MIP Diagnostics Ltd was founded in 2015 as a spin out from the University of Leicester by leading experts in the field, including Prof. Sergey Piletsky, to commercialise various forms of Molecularly Imprinted Polymers (MIPs), sometimes called "plastic antibodies".
NanoMIPs are, as the name suggests, nano-structured polymer particles typically containing a single binding site for their target. Whilst MIPs are exceptionally robust polymers [plastics], nanoMIPS are sufficiently small to be essentially soluble. They can also be fused to solid substrates, such as sensor surfaces, if required. The robust nature of MIPs and nanoMIPs make them ideal reagents for a wide range of applications including diagnostics, purification and separation, detection, analysis and imaging. They can withstand harsh chemical environments, such as extremes of pH, seawater or high concentrations of organic solvents and are stable to 120 degC. MIPs have successfully been created and deployed against all major target classes including peptides, proteins and other macromolecular structures, as well as smaller chemical entities such as drugs, their metabolites and commonly used biochemical species such as enzyme cofactors. Using our proprietary nanoMIP design and development process, MIP Diagnostics can provide a proven nanoMIP within weeks of receiving the target. nanoMIPs are easily functionalised - for example, they can be made to be magnetic, fluorescent and can be biotinylated, making them straightforward to implement in a wide range of assays.
No immune response is required and no animals are used in the manufacture of MIPs.
NanoMIPs - Nanostructured Molecularly Imprinted Polymers as Novel Affinity Reagents
MIP Diagnostics designs and manufactures nano-structured molecularly imprinted polymers (nanoMIPs) for use in a range of assays and diagnostics.
nanoMIPs are prepared via a proprietary imprinting process involving self-assembly of binding monomers around a target template – these monomers are then polymerised to generate a ‘chemical receptor’ with high affinity and specificity to the template.
As chemical polymers nanoMIPs are very stable and robust, have similar affinity and specificity to antibodies, and can be prepared for any target, including: small molecules, proteins, viruses and whole cells. NanoMIPs are also amenable to a wide range of functionalisation, e.g. they can be made magnetic or fluorescent.
Unlike antibodies nanoMIP production does not require use of animals and they have a long shelf life at room temperature. NanoMIPs have broad applications, including: sensing, imaging, purification, analysis and diagnostics. Indeed, they have the potential to displace antibodies in many applications.
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