053
  • Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons. Benleulmi-Chaachoua A, Chen L, Sokolina K, Wong V, Jurisica I, Emerit MB, Darmon M, Espin A, Stagljar I, Tafelmeyer P, Zamponi GW, Delagrange P, Maurice P, Jockers R. J Pineal Res. 2016 Jan;60(1):95-108. Epub 2015 Nov 30. PMID: 26514267
  • Bacterial Interactomes: Interacting Protein Partners Share Similar Function and Are Validated in Independent Assays More Frequently Than Previously Reported. Shatsky M, Allen S, Gold BL, Liu NL, Juba TR, Reveco SA, Elias DA, Prathapam R, He J, Yang W, Szakal ED, Liu H, Singer ME, Geller JT, Lam BR, Saini A, Trotter VV, Hall SC, Fisher SJ, Brenner SE, Chhabra SR, Hazen TC, Wall JD, Witkowska HE, Biggin MD, Chandonia JM, Butland G. Mol Cell Proteomics. 2016 May;15(5):1539-55. doi: 10.1074/mcp.M115.054692. PMID: 26873250
  • Transcriptional feedback regulation of efflux protein expression for increased tolerance to and production of n-butanol. Boyarskiy S, Davis López S, Kong N, Tullman-Ercek D. Metab Eng. 2016 Jan;33:130-7. doi: 10.1016/j.ymben.2015.11.005. PMID: 26656942
  • Pheromone-induced morphogenesis improves osmoadaptation capacity by activating the HOG MAPK pathway. Baltanás R, Bush A, Couto A, Durrieu L, Hohmann S, Colman-Lerner A. Sci Signal. 2013 Apr 23;6(272):ra26. PMID: 23612707
  • Modelling reveals novel roles of two parallel signalling pathways and homeostatic feedbacks in yeast. Schaber J, Baltanas R, Bush A, Klipp E, Colman-Lerner A. Mol Syst Biol. 2012;8:622. doi: 10.1038/msb.2012.53. PMID: 23149687
  • Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development. Kwon YW, Kim IJ, Wu D, Lu J, Stock WA Jr, Liu Y, Huang Y, Kang HC, DelRosario R, Jen KY, Perez-Losada J, Wei G, Balmain A, Mao JH. Mol Cancer Res. 2012 Jun;10(6):834-44. PMID: 22513362
  • Single-cell quantification of molecules and rates using open-source microscope-based cytometry. Gordon A, Colman-Lerner A, Chin TE, Benjamin KR, Yu RC, Brent R. Nat Methods. 2007 Feb;4(2):175-81. Epub 2007 Jan 21. PMID: 17237792
  • Quantifying small numbers of antibodies with a 'near-universal' protein-DNA chimera. Burbulis I, Yamaguchi K,Yu R, Resnekov O, Brent R. Nat Methods. 2007 Dec;4(12):1011-3. Epub 2007 Nov 4. PMID: 17982460
  • Regulated cell-to-cell variation in a cell-fate decision system. Colman-Lerner A, Gordon A, Serra E, Chin T, Resnekov O, Endy D, Pesce CG, Brent R. Nature. 2005 Sep 29;437(7059):699-706. Erratum in: Nature. 2006 Jan 26;439(7075):502. PMID: 16170311
  • Cyclin D3 activates Caspase 2, connecting cell proliferation with cell death. Mendelsohn AR, Hamer JD, Wang ZB, Brent R. Proc Natl Acad Sci U S A. 2002 May 14;99(10):6871-6. PMID: 12011445
  • Systematic interactome mapping of protein-protein interactions for clinically-relevant human GPCRs. Sokolina K, Kittanakom S, Snider J, Kotlyar M, Maurice P, Gandía J, Benleulmi-Chaachoua A, Tadagaki K, Wong V, Malty RH, Deineko V, Aoki H, Amin S, Yao Z, Morató X, Otasek D, Kobayashi H , Menendez H , Auerbach D, Angers S, Pržulj N, Bouvier M, Babu M, Ciruela F, Jockers R, Jurisica I , and Igor Stagljar I. Mol Syst Biol. 2017 Mar 15;13(3):918. doi: 10.15252/msb.20167430. PMID: 28298427
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Yeast Two-Hybrid Screening
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Our rigorous sample preparation and advanced bioinformatics ensure that you receive the best possible candidate protein-protein interactions. Our experienced team members ensure high quality data that you can trust.

What We Provide

  • High-quality cDNA libraries with large complexities from the source of your choice
  • cDNA... Show more »

Our rigorous sample preparation and advanced bioinformatics ensure that you receive the best possible candidate protein-protein interactions. Our experienced team members ensure high quality data that you can trust.

What We Provide

  • High-quality cDNA libraries with large complexities from the source of your choice
  • cDNA library composition analysis with potential background or false positive clones identified
  • Bait fusion protein construction with expression validation, potential toxicity and self-activation
  • Yeast two-hybrid (Y2H) assay with your chosen bait(s) and cDNA library
  • Sanger sequencing (for conventional Y2H screens, or optional pilot screens)
  • Scored Y2H results scored with customized bioinformatics tools
  • Data on a secure cloud-based platform

NGS Yeast Two Hybrid Screening (NGS-Y2H)

Our rigorous sample preparation, advanced next-generation sequencing (NGS)-coupled yeast two-hybrid platform, and advanced bioinformatics ensure that you receive the best possible candidate protein-protein interactions. Our experienced team members ensure high quality data that you can trust.

What We Provide

  • High-quality cDNA libraries with large complexities from the source of your choice
  • cDNA library composition analysis with potential background or false positive clones identified
  • Bait fusion protein construction with expression validation, potential toxicity and self-activation
  • Yeast two-hybrid (Y2H) assay with your chosen bait(s) and cDNA library
  • NGS data from a standard Illumina platform
  • Scored Y2H results scored with customized bioinformatics tools
  • Data on a secure cloud-based platform
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Next Generation Sequencing (NGS)
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Our rigorous sample preparation, advanced next-generation sequencing (NGS)-coupled yeast two-hybrid platform, and advanced bioinformatics ensure that you receive the best possible candidate protein-protein interactions. Our experienced team members ensure high quality data that you can trust.

What We Provide

Our rigorous sample preparation, advanced next-generation sequencing (NGS)-coupled yeast two-hybrid platform, and advanced bioinformatics ensure that you receive the best possible candidate protein-protein interactions. Our experienced team members ensure high quality data that you can trust.

What We Provide

  • High-quality cDNA libraries with large complexities from the source of your choice
  • cDNA library composition analysis with potential background or false positive clones identified
  • Bait fusion protein construction with expression validation, potential toxicity and self-activation
  • Yeast two-hybrid (Y2H) assay with your chosen bait(s) and cDNA library
  • NGS data from a standard Illumina platform
  • Scored Y2H results scored with customized bioinformatics tools
  • Data on a secure cloud-based platform
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Protein-Protein Interaction Analysis
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Comprehensive screening of protein protein interactions
Precision mapping of protein protein interactions

Our rigorous sample preparation and advanced bioinformatics ensure that you receive the best possible candidate protein-protein interactions. Our experienced team members ensure high quality data that you can... Show more »

Comprehensive screening of protein protein interactions
Precision mapping of protein protein interactions

Our rigorous sample preparation and advanced bioinformatics ensure that you receive the best possible candidate protein-protein interactions. Our experienced team members ensure high quality data that you can trust.

What We Provide:

  • High-quality cDNA libraries with large complexities from the source of your choice
  • cDNA library composition analysis with potential background or false positive clones identified
  • Bait fusion protein construction with expression validation, potential toxicity and self-activation
  • Yeast two-hybrid (Y2H) assay with your chosen bait(s) and cDNA library
  • Sanger sequencing (for conventional Y2H screens, or optional pilot screens)
  • Scored Y2H results scored with customized bioinformatics tools
  • Data on a secure cloud-based platform
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Next Generation Sequencing Yeast Two Hybrid screening
Protein interaction analysis
protein interaction binding
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Next Generation Interaction Screening
cDNA Library Construction
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Our rigorous sample preparation, advanced next-generation sequencing (NGS)-coupled yeast two-hybrid platform, and advanced bioinformatics ensure that you receive the best possible candidate protein-protein interactions. Our experienced team members ensure high quality data that you can trust.

What We Provide

Our rigorous sample preparation, advanced next-generation sequencing (NGS)-coupled yeast two-hybrid platform, and advanced bioinformatics ensure that you receive the best possible candidate protein-protein interactions. Our experienced team members ensure high quality data that you can trust.

What We Provide

  • High-quality cDNA libraries with large complexities from the source of your choice
  • cDNA library composition analysis with potential background or false positive clones identified
  • Bait fusion protein construction with expression validation, potential toxicity and self-activation
  • Yeast two-hybrid (Y2H) assay with your chosen bait(s) and cDNA library
  • NGS data from a standard Illumina platform
  • Scored Y2H results scored with customized bioinformatics tools
  • Data on a secure cloud-based platform
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Cell Signaling Analyses
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DNA Libraries
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Yeast Screening
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January 25, 2018

Positive review received for Yeast Two-Hybrid Screening:

"Hi Lauren, It was nice doing business with you and Next Interactions company. Dr. Suter is very professional and an expert in the field of the yeast two hybrid system . I highly recommend to everyone that is interested in performing this kind of project to work with him and his team. Next Interactions were very prompt and delivered the acquired data on at the promised time. Also, Dr. Suter was fair and adjust the cost of the service according to the actual work done and advise on how to solve potential problems with the project. I have no doubt that I will use the Next Interactions services in the future when needed. This recommendation is also on behalf of Dr. Smith , my colleague, that sponsored this project. Thanks and best, Jackob"

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