Neurofit SAS
7.5/10 Overall Rating
100% Positive
5 Orders Completed
ILLKIRCH, FR
NEUROFIT is a preclinical Contract Research Organization (CRO) specialising in the evaluation of treatments for central and peripheral nervous system disorders.
We offer a comprehensive list of in vitro and in vivo models covering a wide range of indications.
NEUROFIT aims to facilitate your preclinical drug development by proposing the best models for your needs. Our goal is to accelerate the development of your programs by providing cost-effective methods for compound evaluation.
We provide to our customers our in depth know-how in the evaluation of treatment for neurodegenerative diseases and neurological disorders. Our goal is to assist you in the choice of the most accurate tools following your needs and to provide you a fast and reliable answer to allow you to move forward in your projects. We provide animal models in the following fields: - Adhd - Allergic Contact Dermatitis - Alzheimer's Disease - ALS - Anxiety - Depression - Epilepsy - Inflammation - Multiple sclerosis - Neuropathic Pain - Parkinson's Disease - Peripheral Neuropathies - Rheumatoid Arthritis - Schizophrenia - Side effects
LPS model
Air pouch model
Inflammation Animal models:
- Carrageeenan Air pouch model The Carrageenan Air pouch model is a highly reproducible animal model designed for the effective screening of potential anti-inflammatory compounds. The air pouch is developed simply by a subcutaneous injection of sterile air into the intra-scapular area on the back of a mouse. The injection of a carrageenan solution into the pouch produces an inflammatory response that is characterized by the infiltration of cells, an increase in exudate and a marked production of pro-inflammatory mediators.
Measurement of electrophysiological parameters such as SNCV (sensory nerve conduction velocity) and CMAP (compound muscle action potential) are useful tools to assess the neuromuscular junction function. Used in combination with fiber morphometry measurement, these measurements can bring you a complete overview of the neuroprotective and neuro-regenerative effect of your compounds. Endpoints for these models are: - CMAP time course - SNCV : Conduction velocity time course - g-ratio - Axon size distribution profile
We provide to our customers our in depth know-how in the evaluation of treatment for neurodegenerative diseases and neurological disorders. Our goal is to assist you in the choice of the most accurate tools following your needs and to provide you a fast and reliable answer to allow you to move forward in your projects. We provide animal models in the following fields: - Adhd - Allergic Contact Dermatitis - Alzheimer's Disease - ALS - Anxiety - Depression - Epilepsy - Inflammation - Multiple sclerosis - Neuropathic Pain - Parkinson's Disease - Peripheral Neuropathies - Rheumatoid Arthritis - Schizophrenia - Side effects
NEUROFIT offers Human iPSC Neurons-based screening to evaluate the capability of test compound to promote dendrite formation and growth. - iPSC dervied neurons (neurite growth): A fully automated analysis of neuritogenesis in 96 well plate of primary neuron cultures, which enables the quantification of : - Neurite total count - Neurite total length - Dendrite branching
Oligodendrocyte Precursor Cells Proliferation: OPC cultures are obtained from cortex of rat pups. Test compounds are added just after cellular adhesion. Proliferation is assayed by an MTT test in 96-multi well plates after 3 days. Endpoints: OPCP survival / proliferation
Compound testing addresses the ability of test compounds to inhibit MPP+ or 6-OHDA - induced cell damage in mesencephalic neuron cultures as assessed by immunostainting of tyrosine hydroxylase neurons.
Amyloid-beta intoxication: Compound testing addresses the ability of test compounds to inhibit Aβ (1-40) - induced cell damage in hippocampal neuron cultures.
Basal Amyloid-beta production: The system is tailored to assess the efficiency of Aβ lowering drugs such as BACE inhibitors. In parallel, the assay also provides information about the potential safety or neurotoxicity of the tested drug.
Cortical nerons (neurite growth): The measuring of neuritogenesis, including neurite outgrowth, is instrumental for the screening of the neuromodulatory, neuroprotective, neuroregenerative and neurotoxic effects of the compounds.
iPSC dervied neurons (neurite growth): A fully automated analysis of neuritogenesis in 96 well plate of primary neuron cultures, which enables the quantification of :
Neurite total count
Neurite total length
Dendrite branching
Neurofit provides three cellular models for ALS:
• Glutamate and NMDA excitotoxicity
• Rat spinal motor neuron - Human Muscle coculture
• Spinal motor neurons
LPS inflammation: Cellular model of BRAIN INFLAMMATION in rat GLIA-MESENCEPHALIC NEURON cultures:
Endpoints:
☐ NO release
☐ Release of proinflammatory cytokines (TNF-α and IL-1β)
☐ Neuronal death
- Relapsing/Remitting EAE model
- Myelin Basic Protein EAE model
- Scopolamine induced memory deficit model
- Aged mice model
- Amyloid-beta model
- LPS model
- MLA model
- 6-OHDA animal model
- Haldol (Catalepsy) model
- Excitotoxicity on cortical neurons
Neurofit can evaluate the neuroprotective or neurotrophic effect of your compounds dedicated to the prevention or cure of spinal cord injuries.
Large range of models and assays for evaluating neurotoxicity, neuroprotection or neurotrophic activity of new test compounds.
One of the strategies mostly used by pharmaceutical industries to prevent or repair neurodegeneration is based on the development of neuroprotectant or neurotrophic compounds. NEUROFIT implements different cellular models to assess the efficacy of these classes of compounds.
Sensorimotor deficit is observed under various diseases that affect the nervous system.
Study of the microscopic organization and structure of a tissue (as skin, nerve) by computer-assisted analysis of images formed by a microscope
Neurofit performs Toxicity studies using OECD Guideline for Testing of Chemicals (423) .
Sensori-motor deficits are implied in a wide range of CNS and PNS diseases. NEUROFIT proposes different tests to study the influence of your compounds in sensori-motor deficit.
Formalin model.
NEUROFIT provides different tests to evaluate the efficacy of your compounds. As each test implying anxiety and depression assessment is specific, we attach a great importance to the prior discussion to propose you the most relevant solution to answer to your question.
We provide to our customers our in depth know-how in the evaluation of treatment for neurodegenerative diseases and neurological disorders.
Our goal is to assist you in the choice of the most accurate tools following your needs and to provide you a fast and reliable answer to allow you to move forward in your projects.
We provide animal models in the following fields:
CNS/Neurology Animal Models Services
We provide to our customers our in depth know-how in the evaluation of treatment for neurodegenerative diseases and neurological disorders.
Our goal is to assist you in the choice of the most accurate tools following your needs and to provide you a fast and reliable answer to allow you to move forward in your projects.
We provide animal models in the following fields:
Cell-Based Assays Services:
We provide a large range of models and assays for evaluating neurotoxicity, neuroprotection or neurotrophic activity of new test compounds. We can perform custom protocols to determine mechanism of action, or define therapeutic indication of new drug candidates.
In vitro Toxicity Testing Services
We provide to our customers our in depth know-how in the evaluation of treatment for neurodegenerative diseases and neurological disorders.
Our goal is to assist you in the choice of the most accurate tools following your needs and to provide you a fast and reliable answer to allow you to move forward in your projects.
We provide animal models in the following fields:
In vivo Toxicity Testing Services:
Each step in the protocol uses three animals. The absence or presence of compound-related mortality of animals dosed at one step determines the next step. Lethal exposure ranges are rapidly established and an estimation of an LD50 value can be made when at least two doses result in mortality > 0 % and < 100 %.
This model facilitates rapid ranking of compounds within a series, or across series, by their toxicity and provides an informed guide to choosing doses for IND-enabling studies.
Pharmacology & Toxicology Services
We provide to our customers our in depth know-how in the evaluation of treatment for neurodegenerative diseases and neurological disorders.
Our goal is to assist you in the choice of the most accurate tools following your needs and to provide you a fast and reliable answer to allow you to move forward in your projects and drug discovery and development.
We provide animal and cellular models in the following fields:
NEUROFIT offers several cognition and behavioral test to assess the efficacy of your compounds. All our tests are run routinely by our experts who are also available to provide you advice in the design of your experiment. Our goal is to provide you the most relevant data following your needs. Please see below a list of the some of the tests we provide:
NEUROFIT offers several cognition and behavioral test to assess the efficacy of your compounds. All our tests are run routinely by our experts who are also available to provide you advice in the design of your experiment. Our goal is to provide you the most relevant data following your needs. Please see below a list of the some of the tests we provide:
NEUROFIT offers several cognition and behavioral test to assess the efficacy of your compounds. All our tests are run routinely by our experts who are also available to provide you advice in the design of your experiment. Our goal is to provide you the most relevant data following your needs. Please see below a list of the some of the tests we provide:
"Rapid communication, initiation of study and turn around of report. Very easy interactions and would use again. Thanks."
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