1352516842556_431a0fe323589e11291b277f08c0f006

New York University Langone Medical Center

New York, New York
1352517118347_431a0fe323589e11291b277f08c0f006

Immunohistochemistry (IHC) Core

New York, New York
  • 100% positive reviews
  • 7 Projects Completed
  • No endorsements

The Immunohistochemistry Core Laboratory, a component of the Experimental Pathology Shared Resource, is currently located on the NYULMC main campus in the Smilow Research Building. For Histopathology Core services, such as H&E staining, please visit our sister lab here: Show more »

The Immunohistochemistry Core Laboratory, a component of the Experimental Pathology Shared Resource, is currently located on the NYULMC main campus in the Smilow Research Building. For Histopathology Core services, such as H&E staining, please visit our sister lab here: https://www.scienceexchange.com/facilities/histopathology-core

The IHC laboratory provides guidance and support for the design and execution of experiments involving histopathology and chromogenic or immunofluorescence immunohistochemistry of human and animal tissues and cells. In collaboration with other components of the Experimental Pathology Shared Resource, the IHC core provides guidance for routine and advanced histopathologic services for cells and tissue specimens, and guidance and expertise for special and routine histochemical staining.

The laboratory serves as immunohistochemical repository with a catalog of over 1200 antibodies. The majority of these antibodies are available for the collection of preliminary or more comprehensive data. In addition, many of these antibodies have been tested in both human and animal tissues, and can be used on any of the laboratories two exisiting Ventana NEXes, or on either Discovery and or Discovery XT automated immunohistochemical staining instruments.

The laboratory optimizes and validates new (commercial or proprietary) antibodies that have not been tested by immunohistochemistry. The laboratory uses both human and animal tissue micro/macro arrays, and can employ a wide variety of antigen retrieval methods to determine the applicability of an antibody to immunohistochemical labeling of fresh, frozen or paraffin embedded cells and tissues. Results can be imaged for immediate review and fast turn around.

The laboratory also prepares human and anaimal Tissue Microarrays using a Pathology Devices semi-automated TMA instrument.

The laboratory faculty and staff are available to provide hands-on formal training, as well as provide consulting for the design and execution of experiments involving histopathology and immunohistochemistry of human and animal cells and tissues. The staff can also assist investigators with routine and advanced histopathologic services for tissue and cell specimens (including guidance on initial processing steps: grossing/tissue preparation, processing, embedding, paraffin/frozen microtomy) for samples destined for histopathological interpretation and analysis.

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1352517057734_431a0fe323589e11291b277f08c0f006

Rodent Behavior Core

New York, New York
  • 100% positive reviews
  • 1 Project Completed
  • No endorsements

The Rodent Behavior Core, located in Berg, is slated to open to the NYULMC research community in September, 2012.

The Rodent Behavior Core will provide facilities and equipment for:

-Spatial Learning and Memory (Morris Water Maze, Place Preference)
-Associative... Show more »

The Rodent Behavior Core, located in Berg, is slated to open to the NYULMC research community in September, 2012.

The Rodent Behavior Core will provide facilities and equipment for:

-Spatial Learning and Memory (Morris Water Maze, Place Preference)
-Associative Memory Formation (Fear Conditioning)
-Anxiety and Depression (Elevated Plus, Forced Swim, Tail Suspension, Sucrose Preference)
-Sensory Motor Gating (Prepulse Inhibition, Acoustic Startle)
-Drug Addiction and Withdrawal (Conditioned Place Preference, Locomotor Hyperactivity)
-Social Learning (Three Chambered Arena)
-Novelty Detection (Objection Recognition)
-Motor Learning (Rotating Rod test)
-Perseverative Learning (Y-Maze)
-Working Memory (Radial Arm Maze)
-Real time video tracking to adapt user designed paradigms

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The Center for Health Informatics and Bioinformatics (CHIBI) handle both low-level (instrument-specific, or “upstream”) informatics as well as higher-level (hypothesis testing and generation oriented, or “downstream informatics”). CHIBI also has the scientific responsibility for the high-end computing needed to process the genomic data.

Our insectary produces five rodent malaria strains weekly and will ship live sporozoite infected Anopheles stephensi to investigators for research use (Plasmodium berghei GFP, luciferase or red-star and P. yoelii-GFP)

Anti-infective testing including in vitro EC50, in vivo mice... Show more »

Our insectary produces five rodent malaria strains weekly and will ship live sporozoite infected Anopheles stephensi to investigators for research use (Plasmodium berghei GFP, luciferase or red-star and P. yoelii-GFP)

Anti-infective testing including in vitro EC50, in vivo mice infection are available against for major parasitic diseases: Malaria, Leishmaniasis, Chagas and African Trypanosomiasis.

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1374180945074_08bbc4d5ec96788906127bd496c7713f

Histopathology Core

New York, New York
  • No reviews
  • 1 Project Completed
  • No endorsements

Both animal model and clinical research require the production of high quality tissue samples for morphological and molecular analyses. The NYU Histopathology Core, one component of the Experimental Pathology Shared Resources provides services, instrumentation and training to... Show more »

Both animal model and clinical research require the production of high quality tissue samples for morphological and molecular analyses. The NYU Histopathology Core, one component of the Experimental Pathology Shared Resources provides services, instrumentation and training to facilitate the generation of these critical materials.

Services offered by the Histopathology Core include: tissue preparation, processing, embedding, sectioning, histochemical staining, digital whole slide scanning, and laser capture microdissection of both animal and fixed human tissues.

The Histopathology Core also makes available several instruments for investigator use on a self-serve basis. This option is valuable for researchers who wish to direct certain stages of specimen preparation and is more cost-effective in some cases. Available instrumentation includes a state-of the-art Laser Dissection Microscope, a microtome, a cryostat and a microscope fitted with a digital camera. Training is provided by Core staff.

The components of pricing for each service include the cost of consumables, the cost for technician time for each service, and a small percentage of any associated service contracts. As with many of our services, the incremental cost of each procedure is affected by overall volume; as volume increases, we pass the resulting savings on to users in the form of reduced prices.

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RNAi Core
1387392043930_3432c209367d3c966a7642c543aacf36
RNAi CoreNew York University Langone Medical CenterNew York, New York
  • 1 Service
  • 2 Members

New York, New York
1387392043930_3432c209367d3c966a7642c543aacf36
RNAi CoreNew York University Langone Medical CenterNew York, New York
  • 1 Service
  • 2 Members
  • No reviews
  • No completed projects
  • No endorsements

The RNAi Core provides an integrated, state-of-the-art, RNA interference (RNAi) based high-throughput screening (HTS) facility at the NYU Langone Medical Center. The core offers screening libraries to researchers for cross-species functional characterization of whole genomes in a... Show more »

The RNAi Core provides an integrated, state-of-the-art, RNA interference (RNAi) based high-throughput screening (HTS) facility at the NYU Langone Medical Center. The core offers screening libraries to researchers for cross-species functional characterization of whole genomes in a systematic, comprehensive, and cost-effective manner. Training on relevant equipment is also provided for researchers to perform their screens.

In addition, the core offers logistical, technical, and bioinformatic support in order to assist screeners in performing and interpreting their genome scale RNAi screens. Importantly, the RNAi Core is strongly committed to being fully accessible to the entire academic community, both at the national and international level, in order to facilitate inter-disciplinary and multi-institutional collaborations.

The core offers the following libraries for HTS:

Human annotated genome (Silencer Select siRNA library from Life Technologies)
Human mimic and inhibitor miRNA (mirVana libraries from Life Technologies)
Mouse genome (Silencer siRNA library from Life Technologies)
Mouse mimic and inhibitor miRNA (mirVana libraries from Life Technologies)
Drosophila whole genome and functional group subsets (dsRNA libraries in collaboration with DRSC, Harvard Medical School)

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1394474104696_2e74afc681aed112f2979fefba59d5d8

NYU Stem Cell Core

New York, New York
  • No reviews
  • No completed projects
  • No endorsements

The Stem Cell Core (SCC) at NYU Langone Medical Center is a NYSTEM-funded integrated facility covering all major aspects of current stem cell biology for the benefit of the research community (http://ocs.med.nyu.edu/stem-cell-core). ... Show more »

The Stem Cell Core (SCC) at NYU Langone Medical Center is a NYSTEM-funded integrated facility covering all major aspects of current stem cell biology for the benefit of the research community (http://ocs.med.nyu.edu/stem-cell-core). Our collaboration with stem cell cores at Weill Cornell Medical College and Memorial Sloan-Kettering Cancer Center allows users to harness the full potential of stem cells in unprecedented ways.

We specialize in the derivation, culture, differentiation and distribution of high-quality human and mouse iPSCs and embryonic stem cells. We also offer lines with lineage reporters, inducible expression, and mutations that are causal for a wide range of human diseases. All our hESC lines are listed in the NIH Stem Cell Registry, enabling usage of NIH funds. We serve both academic institutions and industry.

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