Nanosyn

Nanosyn offers Screening, Profiling and Mechanistic studies for all types of enzymatic targets:

• kinases (>300 different wild types)
• epigenetic targets (KDMs, HMTs, HDAC/SIRTs, HAT)
• phosphatases
• proteases
• phosphodiesterases

The functional assays are developed and performed using a proprietary version of an advanced microfluidic screening platform. Custom enzymatic assays for new targets can be developed.

Advantages:

• data more precise and reproducible than from other screening methods allowing for direct and immediate SAR mining
• direct measurement of enzyme activity accurately identifies inhibitors and activators in the same run
• true selectivity determinations delivered via comparable biochemical and kinetic conditions across the suite of targets
• rigorous quality control principles including reference compounds run with every data set
• very low level of false positive and false negatives
• data reporting customized to your needs
• rapid turnaround time

Nanosyn offers Screening, Profiling and Mechanistic studies for all types of enzymatic targets:

• kinases (>300 different wild types)
• epigenetic targets (KDMs, HMTs, HDAC/SIRTs, HAT)
• phosphatases
• proteases
• phosphodiesterases

The functional assays are developed and performed using a proprietary version of an advanced microfluidic screening platform. Custom enzymatic assays for new targets can be developed.

Advantages:

• data more precise and reproducible than from other screening methods allowing for direct and immediate SAR mining
• direct measurement of enzyme activity accurately identifies inhibitors and activators in the same run
• true selectivity determinations delivered via comparable biochemical and kinetic conditions across the suite of targets
• rigorous quality control principles including reference compounds run with every data set
• very low level of false positive and false negatives
• data reporting customized to your needs
• rapid turnaround time

Nanosyn offers Screening, Profiling and Mechanistic studies for all types of enzymatic targets:

• kinases (>300 different wild types)
• epigenetic targets (KDMs, HMTs, HDAC/SIRTs, HAT)
• phosphatases
• proteases
• phosphodiesterases

The functional assays are developed and performed using a proprietary version of an advanced microfluidic screening platform. Custom enzymatic assays for new targets can be developed.

Advantages:

• data more precise and reproducible than from other screening methods allowing for direct and immediate SAR mining
• direct measurement of enzyme activity accurately identifies inhibitors and activators in the same run
• true selectivity determinations delivered via comparable biochemical and kinetic conditions across the suite of targets
• rigorous quality control principles including reference compounds run with every data set
• very low level of false positive and false negatives
• data reporting customized to your needs
• rapid turnaround time

Chemistry-on-demand, based on Nanosyn's patented techniques, includes know-how, chemical synthesis, software and instrumentation designed to generate novel, pure, and well characterized compounds.

Nanosyn offers:
• medicinal chemistry
• synthetic chemistry
• hit-to-lead
• fragment based lead
• focused library
• custom synthesis

Advantages include:
• reduced iterative cycle time
• array of highly purified small molecule compounds
• maximum flexibility in synthesis (solid phase, solution phase, microwave assisted chemistry, inert atmosphere etc...)
• highly efficient compound production (from mg to Kg in cGMP unit)
• HTS characterization and proprietary systems for data processing