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MPI Research - Discovery Services

Mattawan, Michigan, US

MPI Research is a full drug development contract research organization with the world’s largest single-site preclinical facility. Our Sponsors benefit from our full suite of preclinical research services.

Our Sponsors value our collaborative culture that is uniformly committed to helping them move their compounds from bench to regulatory filing with accuracy, quality, and speed. Our experienced staff is flexible in adapting to changes and quickly responds to challenges as they arise.

MPI Research insists on the highest quality professional standards across all services and at all levels and is in full compliance with international, federal, and state regulatory agencies. We are

  • Fully AAALAC accredited
  • In compliance with all FDA, EPA, EMEA, OECD, ICH, and JMHW guidances and regulations
  • Dedicated to quality performance and continuous improvement, with registered QA professionals (RQAP-GLP) and on-staff... Show more »

MPI Research is a full drug development contract research organization with the world’s largest single-site preclinical facility. Our Sponsors benefit from our full suite of preclinical research services.

Our Sponsors value our collaborative culture that is uniformly committed to helping them move their compounds from bench to regulatory filing with accuracy, quality, and speed. Our experienced staff is flexible in adapting to changes and quickly responds to challenges as they arise.

MPI Research insists on the highest quality professional standards across all services and at all levels and is in full compliance with international, federal, and state regulatory agencies. We are

  • Fully AAALAC accredited
  • In compliance with all FDA, EPA, EMEA, OECD, ICH, and JMHW guidances and regulations
  • Dedicated to quality performance and continuous improvement, with registered QA professionals (RQAP-GLP) and on-staff Lean Six Sigma Blackbelts
  • Continually conducting inspections of GLP and Bioequivalence studies and reports
  • Committed to conducting ongoing operational and subcontractor audits

MPI Research offers the following specialized areas of Discovery Services:

In Vitro Research

The best time to determine the fate of
a new compound is early in the pipeline. Recognizing this, MPI Research has built robust capabilities for in vitro research. We know our Sponsors want a partner that is skilled, thorough, and insightful at this crucial stage of development. That is why we continue to invest in the tools and talent to generate high- quality, reliable data so our Sponsors can make decisions with confidence.

MPI Research applies the highest quality in vitro expertise, from drug discovery through preclinical and early clinical development. By defining efficacy, mechanism of action, metabolism, drug safety and pharmacokinetics at the test-tube level, we help Sponsors determine which compounds work best—and safely—on the target organ or receptor. Our skillset includes precise molecular, cell-based and biochemical analyses, broad experience in study designs and techniques, leading-edge technology in a fully equipped cell and molecular biology laboratory, and a host of customized applications that deliver
high-quality results.

In Vivo Research

With emerging technologies and techniques, investment in in vivo research is yielding greater biological insights more efficiently. MPI Research is on the leading edge of this scientific transformation. We are committed to expanding our capabilities and increasing our knowledge so that we can apply the latest tools to this vital step in drug development and safety assessment. These investments benefit our Sponsors and the people who rely on them.

MPI Research brings immense knowledge and expertise to in vivo research. Comprehending the intricacies of this development step, our scientists devote themselves to increasing their understanding of the cellular and molecular processes involved. As we grow in awareness and skill, we apply these assets to our partnerships with Sponsors. Our goal is to work as a team—across functions and with our Sponsors—to maximize returns on in vivo research and quickly drive the right decisions.

Neurobehavioral Sciences

Neurobehavioral sciences at MPI Research represents a specialized area of inquiry wherein the potential interactions between pharmacology and complex neurological and behavioral phenomena are explored. Such inquiries are a logical elaboration of core safety pharmacology assays, which focus on the potential deleterious effects of off-target pharmacology on key areas of the central nervous system (CNS). These kinds of studies require considerable scientific expertise, technical skill, and innovation to properly identify and characterize safety risks.

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Preclinical PK/PD Studies
in vivo Pharmacokinetics/Pharmacodynamics
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Movement Disorder Animal Models
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Integrative neurological evaluations of objectively verifiable behavioral changes associated with movement disorders, such as

  • Parkinson’s disease
  • Huntington’s disease
  • Dystonia, ataxias, and other paradoxical movement disorders

Integrative neurological evaluations of objectively verifiable behavioral changes associated with movement disorders, such as

  • Parkinson’s disease
  • Huntington’s disease
  • Dystonia, ataxias, and other paradoxical movement disorders
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Parkinsons Disease Animal Models
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Ototoxicity Evaluation
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  • Auditory Brainstem Response(ABR) electrophysiology
  • Distortion product otoacoustic emissions (DPOAE) testing
  • Semi-quantitative middle/inner ear histological evaluations
  • Definitive cytocochleogram preparation and analysis
  • Gross and microscopic middle ear tissue examination
  • Auditory Brainstem Response(ABR) electrophysiology
  • Distortion product otoacoustic emissions (DPOAE) testing
  • Semi-quantitative middle/inner ear histological evaluations
  • Definitive cytocochleogram preparation and analysis
  • Gross and microscopic middle ear tissue examination
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Otology Animal Models
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Epilepsy & Seizure Animal Models
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Morris Water Maze Assay
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Animal Motor Function and Activity Testing
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Rotarod Performance Test
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Custom Pain Animal Models
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Pain/analgesia assessment

  • Tail flick, hot plate, Hargreave’s, von Frey fiber, and writhing assays (rodent)
  • Tail withdrawal (rodent and NHP)

Since pain assessment models should incorporate measures of general motor activity to ensure the selectivity of the new chemical entity and peripheral or CNS pain pathways, we offer number of complementary animal models.

Pain/analgesia assessment

  • Tail flick, hot plate, Hargreave’s, von Frey fiber, and writhing assays (rodent)
  • Tail withdrawal (rodent and NHP)

Since pain assessment models should incorporate measures of general motor activity to ensure the selectivity of the new chemical entity and peripheral or CNS pain pathways, we offer number of complementary animal models.

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Animal Behavior Studies
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GLP-validated assays for

  • Self-administration (rat, NHP)
  • Drug discrimination (rat, NHP)
  • Psychomotor activity assessment (rodent)
  • Dependence potential (rodent, NHP)
  • Conditioned place preference/ aversion (rodent)

GLP-validated assays for

  • Self-administration (rat, NHP)
  • Drug discrimination (rat, NHP)
  • Psychomotor activity assessment (rodent)
  • Dependence potential (rodent, NHP)
  • Conditioned place preference/ aversion (rodent)
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Custom Animal Models
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  • Serial CSF collection methodology (rats)
  • Cyclophosphamide-induced neutropenia (mice)
  • Cecectomized model of diarrheal disease (PGE2; rats)
  • Serial CSF collection methodology (rats)
  • Cyclophosphamide-induced neutropenia (mice)
  • Cecectomized model of diarrheal disease (PGE2; rats)
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Orthopedic Models
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  • Joint/cartilage
  • Bone fracture/defect repair
  • Spinal fusion and spinal instability/fixation
  • Joint/cartilage
  • Bone fracture/defect repair
  • Spinal fusion and spinal instability/fixation
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Von Frey and Carageenan Sensitivity Assay
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Edema Animal Models
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  • Arachidonate-induced ear edema
  • Carrageenan-induced paw edema
  • Arachidonate-induced ear edema
  • Carrageenan-induced paw edema
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Rheumatoid Arthritis Animal Models
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  • Peptidoglycan-polysaccharide (PG-PS)-induced arthritis (rats)
  • Adjuvant-induced arthritis (polyarthritis or monoarthritis in rats)
  • Peptidoglycan-polysaccharide (PG-PS)-induced arthritis (rats)
  • Adjuvant-induced arthritis (polyarthritis or monoarthritis in rats)
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EAE Animal Model
Experimental Autoimmune Encephalomyelitis Animal Model
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Proteolipoprotein (PLP)-induced Experimental Autoimmune Encephalomyelitis (EAE)

Proteolipoprotein (PLP)-induced Experimental Autoimmune Encephalomyelitis (EAE)

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Pulmonary Fibrosis Animal Models
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In vitro Inflammation Models
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Custom Cardiovascular Animal Models
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  • Atherosclerosis models in a variety of species (denudation and high fat diet)
  • Acute myocardial infarction (ischemia/ reperfusion)
  • Congestive heart failure
  • Chronic cardiac and peripheral ischemia
  • Peripheral arterial disease
  • Thrombosis models
  • Surgical models
  • Atherosclerosis models in a variety of species (denudation and high fat diet)
  • Acute myocardial infarction (ischemia/ reperfusion)
  • Congestive heart failure
  • Chronic cardiac and peripheral ischemia
  • Peripheral arterial disease
  • Thrombosis models
  • Surgical models
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Pig
Dog
Toxicity animal model
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Ocular Toxicology
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Neurotoxicity Testing
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Optical Lithography
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Bacterial Infection Animal Models
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  • Mouse peritonitis (MRSA, MSSA; Streptococcus pneumonia, PRSP, PSSP)
  • Chinchilla acute otitis media (Haemophilus influenzae)
  • Rabbit otitis externa (Pseudomonas aeruginosae)
  • Vaccine safety studies (rodents, ferrets, and canines)
  • BSL-2 laboratory and vivarium space
  • Mouse peritonitis (MRSA, MSSA; Streptococcus pneumonia, PRSP, PSSP)
  • Chinchilla acute otitis media (Haemophilus influenzae)
  • Rabbit otitis externa (Pseudomonas aeruginosae)
  • Vaccine safety studies (rodents, ferrets, and canines)
  • BSL-2 laboratory and vivarium space
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Animal Glucose and Insulin Tolerance Testing
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Liver Steatosis Animal Models
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Mouse
NASH (Non-Alcoholic Steatohepatitis)
Obesity Animal Models
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Diabetes Animal Models
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  • Diet-induced and genetic diabetes (rodents)
  • Diabetic nephropathy (rats)
  • Diet-induced hypertriglyceridemia
  • Hypercholesterolemia/atherosclerosis (minipig; gene knockout)
  • High fat diet/low dose STZ-induced diabetes (rats)
  • Diet-induced and genetic diabetes (rodents)
  • Diabetic nephropathy (rats)
  • Diet-induced hypertriglyceridemia
  • Hypercholesterolemia/atherosclerosis (minipig; gene knockout)
  • High fat diet/low dose STZ-induced diabetes (rats)
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Molecular Imaging
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Molecular imaging capabilities for test article assessment and biodistribution

Molecular imaging capabilities for test article assessment and biodistribution

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Western Blot
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ELISA
Enzyme-linked immunosorbent assay
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Immunofluorescence
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Apoptosis Assays
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Cytotoxicity Assays
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Cell Proliferation Assays
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Primary Cell Isolation
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Isolation and culture of dendritic cells and Peripheral Blood Mononuclear Cells (PBMCs)

Isolation and culture of dendritic cells and Peripheral Blood Mononuclear Cells (PBMCs)

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Flow Cytometry
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GLP flow cytometry and cellular immunology

  • Validated immunophenotyping panels for peripheral blood leukocytes evaluation in various species (rat, dog, nonhuman primate, mouse, and swine)
  • T-regulatory cell characterization (nonhuman primate, mouse, canine, and rat)
  • Phenotypic characterization of cell types
  • Customized... Show more »

GLP flow cytometry and cellular immunology

  • Validated immunophenotyping panels for peripheral blood leukocytes evaluation in various species (rat, dog, nonhuman primate, mouse, and swine)
  • T-regulatory cell characterization (nonhuman primate, mouse, canine, and rat)
  • Phenotypic characterization of cell types
  • Customized assay development and GLP-validation (up to10 unique cellular parameters simultaneously detected)
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Single Nucleotide Polymorphism (SNP) Genotyping
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RT-PCR
Reverse transcription polymerase chain reaction
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DNA Quantification
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GLP purification and quantification of DNA/RNA from tissues, blood, and body fluids of various species and cultured cells

GLP purification and quantification of DNA/RNA from tissues, blood, and body fluids of various species and cultured cells

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DNA Purification
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GLP purification and quantification of DNA/RNA from tissues, blood, and body fluids of various species and cultured cells

GLP purification and quantification of DNA/RNA from tissues, blood, and body fluids of various species and cultured cells

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Luminescence Imaging
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Fluorescence-Based Microscopy
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UV-VIS Spectroscopy
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Multi-sample, micro-volume UV-Vis spectrophotometry

Multi-sample, micro-volume UV-Vis spectrophotometry

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Microfluidization
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High Content Screening
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High-content imaging analysis of potential hepatotoxicity or cardiotoxicity of a test compound

High-content imaging analysis of potential hepatotoxicity or cardiotoxicity of a test compound

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qRT-PCR
Quantitative reverse transcription polymerase chain reaction
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GLP qPCR or qRT-PCR analysis of tissue/ blood/fluid samples for preclinical vector biodistribution studies in
animals and clinical vector shedding studies in human trials

  • Plasmid- and viral vector-based therapy
  • Human stem cell-based therapy
  • siRNA therapy
  • Vaccines

GLP qPCR or qRT-PCR analysis of tissue/ blood/fluid samples for preclinical vector biodistribution studies in
animals and clinical vector shedding studies in human trials

  • Plasmid- and viral vector-based therapy
  • Human stem cell-based therapy
  • siRNA therapy
  • Vaccines
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qPCR
Quantitative PCR
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GLP qPCR or qRT-PCR analysis of tissue/ blood/fluid samples for preclinical vector biodistribution studies in
animals and clinical vector shedding studies in human trials

  • Plasmid- and viral vector-based therapy
  • Human stem cell-based therapy
  • siRNA therapy
  • Vaccines

GLP qPCR or qRT-PCR analysis of tissue/ blood/fluid samples for preclinical vector biodistribution studies in
animals and clinical vector shedding studies in human trials

  • Plasmid- and viral vector-based therapy
  • Human stem cell-based therapy
  • siRNA therapy
  • Vaccines
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Animal Ophthalmoscopy
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Indirect and direct ophthalmoscopy, slit-lamp biomicroscopy, corneal fluorescein staining

Indirect and direct ophthalmoscopy, slit-lamp biomicroscopy, corneal fluorescein staining

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High-resolution gel molecular imaging
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High throughput flow cytometry
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Metabolic Animal Models
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Cells and Tissues
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Animal Learning, Memory, and Behavior Tests
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Spectrophotometry
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Cell and Tissue Culture
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Cytometry
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Immunology Animal Models
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Protein Quantification
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Cardiovascular Animal Models
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Nucleic Acid Services
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Cell-Based Assays
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Animal Model in vivo Analyses
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Infectious Disease Animal Models
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DNA
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Optical Microscopy
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Animal Nociception Tests
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Pharmacology & Toxicology
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Nuclear imaging
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Cell Disruption
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In vivo Toxicity Testing
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Primary Cell Culture
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PCR
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Animal Cognition & Behavior Tests
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Respiratory Disease Animal Models
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Animal Models of Disease
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Biology
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Hepatic Animal Models
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Functional Human Tissue Assays
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Lithography
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CNS/Neurology Animal Models
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Radiography
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Toxicology
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Bone/Cartilage Animal Models
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Imaging & Spectroscopy
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Microfabrication Services
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Spectroscopy
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Cell-Based Screening Methods
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Protein Services
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Gel Electrophoresis
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Protein Expression Visualization
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Analytical Chemistry Services
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Genotyping Services
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Cell Death Assays
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Pain/Neuropathy Animal Models
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In vitro Toxicity Testing
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Immunostaining
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Animal Physiology Analyses
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Engineering
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In vitro Disease Models
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Inflammation Animal Models
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Purification Services
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DNA Extraction and Purification
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Animal Models and Studies
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Fabrication Services
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Biochemistry & Molecular Biology
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Chemistry and Materials
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Ear, Nose & Throat Animal Models
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Electrophoresis
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Cell Viability & Proliferation Assays
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ADME/DMPK Studies
Drug Metabolism and Pharmacokinetics
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ADME and DMPK Studies Services

ADME and DMPK Studies Services

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Animal Motor Function Tests
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Microscopy
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