Neuroservice is a private Contract Research Organization (CRO) providing pharmacological assays based on electrophysiological recordings of acute brain slices, spinal cord slices, cultured neurons, human brain slices and iPSC-derived neurons.
These assays are performed with complementary techniques: Multi-Electrode Array (MEA), Patch Clamp and Calcium Imaging.
The mission of Neuroservice is to support the early phases of CNS and PAIN R&D programs in Lead Selection & Optimization as well as in the investigation of Mechanism of Action for pre-clinical compounds.
Neuroservice is also able to perform electrophysiological recordings of slices from genetically engineered rodents and to address CNS Safety/Toxicology issues for any given compound thanks to its cutting-edge electrophysiological screening platform.
Neuroservice provides a wide range of electrophysiological assays to validate target(s) and to understand the Mechanism(s) Of Action of lead compounds:
The recordings are performed in acute brain and spinal cord slices from rodents (mice or rats) with the Multi-Electrode Array (MEA) and the Patch-Clamp techniques and enable the investigation of Mechanism Of Action from a neuronal network down to a single channel.
The electrophysiological recordings are performed in acute brain and spinal cord slices from rodents (mice or rats) with the Multi-Electrode Array (MEA) and Patch-Clamp techniques.
NEUROSERVICE provides electrophysiological recordings in brain and spinal cord slices of Transgenic (Tg) rodents*.
The recordings are performed with the Multi-Electrode Array (MEA) and Patch-Clamp techniques.
* The Tg rodents are supplied from the customers or commercial providers.
NEUROSERVICE provides an innovative screening platform utilizing electrophysiological slice recordings to detect the pro-convulsive properties of compounds and to investigate their acute or chronic toxicity on basal synaptic transmission/plasticity. Slices for chronic toxicity studies are prepared from vehicle-treated and compound-treated animals.
The recordings are performed in acute brain slices from rodents (mice or rats) with the Multi-Electrode Array (MEA) technique.
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NEUROSERVICE has not received any endorsements.