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Neuro-DVI LLP

London, GB

Since its founding in 2012, Neuro-DVI has developed and optimized technologies to reveal and quantify gene expression patterns and the resultant morphological details of brain structures in a novel rodent that naturally develops Alzheimer´s with an unprecedented level of sensitivity, specificity and resolution. Neuro-DVI's unique technologies to measure and assess neurodevelopmental and neurodegenerative processes at work at the molecular, cellular and macroscopic levels are ideally suited to identify the earliest evidence of pathology in animal models of human diseases of the Central Nervous System, as well as to evaluate the comparative effectiveness of pharmaceutical candidates for intervention. The company dedicates these technologies to discovery and development of drugs to provide effective treatments for diseases characterized by neurodevelopment and neurodegeneration.

Neuro-DVI is a drug discovery and... Show more »

Since its founding in 2012, Neuro-DVI has developed and optimized technologies to reveal and quantify gene expression patterns and the resultant morphological details of brain structures in a novel rodent that naturally develops Alzheimer´s with an unprecedented level of sensitivity, specificity and resolution. Neuro-DVI's unique technologies to measure and assess neurodevelopmental and neurodegenerative processes at work at the molecular, cellular and macroscopic levels are ideally suited to identify the earliest evidence of pathology in animal models of human diseases of the Central Nervous System, as well as to evaluate the comparative effectiveness of pharmaceutical candidates for intervention. The company dedicates these technologies to discovery and development of drugs to provide effective treatments for diseases characterized by neurodevelopment and neurodegeneration.

Neuro-DVI is a drug discovery and pre-clinical validation biotechnology company with an innovative drug screening technology and a development-stage drug candidate

NEURO-DVI provides the necessary infrastructure, workforce, animal models and scientific targets to facilitate the pursuit of a high-level drug validation system in a synergistic environment with a well-established international support network. 

Recent Publications:

  • Robert M.J. Deacon, Francisco J. Altimiras, Enrique A. Bazan-Leon, Rhada D. Pyarasani, Fabiane M. Nachtigall, Leonardo S. Santos, Anthony G. Tsolaki, Lina Pednekar, Uday Kishore, Rodolfo R. Biekofsky, Rodrigo A. Vasquez and Patricia Cogram, 'Neural AD-like Neuropathy in Octodon degus: Impaired Burrowing and Neuroinflammation SDO', Current Alzheimer's, 2015
  • Deacon RM, Glass L, Snape M, Hurley MJ, Altimiras FJ, Biekofsky RR, Cogram P, 'NNZ-2566, a Novel Analog of (1-3) IGF-1, as a Potential Therapeutic Agent for Fragile X Syndrome', Neuromolecular Med. 2015 Mar; 17 (1): 71-82
  • Yrigollen CM, Sweha S, Durbin-Johnson B, Zhou L, Berry-Kravis E, Fernanez-Carvajal I, Faradz SM, Amiri K, Shaheen H, Polli R, Murillo-Bonilla L, Silva Arevalo Gde J, Cogram P, Murgia A, Tassone F, 'Distribution of AGG interruption patterns with nine world populations', Intractable Rare Dis Res. 2014 Nov; 3(4): 153-61
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Immunohistochemistry (IHC)
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Custom Cell-Based Assays
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Whether a small molecule drug discovery or developing biologics, we can create an assay that suits the customer requirements.

Cell Biology assays inclue: primary cell cultures, cell death assays, RNA interference and gene over expression assays, cellular imaging & analysis.

Whether a small molecule drug discovery or developing biologics, we can create an assay that suits the customer requirements.

Cell Biology assays inclue: primary cell cultures, cell death assays, RNA interference and gene over expression assays, cellular imaging & analysis.

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Western Blot
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Whether a small molecule drug discovery or developing biologics, we can create an assay that suits the customer requirements including Quantitative Wstern Blots.

Whether a small molecule drug discovery or developing biologics, we can create an assay that suits the customer requirements including Quantitative Wstern Blots.

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qPCR Arrays
quantitative PCR array
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Whether a small molecule drug discovery or developing biologics, we can create an assay that suits the customer requirements:

  • In vitro and ex vivo capabilities
  • Quantitative RT-PCR

Whether a small molecule drug discovery or developing biologics, we can create an assay that suits the customer requirements:

  • In vitro and ex vivo capabilities
  • Quantitative RT-PCR
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Animal Behavior Studies
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Our functional outcome measures target specific behaviours including:

  • Anxiety
  • Cognition
  • Motor Behaviour
  • Species-typical behaviour
  • Epilepsy
  • Behaviour tests for young mouse pups

Drug Delivery Systems:

We use a variety of drug-delivering systems according to your needs from:

Our functional outcome measures target specific behaviours including:

  • Anxiety
  • Cognition
  • Motor Behaviour
  • Species-typical behaviour
  • Epilepsy
  • Behaviour tests for young mouse pups

Drug Delivery Systems:

We use a variety of drug-delivering systems according to your needs from:

  • Gavage
  • Drinking water
  • Intraperitoneal injection
  • Subcutaneous injections
  • Osmotic minipumps

We offer tailoring behaviourbased on your drug of interest we will advise you on the specific behavioural tests that best suit your study.

Drosophila:

We monitor behavioral alterations in the fly under pharmacological treatment including:

  • Circadian motor activity
  • Olfaction
  • Vision (phototactism)
  • Courtship behaviour
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Animal Models and Studies
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Cell-Based Assays
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Animal Model in vivo Analyses
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Protein Expression Visualization
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Protein Services
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Biology
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Immunostaining
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PCR
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Animal Learning, Memory, and Behavior Tests
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DNA
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Animal Cognition & Behavior Tests
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Specialized Cell-Based Assays
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Biochemistry & Molecular Biology
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Nucleic Acid Services
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