MGS laboratories is a microbiological contract testing laboratory and consultancy service with a reputation for technical excellence and customer service.
We perform most industrial microbiological methods but are specialists in the area of disinfectant efficacy testing and the only laboratory in the UK with 14 different European standard test methods for disinfectant efficacy UKAS accredited.
In the Pharmaceutical and associated industries, the subject of disinfectant validation is attracting ever increasing attention from regulatory bodies such as MHRA, HPRA and FDA.
Companies are now expected to be able to demonstrate conclusively that their disinfectants of choice are effective under the conditions in which they are used.
A recognised approach to disinfectant validation is to follow the CEN (European Committee for Normalisation) Technical committee 216 work programs which provide a systematic approach to the validation of disinfectant efficacy.
A number of BS EN methods have been issued as a result of the CEN work program. The literature defines in detail how disinfectants should be tested against a range of type cultures under controlled conditions. There are clearly defined pass criteria and results are expressed as either pass or fail. All the methods include rigorous validation requirements which are performed in parallel to the test itself.
Test In-house or Outsource?
There are two compelling reasons for outsourcing disinfectant validation:
Wider Application of the BS EN Methods
The BS EN methods themselves are of value as a means of determining the efficacy of a disinfectant under controlled conditions. However, in normal working conditions, environmental organisms are encountered which can provide a greater challenge to disinfectant products.
The nature of the BS EN methods is such that they can be adapted to form the basis of more informative studies into the performance of disinfectants in practice. This can yield valuable information about the comparative performances of a number of products and the adapted methods facilitate studies of the effects of changes in product concentration, contact time, test temperature and the use of water produced in your facility, all of which help to evaluate your specific in house cleaning procedures.
Handwashes and Handrubs
BS EN 1499 and BS EN 1500 are specifically designed to test handwashes and handrubs. Both methods involve the use of a panel of volunteers who use the product under test and a reference material.
BS EN 12791 evaluates the sustained action of surgical hand disinfectants.
BS EN 14348 is a quantitative suspension test for the evaluation of mycobactericidal activity of chemical disinfectants for instruments used in the medical area - Test method and requirements (Phase 2, Step 1).
BS EN 14204 is a quantitative suspension test for the evaluation of mycobactericidal activity of chemical disinfectants for instruments used in the veterinary area - Test method and requirements (Phase 2, Step 1).
BS EN 13623 Chemical disinfectants and antiseptics — Quantitative suspension test for the evaluation of bactericidal activity against Legionella of chemical disinfectants for aqueous systems — Test method and requirements (Phase 2, Step 1)
Alternative Disinfectant Test methods
For companies not wishing to follow the CEN approach, a number of alternative methods are available for the evaluation of disinfectant products, including but not limited to AOAC, ASTM, EPA/OECD methods.
Total Viable Counts
Total viable aerobic counts performed to BP, EP, USP, JP etc for
We can also perform verification of neutralisation (method suitability) for the microbiological examination of products using procedures that meet the harmonized pharmacopoeias USP <61> and <62>; and Ph.Eur. 2.6.12 and 2.6.13.
BS EN 21149 Cosmetics microbiology – Enumeration and detection of aerobic mesophilic bacteria.
BS EN 16212 Cosmetics microbiology – Enumeration of yeast and mould
BS EN 22717 Cosmetics microbiology – Detection of Pseudomonas aeruginosa
BS EN 22718 Cosmetics microbiology – Detection of Staphylococcus aureus
BS EN 18416 Cosmetics microbiology – Detection of Candida albicans
Absence of Specified Organisms
Presence/Absence tests performed for most types of organisms from a variety of source materials Including food, water, consumer, household, cosmetics, toiletries and pharmaceutical medicinal products.
Water Testing and Monitoring to a variety of standards or specifications using standard microbiological techniques.
Why identify? To assess risk, identify source of contamination or prepare a strategy for contamination control.
We use a combination of traditional and rapid biochemical identification methods.
Environmental monitoring can be carried out at our client’s premises as a service and can include microbiological active air sampling, settle plates, surface monitoring using contact plates or swabs. Hygiene audits can also be performed.
With the ever increasing pressure on headcount suffered by most companies, time consuming method development activities become increasingly difficult. We are able to perform these activities to your specified criteria or if you have existing microbiological methods which have not been validated we are able to write the validation protocols and perform the validation to help you achieve compliance.
MGS are keen to work in partnership with our customers to achieve the technical excellence and the level of customer service you require.
We are able to offer bacterial endotoxin testing of water and finished products using
Population determinations and enumeration performed on a range of different biological indicator types.
Microbiological assays performed to determine the potency of various:
Both EP and USP assays performed.
Preservative Efficacy Testing (PET) / Antimicrobial effectiveness testing (AET)
PET/AET testing is used to assess the performance of the preservative system in a finished product or as a tool in formulation/product development.
A known high level of the organisms under study are inoculated into the product under test and thoroughly mixed.
Aliquots of the inoculated product are withdrawn at pre-defined time points and enumerated using standard microbiological techniques and reduction in population calculated by subtraction from the initial inoculum level.
MGS personnel are fully trained and experienced in Preservative Efficacy testing and conduct hundreds of such tests annually.
Tests performed to either:
AATCC 147, Antibacterial activity assessment of textile materials parallel streak method.
AATCC Test Method 30, Antifungal activity, assessment of textile materials: mildew and rot resistance of textile materials.
AATCC Test method 100, Antibacterial finishes on textile materials: Assessment of
ISO 22196 / JIS Z 2801, Antimicrobial products – Test for antimicrobial activity and efficacy.
ISO 20743 / JIS Z 1902, Textiles – determination of antibacterial activity of antibacterial finished products
ISO 20645, Textile fabrics, determination of antibacterial activity – agar diffusion test.
ASTM E2149-01 Standard test method for determining the antimicrobial activity of immobilized antimicrobial agents under dynamic contact conditions.
MGS undertakes microbiological shelf life stability testing. We are able to store samples under controlled conditions of temperature and humidity as defined in ICH Q1 guidelines.
Current storage conditions offered:
All chambers wirelessly monitored 24 hours a day, 7 days a week with electronic alarm notifications enabled.
Dependent upon demand, additional capacity may be available for storage under conditions different to those above. Please enquire for details.
For customers who prefer to store their own stability samples, we can offer a service whereby we manage all other aspects of the testing program including ensuring samples are removed from storage at the correct time, sample collection, testing and communication of results either by exception or in full.
Product Development, Testing, and Packaging Services
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