Nexomics Biosciences
About Nexomics Biosciences
Nexomics proudly offers gene-to-structure services to the biopharmaceutical and biological research community. With a strong focus on discovery and analytical R&D services, our core capabilities include target selection and construct design using bioinformatics tools, cloning of genes into protein... Show more »
Nexomics proudly offers gene-to-structure services to the biopharmaceutical and biological research community. With a strong focus on discovery and analytical R&D services, our core capabilities include target selection and construct design using bioinformatics tools, cloning of genes into protein production vectors, recombinant protein expression, laboratory-scale fermentation, protein purification, crystallization screening, NMR structural studies, X-ray crystallographic structural studies, and functional assay development.
Selected Publications
Gold L, Ayers D, Bertino J, Bock C, Bock A, Brody EN, Carter J, Dalby AB, Eaton BE, Fitzwater T, Flather D, Forbes A, Foreman T, Fowler C, Gawande B, Goss M, Gunn M, Gupta S, Halladay D, Heil J, Heilig J, Hicke B, Husar G, Janjic N, Jarvis T, Jennings S, Katilius E, Keeney TR, Kim N, Koch TH, Kraemer S, Kroiss L, Le N, Levine D, Lindsey W, Lollo B, Mayfield W, Mehan M, Mehler R, Nelson SK, Nelson M, Nieuwlandt D, Nikrad M, Ochsner U, Ostroff RM, Otis M, Parker T, Pietrasiewicz S, Resnicow DI, Rohloff J, Sanders G, Sattin S, Schneider D, Singer B, Stanton M, Sterkel A, Stewart A, Stratford S, Vaught JD, Vrkljan M, Walker JJ, Watrobka M, Waugh S, Weiss A, Wilcox SK, Wolfson A, Wolk SK, Zhang C, Zichi D. Aptamer-based multiplexed proteomic technology for biomarker discovery. PLoS One. 2010 Dec 7;5(12):e15004. doi: 10.1371/journal.pone.0015004.
Our Services (35)
Protein Production
Nexomics offers protein expression services at various scales (small, midi, and large scales, up to 30 L Bioreactor scale).
We support a wide range of expression systems and media types (LB / TB with Animal-Free Soytone, MJ9).
We have unique expertise in preparing stable isotope-enriched media (15N, 15N13C, 15N13C2D-ILV, 19F) for protein specific isotope labeling.
Nexomics offers protein expression services at various scales (small, midi, and large scales, up to 30 L Bioreactor scale).
We support a wide range of expression systems and media types (LB / TB with Animal-Free Soytone, MJ9).
We have unique expertise in preparing stable isotope-enriched media (15N, 15N13C, 15N13C2D-ILV, 19F) for protein specific isotope labeling.
Protein Purification
Nexomics uses ÄKTA Protein Purification Systems to obtain the highest purity protein samples.
Large scale protein purification (up to grams range) using affinity or ion exchange chromatography (up to 500 ml column volume).
Molecular weight is confirmed by MALDI-TOF Mass Spectrometry.
Nexomics uses ÄKTA Protein Purification Systems to obtain the highest purity protein samples.
Large scale protein purification (up to grams range) using affinity or ion exchange chromatography (up to 500 ml column volume).
Molecular weight is confirmed by MALDI-TOF Mass Spectrometry.
NMR
Nuclear magnetic resonance spectroscopy
Nexomics has deep experience with NMR structural biology techniques. We offer a full range of services from data collection, data processing, data analysis and structure determination.
Backbone Resonance Assignments
Sidechain Resonance Assignments
Protein-Protein and Protein-Ligand Interactions
Protein Structure... Show more »
Nexomics has deep experience with NMR structural biology techniques. We offer a full range of services from data collection, data processing, data analysis and structure determination.
Backbone Resonance Assignments
Sidechain Resonance Assignments
Protein-Protein and Protein-Ligand Interactions
Protein Structure Determination
Small Molecule Screening
Dynamics
19F NMR
Structure mapping by NMR
Quality control and Quantitative analysis
X-ray Crystallography
Nexomics has extensive experience solving protein crystal structures, including protein-protein, and protein-nucleic acid complexes, using X-ray crystallography.
Crystallization Screening
Crystallization Optimization
Diffraction Data Collection
Protein Structure Determination
Nexomics has extensive experience solving protein crystal structures, including protein-protein, and protein-nucleic acid complexes, using X-ray crystallography.
Crystallization Screening
Crystallization Optimization
Diffraction Data Collection
Protein Structure Determination
Homology Modeling
Homology models are useful for pathway modeling, predictive protein-protein / protein-ligand interactive simulations and in general as a guide in the protein structure determination process. Nexomics Biosciences offers homology modeling using our proprietary modeling and structure validation software.
Homology models are useful for pathway modeling, predictive protein-protein / protein-ligand interactive simulations and in general as a guide in the protein structure determination process. Nexomics Biosciences offers homology modeling using our proprietary modeling and structure validation software.
Protein Biophysical Characterization
Nexomics utilizes a number of experimental biophysical techniques to ensure quality control as well as for further understanding of the biological system under study.
Nexomics utilizes a number of experimental biophysical techniques to ensure quality control as well as for further understanding of the biological system under study.
PCR Primer Design
Designing the correct primer sequence can have a large impact on the success of a PCR reaction.
Through our automated proprietary primer design software we can design and deliver the optimal set of primers to ensure success.
Designing the correct primer sequence can have a large impact on the success of a PCR reaction.
Through our automated proprietary primer design software we can design and deliver the optimal set of primers to ensure success.
Gene Synthesis
Gene Synthesis is a powerful new technology for delivering difficult-to-isolate genes.
Gene synthesis is particularly useful when applying domain parsing techniques, mutagenesis techniques, or when working with difficult-to-isolate eukaryotic cDNA pools.
Gene Synthesis is a powerful new technology for delivering difficult-to-isolate genes.
Gene synthesis is particularly useful when applying domain parsing techniques, mutagenesis techniques, or when working with difficult-to-isolate eukaryotic cDNA pools.
MALDI TOF MS
Matrix-assisted laser desorption ionization time-of-flight mass spectrometry
MALDI-TOF mass spectroscopy is used as a quality control check for all protein production projects. The technology can also be used to measure regions of disorder within a protein.
MALDI-TOF mass spectroscopy is used as a quality control check for all protein production projects. The technology can also be used to measure regions of disorder within a protein.
Light Scattering Services
Light scattering data are useful for confirming oligomerization states of protein (e.g., monomer, dimer, etc.). And for determining shape-independent molecular weights.
Lights scattering studies are also valuable for construct optimization to enhance crystallization propensities of proteins.
Light scattering data are useful for confirming oligomerization states of protein (e.g., monomer, dimer, etc.). And for determining shape-independent molecular weights.
Lights scattering studies are also valuable for construct optimization to enhance crystallization propensities of proteins.
Biolayer Interferometry
BLI optical analytical technique to evaluate and characterize bimolecular interactions.
It can be used in assay development and to determine protein interaction affinities.
BLI optical analytical technique to evaluate and characterize bimolecular interactions.
It can be used in assay development and to determine protein interaction affinities.
Static Light Scattering
Radiolabeling/Radiosynthesis
Protein specific stable isotope labeling Services
Nexomics has extensive experience incorporating stable isotopes (e.g. 15N, 13C, 2H, 19F) into native protein to facilitate NMR and mass spectrometry studies.
Protein specific stable isotope labeling Services
Nexomics has extensive experience incorporating stable isotopes (e.g. 15N, 13C, 2H, 19F) into native protein to facilitate NMR and mass spectrometry studies.
Protein Services
Imaging & Spectroscopy
Structural Biology
PCR
MALDI Mass Spectrometry Methods
Nucleic Acid Services
DNA Services
Interferometry
Biology
DNA Synthesis and Probe Development
Biochemistry & Molecular Biology
Scattering Techniques
Spectroscopy
Chemistry and Materials
Computational Modeling
Protein Characterization
Mass Spectrometry
Liquid Chromatography (LC)
Liquid Chromatography Services
Liquid Chromatography Services
Chromatography
Chromatography Services
Chromatography Services
Separation/Purification Services
Purification Services
Purification Services
Analytical Chemistry Services
Analytical Chemistry Services
Analytical Chemistry Services
FPLC
Fast Performance liquid chromatography
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