NEUROSERVICE is a private CRO (Contract Research Organization) exclusively providing pharmacological recordings of acute brain & spinal cord slices.
The mission of NEUROSERVICE is to support the early phases of CNS and PAIN R&D programs in Lead Selection & Optimization as well as in the investigation of Mechanism Of Action for experimental compounds.
NEUROSERVICE is also able to perform electrophysiological recordings of slices from genetically engineered rodents and to address CNS Safety/Toxicology issues for any given compound, thanks to our cutting-edge electrophysiological screening platform.
These assays are performed with the Multi-Electrode Array (MEA) and Patch-Clamp techniques.
NEUROSERVICE strives to meet each customer’s needs with assays from its portfolio or with individually customized protocols.
NEUROSERVICE, your CRO partner for hands-on CNS electrophysiology
Neuroservice provides a wide range of electrophysiological assays to validate target(s) and to understand the Mechanism(s) Of Action of lead compounds:
The recordings are performed in acute brain and spinal cord slices from rodents (mice or rats) with the Multi-Electrode Array (MEA) and the Patch-Clamp techniques and enable the investigation of Mechanism Of Action from a neuronal network down to a single channel.
The electrophysiological recordings are performed in acute brain and spinal cord slices from rodents (mice or rats) with the Multi-Electrode Array (MEA) and Patch-Clamp techniques.
NEUROSERVICE provides an innovative screening platform utilizing electrophysiological slice recordings to detect the pro-convulsive properties of compounds and to investigate their acute or chronic toxicity on basal synaptic transmission/plasticity.
Slices for chronic toxicity studies are prepared from vehicle-treated and compound-treated animals.
2 packages are available for this platform:
1/ Neurotox package: to detect the effects of compounds on general synaptic properties.
2/ Pro-convulsive package: to detect the pro-convulsive properties of compounds.
The recordings are performed in acute brain slices from rodents (mice or rats) with the Multi-Electrode Array (MEA) technique.
NEUROSERVICE provides electrophysiological recordings in brain and spinal cord slices of Transgenic (Tg) rodents*.
-Tg rodent deficit or gain determination versus WildType (WT).
The recordings are performed with the Multi-Electrode Array (MEA) and Patch-Clamp techniques.
NEUROSERVICE has not received any reviews.
NEUROSERVICE has not received any endorsements.