The Neurobehavioral Core was established by the Gladstone Institute of Neurological Disease to analyze neurobehavioral functions, such as motor coordination or learning and memory, in rodent models of human neurological diseases. Understanding the molecular pathways that impair such functions in experimental models can provide important insights into clinically relevant disease processes as well as into basic functions of the nervous system.
The Neurobehavioral Core offers a wide array of customizable behavioral paradigms to fit your specific research needs. We offer over 60 types of behavioral assessments in mice that fall within 3 broad domains: Sensorimotor, Anxiety/Emotional, and Cognitive. These behavioral assessments can help validate the effects of experimental compounds as well as animal models of neurological or disease states. The Core can create a customized behavioral research battery as well as develop new tasks to fit your specific research needs. The Core is staffed with 4 highly skilled research technicians with an average of 8 yrs of behavioral testing experience.
Spatial learning and memory assessment using aversive stimulation to motivate avoidance
Taurine administration during lactation modifies hippocampal CA1 neurotransmission and behavioural programming in adult male mice
|Behavioral Test||Implicated Brain Region||References|
|Balance Beam||Basal Ganglia||Longitudinal evaluation of the Hdh(CAG)150 knock-in murine model of Huntington's disease.|
|Challenging Beam Traversal||Basal Ganglia||Phenotypical Characterization of Genetic Mouse Models of Parkinson Disease; Early and Progressive Sensorimotor Anomalies in Mice Overexpressing Wild-Type Human α-Synuclein|
|Climbing Cylinder||Basal Ganglia||Early behavioral deficits in R6/2 mice suitable for use in preclinical drug testing|
|Grip Strength||Basal Ganglia||A lateralised grip strength test to evaluate unilateral nigrostriatal lesions in rats|
|Open Field||Amygdala; Hippocampus||Adaptation and habituation to an open field and responses to various stressful events in animals with neonatal lesions in the amygdala or ventral hippocampus|
|Pole Test||Basal Ganglia||3,4-Dihydroxyphenylalanine Reverses the Motor Deficits in Pitx3-Deficient Aphakia Mice: Behavioral Characterization of a Novel Genetic Model of Parkinson’s Disease|
|Rotarod||Cerebellum||Long-term deficits in cerebellar growth and rotarod performance of rats following "binge-like" alcohol exposure during the neonatal brain growth spurt.|
|Suok Test||Parabrachial Nucleus||Extended Central Amygdaloid Nucleus|
|Infralimbic Cortex||Hypothalamus||The regular and light–dark Suok tests of anxiety and sensorimotor integration: utility for behavioral characterization in laboratory rodents|
Developmental Milestones: Unit 8.18 assessment of developmental milestones in rodents
General Neurological Screen: Abnormal GABA A receptor-mediated currents in dorsal root ganglion neurons isolated from
Ultrasonic Vocalizations: Altered ultrasonic vocalization in mice with a disruption in the Foxp2 gene
Injection of oxytocin into the medial preoptic-anterior hypothalamus increases ultrasound production by female hamsters - from behavior to gene expression
Ultrasonic Vocalizations Induced by Sex and Amphetamine in M2, M4, M5 Muscarinic and D2 Dopamine Receptor Knockout Mice
Social Approach: The neurobiology of social recognition, approach, and avoidance
Social Recognition: Long-term memory underlying hippocampus-dependent social recognition in mice
Selective antiaggressive effects of alnespirone in resident-intruder test are mediated via 5-hydroxytryptamine1A receptors: a comparative pharmacological study with 8-Hydroxy-2-dipropylaminotetralin, ipsapirone, buspirone, eltoprazine, and WAY-100635
Unit 8.5B assessment of spatial memory using the T-maze
Permanent and temporary inactivation of the hippocampus impairs T-maze footshock avoidance acquisition and retention
The olfactory habituation test is used to assess the ability of a subject to discriminate between novel and familiar odors. With repeated exposure, mice should habituate to a scent and investigation should rebound once a new scent has been introduced.
On the delay-dependent involvement of the hippocampus in object recognition memory
Allopregnanolone inhibits learning in the Morris water maze
Amygdala, hippocampus and discriminative fear conditioning to context
Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning
Antidepressant-like effects of ceftriaxone in male C57BL/6J mice
The regular and light–dark Suok tests of anxiety and sensorimotor integration: utility for behavioral characterization in laboratory rodents
Unit 8.7 measurement of startle response, prepulse inhibition, and habituation
Relationship between limbic and cortical 5-HT neurotransmission and acquisition and reversal learning in a go/no-go task in rats
The rostral anterior cingulate cortex modulates depression but not anxiety-related behaviour in the rat
Rostral cingulate gyrus: A putative target for deep brain stimulation in treatment-refractory depression
Serotonin laterality in amygdala predicts performance in the elevated plus maze in rats.
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Neurobehavioral Core has not received any endorsements.