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Nexelis (formerly PAIRimmune)

18 Orders Completed
Montréal, Quebec, CA

About Nexelis (formerly PAIRimmune)

**Nexelis offers services and/or reagents specific to COVID-19 research. Submit a quote request containing the word ‘COVID-19’ to receive more details.**

Nexelis (formerly PAIRimmune) is a Contract Research Organization (CRO) specialized in immunology evaluation for vaccine research and immunotherapy proof of principle. We offer to our clients key-in-hand solutions (in vivo, in vitro, readouts, reporting, etc). We have state-of-the-art scientific methods combined with an extensive preclinical biopharma and CRO expertise to move forward early biological products. PAIRimmune is a key-in-hand solution for the benefit of industry, academic and small biotech sponsors. I June 2019, PAIRimmune joined forces with Nexelis to propose a wider range of services.

With unrivaled expertise in immunology on both sides of the client/CRO relationship, we are a leading provider of assay development and specialty laboratory testing.
Our versatile team of scientists, working with our advanced technology platforms, were instrumental in the development, qualification, validation, and large-scale sample testing of assays that supported the FDA filing of almost 100 new molecular entities, including blockbuster vaccines and soluble large molecules.

Certifications & Qualifications

AAALAC BSL-2 IACUC

Our Services (41)


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Animal Immunization for Antibody Production

Price on request
Request a quote for more information about this service.
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Viral Infection Animal Models

Price on request

Lymphocytic Choriomeningitis

PAIRimmune has got a strong experience in the manipulation of this murine model of chronic infections. We are familiar with different strains of this virus, whether it is Clone 13, Armstrong of WE.

Different outcomes can occur depending of the parameters of infection:

  • Strain used
  • Route of infection
  • Dose injected
  • Age of the mice
    Ask us what would fit the best for your application !

We can do many procedures like:

  • Viral production, titrations and challenges
  • ELISA for antibody responses
  • Neutralization assays
  • Flow cytometry to analyze the immune response triggered
  • Other procedures on demand

Lymphocytic Choriomeningitis (LCMV) Mouse Vaccinia virus infection

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Cytotoxicity Assays

Price on request

PAIRimmune offers in vitro cell-mediated (T cells, NK, ADCC) cytotoxicity measurements in 96-well plates notably for cancer and antiviral immunotherapy testing.

Available using GAPDH measurement technology or flow cytometry approach.

Possibility to monitor cytotoxicity and viability in the same assay.


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Preclinical Study Design

Price on request

PAIRimmune takes advantage of its long experience in the pharma industry to help you design pre-clinical studies perfectly fitting your research goals. Our communicative approach allows us to identify exactly your needs and lower the costs as much as possible.

Consulting in study design includes the optimization of the different steps of a study: identification of the best animal model, ideal experimental in vivo parameters, animal protocol writing, relevant analysis depending of your goals, legal paperwork, etc.


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Therapeutic Monoclonal Antibody (mAb) Development

Price on request

PAIRimmune offers monoclonal and polyclonal antibody production fitting to the needs of your projects.

Polyclonal anti-sera production in mice, rats, rabbits, ferrets, sheep and goats.
Development of hybridoma lines for monoclonal antibody production.

Antibody characterization and titration for WB, ELISA, Dot Blot, IHC, IF, etc.).

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ELISpot Assays

Enzyme-Linked ImmunoSpot Assays
Price on request

Kit-based recognized technology to quantify cells able to secrete:

  • Cytokines: Granzyme B, IFNg, ILs, TNFa, etc.
  • Antibodies: Total IgG, IgM, IgA, antigen-specific antibodies

Can be used to verify Th1/Th2/Th17 or B cell responses.
Available for mice, primate, rat, pigs, monkeys, depending of the target to screen.

Deliverables: raw data or full reports.

Mouse Non-human primates (NHP) Rat Pig

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Flow Cytometry

Price on request

PAIRimmune has a sustained expertise in flow cytometry analysis (FACS).

Phenotyping: Identification and counting of specific cell populations
Intracellular staining (ICS): Identification of cytokines and transcription factors.
Proliferation: Quantification of cellular proliferation levels.
Survival: Identification of apoptotic/necrotic cells, quantification of viability.

Consulting for antibody cocktails design, gating strategies, troubleshooting.
Acquisition up to 10 colors at the same time.
Available for human, mouse, rats, pigs, and other species on demand.

Equipment:
BD LSR II

Deliverables: samples, raw data or full reports

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Immunofluorescence

Price on request

PAIRimmune offers whole or separate IF packages including: organ collection, embedding, preparation of slides, staining, acquisition and analysis.

Tissues can be Formalin Fixed Paraffin Embedded (FFPE) or frozen (OCT).

Immunofluorescence and counterstains available.

Consulting for protocol development and antibody selection whether commercial or custom (separate procedure), depending of your needs.

Optimization of new antibodies.

Deliverables: samples, cut sections, stained slides, acquired images or full reports.


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Diabetes Animal Models

Price on request

We propose services adapted to the needs of your research for type 1 and type 2 diabetes study.

  • Type 1 models:
    Can be used to study different aspects: new formulations of insulin, transplantation models, prevention of beta cell death, mechanistic of genetic understanding, etc.
    Chemicaly induced diabetes: Streptozocin (STZ) or allocan injections.
    Spontaneous autoimmune models

  • Type 2 models:
    Can be used to study treatments to improve insulin resistance, beta cell function or to prevent diet-induced obesity.
    Chemicaly induced obesity: High fat fed mice or rats.
    Spontaneous obesity models

  • Available procedures:
    Fasting glucose and insulin measurements.
    Glucose (GTT) and insulin (ITT) tolerance tests.
    Specific procedures could also be discussed depending of the needs.

Deliverables: samples, raw data or full reports.

Pricing can vary depending of the model chosen, the procedures and the subsequent analysis selected.

Diabetes Metabolism and Endocrinology Serum Plasma Blood Mouse Show 6 more tags Show less

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Immunohistochemistry (IHC)

Price on request

PAIRimmune offers whole or separate IHC/IF packages including: organ collection, embedding, preparation of slides, staining, acquisition and analysis.

Tissues can be Formalin Fixed Paraffin Embedded (FFPE) or frozen (OCT).

Immunochemistry, immunofluorescence and counterstains available.

Consulting for protocol development and antibody selection whether commercial or custom (separate procedure), depending of your needs.

Optimization of new antibodies.

Deliverables: samples, cut sections, stained slides, acquired images or full reports.


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Histology and Pathology Services

Starting at $20.00 per slide

PAIRimmune offers whole or separate histology packages including: organ collection, embedding, preparation of slides and analysis.

Tissues can be Formalin Fixed Paraffin Embedded (FFPE) or frozen (OCT).
Standard (H&E or HPS) and special (Prussian blue, β-amyloid, Periodic Acid Shiff (PAS)) colorations available.

Slides can be sent to our collaborator certified pathologist.

Deliverables: samples, cut sections, acquired images or full reports.

See also our IHC and IF services.


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IACUC Review

Starting at $1.00 per word

IACUC review and writing services available


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ELISA

Enzyme-linked immunosorbent assay
Starting at $17.00 per sample

PAIRimmune provides kit or custom ELISA analysis depending of the needs of our client.
Direct, indirect, sandwich or competitive analysis available.

Analysis of serum, plasma, supernatants, tissue homogenates/lysates.
Available for cytokines, hormones or antigen-specific detection.

Equipment:
Automatic multi-channel pipets – Automatic plate washer – Fluorescence and visible light plate reader – Softmax Pro Acquisition Software

Deliverables: sample, raw data or full reports.

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In vivo Immunogenicity Assays

Price on request

Pre-clinical testing against a great variety of pathogens and pathologies.

Consulting for determining the best approach for you study.

Multiple models for immunization: mouse, rat, hamster, guinea pig, ferret, pig, etc.
Various routes of administration: intravenous, intramuscular, intranasal, intradermal, oral, sublingual, intraperitoneal, etc.

Mini pigs and farm pigs (relevant model for skin administration) including adapted readouts (humoral, DC, T cell analysis)
Ferret Flu challenge model and mouse challenge model
Cancer models (xenograft)

Analysis technologies: ELISA, ELISPOT, FACS, IHC, IF, neutralization assays, ADCC, etc.

Antibody production in mice, rats, ferrets, rabbits, sheep and goats,

AAALAC and CALAS accreditation.

Deliverables: samples, raw data or full reports.

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In vitro Immunogenicity Assays

Price on request

Immunogenicity testing in animal for various compounds testing:

  • Vaccines (antigen specific antibody)
  • Anti mAb immunogenicity
  • Anti drug immunogenicity
  • Anti conjugate immuno
  • Adjuvants testing

Deliverables: samples, raw data or full reports

Molecular device microplate reader versamax Bio Tek Microplate Washer EL404 BD FacsCantoII/LSRII Molecular Devices Softmax Pro GraphPad Prism DIVA Show 6 more tags Show less

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Vaccine Development

Price on request

Consultation in vaccine and immunotherapy product development (early discovery PoC to pre-IND)

We possess 30 years of total experience in large biopharma vaccine organization as well as in biotech startups. We could help you to build a pre-clinical package attractive to large biopharma.


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In vivo Drug Efficacy Testing

Price on request

PAIRimmune proposes evaluation of vaccine candidates in different models adapted to your project. We guaranty high-quality screening to identify value candidates.

Flu Vaccine testing in relevant animal models (mouse, ferret challenge model, farm pig).
Efficacy challenge for BSL2 pathogen vaccine candidates.

Available procedures: Viral load, clinical signs, biofilm measurement, quorum-sensing monitoring, pathogen-specific procedure, etc.

Deliverables: samples, raw data or full reports.

Mouse Ferret Pig

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Cytometry

Price on request
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Protein Services

Price on request
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Immunostaining

Price on request
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Protein Expression Visualization

Price on request
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Immunoassays

Price on request
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Protein Quantification

Price on request
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Formulation Services

Price on request
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Infectious Disease Animal Models

Price on request
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Toxicology

Price on request
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In vivo Toxicity Testing

Price on request
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Animal Models of Disease

Price on request

We're AAALAC and CALAS accredited

Small animals (mice, rats, hamsters, rabbits, etc.)
Large animals (dog, sheep, goats)
Pigs, notably for transdermal studies
Ferrets, notably for flu challenges
Non-human primates

Mouse Rat Ferret Non-human primates (NHP) Dog Pig Sheep Goat Show 8 more tags Show less

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Biochemistry & Molecular Biology

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Biology

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Pharmacology & Toxicology

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Regulatory Affairs Services

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Antibody Services

Price on request
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Animal Models and Studies

Price on request
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Project Management

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Cells and Tissues

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Metabolic Animal Models

Price on request
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Protein Purification

Price on request

Protein Purification and Quantification Services


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Drug Discovery & Development

Price on request

Drug Discovery & Development Services


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Pharmacology

Price on request

Pharmacology Services


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Safety Pharmacology

Price on request

Safety Pharmacology & Efficacy Testing Services


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XC

Xi-Lin Chen

Scientist
MD

Matthieu Daugan

Associate Director Preclinical Services
JD

Janna de Guzman

Business Development
GO

Gabriel Ouellet

Scientist
DP

Danielle Poirier

Director Preclinical Services

Nexelis (formerly PAIRimmune) has not received any reviews.

  • PR

    Paul RiceApril 2016

    Biodextris has known the PairImmune team for many years, and recognises their customer-focused dedication to providing high-quality scientific support in an efficient and timely manner. Their expertise and capabilities are ideal for clients who need reliable and robust in vitro and in vivo immunology evaluation data, and we would not hesitate to recommend them as a valued partner.

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