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MPI Research

Mattawan, Michigan, US

MPI Research strives to be the best CRO in preclinical and early clinical contract research.

We partner with Sponsors around the world to develop their drug and device programs. Every year, our experienced scientists and dedicated technical team conduct thousands of discovery, drug safety, bioanalytical, analytical, medical device, and clinical research studies.

We are committed to bring safer and more effective drugs and devices to the market faster and more efficiently.

We offer extensive support and resources including, but not limited to

  • A wide and diverse range of classes of compounds
  • All routes of administration except inhalation
  • Studies with numerous species and models
  • Comprehensive reporting capabilities

Flexibility and ample capacity enable us to

  • Accommodate multiple requirements simultaneously
  • Adjust schedules readily
  • Produce results quickly

With over 32,000... Show more »

MPI Research strives to be the best CRO in preclinical and early clinical contract research.

We partner with Sponsors around the world to develop their drug and device programs. Every year, our experienced scientists and dedicated technical team conduct thousands of discovery, drug safety, bioanalytical, analytical, medical device, and clinical research studies.

We are committed to bring safer and more effective drugs and devices to the market faster and more efficiently.

We offer extensive support and resources including, but not limited to

  • A wide and diverse range of classes of compounds
  • All routes of administration except inhalation
  • Studies with numerous species and models
  • Comprehensive reporting capabilities

Flexibility and ample capacity enable us to

  • Accommodate multiple requirements simultaneously
  • Adjust schedules readily
  • Produce results quickly

With over 32,000 studies and counting and high satisfaction, MPI Research aims to be the CRO partner for your drug and device programs.

Recent Publications

  • Mark Johnson, Targeted Delivery of Gene and Cell Therapies, BioPharm International Summer 2015
  • Dustin Kentala, Molecular Imaging and its Impact on Drug Development, Drug Discovery and Development
    Summer 2015
  • Christopher Dillon, Optimizing Research Through Regulatory Standards and Quality, Pharmaceutical Technology Summer 2015
  • Scott Haller, Jacob Hesterman, Multivariate Study Design Using Short- and Long-lived Radioisotopes, In Vivo Positron Emission Tomography (PET/CT) and Planar Scintigraphy, and Ex Vivo Autoradiography to Assess Biodistribution and Pharmacokinetics of Bone-Targeting Test Material in a Canine Surgical Model, Outsourced Pharma Spring 2015
  • Dean Knuth, How Companies Can Make the Most of Their Early Drug Development Stage, Clinical Leader
    Spring 2015
  • Ed Amat, Partnering with CROs, Outsourced Pharma Spring 2015
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MPI Research - Drug Safety Evaluation

Mattawan MI
Orders Completed

MPI Research is a full drug development contract research organization with the world’s largest single-site preclinical facility. Our Sponsors benefit from our full suite of preclinical research services.

Our Sponsors value our collaborative culture that is uniformly committed... Show more »

MPI Research is a full drug development contract research organization with the world’s largest single-site preclinical facility. Our Sponsors benefit from our full suite of preclinical research services.

Our Sponsors value our collaborative culture that is uniformly committed to helping them move their compounds from bench to regulatory filing with accuracy, quality, and speed. Our experienced staff is flexible in adapting to changes and quickly responds to challenges as they arise.

MPI Research insists on the highest quality professional standards across all services and at all levels, and is in full compliance with international, federal, and state regulatory agencies. We are

  • Fully AAALAC accredited
  • In compliance with all FDA, EPA, EMEA, OECD, ICH, and JMHW guidances and regulations
  • Dedicated to quality performance and continuous improvement, with registered QA professionals (RQAP-GLP) and on-staff Lean Six Sigma Blackbelts
  • Continually conducting inspections of GLP and Bioequivalence studies and reports
  • Committed to conducting ongoing operational and subcontractor audits

In the field of Drug Safety MPI Research offers expert services in the following areas:

Developmental and Reproductive Toxicology

Understanding a compound’s effect on a mature organism is an essential step in drug development—but hardly the only one. Equally compelling is the need to know how a drug candidate affects reproductive and developmental functions, from fertility to embryonic, prenatal and postnatal development, as well as maternal and juvenile effects. Developmental and reproductive toxicology (DART) testing of chemicals and pesticides, small-molecules, and biologics must be vigorous, comprehensive, and reliable.

Drug Metabolism and Pharmacokinetics Research

Attrition rates during clinical development of new therapeutics are as high as 95%—disturbing news for both patients and drug developers. In addition to failure from efficacy and safety concerns, clinical failures can also be attributed to poor pharmacokinetic (PK) properties. Providing early critical drug metabolism and pharmacokinetic (DMPK) information is the secret to addressing DMPK failures. Companies with solid DMPK drug development programs have been able to cut clinical failures that are due to DMPK reasons from 40 percent to 10 percent, a four-fold decrease. MPI Research has the expertise and experience to ensure that your studies are conducted quickly and
successfully. MPI Research is committed to helping our Sponsors achieve the best possible clinical success rates.

General Toxicology

Regulatory agencies require that Sponsors understand the potential risks for their products; much of that information comes from general toxicology studies. The foundational role of toxicology is to define the effects of a substance on a living organism, including symptoms and mechanisms of action. As the breadth of compounds in development grows more diverse, toxicology studies are becoming increasingly complex.

Infusion Toxicology

The curve of advancements in infusion technology is progressing and rapidly advancing new equipment, more routes of administration, targeted tissue dosing, and increasingly complex routines. With greater capabilities come bigger demands for relevant knowledge and proficiency. Skillfully applying advanced technologies, customized studies, and exceeding expectations in quality, speed, accuracy, and cost-effectiveness, MPI Research offers the competitive edge that Sponsors need.

Nonclinical Dose Formulation and Analysis

Optimizing drug exposure is a crucial element in assessing drug safety and requires careful choice of formulation. Even with an appropriate formulation, determining the appropriate dosing levels requires careful consideration. This is no small consideration; the benefit of any medication, defined by its pharmacokinetic and pharmacodynamics profile is affected tremendously by how it is made and administered. Careful, precise analysis of test formulations assures proper dosing and accurate interpretation of the effect of the drug on the test system.

Safety Pharmacology

Developing a predictive understanding of a medication safety profile is more important than ever. As part of this endeavor, modern safety pharmacology studies must be designed to precisely characterize potential functional liabilities, ideally determining dose-response relationships including onset, peak response, resolution of effect, and mechanism(s) of action and/or potential reversibility. Translating data from key preclinical safety pharmacology studies to human clinical trials and beyond represents a complex enterprise that must be expertly conducted to ensure progression of therapeutic, palatable, and safe drug candidates.

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MPI Research - Discovery Services

Mattawan MI
Order Completed

MPI Research is a full drug development contract research organization with the world’s largest single-site preclinical facility. Our Sponsors benefit from our full suite of preclinical research services.

Our Sponsors value our collaborative culture that is uniformly committed... Show more »

MPI Research is a full drug development contract research organization with the world’s largest single-site preclinical facility. Our Sponsors benefit from our full suite of preclinical research services.

Our Sponsors value our collaborative culture that is uniformly committed to helping them move their compounds from bench to regulatory filing with accuracy, quality, and speed. Our experienced staff is flexible in adapting to changes and quickly responds to challenges as they arise.

MPI Research insists on the highest quality professional standards across all services and at all levels and is in full compliance with international, federal, and state regulatory agencies. We are

  • Fully AAALAC accredited
  • In compliance with all FDA, EPA, EMEA, OECD, ICH, and JMHW guidances and regulations
  • Dedicated to quality performance and continuous improvement, with registered QA professionals (RQAP-GLP) and on-staff Lean Six Sigma Blackbelts
  • Continually conducting inspections of GLP and Bioequivalence studies and reports
  • Committed to conducting ongoing operational and subcontractor audits

MPI Research offers the following specialized areas of Discovery Services:

In Vitro Research

The best time to determine the fate of
a new compound is early in the pipeline. Recognizing this, MPI Research has built robust capabilities for in vitro research. We know our Sponsors want a partner that is skilled, thorough, and insightful at this crucial stage of development. That is why we continue to invest in the tools and talent to generate high- quality, reliable data so our Sponsors can make decisions with confidence.

MPI Research applies the highest quality in vitro expertise, from drug discovery through preclinical and early clinical development. By defining efficacy, mechanism of action, metabolism, drug safety and pharmacokinetics at the test-tube level, we help Sponsors determine which compounds work best—and safely—on the target organ or receptor. Our skillset includes precise molecular, cell-based and biochemical analyses, broad experience in study designs and techniques, leading-edge technology in a fully equipped cell and molecular biology laboratory, and a host of customized applications that deliver
high-quality results.

In Vivo Research

With emerging technologies and techniques, investment in in vivo research is yielding greater biological insights more efficiently. MPI Research is on the leading edge of this scientific transformation. We are committed to expanding our capabilities and increasing our knowledge so that we can apply the latest tools to this vital step in drug development and safety assessment. These investments benefit our Sponsors and the people who rely on them.

MPI Research brings immense knowledge and expertise to in vivo research. Comprehending the intricacies of this development step, our scientists devote themselves to increasing their understanding of the cellular and molecular processes involved. As we grow in awareness and skill, we apply these assets to our partnerships with Sponsors. Our goal is to work as a team—across functions and with our Sponsors—to maximize returns on in vivo research and quickly drive the right decisions.

Neurobehavioral Sciences

Neurobehavioral sciences at MPI Research represents a specialized area of inquiry wherein the potential interactions between pharmacology and complex neurological and behavioral phenomena are explored. Such inquiries are a logical elaboration of core safety pharmacology assays, which focus on the potential deleterious effects of off-target pharmacology on key areas of the central nervous system (CNS). These kinds of studies require considerable scientific expertise, technical skill, and innovation to properly identify and characterize safety risks.

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MPI Research is a full drug development contract research organization with the world’s largest single-site preclinical facility. Our Sponsors benefit from our full suite of preclinical research services.

Our Sponsors value our collaborative culture that is uniformly committed... Show more »

MPI Research is a full drug development contract research organization with the world’s largest single-site preclinical facility. Our Sponsors benefit from our full suite of preclinical research services.

Our Sponsors value our collaborative culture that is uniformly committed to helping them move their compounds from bench to regulatory filing with accuracy, quality, and speed. Our experienced staff is flexible in adapting to changes and quickly responds to challenges as they arise.

MPI Research insists on the highest quality professional standards across all services and at all levels, and is in full compliance with international, federal, and state regulatory agencies. We are

  • Fully AAALAC accredited
  • In compliance with all FDA, EPA, EMEA, OECD, ICH, and JMHW guidances and regulations
  • Dedicated to quality performance and continuous improvement, with registered QA professionals (RQAP-GLP) and on-staff Lean Six Sigma Blackbelts
  • Continually conducting inspections of GLP and Bioequivalence studies and reports
  • Committed to conducting ongoing operational and subcontractor audits

MPI Research offers expert bioanalytical and analytical services in the following specialized areas:

Small Molecule Clinical Bioanalytical Analysis

There was a time when bioanalytical services were relatively simple, but not especially useful. That time has passed. MPI Research has moved from nonspecific assays to the current discipline that precisely analyzes small molecules, biopharmaceuticals, and their metabolites. Drug development has come to depend upon scientists’ abilities to quantify these substances in biological samples by using cutting-edge technology and processes.

Small Molecule Preclinical Bioanalytical Analysis

When it comes to bioanalytical services, one-stop shopping is more than convenient. It is vital to the integrity of the process and to the value of the results—that is, as long as your partner has integrated the right scientific expertise across its operations. This is especially important at the preclinical level in drug development, where go/no-go decisions need to be made early and confidently. A misstep here means lost time and resources. MPI Research offers unrivaled bioanalytical services, fully integrated with our on-site preclinical research laboratories that expedite results and facilitate collaboration. From method development through sample analysis and reporting, we maintain high-quality standards in a responsive working environment.

As a contract research organization, MPI Research offers immense experience and valuable contributions to our Sponsors. In preclinical bioanalytical analysis, we provide a rich, comprehensive perspective that our Sponsors rely on to accelerate moving their compounds along the drug development pathway.

MPI Research brings superior bioanalytical services to the preclinical realms that are fully intertwined with their discovery and clinical capabilities. Our researchers understand the magnitude of investment required to develop new medicines, so they work hand-in-glove with Sponsors to design effective studies, streamline analysis, employ the latest technology, and deliver accurate data rapidly. We provide quality services that allow our Sponsors to advance new treatments, bringing hope to patients worldwide.

Nonclinical Ligand Binding Assays

The human body is remarkable in its ability to wage war against a host of diseases and infections. Understanding the immune system’s arsenal provides valuable knowledge that drives some of the latest innovations in drug therapy, especially in biologically derived medicines and vaccines. An experienced, skilled partner in immunology and associated analytical services brings a powerful, competitive advantage to drug developers. MPI Research understands that proper assessments, along with scientific and regulatory expertise, are paramount in advancing your immunochemistry studies.

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MPI Research is a full drug development contract research organization with the world’s largest single-site preclinical facility. Our Sponsors benefit from our full suite of preclinical research services.

Our Sponsors value our collaborative culture that is uniformly committed... Show more »

MPI Research is a full drug development contract research organization with the world’s largest single-site preclinical facility. Our Sponsors benefit from our full suite of preclinical research services.

Our Sponsors value our collaborative culture that is uniformly committed to helping them move their compounds from bench to regulatory filing with accuracy, quality, and speed. Our experienced staff is flexible in adapting to changes and quickly responds to challenges as they arise.

MPI Research insists on the highest quality professional standards across all services and at all levels, and is in full compliance with international, federal, and state regulatory agencies. We are

  • Fully AAALAC accredited
  • In compliance with all FDA, EPA, EMEA, OECD, ICH, and JMHW guidances and regulations
  • Dedicated to quality performance and continuous improvement, with registered QA professionals (RQAP-GLP) and on-staff Lean Six Sigma Blackbelts
  • Continually conducting inspections of GLP and Bioequivalence studies and reports
  • Committed to conducting ongoing operational and subcontractor audits

MPI Research offers expert surgical services and medical device evaluation:

Medical Device Evaluation

Medical devices are used with increasing frequency for diagnostic accuracy and have become increasingly important in developing more effective treatments for longer, healthier lives. Therefore, it is essential that life science companies can count on an experienced, knowledgeable scientific team.

By placing your medical device or combination product study at MPI Research, you can rely on the most advanced methods, effective evaluations, comprehensive verifications, and accurate validation of your medical device designs.

Surgical Efficacy

Ensuring the safety of a drug candidate or medical device is critically important. A developer also needs to know if the product being tested does what it is intended to do and how well it performs. Surgical efficacy—using surgical techniques and analysis across a number of animal models—is a key procedure in making that determination. It requires exceptional skill, experience, and perception, along with an unwavering commitment to delivering reliable results.

Targeted Delivery

Scientists know that most drugs are not targeted to the specific site of the disease in the body. The majority of drugs are delivered throughout the body, which can greatly reduce the drug’s efficacy. Targeted drug delivery offers several, preferred advantages, including decreased dosage frequency, a more constant effect of the drug, and fewer, potential systemic side effects.

MPI Research has the knowledge and expertise to deliver your drug to prolong, localize, and target the correct organs and tissues without creating systemic complications. Our highly trained staff is available to explore how we can assist Sponsors and deliver drugs with improved efficacy.

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MPI Research - Translational Imaging Center

Mattawan MI
No Reviews Available

MPI Research is a full drug development contract research organization with the world’s largest single-site preclinical facility. Our Sponsors benefit from our full suite of preclinical research services.

Our Sponsors value our collaborative culture that is uniformly committed... Show more »

MPI Research is a full drug development contract research organization with the world’s largest single-site preclinical facility. Our Sponsors benefit from our full suite of preclinical research services.

Our Sponsors value our collaborative culture that is uniformly committed to helping them move their compounds from bench to regulatory filing with accuracy, quality, and speed. Our experienced staff is flexible in adapting to changes and quickly responds to challenges as they arise.

MPI Research insists on the highest quality professional standards across all services and at all levels, and is in full compliance with international, federal, and state regulatory agencies. We are

  • Fully AAALAC accredited
  • In compliance with all FDA, EPA, EMEA, OECD, ICH, and JMHW guidances and regulations
  • Dedicated to quality performance and continuous improvement, with registered QA professionals (RQAP-GLP) and on-staff Lean Six Sigma Blackbelts
  • Continually conducting inspections of GLP and Bioequivalence studies and reports
  • Committed to conducting ongoing operational and subcontractor audits

MPI Research's Translational Imaging Center offers services in molecular imaging and radiochemistry. Molecular imaging has become an indispensable tool in evaluating the biological impact of drug and chemical compounds. Through ongoing investment in equipment and expertise, along with our ability to apply them, MPI Research professionally applies imaging technology to advance knowledge that impacts all phases of the drug development process. Our commitment to our Sponsors is to
exceed their expectations and anticipate their programmatic needs for successful entity development. To that end, we have formed a formal partnership with our long-standing collaborators whose capabilities enhance our own, integrated them, and established the MPI Research Translational Imaging Center.

The 10,000 square-foot, two-story Translational Imaging Center is a joint effort between MPI Research, inviCRO, and 3D Imaging.

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MPI - Preclinical Services

Mattawan MI
No Reviews Available

MPI Research is a full drug development contract research organization with the world’s largest single-site preclinical facility. Our Sponsors benefit from our full suite of preclinical research services.

Our Sponsors value our collaborative culture that is uniformly committed... Show more »

MPI Research is a full drug development contract research organization with the world’s largest single-site preclinical facility. Our Sponsors benefit from our full suite of preclinical research services.

Our Sponsors value our collaborative culture that is uniformly committed to helping them move their compounds from bench to regulatory filing with accuracy, quality, and speed. Our experienced staff is flexible in adapting to changes and quickly responds to challenges as they arise.

MPI Research insists on the highest quality professional standards across all services and at all levels, and is in full compliance with international, federal, and state regulatory agencies. We are

  • Fully AAALAC accredited
  • In compliance with all FDA, EPA, EMEA, OECD, ICH, and JMHW guidances and regulations
  • Dedicated to quality performance and continuous improvement, with registered QA professionals (RQAP-GLP) and on-staff Lean Six Sigma Blackbelts
  • Continually conducting inspections of GLP and Bioequivalence studies and reports
  • Committed to conducting ongoing operational and subcontractor audits

MPI Research offers preclinical services in the following areas:

Anatomic and Clinical Pathology

Pathology lies at the heart of life science research and development, providing information on test article-related effects and interpreting the biologic and toxicologic significance of these effects. An intricate and complicated science, doing it well requires time, resources, and talented personnel. The accurate assessment of pathology endpoints in animal models, used to determine the safety profile of a drug or device in its intended population, is a critical phase in the development of a potentially life-saving drug or device.

Clinical Bioanalytical Analysis for Biologics

The human body is remarkable in its ability to wage war against a host of diseases and infections. Understanding the immune system’s arsenal provides valuable knowledge that drives some of the latest innovations in drug therapy, especially in biologically derived medicines and vaccines. MPI Research understands that proper assessments, along with scientific and regulatory expertise, are paramount in advancing your biologic studies.

MPI Research has developed and validated more than 300 bioanalytical methods for biologics over the past five years. These methods have been validated for the analysis of drugs in plasma, serum, urine or CSF, which include TK/PK, immunogenicity, Nab, and biomarker assays. All methods were validated in accordance with FDA and European Medicines Agency (EMA) guidelines for Bioanalytical Method Validation.

MPI Research offers customized development and validation of bioanalytical methods for the detection and quantification of biologics with a wide range of molecule types, including monoclonal therapeutic antibodies, enzymes, proteins, peptides, and oligonucleotides.

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MPI Research has not listed any services.

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