nanoComposix is a world leading manufacturer of precisely engineered and highly characterized nanoparticles. Our mission is to help our customers bring nanotechnology-enabled products to market. Our multi-disciplinary technical teams provide rapid prototyping, characterization, integration, and scale-up solutions to accelerate R&D and commercialization for a wide variety of application areas including biodiagnostics, topical therapeutics, nanomedicine, antimicrobial coatings, and color engineering.
Since 2004, nanoComposix has provided monodisperse and unagglomerated metal and metal-oxide nanomaterials to thousands of customers. Hundreds of different variants of material, size, shape, and surface are available as stock products and we have produced over 2000 custom core/shell, biofunctionalized, fluorescent, and magnetic nanocomposites to meet client specifications. NanoComposix produced the NIST nanosilver reference material and our particles have been utilized in over 400 peer-reviewed publications. All of our materials are supplied with certificates of analysis that include electron microscopy, hydrodynamic diameter, and optical data for each batch to guarantee products meet specifications. Contract manufacturing is performed on scales that range from small beakers to thousands of liters. Nanomaterials for medical devices and clinical trials are produced in our ISO13485 and cGMP compliant cleanroom facility. By leveraging our unique library of nanomaterials, we aim to help our customers rapidly bring nanotechnology-enabled products from conception to commercialization.
Dynamic Light Scattering (DLS) measures the hydrodynamic diameter of nanoparticles in solution and provides information on the aggregation state of nanoparticles in solution.
At nanoComposix, DLS measurements are performed on a Malvern Zetasizer Nano ZS instrument equipped with a HeNe laser operating at 632.8 nm and a scattering detector at 173 degrees.
Endotoxins are components of the outer membranes of bacteria that are released when cells are disrupted. Endotoxin contamination can come from the reagent materials used in nanoparticle fabrication or can be introduced during subsequent fabrication and processing steps.
At nanoComposix we have developed methods that allow for sensitive endotoxin detection in the presence of nanoparticle. Our assay utilizes a Pyros Kinetix Turbidity Assay instrument with a limit of dectection of 0.001 EU/mL in diluted samples.
Nanoparticles have a high surface area to volume ratio and can release ions into solution. Understanding the mass fraction of ionic to solid colloidal material can be critical in assessing the stability and performance of nanoparticles in various applications. Our diverse sample preparation and measurement capabilities enable us to analyze many sample types that extend beyond the realm of colloidal chemistry.
To measure concentration, samples are prepared appropriately and measured on a Thermo X-Series II Quadrupole Inductively Coupled Plasma Mass Spectrometer (ICP-MS).
Transmission Electron Microscopy (TEM) is a technique that uses an electron beam to image a nanoparticle sample, providing much higher resolution than is possible with light-based imaging techniques. TEM is the preferred method to directly measure nanoparticle size, grain size, size distribution, and morphology.
At nanoComposix, we use a JEOL 1010 transmission electron microscope operating at an accelerating voltage of 100 keV and an AMT XR41-B 4-megapixel (2048) bottom mount CCD camera. The camera »s finite-conjugate optical coupler provides high resolution and flat focus with less than 0.1% distortion for magnifications as high as 150,000x.
UV-Visible spectroscopy (UV-Vis) measures the extinction (scatter + absorption) of light passing through a sample. Nanoparticles have unique optical properties that aresensitive to the size, shape, concentration, agglomeration state, and refractive index near the nanoparticle surface, which makes UV-Vis a valuable tool for identifying, characterizing, and studying nanomaterials.
At nanoComposix, spectral analysis is performed with an Agilent 8453 single beam diode array spectrometer which collects spectra from 200-1100 nm using a slit width of 1 nm. Deuterium and tungsten lamps are used to provide illumination across the ultraviolet, visible, and near-infrared electromagnetic spectrum. Spectra can be collected from samples as small as 60 µL using a microcell with a path length of 1 cm.
Zeta potential is a measure of the effective electric charge on the nanoparticle surface. The magnitude of the zeta potential provides information about particle stability, with particles with higher magnitude zeta potentials exhibiting increased stability due to a larger electrostatic repulsion between particles.
At nanoComposix, zeta potential measurements are performed using a Malvern Zetasizer Nano ZS instrument equipped with a HeNe laser operating at 632.8 nm and a scattering detector at 173 degrees.
NanoComposix is a world leader in nanomaterial research and development, manufacturing, and processing. Since 2004, we have developed innovative solutions to meet the specific product requirements of our customers in fields ranging from material manufacturing to medical diagnostics. Project scale ranges from custom fabrication requests to collaborative development projects where we solve R&D and scale-up challenges for the commercial launch of nano-enabled products.
At nanoComposix we have completed over a thousand custom projects ranging from self-healing aerospace composites to targeted cancer drug delivery. In almost every case we’ve been most successful when we have brought the customer’s end metric in-house. By understanding and having the analytical measurements necessary to determine if both the nanoparticle fabrication and integration are successful, we can rapidly iterate the nanoparticle chemistry and processing to achieve your goal. Below are just a few examples of our areas of expertise – please contact us to find out more about our capabilities and expertise.
SYNTHETIC FABRICATION EXAMPLES
NANOPARTICLE INTEGRATION EXAMPLES
NanoComposix produces GMP/ISO13485 compliant nanoparticles for medical devices, topical therapeutics and combination products (drug/device) for Phase I and Phase II clinical trials. In collaboration with our San Diego based partners, we can provide a complete solution of particle fabrication, formulation and sterile fill. Whether you are looking for materials for proof of concept clinical trials or scaling towards production we will work with you to develop a process that is both cost-effective and compliant.
One of the challenges of GMP nanoparticle production is defining the appropriate level of controls and processes that are necessary in order to manage risk. For each customer, we collaboratively work through a multi-stage process to define a GMP transition plan that is appropriate for the target application. At the end of each stage a design review meeting is conducted to review work completed and to plan the next stage.
Other Mass Spectrometry Methods Services
NanoComposix has a multi-disciplinary team of scientists with backgrounds in chemistry, physics, engineering and earth sciences. We have worked with over a hundred different clients to develop materials, composites and formulations with tailored optical and physical properties for a wide range of applications including medical devices, nanoparticle drug delivery, optical sensors, and consumer products. No two applications or experiments are the same – we can modify our standard products or develop new materials to meet your needs. Read below for more information or contact us to begin discussing how we can develop a nanomaterial for your needs.
NanoComposix Customization Capabilities
Our scientists have experience synthesizing a wide variety of metals, oxides, semiconductors and polymeric nanomaterials. We can assist with process optimization, scale-up, and ISO/cGMP compliant manufacturing of an existing protocol, or develop new chemistry to create your desired material.
We stock a wide range of particle sizes, and can fabricate additional sizes on demand. Many of our metal nanoparticles can be fabricated with nanometer control over dimensions up to 200 nm. Polymeric, metal oxide particles and core/shell constructs can be produced with sizes up to 1 µm.
Our standard gold and silver nanoparticles have a variety of different anionic and cationic capping ligands available. In addition, we can fabricate nanomaterials with specific functional groups, polymers, biomolecules, and inorganic coatings. Precisely controlled silica coatings can be applied to the majority of our particles.
Need solutions with a high optical density, or concentrated as an additive for composites? We have developed techniques for processing and stabilizing particles at high concentrations. We use UV-visible spectroscopy and ICP-mass spectroscopy to accurately measure material concentration and extinction coefficients.
We can tune the absorbance and scattering of materials throughout the visible and infrared spectrum by changing the morphology and composition of the nanomaterials (see our Knowledge Base article on Color Engineering for examples). Additionally, we can incorporate fluorophores for light emission at desired wavelengths or attach reporter molecules to give strong Raman signals.
THIN FILMS AND COMPOSITES
Our control over surface chemistry and particle stabilization allows us to incorporate materials into different water-based or organic resins to form well-dispersed composite materials. We also use a variety of custom-designed equipment for spraying and depositing nanomaterials as uniform thin films onto large substrates and attaching nanoparticles to textile fibers.
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