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ModiQuest Research

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Oss, NL

About ModiQuest Research

Founded: 2005 Type: Privately Held Size: 11-50 employees

Your partner in custom antibody development

ModiQuest focuses on offering high-quality custom antibody generation and development solutions fully tailored to the needs and interests of its clients and partners. Since its creation in 2004, ModiQuest successfully performed over 250 antibody projects for... Show more »

Your partner in custom antibody development

ModiQuest focuses on offering high-quality custom antibody generation and development solutions fully tailored to the needs and interests of its clients and partners. Since its creation in 2004, ModiQuest successfully performed over 250 antibody projects for clients in Europe, the US, Asia and Russia.

Over the past 10 years, ModiQuest has built a unique state-of-the-art and fully integrated custom antibody generation and development platform, including antigen design, antibody lead generation, optimization and production. Depending on our clients’ in-house capabilities and the priority and difficulty of their target of interest, they can access the full ModiQuest platform (“from antigen to the production of an optimized antibody”) or choose specific parts of our platform.

To date, ModiQuest has successfully completed over 250 antibody generation and development projects for clients in Europe, the US, Asia and Russia. Typically, we run over 25 different client projects per year with a maximum of 10 projects at any given time.

The ModiQuest team consists of highly skilled and experienced scientists and professionals, fully dedicated and focused on the successful execution and completion of client projects. In addition, the team is constantly working on optimizing and expanding our technology platform to ensure unique and high-quality services and product offering.

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Our Services (59)


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Antibody Fragment Production

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Antibody Screening

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Sony FACS cell sorter Cancer Rheumatoid Arthritis

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Monoclonal Antibody (mAb) Production

Price on request

Hybridoma antibody production: antibody production and purification up to gram scale.

Transient expression: up to gram scale (~300mg/L) transient production of antibodies using our in-house optimized expression platform, ModiXpress™.

Hybridoma antibody production: antibody production and purification up to gram scale.

Transient expression: up to gram scale (~300mg/L) transient production of antibodies using our in-house optimized expression platform, ModiXpress™.

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Stable Cell Line Generation

Price on request

Our stable cell line generation service offeres the generation of stable high-level antibody producing cell lines via our optimized expression platform, ModiXpress™, ClonePix FL technology and/or MTX amplification.

Our stable cell line generation service offeres the generation of stable high-level antibody producing cell lines via our optimized expression platform, ModiXpress™, ClonePix FL technology and/or MTX amplification.

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Custom Cell-Based Assay Development

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ModiQuest Research offers custom assay development services fully tailored to the needs of our clients. In addition, we have developed a number of assays in-house, which we also offer on a fee-for-service basis (e.g. anti-TNF bioactivity assays, CAIA mouse model, etc.).

ModiQuest Research offers custom assay development services fully tailored to the needs of our clients. In addition, we have developed a number of assays in-house, which we also offer on a fee-for-service basis (e.g. anti-TNF bioactivity assays, CAIA mouse model, etc.).

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Phage Display Library Construction and Screening

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The ModiPhage™ approach is an antibody generation approach based on the selection of antigen specific recombinant antibody fragments from ModiQuest’s proprietary human or llama phage libraries or from custom build immune libraries. Our proprietary libraries have been made from human patient and naïve repertoires, as well as from... Show more »

The ModiPhage™ approach is an antibody generation approach based on the selection of antigen specific recombinant antibody fragments from ModiQuest’s proprietary human or llama phage libraries or from custom build immune libraries. Our proprietary libraries have been made from human patient and naïve repertoires, as well as from naïve llama (VHH and scFv) repertoire. Custom immune libraries are prepared from spleen, lymph nodes, and bone marrow of immunized animals or humans. The ModiPhage™ approach captures the immune repertoire of immunized animals or patients and allows sampling of this repertoire by semi-automatic panning procedures, to rescue and identify unique antibodies with pre-specified characteristics. Antibody fragments can be expressed in bacteria or rapidly reformatted into any given Ig format, such as full size IgG of various isotypes, Fc mutants to modify effector functions, or chimera with Fc regions from different species.

Unique features and advantages:

  • Access to human repertoire present in our in-house libraries
  • Access to naïve llama VHH and scFv repertoires present in our in-house libraries
  • Generation of custom (immune) libraries from multiple species
  • Generation of monoclonal antibodies directed to non-immunogenic and toxic targets
  • Unlimited re-screening of the library repertoires
  • Generation of excellent number of antigen positive clones
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Human Rabbit Chicken Mouse Camelids

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Antibody Reformatting

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Our antibody sequencing, cloning, reformatting, and expression service can clone and express any variable antibody domain into any immunoglobulin context required, such as full size mouse, rabbit, chicken, human format, chimeras with any Fc region of choice, including effector mutants or Fc fusions.

Our antibody sequencing, cloning, reformatting, and expression service can clone and express any variable antibody domain into any immunoglobulin context required, such as full size mouse, rabbit, chicken, human format, chimeras with any Fc region of choice, including effector mutants or Fc fusions.

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Hybridoma Generation

Price on request

The ModiFuse™ technology is based on our proprietary electrofusion platform for generating large numbers of hybridomas which allows for rapid and efficient generation of monoclonal antibodies against virtually any target. This technique is combined with optimized immunization protocols, a wide variety of mouse and rat strains, and... Show more »

The ModiFuse™ technology is based on our proprietary electrofusion platform for generating large numbers of hybridomas which allows for rapid and efficient generation of monoclonal antibodies against virtually any target. This technique is combined with optimized immunization protocols, a wide variety of mouse and rat strains, and semi-automated screening facilities.

The ModiFuse™ technology is based on our proprietary electrofusion platform for generating large numbers of hybridomas which allows for rapid and efficient generation of monoclonal antibodies against virtually any target. This technique is combined with optimized immunization protocols, a wide variety of mouse and rat strains, and semi-automated screening facilities.

Unique features and advantages:

  • More than 15 times more hybridomas compared to traditional PEG-fusion
  • Better reproducibility compared to traditional PEG-fusion
  • Less animals required compared to traditional PEG-fusion
  • Scalable to screen up to 50.000 hybridomas from one spleen
  • Allows for generation of therapeutic and diagnostic leads, and specialized reagents such as anti-idiotypic antibodies
  • Full size antibody available after procedure
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Mouse Rat

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Custom Monoclonal Antibody (mAb) Production

Price on request

For over 10 years ModiQuest Research has specialized in the generation of monoclonal antibodies against difficult target antigens for R&D, diagnostic and therapeutic applications. Using our proprietary ModiVacc (cell immunisation) ModiFuse (electrofusion hybridoma), ModiSelect (B-cell selection) and ModiPhage (phage display)... Show more »

For over 10 years ModiQuest Research has specialized in the generation of monoclonal antibodies against difficult target antigens for R&D, diagnostic and therapeutic applications. Using our proprietary ModiVacc (cell immunisation) ModiFuse (electrofusion hybridoma), ModiSelect (B-cell selection) and ModiPhage (phage display) technologies, we can generate monoclonal antibodies from various backgrounds such as mouse, rat, rabbit, chicken, llama and human against virtually any target.

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Transient Antibody Production

Price on request

Up to gram scale (~300mg/L) transient production of antibodies using our in-house optimized expression platform, ModiXpress™.

Up to gram scale (~300mg/L) transient production of antibodies using our in-house optimized expression platform, ModiXpress™.

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Cell Line Rescue

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Protein Services

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Nucleic Acid Services

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Specialized Cell-Based Assays

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Antibody Services

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Therapeutic Monoclonal Antibody (mAb) Development

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Animal Immunization for Antibody Production

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Mouse Rat

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Antibody Purification

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Antibody Modification

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Antigen Expression and Purification

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Assay Development

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Antibody Isotype Analysis

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Random Mutagenesis

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Chemical Crosslinking/Bioconjugation

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Antibody Humanization

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Sequencing data in FASTQ

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Antibody Affinity Maturation

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Cell Lines

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Recombinant Antibody Production

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Protein Production

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Live Cell Assay Development

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Transfection

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Antibody Conjugation

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Antigen Design

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Protein Conjugation

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Hybridoma Production

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Recombinant Antigen Development

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Anti-Idiotype Antibody Production

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Hybridoma Subcloning

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Membrane Protein Antibody Production

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Hybridoma Fusion

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Flow Cytometry Experimental Design

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Hybridoma Screening

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Cytometry

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Cytometry Services

Cytometry Services

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Hybridoma Sequencing

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Antibody Discovery

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Nanobody Libraries

Single Domain Antibody Library
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Fusion Proteins

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Purified Proteins

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Purified Proteins Services

Purified Proteins Services

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Antibody Products

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Bispecific and Trifunctional Antibody Production

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Mutagenesis

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Cell-Based Assays

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Project Management

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DNA Services

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Cells and Tissues

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Cell and Tissue Culture

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Mammalian Cell Culture

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Biochemistry & Molecular Biology

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Maaike de Pooter

Project leader
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Debby Kruijsen

Head contract research
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Jos Raats

CEO
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Ilse Roodink

Senior project manager
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Nienke Smits

Business Development

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