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Neurovasc Preclinical Services, Inc.

5 Orders Completed
ACTON, Massachusetts, US

About Neurovasc Preclinical Services, Inc.

Our mission is to provide the highest-quality preclinical efficacy contract services for Central Nervous System (CNS), vascular and other diseases for our clients, including biotech and pharmaceutical companies, as well as academic investigators.

We have extensive experience and expertise in preclinical... Show more »

Our mission is to provide the highest-quality preclinical efficacy contract services for Central Nervous System (CNS), vascular and other diseases for our clients, including biotech and pharmaceutical companies, as well as academic investigators.

We have extensive experience and expertise in preclinical modelling of CNS and vascular diseases, as well as a thorough understanding of all aspects of the drug development pathway.

We possess special expertise in small animal surgery, drug delivery methods, and behavioral assessment methods.

We provide high-level technical proficiency, as well as expert assistance in the planning, analysis and interpretation of preclinical efficacy studies. We're open, collaborative, and flexible with your needs.

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Our Services (34)


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Metabolic Animal Models

Price on request

Cachexia Animal Models
Diabetes Animal Models
Diabetic Cardiomyopathy Animal Models
Metabolic Disease Animal Models
Muscle Wasting Animal Models
Obesity Animal Models

Hands-on experience with a variety of animal metabolic models
Extensive experience in diabetes and obesity drug development
Animal models available... Show more »

Cachexia Animal Models
Diabetes Animal Models
Diabetic Cardiomyopathy Animal Models
Metabolic Disease Animal Models
Muscle Wasting Animal Models
Obesity Animal Models

Hands-on experience with a variety of animal metabolic models
Extensive experience in diabetes and obesity drug development
Animal models available include:

Diet-induced obesity (rodent and large animal)
db/db mice
ob/ob mice
NOD mouse model
Other genetic models, such as Tubby
Induced models of type 1 diabetes, including STZ

Animal models available include:
In Vivo Assays for Glucose Metabolism
Resting Glucose levels
Glucose Tolerance Test (GTT)
Insulin Tolerance Test (ITT)
Pyruvate Tolerance Test (PTT)

Additional Parameters
Clinical observations
Body weight
Pair-feeding
Weight loss
In-life collection of blood, serum, plasma, urine or feces for metabolite analysis
Necropsy with histopathology and immunostaining

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Stroke Recovery Animal Models

Price on request

Stroke affects people of all ages. There are approximately 7 million stroke survivors in the U.S. Stroke commonly results in substantial and multi-dimensional disability in patients, including disturbances in walking, speech, arm function, balance, memory, vision, swallowing, etc.

Some degree of recovery is common after stroke.... Show more »

Stroke affects people of all ages. There are approximately 7 million stroke survivors in the U.S. Stroke commonly results in substantial and multi-dimensional disability in patients, including disturbances in walking, speech, arm function, balance, memory, vision, swallowing, etc.

Some degree of recovery is common after stroke. However, other than physical, occupational, and speech therapies, there are few drugs, devices, or cell therapies currently on the market that accelerate or enhance recovery after stroke.

Clinically, stroke recovery can be divided into two phases: subacute, occurring days to months after stroke; and chronic, occurring months to years after stroke.

NeuroVasc investigators were among the pioneers in the development of animal models of stroke recovery in the subacute and chronic phases. These include rat models of focal stroke, compatible with long survival of animals, suitable for investigation of recovery-promoting treatments. Treatments can be initiated days to many months after stroke onset. Endpoints for these studies include serial behavioral evaluation of animals and histology.

As of the current time, NeuroVasc has participated in preclinical studies of four stroke recovery-promoting treatments (including small molecule and cell-based therapies) that have been advanced to human clinical trials by their respective sponsors.

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Acute Stroke Animal Models

Price on request

Stroke is a major cause of death and disability worldwide, with approximate 800,000 new cases in the U.S. per year. Eighty-five percent of strokes are "ischemic," due to occlusion of a brain artery, causing death of brain tissue (infarction) supplied by that artery. Acute stroke treatments are given within a few hours after stroke... Show more »

Stroke is a major cause of death and disability worldwide, with approximate 800,000 new cases in the U.S. per year. Eighty-five percent of strokes are "ischemic," due to occlusion of a brain artery, causing death of brain tissue (infarction) supplied by that artery. Acute stroke treatments are given within a few hours after stroke onset. Such treatments include thrombolytic ("clot-busting") and tissue-sparing ("neuroprotective") agents.

NeuroVasc is highly experienced in rodent (mouse and rat) models of acute focal stroke, including suture-occlusion, Chen, Tamura, and embolic methods. These models are suitable for testing of new thrombolytic and neuroprotective strategies. Endpoints of these studies include histology (infarct volume determination) and behavioral testing.

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Rodents

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Intracerebral Hemorrhage Animal Models

Price on request

About 15% of the estimated 800,000 strokes occurring in the U.S. every year represent intracerebral hemorrhage. Spontaneous bleeding into the brain occurs due to longstanding hypertension, cerebral amyloid angiopathy (CAA), or ruptured intracranial aneurysm. Clinical outcome may be devastating, including patient... Show more »

About 15% of the estimated 800,000 strokes occurring in the U.S. every year represent intracerebral hemorrhage. Spontaneous bleeding into the brain occurs due to longstanding hypertension, cerebral amyloid angiopathy (CAA), or ruptured intracranial aneurysm. Clinical outcome may be devastating, including patient death.

NeuroVasc has developed a quantifiable and reproducible model of intracerebral hemorrhage (ICH) in rodents. This model is useful for testing the effects of anticoagulant and procoagulant drugs, as well as treatments that reduce the secondary consequences (swelling, mass effect, etc.) that accompany ICH.

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Traumatic Brain Injury Animal Models

Price on request

More than 400,000 Americans suffer significant traumatic brain injury (TBI) requiring medical attention each year. This number includes those involved in motor vehicle, sports, and other injuries domestically, but not the increasing number of American soldiers sustaining both open and closed TBI overseas.

NeuroVasc has... Show more »

More than 400,000 Americans suffer significant traumatic brain injury (TBI) requiring medical attention each year. This number includes those involved in motor vehicle, sports, and other injuries domestically, but not the increasing number of American soldiers sustaining both open and closed TBI overseas.

NeuroVasc has expertise in models of focal TBI in rodents. Endpoints in these models are behavioral and histological. These models are useful for the assessment of new treatments designed to limit cerebral damage and/or enhance neurological recovery following TBI.

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In vivo PK/PD Studies

Price on request

NeuroVasc is expert in pharmacokinetic and pharmacodynamic (PK/PD) studies, especially as they involve the nervous or vascular systems. NeuroVasc can administer test therapeutic agents into rodents via any route, including systemic (oral, intravenous, subcutaneous, intraperitoneal, etc.), as well as directly into the central... Show more »

NeuroVasc is expert in pharmacokinetic and pharmacodynamic (PK/PD) studies, especially as they involve the nervous or vascular systems. NeuroVasc can administer test therapeutic agents into rodents via any route, including systemic (oral, intravenous, subcutaneous, intraperitoneal, etc.), as well as directly into the central nervous system (intraventricular, intracisternal, intrathecal, etc.). This can be done by single or repeated administration, or continuously using a subcutaneously-implanted infusion pump. Moreover, NeuroVasc is capable of rapid fluid and tissue sampling, including blood, brain, CSF, spinal cord, and other tissues.

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ALS Animal Models

Amyotrophic Lateral Sclerosis Animal Models
Price on request

Amyotrophic lateral sclerosis (ALS, Lou Gehrig's Disease) is a progressive neurodegenerative disease resulting in generalized muscle weakness and atrophy, and, usually, death within a few years. In the U.S., approximately 10,000 patients are newly diagnosed with ALS each year. The disease strikes men and women of all... Show more »

Amyotrophic lateral sclerosis (ALS, Lou Gehrig's Disease) is a progressive neurodegenerative disease resulting in generalized muscle weakness and atrophy, and, usually, death within a few years. In the U.S., approximately 10,000 patients are newly diagnosed with ALS each year. The disease strikes men and women of all ages.

Amyotrophic lateral sclerosis (ALS, Lou Gehrig's Disease) is a progressive neurodegenerative disease resulting in generalized muscle weakness and atrophy, and, usually, death within a few years. In the U.S., approximately 10,000 patients are newly diagnosed with ALS each year. The disease strikes men and women of all ages.

NeuroVasc has considerable experience in the use of this SOD-1 mutant transgenic mouse model to test possible new treatments for both sporadic and familial ALS. This transgenic mouse strain also serves as a general model of neurodegenerative diseases and neurodegenerative treatments. Endpoints are animal survival, behavior, and histology.

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Myocardial Infarction Animal Models

Price on request

Cardiac disease is a major cause of death and disability in the U.S. and worldwide. This is often due to atherosclerosis ("hardening of the arteries") and occlusion of the coronary arteries, leading to myocardial infarction (MI, "heart attack") and its late complications. About 1 million Americans suffer an acute MI each year,... Show more »

Cardiac disease is a major cause of death and disability in the U.S. and worldwide. This is often due to atherosclerosis ("hardening of the arteries") and occlusion of the coronary arteries, leading to myocardial infarction (MI, "heart attack") and its late complications. About 1 million Americans suffer an acute MI each year, accounting for 180,000 deaths. About 5.8 million Americans have chronic congestive heart failure (CHF), most often due to ischemic heart disease and previous MIs.

NeuroVasc is experienced in models of myocardial infarction (MI) in mice and rats. In these models, the left coronary artery (LCA) is surgically ligated, resulting in low blood flow (ischemia) and death of cardiac tissue supplied by that artery. MI volume is assessed by histological methods. Both permanent and temporary (ischemia/reperfusion) MI models are available.

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Rodents

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Peripheral Vascular Disease Animal Model

Price on request

Peripheral vascular disease (PVD) refers to blockage of peripheral arteries supplying the lower extremities, resulting in leg pain and cramping with walking. PVD arises from the process of atherosclerosis that is also the general cause of myocardial infarction (MI, “heart attack”) and stroke. NeuroVasc is experienced in rodent... Show more »

Peripheral vascular disease (PVD) refers to blockage of peripheral arteries supplying the lower extremities, resulting in leg pain and cramping with walking. PVD arises from the process of atherosclerosis that is also the general cause of myocardial infarction (MI, “heart attack”) and stroke. NeuroVasc is experienced in rodent models of PVD, esp. unilateral ligation of the femoral artery in rats and mice (also called critical limb ischemia or hindlimb ischemia, CLI or HLI models). Endpoints of these studies include blood flow (laser Doppler flowmetry), histology, and functional status in ischemic limbs.

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Endometriosis Animals Model

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Laser Doppler Vibrometry

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Animal Behavior Studies

Price on request
  • Novel Object Recognition Test
  • Limb Placing Test
  • Body Swing Test
  • Modified Beam Balance Test
  • Sticky Tape Test
  • Modified Neurological Severity Scores (mNSS)
  • Cylinder Test
  • Rotarod
  • Von Frey
  • Novel Object Recognition Test
  • Limb Placing Test
  • Body Swing Test
  • Modified Beam Balance Test
  • Sticky Tape Test
  • Modified Neurological Severity Scores (mNSS)
  • Cylinder Test
  • Rotarod
  • Von Frey
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Animal Model Neurological Severity Scoring

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Object Recognition Test

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Cylinder Test

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Rotarod Performance Test

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Von Frey and Carageenan Sensitivity Assay

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Animal Nociception/Pain Tests

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Animal Nociception Tests Services

Animal Nociception Tests Services

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Animal Cognition & Behavior Tests

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Animal Cognition & Behavior Tests Services

Animal Cognition & Behavior Tests Services

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Animal Model in vivo Analyses

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Animal Model in vivo Analyses Services

Animal Model in vivo Analyses Services

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ADME/DMPK Studies

Drug Metabolism and Pharmacokinetics
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ADME and DMPK Studies Services

ADME and DMPK Studies Services

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Pharmacology & Toxicology

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Pharmacology & Toxicology Services

Pharmacology & Toxicology Services

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CNS/Neurology Animal Models

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CNS/Neurology Animal Models Services

CNS/Neurology Animal Models Services

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Cardiovascular Animal Models

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Cardiovascular Animal Models Services

Cardiovascular Animal Models Services

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Animal Neurologic Evaluation

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Animal Neurologic Evaluation Services

Animal Neurologic Evaluation Services

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Animal Models of Disease

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Animal Models of Disease Services

Animal Models of Disease Services

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Animal Learning, Memory, and Behavior Tests

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Animal Learning, Memory, and Behavior Tests Services

Animal Learning, Memory, and Behavior Tests Services

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Animal Motor Function Tests

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Animal Motor Function Tests Services

Animal Motor Function Tests Services

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Material Testing Services

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Material Characterization Services

Material Characterization Services

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Animal Models and Studies

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Animal Models and Studies Services

Animal Models and Studies Services

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Analytical Chemistry Services

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Analytical Chemistry Services

Analytical Chemistry Services

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Chemistry and Materials

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Chemistry and Materials Services

Chemistry and Materials Services

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Reproductive System Animal Models

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Reproductive System Animal Models Services

Reproductive System Animal Models Services

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Alzheimer's Disease Animal Models

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