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MultiplexDX Inc.

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Gaithersburg, Maryland, US

About MultiplexDX Inc.

MultiplexDX™ is an international corporation established in 2015 consisting of two units: MultiplexDX Inc. located in Maryland U.S.A. and MultiplexDX s.r.o. located in Slovakia.

The primary objectives of the company are:

  • development of the technologies and the products for molecular diagnostic markets superior to currently available products;
  • core facility services focused on production of:
    -customized sequencing pre-adenylated 3'-adapters good for:
    PAR – CLIP
    small RNA profiling (micro RNA sequencing)
    Total RNA sequencing by hydro RNA-seq
    -multi-color RNA FISH kits and individual customized FISH probes providing solution for fluorescence in situ hybridization (FISH) applications.

Selected Publications

- Anastasakis DG, Jacob A, Konstantinidou P, Meguro K, Claypool D, Cekan P, Haase AD, Hafner M. A non-radioactive, improved PAR-CLIP and small RNA cDNA library preparation protocol. Nucleic Acids Research 2021; gkab011.

- Renwick N, Cekan P, Bognanni C, Tuschl T. Multiplexed miRNA fluorescence in situ hybridization for formalin-fixed paraffin-embedded tissues. Methods Mol Biol. 2014;1211:171-87.

  • Renwick N, Cekan P, Masry PA, McGeary SE, Miller JB, Hafner M, Li Z, Mihailovic A, Morozov P, Brown M, Gogakos T, Mobin MB, Snorrason EL, Feilotter HE, Zhang X, Perlis CS, Wu H, Suárez-Fariñas M, Feng H, Shuda M, Moore PS, Tron VA, Chang Y, Tuschl T. Multicolor microRNA FISH effectively differentiates tumor types. J Clin Invest. 2013 Jun;123(6): 2694-702.
  • Cekan P, Sigurdsson ST. Identification of Single-Base Mismatches in Duplex DNA by EPR Spectroscopy. J. Am. Chem. Soc., 2009, 131 (50): 18054–18056.
  • Cekan P, Jonsson EO, Sigurdsson ST. Folding of the cocaine aptamer studied by EPR and fluorescence spectroscopies using the bifunctional spectroscopic probe Ç. Nucleic Acids Res. 2009 Jul; 37(12): 3990–3995.
  • Schiemann O, Cekan P, Margraf D, Prisner TF, Sigurdsson ST. Relative orientation of rigid nitroxides by PELDOR: beyond distance measurements in nucleic acids. Angew Chem Int Ed Engl. 2009;48(18):3292-5.

Diversity Certificates

Small business

Our Services (3)


Oligonucleotide Synthesis

Price on request

MultiplexDX is your partner of choice for the synthesis of:

• aptamers

• siRNA

• miRNA

• antagomirs

• qPCR probes

• oligonucleotide triphosphates

• multicolor in situ probes

Length: up to 120 nt

Synthesis scale: from 5 nmol up to 1 μmol

Available backbones: DNA, RNA, LNA, 2’-OMe, 2’-F, phosphorothioate, DNA/RNA hybrids/chimeras, etc.

Wide choice of modifiers, fluorescent labels, quenchers, etc.

PAGE purification for outstanding sample purity

Delivery: lyophilized, in tubes


Fluorescence in situ Hybridization (FISH)

Price on request

MultiplexDX is offering optimized multi-color RNA FISH probes:

Our RNA FISH probes are designed for high specificity, low background and high stability.
Multiple chromophores are available (your choice).

You can choose from already available designs:
28S rRNA, 5S rRNA, 5.8S rRNA, 18S rRNA, 12S rRNA, 16S rRNA, U1 snRNA, U2 snRNA, U3 snoRNA, 7SL scRNA, hy3 scRNA, polyT probe (for total mRNA visualization), ERBB2 probe (for HER2 mRNA visualization)


Barcoded Sequencing Adapter Synthesis

Starting at $795.00 per unit


  • 30%cheaper than our competitors
  • good for adding a linker to any RNA you like
  • Illumina sequencing compatible
  • great for massive multiplexing for economical high-throughput RNA sequencing and profiling

Our adapters are designed for following applications:

  • PAR – CLIP
  • small RNA profiling (micro RNA sequencing)
  • Total RNA sequencing by hydro RNA-seq

WE GUARANTEE - 10 nmol final yield = 100 ligations (each adapter/unit) - 100% purity -> we use gel purification in final steps to eliminate most common impurities (reducing n-1 and n-2 significantly) - One week turnaround time - Customer satisfaction - we will troubleshoot your problems with you

You can choose from the list of pre-designed adapters available here: https://www.multiplexdx.com/product/barcoded-pre-adenylated-3-prime-adapters#order

Our Prices: (Units / Price per Unit)

  1-5 / $795
6-10 / $750
11-15 / $720
16-20 / $695
21-30 / $670
31-50 / $650
51 + / $625

Volume discounts applicable.


VERSATILITY: we will modify adapters to your needs - length, barcode, sequence, linker, Illumina compatibility, etc.

If you have any questions, please don’t hesitate to contact us, and we’ll be happy to discuss your project needs with you. We look forward to working with you.

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