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NEURO-SYS

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Gardanne, FR

About NEURO-SYS

Founded: 2013

Neuro-Sys is an innovative French Drug Discovery and Services company focusing on neurological diseases. Neuro-Sys has developed specific preclinical in vitro models of CNS (Central Nervous System) and PNS (Peripheral Nervous System) diseases such as:

·         Alzheimer’s disease (AD)

·         Parkinson’s disease (PD)

·         Huntington’s disease (HD)

·         Amyotrophic Lateral Sclerosis (ALS or Lou Gehrig’s disease)

·         Rare diseases (e.g. Multiple System Atrophy, Adrenoleukodystrophy)

·         Multiple Sclerosis (MS)

·         Peripheral Neuropathies (Charcot-Marie Tooth, anti-mitotic)

·         Disruption of the BBB

    Our pharmacology platforms have been designed to accept different entity sources such as: 

·         Compounds (from natural or chemical sources)

·         Plants      

·         Plant extracts 

 

Activities

 

Drug Development services:

 

          Our experts in Drug and Pharmaceutical development can accompany you:

› in your drug discovery development plan design (pre-clinical testing in vitro and in vivo models),

› in the design of your preclinical research programs (vitro/ vivo, MOA…),

› in the preclinical (Pharmacology, PK and ADME) development and early clinical designs (PoC studies),

› in the writing of research projects, your Investigator Brochure (IB), IMPD, ODD submission (FDA/EMA) in neuro indication.

 

Pharmacological services:

 

We determine the pharmacological profiling of lead compounds and explore their underlying mechanism of action. We provide studies to determine the neuroprotective activity of lead compounds but also of dietary supplements and medical nutrition. 

Neuro-Sys has also defined a unique model of the blood-brain barrier. Our scientific experts are able to say which active compound can cross this barrier and have an active effect(s) on the brain.

 

Analytical services:

 

Our UPLC-DAD-ELSD platform allows the characterisation and quantification of active compounds in biological matrices. 

Neuro-Sys knows that each client is unique and so we are dedicated to adapting our procedures and protocol to meet each clients’ specific needs.

 

Our Services (11)


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Cell-Based Assays

Price on request

At Neuro-Sys, we support clients’ projects by designing dedicated cell-based assays on neurodegenerative diseases. Our assays based on primary cultures of neurons have been highly improved and miniaturized to 96 well plates increasing the number of conditions per plate and decreasing the study times and costs compared to in vivo testing.

Alzheimers Disease Parkinson's disease (PD) Amyotrophic Lateral Sclerosis (ALS) Multiple sclerosis (MS) Neuropathy Biomek FX Laboratory Automation Systems Molecular Devices ImageXpress Milestone Ethos Ex ProteinSimple WES NanoDrop 2000 Rodents CNS/Neurology Show 12 more tags Show less

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In vitro Neurodegeneration Models

Price on request

Neuro-Sys offers a wide range of in vitro (to in vivo with partners) services via state of the art screening assays through its proprietary innovative and automated pharmacological platforms.


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Primary Cell Culture

Price on request

Primary nerve cell cultures are powerful models that we use to evaluate the responses of target cells at the cellular and molecular levels to the deleterious effects of neurotoxic substances or neuroprotective effects. Primary cultures of nerve cells are prepared from either fetal or new born rat brains, cultured with specific media. By using cells with different days-in-culture it is possible to mimic and evaluate developmental-related modifications.

Rat CNS/Neurology

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Pharmacology & Toxicology

Price on request

Pharmacological profiling and Mode of Action (MOA)

Accurate in vitro pharmacological profiling at an early stage is critical for lead optimization. Combining live content and high-content imaging as well as molecular biology, Neuro-Sys has developed a cost-efficient strategy to accurately determine the efficacy and toxicity profile of lead compounds, and explore their underlying mechanism of action.

Alzheimers Disease Parkinson's disease (PD) Amyotrophic Lateral Sclerosis (ALS) Multiple sclerosis (MS) Neuropathy ProteinSimple WES Biomek FX Laboratory Automation Systems NanoDrop 2000 Molecular Devices ImageXpress Milestone Ethos Ex Rodents CNS/Neurology Show 12 more tags Show less

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Drug Discovery & Development

Price on request

Neuro-Sys’ Drug Discovery department, NS-Pharma, which includes a dedicated laboratory and scientists has been setup to realize in-house R&D programs to find new compounds coming from specific medicinal plants as a perspective.

Going forward, the brand new compounds with a proven and demonstrated activity on neurological disorders are put on the market for the pharmacological industry, capable to make all further development.


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In vitro Neural Models

Price on request
Request a quote for more information about this service.

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In vivo Pharmacology Studies

Price on request

Pharmacological profiling and Mode of Action (MOA)

Accurate in vitro pharmacological profiling at an early stage is critical for lead optimization. Combining live content and high-content imaging as well as molecular biology, Neuro-Sys has developed a cost-efficient strategy to accurately determine the efficacy and toxicity profile of lead compounds, and explore their underlying mechanism of action.


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In vitro Disease Models

Price on request
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In vivo PK/PD Studies

Price on request
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Biology

Price on request
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Cells and Tissues

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