NEUROSERVICE

Neuroservice provides a wide range of electrophysiological assays to validate target(s) and to understand the Mechanism(s) Of Action of lead compounds:

• Molecular effects under real physiological conditions.
• Dose-Response or Dose-Inhibition Protocols.
• Characterization of Allosteric Modulators.
• Drug-Drug interactions.
• Effects on Synaptic Transmission.
• Effects on Synaptic Plasticity.

The recordings are performed in acute brain and spinal cord slices from rodents (mice or rats) with the Multi-Electrode Array (MEA) and the Patch-Clamp techniques and enable the investigation of Mechanism Of Action from a neuronal network down to a single channel.

• Validation of multiple series of compounds with real physiological data.
• Determination of Dose-Response or Dose-Inhibition profiles for reference & test compounds.
• Mid-throughput Screening of series of compounds under physiological conditions.
• Precise determination of lead pharmacological profiles for selection and optimization.

The electrophysiological recordings are performed in acute brain and spinal cord slices from rodents (mice or rats) with the Multi-Electrode Array (MEA) and Patch-Clamp techniques.

NEUROSERVICE provides an innovative screening platform utilizing electrophysiological slice recordings to detect the pro-convulsive properties of compounds and to investigate their acute or chronic toxicity on basal synaptic transmission/plasticity.

Slices for chronic toxicity studies are prepared from vehicle-treated and compound-treated animals.

2 packages are available for this platform:
1/ Neurotox package: to detect the effects of compounds on general synaptic properties.
2/ Pro-convulsive package: to detect the pro-convulsive properties of compounds.

The recordings are performed in acute brain slices from rodents (mice or rats) with the Multi-Electrode Array (MEA) technique.

NEUROSERVICE provides electrophysiological recordings in brain and spinal cord slices of Transgenic (Tg) rodents*.
-Tg rodent deficit or gain determination versus WildType (WT).

• Physiological / pharmacological characterization versus WT.
• Compound evaluation in disease models.
• Drug-candidate target investigation.
• Drug-candidate efficacy evaluation.

The recordings are performed with the Multi-Electrode Array (MEA) and Patch-Clamp techniques.

• The Tg rodents are supplied from the customers or commercial providers.