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Microsynth AG

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Balgach, CH

About Microsynth AG

As a private and independent Swiss company, Microsynth provides services related to DNA/RNA synthesis, various kinds of DNA/RNA analyses and molecular biology project outsourcing. For more than two decades, our objective has been to serve our customers by delivering products and services of the highest quality,... Show more »

As a private and independent Swiss company, Microsynth provides services related to DNA/RNA synthesis, various kinds of DNA/RNA analyses and molecular biology project outsourcing. For more than two decades, our objective has been to serve our customers by delivering products and services of the highest quality, on time and with outstanding service – and all this at competitive prices.

As a pioneer in our field, we have gained a lot of critical know-how and experience since our incorporation in 1989. This expertise is our most valuable asset. And we attach great importance to increasing our expertise through our commitment to technical competence, diligence and reliability.

As an open and learning organization, Microsynth endeavors to conduct a constant dialogue with renowned experts, universities and research institutions. We assume far-ranging responsibility for our stakeholders. Last but not least, we are committed to sustainable development and to the protection of the natural resources of our planet. Through constant adherence to this philosophy, Microsynth has become an internationally acclaimed company in the field of molecular biology.

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Our Services (38)


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Scientific Sourcing

Price on request

Microsynth has vast experience (>12 years) with a full range of outsourcing transactions for life sciences clients ranging from start-up biotechnology firms to large multinational pharmaceutical companies to renowned research hospitals and scientific institutions. All our molecular biology services are modular and can be assembled... Show more »

Microsynth has vast experience (>12 years) with a full range of outsourcing transactions for life sciences clients ranging from start-up biotechnology firms to large multinational pharmaceutical companies to renowned research hospitals and scientific institutions. All our molecular biology services are modular and can be assembled in any order to a customized project. Professional project management will put your needs at the heart of the project. Our expertise in the area of lab automation and bioinformatics/data analysis will ensure that the results are meaningful and the costs are highly competitive.

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Gene Expression Analysis

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DNA Sequencing Data Analysis

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Oligonucleotide Synthesis

Price on request

Microsynth is a pioneer in the area of oligonucleotide synthesis and can look back on more than 25 years of experience. This valuable know-how combined with the application of state-of-the art synthesizer technologies, purification as well as analytical systems allow us to produce a broad range of high-quality products on a... Show more »

Microsynth is a pioneer in the area of oligonucleotide synthesis and can look back on more than 25 years of experience. This valuable know-how combined with the application of state-of-the art synthesizer technologies, purification as well as analytical systems allow us to produce a broad range of high-quality products on a consistent basis. Microsynth’s highly automated production systems ensure that you receive your oligos at your earliest convenience for a competitive price. Further, an easy ordering system and our competent customer support help to make your life easier.

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Oligonucleotide Modification

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Oligonucleotides to be used in antisense experiments must be modified to increase their resistance against nucleases. There are several possibilities to protect oligonucleotides from enzymatic degradation during in vitro or in vivo applications. Microsynth can offer you the following three modifications::

Oligonucleotides to be used in antisense experiments must be modified to increase their resistance against nucleases. There are several possibilities to protect oligonucleotides from enzymatic degradation during in vitro or in vivo applications. Microsynth can offer you the following three modifications::

  • PTO (phosphorothioates) modifications: PTOs contain one sulfur atom in place of an oxygen atom in the internucleotide linkage of DNA or RNA. This modification of the normal phosphodiester backbone is characterized by an increased cell uptake, high nuclease resistance and elicitation of RNAse H activity.
  • 2'-O-Me-RNA modifications: The incorporation of 2'-O-Methyl RNA nucleotides induces a resistance to a wide variety of nucleases, in particular RNase. Furthermore, 2’-OMe oligonucleotides show slightly increased affinity towards their complementary mRNA target sequence, thereby forming more stable hybrid duplexes compared to their non-modified DNA or RNA counterparts. This enables the formation of more stable hybrids with complementary RNA strands than would be the case for non-modified DNA and RNA sequences.
  • 2'-MOE-RNA modifications: Oligonucleotides incorporating 2'-O-methoxyethyl (MOE)-modified nucleotides, can support most, if not all antisense mechanisms of action. Further key distinctive characteristics are nuclease resistance, lower toxicity, superior target binding specificity, as well as increased affinity towards complementary RNA.
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Sanger Sequencing

Price on request

For more than two decades Microsynth is commercializing services in the area of DNA Sanger sequencing. Since its beginnings in 1992, Microsynth has continuously expanded its service portfolio and is today able to basically cover all common sequencing applications. The following table gives an overview about the various services... Show more »

For more than two decades Microsynth is commercializing services in the area of DNA Sanger sequencing. Since its beginnings in 1992, Microsynth has continuously expanded its service portfolio and is today able to basically cover all common sequencing applications. The following table gives an overview about the various services which we are currently covering in the field of traditional Sanger DNA sequencing.

Name Description Service Segmentation
Standard Sequencing in 1,5 ml Single Tubes
Barcode Economy Run Service Pre-paid service; generic samples; one tube = one reaction Best Price Segment
Economy Run Service Generic samples; one tube = one reaction Standard Segment
Premium Run Service Difficult samples; one tube = one or several reactions Premium Segment
Standard Sequencing within MTP (Microtiter Plate) Format
Barcode High-Throughput Service Pre-paid service; 96-well plate format Best Price Segment
High-Throughput Service 96- and 384-well plate format Best Price & Standard Segment
Ready-to-Load High-Throughput Service Post-BigDye cleanup samples; 96- and 384-well plate format Best Price & Standard Segment
Other Sequencing Services
Primer Walking Service De novo as well as verification sequencing (single- or double stranded) Premium Segment
Large Construct Sequencing Partial and entire sequencing of BACs, PACs, FOSMIDs and COSMIDs; Partial sequencing of genomic DNA (up to 5 MB) Premium Segment
Clone & Sequence Cloning of PCR products into a vector and subsequent sequencing Premium Segment
Exon Sequencing and Mutation Detection Identification of (point) mutations in genes or exons with great accuracy on a nucleotide level Premium Segment
GLP/GMP-Compliant Sequencing High-Quality double strand sequencing compliant with Good Manufacturing Practice (GMP) Premium Segment
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Next Generation Sequencing (NGS)

Price on request

Microsynth offers a wide range of comprehensive next-generation sequencing (NGS) services based on several state-of-the-art NGS platforms:

  • Illumina - MiSeq
  • Illumina - NextSeq
  • Illumina - HiSeq
  • PacBio

Next-generation sequencing at Microsynth means that you will get much more than the access to state-of-the-art NGS... Show more »

Microsynth offers a wide range of comprehensive next-generation sequencing (NGS) services based on several state-of-the-art NGS platforms:

  • Illumina - MiSeq
  • Illumina - NextSeq
  • Illumina - HiSeq
  • PacBio

Next-generation sequencing at Microsynth means that you will get much more than the access to state-of-the-art NGS technologies. It is the profound expertise of more than 20 years in DNA sequencing as well as related molecular biology knowledge such as DNA/RNA isolation, PCR/realtime PCR analysis and/or synthesis of DNA oligos, which you can rely on.

In addition, you can expect extensive consultation during the entire phase of your NGS project. A study manager is interacting with you but also internally with a team of molecular biology experts to ensure that your project is optimally designed and carefully executed.

Once your data will have been generated, you can make use of our in-depth bioinformatics knowhow and solutions. Hence, your sequencing project will be in good hands at Microsynth and we do everything possible to deliver you high-quality results where you can build on your further ongoing scientific work.

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qPCR Assay Design

Quantitative PCR experimental design
Price on request

Are you interested in a functional, specific and tailor-made real-time PCR assay?

Then we encourage you to hand over us your target sequence or accession number. Simply leave it up to us to design, synthesize as well as to perform functionality testing of your primer-probe set; and receive your real-time PCR assay 2-3 weeks... Show more »

Are you interested in a functional, specific and tailor-made real-time PCR assay?

Then we encourage you to hand over us your target sequence or accession number. Simply leave it up to us to design, synthesize as well as to perform functionality testing of your primer-probe set; and receive your real-time PCR assay 2-3 weeks after ordering.

Main Product Features and Benefits:

  • Real-time PCR assays with proven functionality due to comprehensive testing using a specific positive control as well as a no template control
  • High degree of customization: you as our customer will decide
    • whether the assay should be singleplex or multiplex
    • which pair(s) of possible reporter dyes and quenchers should be selected
    • which sequence areas should be considered or not considered when designing the primer/probe set(s)
  • High sensitivity due to optimization of PCR working conditions: we design, synthesize and test your primer set(s) for their PCR performance
  • Easy publishing due to compliance with MIQE guidelines (full transparency with respect to sequence information of used primer and probes)
  • Low-cost reordering of primer/probe sets, e.g. via our own oligonucleotide production facility (you will be provided with complete sequence of all oligonucleotides)
  • High quantity delivered: QC-tested primer/probe set(s) in single tubes (aliquoted) are sufficient for more than 2000 PCR reactions

Potential Applications:

  • Gene expression analysis in any organism
  • Gene quantification at genomic level
  • SNP (single nucleotide analysis) genotyping and analysis of polymorphisms
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Project Management

Price on request

Microsynth has vast experience (>12 years) with a full range of outsourcing transactions for life sciences clients ranging from start-up biotechnology firms to large multinational pharmaceutical companies to renowned research hospitals and scientific institutions. All our molecular biology services are modular and can be assembled... Show more »

Microsynth has vast experience (>12 years) with a full range of outsourcing transactions for life sciences clients ranging from start-up biotechnology firms to large multinational pharmaceutical companies to renowned research hospitals and scientific institutions. All our molecular biology services are modular and can be assembled in any order to a customized project. Professional project management will put your needs at the heart of the project. Our expertise in the area of lab automation and bioinformatics/data analysis will ensure that the results are meaningful and the costs are highly competitive.

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RNA Services

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Nucleic Acid Analysis

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Biology

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Computational Modeling

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Biostatistics & Bioinformatics

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Assay Development

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Nucleic Acid Data Analysis

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Targeted Sequencing

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Separation/Purification Services

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Multiplex PCR

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Metatranscriptomics

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Metagenomics

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DNA Synthesis and Probe Development

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Targeted Gene Sequencing

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Amplicon Sequencing

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RNA Synthesis

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Nucleic Acid Services

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RNA Extraction and Purification

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NGS Data Analysis

Next generation sequencing data analysis
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Genotyping and Gene Expression Assays

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DNA Sequencing

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DNA Extraction and Purification

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Bioinformatics

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DNA Services

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Biochemistry & Molecular Biology

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PCR

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Chemistry and Materials

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Analytical Chemistry Services

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Sequencing Data Analysis and Management

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Rupert Hagg

Sales Manager
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Elges Lardi

Marketing & Sales Manager
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Catalog_Microsynth_2016_17.pdf

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Microsynth_EBHorn_2016.pdf

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