The Mass Spectrometry Facility is an open-access core facility located in the Department of Chemistry at Montana State University. Directed by Dr. Brian Bothner, the MS Facility is managed by Dr. Jonathan Hilmer and offers a variety of services and... Show more »
The Mass Spectrometry Facility is an open-access core facility located in the Department of Chemistry at Montana State University. Directed by Dr. Brian Bothner, the MS Facility is managed by Dr. Jonathan Hilmer and offers a variety of services and instrumention.
Agilent 6340 XCT ion trap with nano-1100 HPLC and ChipCube nanospray interface.
Bruke micrOTOF with Agilent 1290 UHPLC.
Agilent 6520 Q-TOF with nano-1100 HPLC and ChipCube nanospray interface.
Agilent 6538 Q-TOF with Agilent 1290 UHPLC. ESI and APCI sources.
Bruker maXis Impact with Dionex 3000 nano-HPLC and CaptiveSpray source.
Bruker Autoflex III (MALDI, MS/MS-capable).
Bruker Amazon Ion Trap with ETD, Waters NanoAcquity HPLC, and CaptiveSpray source.
Agilent 7890 GCMS, multiple sources.
We specialize in method development for challenging mass-spectrometry based assay. Our experience ranges from small volatile compounds up to megadalton viral complexes: please contact us to discuss your particular needs.
Routine analyses in the MS Facility include metabolomics, proteomics, and high-throughput small molecule assays. Metabolomics experiments are typically conducted on our Agilent 6538 Q-TOF with 1290 UHPLC: we can detect thousands of metabolites in a 30 minute analysis. Proteomics experiments can be performed via in-gel digests analyzed on our high-sensitivity ChipCube Q-TOF system, or via shotgun proteomics with the Bruker maXis Impact. High-throughput and online experiments are conducted with a variety of instrument, frequently our Bruker micrOTOF with UHPLC: this system can be used to perform enzyme assays with spectroscopically "silent" precursors or products, as well as other challenging applications.
provides access to mass spectrometers and mass spectrometry expertise. The facility currently maintains the following equipment.
A Bruker microflex MALDI-TOF mass spectrometer equipped with a microScout ion source using the Compass Software for data acquisition and spectral optimization as well as Bruker’s Biotools software. The spectrometer is well suited for biomolecules of MW up to 300,000 and proteomic analysis of tryptic digests of proteins.« Show less
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