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NanoImaging Services

4 Orders Completed
San Diego, California, US

About NanoImaging Services

Founded: 2007 Type: Privately Held Size: 11-50 employees

**_Technical Expertise_** NanoImaging Services' technical expertise is grounded in a long and successful history of innovation in developing new technologies and automated methods for transmission electron microscopy and analysis. NanoImaging Services founders are also responsible for directing the... Show more »

**_Technical Expertise_** NanoImaging Services' technical expertise is grounded in a long and successful history of innovation in developing new technologies and automated methods for transmission electron microscopy and analysis. NanoImaging Services founders are also responsible for directing the Automated Molecular Imaging (AMI) research group at The Scripps Research Institute (TSRI). Their experience, insight and unwavering commitment to perfecting biological imaging tools and methods is reflected in NanoImaging Services' portfolio of advanced techniques which exhibit unparalleled performance characteristics. **_Rapid Reliable Information_** NanoImaging Services understands when rapid turnaround and information access is important and they respond accordingly. They are "aligned" with the needs of process development and formulation end-users and keep them constantly in mind. They define the standard for reliable, accurate and accessible image analysis. NanoImaging Services is dedicated to meeting timelines and is rigorous about delivering annotated results and a final summary report for every specimen, and not just a stack of micrographs. This attention ensures it's services are reliable and thorough every step along the way. **_Customer Dedication_** NanoImaging Services makes it a priority to offer exceptional service to its customers. While many companies make this claim, few truly deliver to the promise -- NanoImaging Services does. Yet exceptional service in today's market is still no guarantee of customer loyalty. NanoImaging Services earns outstanding customer loyalty levels through exceptional services, unrivaled responsiveness, and an unerring commitment to anticipating customers' nanoparticle imaging and characterization needs.

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Our Services (35)


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Cryo-Electron Microscopy

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Cryo-electron Tomography (CryoET)

3D volume of the sample can be reconstructed from a series of 2D projection images acquired by incrementally tilting the sample over a range of angles and acquiring a different image for each tilt. The tilted set of projection images can then be mathematically combined to reconstruct a... Show more »

Cryo-electron Tomography (CryoET)

3D volume of the sample can be reconstructed from a series of 2D projection images acquired by incrementally tilting the sample over a range of angles and acquiring a different image for each tilt. The tilted set of projection images can then be mathematically combined to reconstruct a 3D volume of the sample, essentially using tomographic methods (analogous to those used for CT scanning and other medical imaging procedures).

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Structure Determination

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3D Structure Determination

Three dimensional structural determination can answer questions about drug products and therapeutics that are not accessible by traditional methods. What is the lamellarity of your micelle preparation? Where on your drug delivery vehicle are the receptor proteins located? What is the encapsulation... Show more »

3D Structure Determination

Three dimensional structural determination can answer questions about drug products and therapeutics that are not accessible by traditional methods. What is the lamellarity of your micelle preparation? Where on your drug delivery vehicle are the receptor proteins located? What is the encapsulation efficiency for your drug product? NanoImaging Services performs three dimensional structural determinations of nanoscale structures using advanced tomography or single particle averaging (SPA) methods developed specifically to extract important information from drug product preparations.

Lamellarity Determination
How many continuous lipid layers do your liposomes or micelles contain?
Drug Delivery Vehicle Characterization
What is the distribution of receptor proteins on your drug delivery vehicle?
Drug Product Encapsulation
Has your drug product been efficiently encapsulated?

Applications
Case Studies: Read more about our 3D structure determination services in the "Characterization of Biopharmaceuticals: Gardisil," "Characterization of Viruses and Vaccines: Adeno5 and H1N1," and "Characterization of Liposomes in Solution" case studies.

Drug Development: Support for pharmaceutical and biotechnology process development and formulation development and scale-up functions related to chemistry, manufacturing, and control (CMC).
Regulatory Review: Support for demonstrating that procedures are developed to ensure stability, batch-to-batch uniformity, and overall quality for IND and NDA submissions.

Validation: Support for demonstration of established protocols and specifications for production process as well as demonstration of bioequivalence when manufacturing protocols are modified or improved.

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Titan Krios cryoEM Drug Discovery

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Protein Characterization

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Proteins and Protein Complex Characterization

Direct visualization of proteins and protein complexes in solution can save hundreds of thousands of dollars spent in time and reagents during process development and formulation analysis. Is your formulation plagued by submicron aggregation? Are denatured proteins decreasing the... Show more »

Proteins and Protein Complex Characterization

Direct visualization of proteins and protein complexes in solution can save hundreds of thousands of dollars spent in time and reagents during process development and formulation analysis. Is your formulation plagued by submicron aggregation? Are denatured proteins decreasing the shelf life of your drug? Does your protein complex of interest remain morphologically intact across different batch processes? NanoImaging Services performs full characterization of proteins and protein complexes in solution using state of the art Molecular Microscopy methods developed specifically to preserve the native structure of your sample and provide a direct measure of protein and protein complex morphology, aggregation state, and structure.

Morphology Analysis
How clean and intact are the proteins in your formulation really?
Particle Contents
Are your particles full or empty?
Complex Characterization
What does your protein-adjuvant complex look like?
Aggregation Assessment
Are your solubility issues a result of submicron aggregation?

Applications
Case Studies: "Characterization of Submicron Aggregates: IgG and IgM" and "Characterization of Biopharmaceuticals: Gardisil"

Drug Development: Support for pharmaceutical and biotechnology process development and formulation development and scale-up functions related to chemistry, manufacturing, and control (CMC).

Regulatory Review: Support for demonstrating that procedures are developed to ensure stability, batch-to-batch uniformity, and overall quality for IND and NDA submissions.

Validation: Support for demonstration of established protocols and specifications for production process as well as demonstration of bioequivalence when manufacturing protocols are modified or improved.

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Material Testing Services

Price on request

Sub-micron Aggregate Characterization

Thorough characterization of sub-micron aggregates contained in drug products is increasingly important, but standard methods such as size exclusion chromatography (SEC) and dynamic light scattering (DLS) are indirect and fall short when it comes to the really small stuff. Visualization... Show more »

Sub-micron Aggregate Characterization

Thorough characterization of sub-micron aggregates contained in drug products is increasingly important, but standard methods such as size exclusion chromatography (SEC) and dynamic light scattering (DLS) are indirect and fall short when it comes to the really small stuff. Visualization of sub-micron aggregate particulates in solution by Molecular Microscopy gives a direct measure of aggregate size, morphology, and distribution.

Shape and Morphology
What do the sub-micron aggregates in your drug product look like?
Direct Measurement
Are the actual sub-micron aggregate sizes and counts comparable to indirect measurements?
Loss of Soluble Protein
What is the percent loss of soluble protein during aggregate formation?

Applications
Case Studies: Read more about our submicron aggregation studies in the "Characterization of Submicron Aggregates: IgG and IgM" case study.

Drug Development: Support for pharmaceutical and biotechnology formulation discovery, development and scale-up functions related to chemistry, manufacturing, and control (CMC).

Regulatory Review: Provided supplemental and potential critical data for demonstrating procedures to ensure stability, batch-to-batch uniformity, and overall quality for IND and NDA submissions have been development.

Validation: Qualified evidence of established protocols and specifications for production process as well as demonstration of bioequivalence when manufacturing protocols are modified or improved.

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Drug Discovery

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Nano-Imaging

Price on request

NanoImaging Services provides Molecular Microscopy imaging and analysis of samples in solution.

NanoImaging Services provides Molecular Microscopy imaging and analysis of samples in solution.

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Titan Krios cryoEM

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Microscopy Image Analysis

Price on request

Sizing and Counting

Accurately defining the size distribution of particles in a given sample is essential for characterization during pharmaceutical and biotechnology process development, formulation and production. Standard nanoparticle sizing methods such as dynamic light scattering (DLS) can be plagued by biases... Show more »

Sizing and Counting

Accurately defining the size distribution of particles in a given sample is essential for characterization during pharmaceutical and biotechnology process development, formulation and production. Standard nanoparticle sizing methods such as dynamic light scattering (DLS) can be plagued by biases introduced by contaminants. NanoImaging Services has developed advanced Molecular Microscopy image analysis software for semi-automated particle sizing and contouring that provides precise, statistically determined, and accurate sample size distribution measurement for nanometer to sub-micron particles in heterogeneous and homogeneous sample solutions.

*Size Distribution of the Sample"
Does the size distribution compare with other batches or lots?

Biosimilarity
Is the size distribution similar to existing formulations?

Direct Measurement
Is the actual size comparable to indirect measurements?

Applications
Case Studies: Read more about our sizing and counting services in the "Characterization of Biopharmaceuticals: Gardisil" case study.

Drug Development: Support for pharmaceutical and biotechnology formulation discovery, development and scale-up functions related to chemistry, manufacturing, and control (CMC).

Regulatory Review: Provide supplemental and potential critical data for demonstrating procedures to ensure stability, batch-to-batch uniformity, and overall quality for IND and NDA submissions.

Validation: Qualified evidence of established protocols and specifications for production process as well as demonstration of bioequivalence when manufacturing protocols are modified or improved.

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Virus Characterization

Price on request

Virus and Virus Like Particle Characterization

Direct determination of the morphology, size distribution, shape and concentration of stock solution of viruses and virus vaccines is vital for sample characterization during pharmaceutical and biotechnology process development and formulations analysis. NanoImaging Services... Show more »

Virus and Virus Like Particle Characterization

Direct determination of the morphology, size distribution, shape and concentration of stock solution of viruses and virus vaccines is vital for sample characterization during pharmaceutical and biotechnology process development and formulations analysis. NanoImaging Services performs full characterization of viruses and virus vaccines using advanced transmission electron microscopy methods.

Morphology Characterization
Determination of particle shape and size distribution
Titer Determination
The concentration of the stock solution of a given sample is readily determined from TEM images for suitable samples
3D Structure
In silico reconstruction of detailed 3D virus or VLP model

Applications
Case Studies: Read more about our virus and virus like particle characterization services in the "Characterization of Viruses and Vaccines: Adeno5 and H1N1" and "Characterization of Biopharmaceuticals: Gardisil" case studies.

Drug Development: Support for pharmaceutical and biotechnology process development and formulation development and scale-up functions related to chemistry, manufacturing, and control (CMC).
Regulatory Review: Support for demonstrating that procedures are developed to ensure stability, batch-to-batch uniformity, and overall quality for IND and NDA submissions.

Validation: Visual demonstration of established protocols and specifications for production process as well as demonstration of bioequivalence when manufacturing protocols are modified or improved.

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Morphology Characterization Titer Determination Drug Discovery

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Liposome Characterization

Price on request

Liposome and Emulsion Characterization

Direct determination of liposome nanoparticle morphology (size distribution and shape), and assembly (lamellarity) for therapeutic lipid particles are critical to characterization. These factors are known to influence biological activity, biodistribution and toxicity. Quantitative data... Show more »

Liposome and Emulsion Characterization

Direct determination of liposome nanoparticle morphology (size distribution and shape), and assembly (lamellarity) for therapeutic lipid particles are critical to characterization. These factors are known to influence biological activity, biodistribution and toxicity. Quantitative data is essential for accurate pharmaceutical and biotechnology formulation discovery and development. NanoImaging Services performs full characterization of nanoscale liposome particles using advanced Molecular Microscopy methods developed specifically to preserve the native fully hydrated biological structure of liposomes. Our automated methods provide reliable high throughput image acquistion.

Size
What is the exact size fo your liposome or micelle?
Shape Characterization
Is the shape consistently spherical, elliptical, elongated?
Lamellarity
Is the particle single or multi-layered?
Particle Sub-structure
Does the particle contain drug cargo?

Applications
Case Studies: Read more about liposome characterization services in the "Characterization of Liposomes in Solution" case study.

Drug Development: Support for pharmaceutical and biotechnology formulation discovery, development and scale-up functions related to chemistry, manufacturing, and control (CMC).

Regulatory Review: Provided supplemental and potentially critical data for demonstrating procedures to ensure stability, batch-to-batch uniformity, and overall quality for IND and NDA submissions have been development.

Validation: Qualified evidence of established protocols and specifications for production process as well as demonstration of bioequivalence when manufacturing protocols are modified or improved.

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Virology Services

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Regulatory Affairs Consulting

Price on request

We provide supplemental and potentially critical data for demonstrating procedures to ensure stability, batch-to-batch uniformity, and overall quality for IND and NDA submissions.

Qualified evidence of established protocols and specifications for production process as well as demonstration of bioequivalence when manufacturing protocols are modified or improved.

We provide supplemental and potentially critical data for demonstrating procedures to ensure stability, batch-to-batch uniformity, and overall quality for IND and NDA submissions.

Qualified evidence of established protocols and specifications for production process as well as demonstration of bioequivalence when manufacturing protocols are modified or improved.

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Chemistry and Materials

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Data Services

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Formulation Services

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Nuclear Imaging

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Histological Staining

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Computational Modeling

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Biology

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Negative Staining

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We select one of many different heavy metal reagents to optimize visualizing the structural features of your particular sample (lipid, protein, nucleic acid) in its own native buffer conditions (salt, pH, surfactant). For vitrification, we preserve your sample in its native hydrated state using cryo plunge freezing methods.

We select one of many different heavy metal reagents to optimize visualizing the structural features of your particular sample (lipid, protein, nucleic acid) in its own native buffer conditions (salt, pH, surfactant). For vitrification, we preserve your sample in its native hydrated state using cryo plunge freezing methods.

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cryoEM

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Protein Services

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Particle Analysis and Characterization

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Microscopic Analysis

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Liposome Formulation

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Single Particle Analysis

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Nanoscale Analysis and Characterization

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Molecular Imaging

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Microscopy

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Image Analysis

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Viral Assays

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Electron Microscopy

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Biochemistry & Molecular Biology

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Bioparticle Technology

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Imaging & Spectroscopy

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Three Dimensional Electron Microscopy

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Transmission Electron Microscopy (TEM)

Transmission Electron Microscopy services
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Regulatory Affairs Services

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Regulatory Affairs Services

Regulatory Affairs Services

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