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MPI Research - Surgical Services and Medical Device Evaluation

Mattawan, Michigan, US

MPI Research is a full drug development contract research organization with the world’s largest single-site preclinical facility. Our Sponsors benefit from our full suite of preclinical research services.

Our Sponsors value our collaborative culture that is uniformly committed to helping them move their compounds from bench to regulatory filing with accuracy, quality, and speed. Our experienced staff is flexible in adapting to changes and quickly responds to challenges as they arise.

MPI Research insists on the highest quality professional standards across all services and at all levels, and is in full compliance with international, federal, and state regulatory agencies. We are

  • Fully AAALAC accredited
  • In compliance with all FDA, EPA, EMEA, OECD, ICH, and JMHW guidances and regulations
  • Dedicated to quality performance and continuous improvement, with registered QA professionals (RQAP-GLP) and on-staff... Show more »

MPI Research is a full drug development contract research organization with the world’s largest single-site preclinical facility. Our Sponsors benefit from our full suite of preclinical research services.

Our Sponsors value our collaborative culture that is uniformly committed to helping them move their compounds from bench to regulatory filing with accuracy, quality, and speed. Our experienced staff is flexible in adapting to changes and quickly responds to challenges as they arise.

MPI Research insists on the highest quality professional standards across all services and at all levels, and is in full compliance with international, federal, and state regulatory agencies. We are

  • Fully AAALAC accredited
  • In compliance with all FDA, EPA, EMEA, OECD, ICH, and JMHW guidances and regulations
  • Dedicated to quality performance and continuous improvement, with registered QA professionals (RQAP-GLP) and on-staff Lean Six Sigma Blackbelts
  • Continually conducting inspections of GLP and Bioequivalence studies and reports
  • Committed to conducting ongoing operational and subcontractor audits

MPI Research offers expert surgical services and medical device evaluation:

Medical Device Evaluation

Medical devices are used with increasing frequency for diagnostic accuracy and have become increasingly important in developing more effective treatments for longer, healthier lives. Therefore, it is essential that life science companies can count on an experienced, knowledgeable scientific team.

By placing your medical device or combination product study at MPI Research, you can rely on the most advanced methods, effective evaluations, comprehensive verifications, and accurate validation of your medical device designs.

Surgical Efficacy

Ensuring the safety of a drug candidate or medical device is critically important. A developer also needs to know if the product being tested does what it is intended to do and how well it performs. Surgical efficacy—using surgical techniques and analysis across a number of animal models—is a key procedure in making that determination. It requires exceptional skill, experience, and perception, along with an unwavering commitment to delivering reliable results.

Targeted Delivery

Scientists know that most drugs are not targeted to the specific site of the disease in the body. The majority of drugs are delivered throughout the body, which can greatly reduce the drug’s efficacy. Targeted drug delivery offers several, preferred advantages, including decreased dosage frequency, a more constant effect of the drug, and fewer, potential systemic side effects.

MPI Research has the knowledge and expertise to deliver your drug to prolong, localize, and target the correct organs and tissues without creating systemic complications. Our highly trained staff is available to explore how we can assist Sponsors and deliver drugs with improved efficacy.

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Device Testing
Price on request

Like our Sponsors, MPI Research recognizes the incredible advancements and equally superior diagnostic potential that medical devices and combination products provide to healthcare in our society. Our dedicated scientific team works closely with Sponsors to deliver accurate results quickly, consistently, and cost-effectively.
MPI... Show more »

Like our Sponsors, MPI Research recognizes the incredible advancements and equally superior diagnostic potential that medical devices and combination products provide to healthcare in our society. Our dedicated scientific team works closely with Sponsors to deliver accurate results quickly, consistently, and cost-effectively.
MPI Research provides decades of experience and collaborates with Sponsors to develop customized studies using advanced techniques that best meet their needs. Our industry-leading surgical facilities and highly trained
staff are all available at one location to provide Sponsors with advanced research capabilities in a wide range
of species.

Scientific Staff

  • Dedicated Study Directors with more than 70 years of combined experience
  • Experienced technical surgeons
    • Certified by the Academy of Surgical Research
    • More than 60 years of combined experience
  • Full staff of surgical and in-life technicians
  • On-site clinical/surgical veterinarians (DVMs)
  • On-site veterinary and clinical pathologists
  • Dedicated necropsy staff
  • Consulting MDs and surgical DVMs

Surgical Facilities

  • Three dedicated large animal surgical suites
  • One dedicated small animal surgical suite

State-of-the-Art-Equipment

  • Fluoroscopes
  • Ultrasounds
  • X-ray/faxitron
  • Siemens microCT
  • Mobile MRI (Siemens 1.0 or 1.5 T Magnet/mobile CT)
  • Intravascular ultrasound
  • Micro-PET and SPECT scanners

Medical Device Models

  • Cardiac and peripheral models for cardiovascular
  • Orthopaedic models
  • Central Nervous System (CNS) and peripheral models for neurological
  • Dental, gastroenterological, drug delivery, urologic, and wound healing

Biocompatibility Evaluation Models

  • Guinea pig sensitization/maximization
  • Skin irritation/intracutaneous reactivity
  • Acute systemic toxicity
  • Hemocompatibility
  • Biodegradation evaluations
  • Subcutaneous or intramuscular implantation
  • Subchronic and chronic toxicity
  • Developmental and reproductive testing
  • Carcinogenicity
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Targeted Preclinical Drug Administration
Price on request

Targeted delivery of drug therapies provides greater expectations for improved/positive medical outcomes. Exceeding those expectations is the vision of our Sponsors—a vision MPI Research shares. Our highly experienced team applies the latest technologies and insights to assist our Sponsors in their work with our cutting- edge,... Show more »

Targeted delivery of drug therapies provides greater expectations for improved/positive medical outcomes. Exceeding those expectations is the vision of our Sponsors—a vision MPI Research shares. Our highly experienced team applies the latest technologies and insights to assist our Sponsors in their work with our cutting- edge, high-quality, and customized study protocols. Just as our Sponsors target diseases in unique ways, we target our work to help them succeed.

MPI Research has the expertise to lead the charge and collaborate with Sponsors to develop customized studies, assuring candidates are moving along the drug development pathway accurately and quickly. Our robust study designs, state-of-the-art surgical facilities, wide selection of animal models, and comprehensive array of delivery routes assure an ideal environment for targeted delivery evaluation.

Service Highlights

  • Dedicated Study Directors with more than 70 years of combined experience
  • Experienced technical surgeons
    • Certified by the Academy of Surgical Research
    • More than 60 years of combined experience
  • Full staff of surgical and in-life technicians
  • On-site clinical/surgical veterinarians (DVMs)
  • On-site veterinary and clinical pathologists
  • Dedicated necropsy staff
  • Consulting MDs and surgical DVMs
  • Three dedicated large animal surgical suites
  • One dedicated small animal surgical suite

Delivery Routes

Targeted test-article delivery routes available include but are not limited to

  • Direct intestinal
  • Intrahepatic
  • Portal vein
  • Intramyocardial
  • Intra-aortic
  • Intraventricular
  • Intra-articular
  • Arterial/venous
  • Intravesicular (bladder)
  • Intrathecal/epidural
  • Organ-specific
  • Intracranial
  • Intraprostatic
  • Bile duct cannulation
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Preclinical Surgical Efficacy Studies
Price on request

When it comes to surgical efficacy, MPI Research doesn’t settle for conventional wisdom. We pay attention to the latest developments in the field while tuning in to the evolving needs of our Sponsors. Our surgical team is determined to bring finely-tuned skills and exceptional capabilities to their work with drug developers and... Show more »

When it comes to surgical efficacy, MPI Research doesn’t settle for conventional wisdom. We pay attention to the latest developments in the field while tuning in to the evolving needs of our Sponsors. Our surgical team is determined to bring finely-tuned skills and exceptional capabilities to their work with drug developers and medical device manufacturers—now and in the future. That foresight provides our competitive advantage to the Sponsors
we serve.

The surgery staff of MPI Research has decades of experience conducting surgical efficacy studies. The experienced team understands all compliance requirements of regulatory agencies worldwide, and MPI Research has developed a dedicated staff to ensure Sponsors receive timely and accurate studies.

Services Highlights

  • Dedicated Study Directors with more than 70 years of combined experience
  • Experienced technical surgeons
    • Certified by the Academy of Surgical Research
    • More than 60 years of combined experience
  • Full staff of surgical and in-life technicians
  • On-site clinical/surgical veterinarians (DVMs)
  • On-site veterinary and clinical pathologists
  • Dedicated necropsy staff
  • Consulting MDs and surgical DVMs
  • Three dedicated large animal surgical suites
  • One dedicated small animal surgical suite

State-of-the-Art-Equipment

  • Fluoroscopes
  • Ultrasounds
  • X-ray/faxitron
  • Siemens microCT
  • Mobile MRI (Siemens 1.0 or 1.5 T Magnet/mobile CT)
  • Intravascular ultrasound
  • Micro-PET and SPECT scanners

Surgical Capabilities and Models

  • Orthopaedic models
    • Joint/cartilage
    • Bone fracture/defect repair
    • Spinal fusion and spinal instability/fixation
  • Renal models
    • Aminoglycoside nephrotoxicity
    • Renal ischemia-reperfusion injury
    • Streptozotocin-induced diabetic nephropathy
    • Glomular filtration rate and renal blood flow evaluations
    • Renal transplantation
    • Goldblatt hypertension
    • Partial nephrectomy for evaluating hemostasis
  • Neurological capabilities
    • Spinal cord contusion
    • Intrathecal device implantation
    • Epidural device implantation
    • Intracranial device implantation
    • Stereotaxic administration
  • Wound healing models
    • Full thickness excision
    • Split thickness wound created with dermatome
    • Full thickness incision
  • Cardiovascular models
    • Acute myocardial infarction
    • Congestive heart failure
    • Chronic cardiac and peripheral ischemia
    • Peripheral arterial disease

Stem Cell Surgical Therapies and Study Designs

  • Therapies
    • Autologous cell therapy
    • Allogeneic cell therapy
    • Embryonic cell therapy
  • Study designs
    • Proof-of-concept
    • Safety and biodistribution
    • Tumorigenicity
    • Allogeneic cell types
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Animal Models and Studies
Price on request
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Devices
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Engineering
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