MtoZ Biolabs is an international contract research organization (CRO) providing advanced proteomics, metabolomics, bioinformatics, and biopharmaceutical analysis services to researchers in biochemistry, biotechnology, and biopharmaceutical fields. The name of MtoZ represents “mass to charge ratio” in mass spectrometry analysis, as most of our services are provided based on our well-established mass spectrometry platforms. Our services allow for the rapid and efficient development of research projects, including protein analysis, proteomics, and metabolomics programs.
MtoZ Biolabs is specialized in quantitative multiplexed proteomics and metabolomics applications through the establishment of state-of-the-art mass spectrometry platforms, coupled with high-performance liquid chromatography technology. We are committed to developing efficient, and effective tools for addressing core bioinformatics problems. With a continuing focus on quality, MtoZ Biolabs is well equipped to help you with your needs in proteomics, metabolomics, bioinformatics, and biopharmaceutical research. Our ultimate aim is to provide more rapid, high-throughput, and cost-effective analysis, with exceptional data quality and minimal sample consumption.
MtoZ Biolabs utilizes 2D-nano LC-MS/MS technology for protein identification. This service is compatible for analyzing both single and complex protein samples with high confidence.
Protein primary sequence determines the advanced structure of a protein, influencing a protein’s function. Therefore, it is essential to analyze the sequence of a protein, to verify the integrity and correct translation of a protein sample. MtoZ Biolabs has developed a comprehensive protein sequencing platform to meet various needs of our clients, from N-terminal and C-terminal sequencing to full-length and de novo sequencing. Our featured services are presented below, but if you have any special requirement, you are welcome to contact us for custom service.
Proteomics is a large-scale study of proteins in a certain organism. Depending on specific research objective, there are many analytical techniques for proteomics study. To better meet our clients’ needs, MtoZ Biolabs is proud to offer 5 quantitative proteomics service, including Label-free, iTRAQ/TMT, SILAC, MRM, and SWATH. We also provide custom proteomics service for specific project. You are welcome to contact us for more detailed information on project design and sample requirements.
Post-translational modifications (PTMs) are covalent and usually enzymatic modifications on proteins. Common PTMs include phosphorylation, acetylation, ubiquitination, glycosylation, and so on. These PTMs can cause huge influences on protein structure, distribution, and function, hence, increasing the complexity of proteome to a greater extent. Protein PTMs is generally analyzed by measuring the mass increased on the modified peptides. Since PTMs are generally present in very low abundance, specific enrichment procedures are required before PTMs identification. MtoZ Biolabs has established a powerful and professional PTMs analysis platform, which includes Thermo Fisher Q ExactiveHF and Obitrap Fusion Lumos mass analyzer system, coupled with Nano-LC system. Our aim is to provide the most professional support for our clients’ research.
Targeted metabolomics is a study in which defined metabolites in a sample are identified and quantitatively analyzed. Quantitation and semi-quantitation of defined metabolites are undertaken through the use of internal standard compounds. Targeted metabolomics has an advantage of high specificity and accuracy. Thus, this method has been widely used to analyze and compare multiple targeted metabolites under different physiological states, and is a critical analytical method for discovery of new biomarker in metabolic diseases and study of early diagnosis of diseases.
MtoZ Biolabs offers targeted metabolomics analysis service using an LC-MS-based multiple reaction monitoring (MRM) and GC-MS-based single ion monitoring (SIM) metabolomics platforms, which have characteristics of high accuracy, specificity, and sensitivity. We guarantee accurate analysis of targeted metabolites, even in low abundance. With our optimized sample preparation methods, interference from high-abundance dominant metabolites can be hugely reduced, thus further increase the detecting sensitivity.
Analytical steps of targeted metabolomics
Untargeted metabolomics is a study in which all detectable metabolites are identified and quantitated for analyzing the overall metabolic characteristics and discovering metabolic mechanisms behind the phenomenon. Also known as discovery metabolomics, untargeted metabolomics is a powerful tool for large-scale early phase diagnosis and discovery of new biomarkers. Compared to traditional metabolic quantitation methods, untargeted metabolomics is a high-throughput technology, enabling more comprehensive analysis with more accurate data acquisition, eliminating biased research direction.
MtoZ Biolabs offers untargeted metabolomics analysis service using an LC-MS-based multiple reaction monitoring (MRM) and GC-MS-based single ion monitoring (SIM) metabolomics platforms.
Drugs with biological origins are still the mainstream treatments for many diseases. These drugs include antibodies, recombinant proteins, vaccines, etc. With technological progression and expending demands, hundreds and thousands of new biopharmaceutical drugs have been developed each year. However, successful development of these drugs relies on ensuring the quality, potency, and safety of your biopharmaceutical product, as impurity and defection of these biopharmaceutical products may compromise the efficacy and place potential risks when applied in clinical stage. Therefore, evaluation of biopharmaceuticals is critical and necessary before clinical trials. To help solve the challenges in the developmental process of biopharmaceutical products, MtoZ Biolabs has established a comprehensive analytical platform for biopharmaceutical analysis, and is able to cover most biopharmaceutical related requirements. We strictly follow the International Conference on Harmonisation (ICH) guidelines of technical requirements for registration of pharmaceuticals for human use.
• Capillary Isoelectric Focusing
• Size Exclusion Chromatography (SEC)
• High Performance Liquid Chromatography (HPLC)
• Reversed-phase Chromatography (RP)
• Native MS
• Hydrogen-deuterium exchange (HDX) MS
Researchers in proteomics and metabolomics have made tremendous progress, providing thorough and comprehensive views of the biological states of a certain organism. However, the large number of experimental data generated by proteomic and metabolomic analyses have posed great analytical challenges for downstream interpretation. To better facilitate your proteomics and metabolomics research, MtoZ Biolabs offers a wide range of statistical and bioinformatics analyses targeted for proteomics and metabolomics, ranging from quality control, function annotation, and clustering analysis, to extended pathways and biological significance explanation.
We provide two levels of analyses, Basic and Advanced bioinformatics analyses for proteomics and metabolomics.
Biostatistics & Bioinformatics Services
Biochemistry & Molecular Biology Services
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