NeoGenomics Laboratories is a specialized oncology reference laboratory providing the latest testing technologies, global/tech-only options, and interactive education to the pathology community
NeoGenomics offers the complete spectrum of diagnostic services in immunohistochemistry, FISH, flow cytometry, cytogenetics, and molecular testing through our nationwide network of laboratories. We are dedicated to providing superior service, faster turn-around times, and complete attention to the needs of our clients and their patients.
Business Expansion Award – September 2010
Presented by: Fort Myers Economic Development Organization
CDx development and commercialization
Full services on DNA, RNA. RNAseq, CHiP seq, whole exome sequencing, gene panels, mitochondrial sequencing
Fluorescence in-situ Hybridization (FISH) is a branch of cancer genetics that focuses on detecting and locating the presence or absence of specific DNA sequences on chromosomes. FISH is also referred to as Molecular Cytogenetics.
To perform FISH, cells are fixed onto the surface of a slide, and then the slide is treated so that the chromosomal DNA is denatured into single strands.
Then, special fluorescently labeled DNA probes are applied onto the slide. The DNA probes are small pieces of single stranded DNA with a sequence from the gene of interest. Probes are only able to hybridize with their complimentary sequence, which is the gene or locus of interest on a particular chromosome. The DNA probes are allowed to hybridize with the denatured chromosomal DNA, and any excess probes are washed away.
After the excess probes are washed away, the slide is then viewed under a fluorescence microscope. The fluorescently labeled molecules reveal the physical location of the gene or locus of interest. Pathologists will then use specified cut off values to assess the results of the FISH test.
Frequently Ordered Test(s):
Cytogenetics is the specialized area of laboratory medicine involving the study of normal and abnormal chromosomes and their relationship to disease. Cytogenetic studies are often ordered to answer diagnostic, prognostic and predictive questions in the treatment of hematologic malignancies and solid tumors.
We offer traditional G-banding for metaphase analysis which includes the detection of chromosomal translocations, insertions, inversions, deletions and duplications. Additionally, proprietary wet lab processes increase the length of chromosomes and improve resolution, allowing our team members to ensure the highest quality karotype is performed.
NeoGenomics uses 10-color flow cytometry for improved efficiency and reliability in evaluation and diagnosis of hematopoietic diseases. Some of the advantages of our 10-color flow cytometry service over those detecting fewer fluorochromes are:
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