1337614870000

NEUROSERVICE

7 Orders Completed
Aix En Provence, FR

About NEUROSERVICE

NEUROSERVICE is a private CRO (Contract Research Organization) exclusively providing pharmacological recordings of acute brain & spinal cord slices.
The mission of NEUROSERVICE is to support the early phases of CNS and PAIN R&D programs in Lead Selection & Optimization as well as in the investigation of Mechanism Of Action for experimental compounds.
NEUROSERVICE is also able to perform electrophysiological recordings of slices from genetically engineered rodents and to address CNS Safety/Toxicology issues for any given compound, thanks to our cutting-edge electrophysiological screening platform.

These assays are performed with the Multi-Electrode Array (MEA) and Patch-Clamp techniques.

NEUROSERVICE strives to meet each customer’s needs with assays from its portfolio or with individually customized protocols.

NEUROSERVICE, your CRO partner for hands-on CNS electrophysiology

Our Services (19)


ic

Patch Clamp Recording

Price on request
Request a quote for more information about this service.
Mouse Rat

ic

Microelectrode Array (MEA) Recordings

Price on request
Request a quote for more information about this service.

ic

Spontaneous Locomotor Activity Test

Price on request
Request a quote for more information about this service.

ic

Drug Mechanism of Action Studies

Mechanism of Action Studies
Price on request

Neuroservice provides a wide range of electrophysiological assays to validate target(s) and to understand the Mechanism(s) Of Action of lead compounds:

  • Molecular effects under real physiological conditions.
  • Dose-Response or Dose-Inhibition Protocols.
  • Characterization of Allosteric Modulators.
  • Drug-Drug interactions.
  • Effects on Synaptic Transmission.
  • Effects on Synaptic Plasticity.

The recordings are performed in acute brain and spinal cord slices from rodents (mice or rats) with the Multi-Electrode Array (MEA) and the Patch-Clamp techniques and enable the investigation of Mechanism Of Action from a neuronal network down to a single channel.

Mouse Rat

ic

Hit to Lead and Lead Optimization

Price on request
  • Validation of multiple series of compounds with real physiological data.
  • Determination of Dose-Response or Dose-Inhibition profiles for reference & test compounds.
  • Mid-throughput Screening of series of compounds under physiological conditions.
  • Precise determination of lead pharmacological profiles for selection and optimization.

The electrophysiological recordings are performed in acute brain and spinal cord slices from rodents (mice or rats) with the Multi-Electrode Array (MEA) and Patch-Clamp techniques.

Mouse Rat

ic

In vivo Electrophysiology

Price on request

NEUROSERVICE provides an innovative screening platform utilizing electrophysiological slice recordings to detect the pro-convulsive properties of compounds and to investigate their acute or chronic toxicity on basal synaptic transmission/plasticity.

Slices for chronic toxicity studies are prepared from vehicle-treated and compound-treated animals.

2 packages are available for this platform:
1/ Neurotox package: to detect the effects of compounds on general synaptic properties.
2/ Pro-convulsive package: to detect the pro-convulsive properties of compounds.

The recordings are performed in acute brain slices from rodents (mice or rats) with the Multi-Electrode Array (MEA) technique.

Mouse Rat

ic

Ex vivo Electrophysiology

Price on request

NEUROSERVICE provides electrophysiological recordings in brain and spinal cord slices of Transgenic (Tg) rodents*.
-Tg rodent deficit or gain determination versus WildType (WT).

  • Physiological / pharmacological characterization versus WT.
  • Compound evaluation in disease models.
  • Drug-candidate target investigation.
  • Drug-candidate efficacy evaluation.

The recordings are performed with the Multi-Electrode Array (MEA) and Patch-Clamp techniques.

  • The Tg rodents are supplied from the customers or commercial providers.


ic

Animal Cognition & Behavior Tests

Price on request
Request a quote for more information about this service.
Mouse Rat

ic

Animal Models and Studies

Price on request
Request a quote for more information about this service.
Mouse Rat

ic

Pharmacology & Toxicology

Price on request
Request a quote for more information about this service.
Mouse Rat

ic

Medicinal Chemistry

Price on request
Request a quote for more information about this service.

ic

Biology

Price on request
Request a quote for more information about this service.

ic

In vivo Toxicity Testing

Price on request
Request a quote for more information about this service.
Mouse Rat

ic

Toxicology

Price on request
Request a quote for more information about this service.
Mouse Rat

ic

Lead Identification and Validation

Price on request
Request a quote for more information about this service.

ic

Drug Discovery

Price on request
Request a quote for more information about this service.

ic

Drug Discovery & Development

Price on request
Request a quote for more information about this service.

ic

Animal Motor Function Tests

Price on request
Request a quote for more information about this service.
Mouse Rat

ic

Animal Model in vivo Analyses

Price on request
Request a quote for more information about this service.
Mouse Rat

Not finding what you're looking for?

Get info on this provider's capabilities without requesting a quote.

NEUROSERVICE has not received any reviews.

NEUROSERVICE has not received any endorsements.