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Nathan Edwards Lab

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Washington, District of Columbia, US

About Nathan Edwards Lab

Dr. Edwards joined the Department of Biochemistry and Molecular & Cellular Biology at Georgetown University in 2007. With a background in computer science, applied probability and statistics, scientific computing, and computer algorithms, Dr. Edwards has worked in proteomics informatics, particularly the... Show more ยป

Dr. Edwards joined the Department of Biochemistry and Molecular & Cellular Biology at Georgetown University in 2007. With a background in computer science, applied probability and statistics, scientific computing, and computer algorithms, Dr. Edwards has worked in proteomics informatics, particularly the analysis of spectral data from discovery-focused proteomics workflows, since 2000.

Active projects include the Rapid Microorganism Identification Database, which characterizes unknown bacteria by matching protein sequences with biomarker peaks in MALDI mass-spectra; and NCI funded tool development for the discovery and characterization of known, novel, unexpected, and poorly annotated alternate splicing and cSNP protein isoforms, as potential cancer biomarkers.

At Celera Genomics, Dr. Edwards was a lead developer of SCOPE, one of the first sequence database search engines to use sequence dependent probabilistic scoring to match peptides to tandem mass-spectra for protein identification for high-throughput proteomics workflows. At Applied Biosystems, Dr. Edwards lead and co-developed an exploratory software product "Biomarker Toolbox" for the analysis of protein profiling mass-spectra. For the USDA, Dr. Edwards worked to identify characteristic biomarker tandem mass-spectra which could reliably identify soy-bean pathogens using spectral matching. For DARPA, Dr. Edwards lead an informatics-directed biomarker strategy for the detection of genetic engineering in otherwise benign microorganisms.

Education:

  • Ph.D. (2001) Cornell University, Operations Research
  • M.S. (1998) Cornell University, Operations Research
  • B. Sc (Hons) (1992) University of Western Australia, Mathematics & Computer Science

Recent Publications:

  • N. J. Edwards, M. Oberti, R. R. Thangudu, S. Cai, P. B. McGarvey, S. Jacob, S. Madhavan, K. A. Ketchum. "The CPTAC Data Portal: A Resource for Cancer Proteomics Research." Journal of Proteome Research (2015): Available online.
  • P. Mudvari, M. Movassagh, K. Kowsari, A. Seyfi, M. Kokkinaki, N. J. Edwards, N. Golestaneh, and A. Horvath. "SNPlice: Variants that Modulate Intron-retention from RNA-sequencing Data." Bioinformatics 31.8 (2015): 1191-1198.
  • M. Burke, W. Choksawangkarn, N. Edwards, S. Ostrand-Rosenberg, and C. Fenselau. "Exosomes from myeloid derived suppressor cells carry biologically active proteins." Journal of Proteome Research 13.2 (2014): 836โ€“843.
  • L. Geis-Asteggiante, A. Dhabaria, N. Edwards, S. Ostrand-Rosenberg, and C. Fenselau. "Top-down analysis of low mass proteins in exosomes shed by murine myeloid-derived suppressor cells." International Journal of Mass Spectrometry 378 (2014): 264โ€“269.
  • B. Zhang, J. Wang, X. Wang, J. Zhu, Q. Liu, Z. Shi, M. C. Chambers, L. J. Zimmerman, K. F. Shaddox, S. Kim, S. R. Davies, S. Wang, P. Wang, C. R. Kinsinger, R. C. Rivers, ..., R. R. Townsend. "Proteogenomic characterization of human colon and rectal cancer." Nature 513.7518 (2014): 382-387.
  • M. C. Burke, M. S. Oei, N. J. Edwards, S. Ostrand-Rosenberg, and C. Fenselau. "Ubiquitinated Proteins in Exosomes Secreted by Myeloid-derived Suppressor Cells." Journal of Proteome Research 13.12 (2014): 5965โ€“5972.
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