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Nexomics Biosciences

13 Orders Completed

About Nexomics Biosciences

Founded: 2007 Type: Privately Held Size: 1-10 employees

Nexomics proudly offers gene-to-structure services to the biopharmaceutical and biological research community. With a strong focus on discovery and analytical R&D services, our core capabilities include target selection and construct design using bioinformatics tools, cloning of genes into protein production vectors, recombinant protein expression, laboratory-scale fermentation, protein purification, crystallization screening, NMR structural studies, X-ray crystallographic structural studies, and functional assay development.

Selected Publications

Gold L, Ayers D, Bertino J, Bock C, Bock A, Brody EN, Carter J, Dalby AB, Eaton BE, Fitzwater T, Flather D, Forbes A, Foreman T, Fowler C, Gawande B, Goss M, Gunn M, Gupta S, Halladay D, Heil J, Heilig J, Hicke B, Husar G, Janjic N, Jarvis T, Jennings S, Katilius E, Keeney TR, Kim N, Koch TH, Kraemer S, Kroiss L, Le N, Levine D, Lindsey W, Lollo B, Mayfield W, Mehan M, Mehler R, Nelson SK, Nelson M, Nieuwlandt D, Nikrad M, Ochsner U, Ostroff RM, Otis M, Parker T, Pietrasiewicz S, Resnicow DI, Rohloff J, Sanders G, Sattin S, Schneider D, Singer B, Stanton M, Sterkel A, Stewart A, Stratford S, Vaught JD, Vrkljan M, Walker JJ, Watrobka M, Waugh S, Weiss A, Wilcox SK, Wolfson A, Wolk SK, Zhang C, Zichi D. Aptamer-based multiplexed proteomic technology for biomarker discovery. PLoS One. 2010 Dec 7;5(12):e15004. doi: 10.1371/journal.pone.0015004.

Our Services (35)


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Protein Production

Price on request

Nexomics offers protein expression services at various scales (small, midi, and large scales, up to 30 L Bioreactor scale).

We support a wide range of expression systems and media types (LB / TB with Animal-Free Soytone, MJ9).

We have unique expertise in preparing stable isotope-enriched media (15N, 15N13C, 15N13C2D-ILV, 19F) for protein specific isotope labeling.

SARTORIUS Braun Biotech Biostat 30 L Fermenter New Brunswick Scientific Incubator Shakers Fed-Batch Fermentation Fermentation Bacteria Yeast bacterial based recombinant protein production E. coli Show 8 more tags Show less

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Protein Purification

Price on request

Nexomics uses ÄKTA Protein Purification Systems to obtain the highest purity protein samples.

Large scale protein purification (up to grams range) using affinity or ion exchange chromatography (up to 500 ml column volume).

Molecular weight is confirmed by MALDI-TOF Mass Spectrometry.

ÄKTA Protein Purification Systems Biology Drug Discovery Affinity chromatography Chromatographic tests Antibody Production Human protein microarray gram GE Unicorn protein antibody antigen bacterial based recombinant protein production Show 13 more tags Show less

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NMR

Nuclear magnetic resonance spectroscopy
Price on request

Nexomics has deep experience with NMR structural biology techniques. We offer a full range of services from data collection, data processing, data analysis and structure determination.

Backbone Resonance Assignments
Sidechain Resonance Assignments
Protein-Protein and Protein-Ligand Interactions
Protein Structure Determination
Small Molecule Screening
Dynamics
19F NMR
Structure mapping by NMR
Quality control and Quantitative analysis

Bruker Avance 800 MHz Bruker Avance 600 MHz cryoprobe 500 MHz Varian 19F and 1H, 2H, 13C, 15N-TR NMR Probes Backbone assignments Side-chain assignment Protein-Protein, Protein-Nucleic Acid complex analysis Dynamics, disorder, stability Biosimilarity analysis NMR Show 10 more tags Show less

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X-ray Crystallography

Price on request

Nexomics has extensive experience solving protein crystal structures, including protein-protein, and protein-nucleic acid complexes, using X-ray crystallography.

Crystallization Screening
Crystallization Optimization
Diffraction Data Collection
Protein Structure Determination

HTP screening (1536 conditions) Standard kit-based screening Crystal Optimization X-ray crystallography Data Collection

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Homology Modeling

Price on request

Homology models are useful for pathway modeling, predictive protein-protein / protein-ligand interactive simulations and in general as a guide in the protein structure determination process. Nexomics Biosciences offers homology modeling using our proprietary modeling and structure validation software.

protein modelling Bioinformatics structural bioinformatics

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Protein Biophysical Characterization

Price on request

Nexomics utilizes a number of experimental biophysical techniques to ensure quality control as well as for further understanding of the biological system under study.


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PCR Primer Design

Price on request

Designing the correct primer sequence can have a large impact on the success of a PCR reaction.

Through our automated proprietary primer design software we can design and deliver the optimal set of primers to ensure success.


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Gene Synthesis

Price on request

Gene Synthesis is a powerful new technology for delivering difficult-to-isolate genes.

Gene synthesis is particularly useful when applying domain parsing techniques, mutagenesis techniques, or when working with difficult-to-isolate eukaryotic cDNA pools.


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MALDI TOF MS

Matrix-assisted laser desorption ionization time-of-flight mass spectrometry
Price on request

MALDI-TOF mass spectroscopy is used as a quality control check for all protein production projects. The technology can also be used to measure regions of disorder within a protein.

Mass Spectrometry MALDI-TOF Mass Spec MALDI-TOF

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Light Scattering Services

Price on request

Light scattering data are useful for confirming oligomerization states of protein (e.g., monomer, dimer, etc.). And for determining shape-independent molecular weights.

Lights scattering studies are also valuable for construct optimization to enhance crystallization propensities of proteins.


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Biolayer Interferometry

Price on request

BLI optical analytical technique to evaluate and characterize bimolecular interactions.
It can be used in assay development and to determine protein interaction affinities.


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Static Light Scattering

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Radiolabeling/Radiosynthesis

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Protein specific stable isotope labeling Services

Nexomics has extensive experience incorporating stable isotopes (e.g. 15N, 13C, 2H, 19F) into native protein to facilitate NMR and mass spectrometry studies.


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Protein Services

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Imaging & Spectroscopy

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Structural Biology

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PCR

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MALDI Mass Spectrometry Methods

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Nucleic Acid Services

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DNA Services

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Interferometry

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Biology

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DNA Synthesis and Probe Development

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Biochemistry & Molecular Biology

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Scattering Techniques

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Spectroscopy

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Chemistry and Materials

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Computational Modeling

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Protein Characterization

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Mass Spectrometry

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Liquid Chromatography (LC)

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Liquid Chromatography Services


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Chromatography

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Chromatography Services


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Separation/Purification Services

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Purification Services


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Analytical Chemistry Services

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Analytical Chemistry Services


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FPLC

Fast Performance liquid chromatography
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