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Metrion Biosciences

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Cambridge, GB

About Metrion Biosciences

Founded: 2015 Type: Public Company Size: 1-10 employees

Metrion Biosciences is an ion channel specialist contract research organization (CRO) located in the Cambridge (UK) biocluster. Our team of experts provide highly skilled electrophysiology screening services to support client medicinal chemistry optimisation programmes ranging from routine screening support through to a fully integrated drug discovery service.

Additionally, we offer an extensive range of cardiac safety profiling assays, neuroscience assays and translational assays - including a range of validated induced Pluripotent Stem Cell (iPSC) assays. We pride ourselves on being able to provide a high quality, flexible and cost effective service with an unparalleled level of expertise. Collectively, our management team have amassed over 100 years of experience in ion channel drug discovery, with extensive experience in a CRO environment. Our clients can access this high level of expertise, combined with expert project management, as part of our dedicated service.

Diversity Certificates

Small business

Our Services (19)


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hERG Channel Inhibition Assay

Price on request

Metrion offers non-GLP hERG screening services using the QPatch automated gigaseal patch clamp platform and manual patch clamp. On QPatch we offer four-point and eight-point concentration-response hERG screening assays that are performed at room temperature. The compounds are applied in cumulative concentration-response format, with double additions of compound at each concentration. A concentration-response curve is also provided using the positive control reference compound, Verapamil.

Concentration-response format using manual patch clamp can be mutually agreed with the client.

Cardiovascular electrophysiology hERG QPatch Toxicology Drug Discovery Show 6 more tags Show less

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Ion Channel Screening Assays

Price on request

Metrion has developed validated screening assays against an extensive panel of ion channel cell lines using a number of high quality screening platforms with a range of throughput capabilities. Metrion have worked on a very wide range of targets, including voltage-gated (e.g. Nav, Cav and Kv), inward rectifiers (e.g. Kir3.1/3.4) and a variety of ligand-gated ion channels (e.g. TRP and ASIC). In addition, Metrion can offer cell line optimisation and bespoke assay development services to our clients for their ion channel targets. This includes both viral (e.g. BacMam) and non-viral transfection techniques.

QPatch Patchliner Manual Patch electrophysiology platforms Drug Discovery Neuroscience Toxicology assay development Show 7 more tags Show less

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Assay Development

Price on request

For more than a decade, Metrion’s scientists have been involved in developing, optimising and validating automated and manual patch clamp assays for ion channel targets. We can fully customise ion channel assays at different stages of the screening cascade, from hit finding and medium throughput structure activity studies, through to specialised biophysical and mechanism-of-action studies for hit series or lead compounds.

QPatch Manual Patch Clamp Patchliner

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Cardiac Channel Assays

Price on request

Metrion offers cardiac safety screening services against the full panel of Comprehensive in Vitro Proarrhythmia Assay (CiPA) compliant human cardiac ion channels (hERG, Nav1.5, Cav1.2, KvLQT1, Kv4.3 and Kir2.1) as well as other important cardiac ion channels (e.g. Kv1.5 and HCN4). These studies are performed on automated platforms with true gigaseal quality. Clients may elect to evaluate hERG alone, our core cardiac panel (hERG, Nav1.5, Cav1.2), the full CiPA panel or a custom selection of channels. Contact us for a discussion about your requirements.

Cardiovascular Cav1.2 nav1 hERG Automated Patch Clamp Manual Patch Clamp Show 6 more tags Show less

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Cell-Based Compound Screening

Price on request

Metrion are developing a number of phenotypic assays to aid the translation of in vitro cardiac safety and neuroscience data to the preclinical stage. We are working towards a full CiPA predictive cardiac safety package by developing patch clamp and label-free phenotypic assays using human stem cell-derived cardiomyocytes. In addition, we are developing phenotypic neuroscience assays with native and iPSC-derived neurons on the manual patch clamp and multielectrode array (MEA) platforms.

electrophysiology Cardiovascular CNS/Neurology Pain Automated patch clamp Manual patch clamp Show 6 more tags Show less

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Potassium Channel Assays

Price on request

Metrion are highly experienced at developing screening assays for potassium channel targets. This includes voltage-gated (hERG, Kv1.3, Kv1.5, Kv7 etc) and inward rectifier potassium channels.

Automated Patch Clamp Manual Patch Clamp Patchliner QPatch

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In vitro Cardiotoxicity Screening

Price on request

Metrion provides a fully integrated Cardiac Safety Screening / CiPA Screening service incorporating all three components of the Comprehensive In vitro Proarrhythmia (CiPA) initiative. Our services include:

  • Automated electrophysiology screening against an expanded panel of six cardiac ion channels, including hERG.
  • In silico modelling using electrophysiology data from the expanded ion channel panel.
  • Confirmation of in silico predictions using translational assays employing human iPSC-derived cardiomyocytes.

Metrion is a member of the HESI Cardiac Safety committee and, as part of its role in the HTS sub team, is involved in validating automated screening assays. The company also has access to multiple commercially available iPSC-derived cardiomyocyte cell lines, which have been fully validated in-house.

Automated Patch Clamp Manual Patch Clamp Patchliner QPatch

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Voltage-Gated Ion Channel Assays

Price on request

Metrion are highly experienced at developing and performing screening assays against voltage-gated ion channels, such as Nav, Cav and Kv channels.

Automated Patch Clamp Manual Patch Clamp QPatch Patchliner

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Drug Discovery

Price on request

Our highly experienced team is able to provide clients with a fully integrated drug discovery service including biology, medicinal chemistry and early ADMET. This integrated service spans initial assay development, validation and high throughput screening in 384-well plate-based assays, automated electrophysiology-based support for medicinal chemistry optimisation of compounds, conventional electrophysiology profiling of lead compounds, translational assays and safety profiling. Along with our partners Assay.Works and Concept Life Sciences Metrion has the experience to steer your research programme to a successful, and cost effective, conclusion.


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Cardiomyocyte Toxicity Assay

Price on request

Metrion can perform comprehensive studies to evaluate the cardiotoxicity liability of compounds in short (<24hrs) and chronic (up to 72 hrs) assays using MEA and Impedance assays.

Multi-Electode Array Impedence Axion Maestro

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Action Potential Duration Assay

Price on request

Metrion are highly experienced at recording action potentials from iPSC-derived cardiomyocytes (iPSC-CM). Metrion have characterised a range of different commercially available iPSC-CM lines and can advise our clients on which lines to use for their Action Potential Duration Assays.

electrophysiology stem cells Cardiovascular

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Compound Profiling

Price on request

Metrion perform compound profiling against ion channel targets. We are able to undertake screening services from small studies with a few compounds up to hundreds of thousands of compounds. We can prosecute screening studies against the primary target and selectivity panels.

QPatch Manual Patch Clamp Patchliner Automated Patch Clamp

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Patch Clamp Recording

Price on request

Metrion are a UK-based CRO that specialises in investigating the function of ion channels using the patch clamp technique. Metrion has a plethora of automated patch clamp devices and manual patch clamp platforms are used for patch clamp studies.

Automated Patch Clamp Manual Patch Clamp QPatch Patchliner

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Custom Cell-Based Assay Development

Price on request

Metrion is highly proficient at developing custom cell-based ion channel assays for clients.


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Electrophysiology

Price on request

We provide highly skilled electrophysiology screening services to support client medicinal chemistry optimisation programmes, CiPA compliant cardiac safety profiling assays, neuroscience assays and translational assays.


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Specialized Cell-Based Assays

Price on request

Specialized Cell-Based Assays Services

Manual Patch Clamp Automated Patch Clamp Patchliner QPatch

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Cell-Based Assays

Price on request

Metrion is highly proficient at developing custom cell-based ion channel assays for clients.

QPatch Manual Patch Clamp Automated Patch Clamp Patchliner

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In silico Cardiac Safety Assessment

Price on request
Request a quote for more information about this service.

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Compound IC50 Assays

Price on request
Request a quote for more information about this service.

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RK

Robert Kirby

Head of Client Research Services
JR

John Ridley

Business Manager
SR

Sophie Rose

Sales and Marketing Manager

FileType/PDF Created with Sketch. Axol-atrial-poster_Metrion-Final-.pdf

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FileType/PDF Created with Sketch. Characterisation of vCor4U cells - European Cardio Symposium 2018.pdf

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FileType/PDF Created with Sketch. CiPA-refining-in-vitro-models_Final.pdf

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FileType/PDF Created with Sketch. Domainex_Metrion_Poster_Trpa1_case_study_2019_Final.pdf

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FileType/PDF Created with Sketch. HESI CiPA Ph II HTS sub-team cardiac ion channel screening paper (Kramer_Nat Sci Rep_2020).pdf

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FileType/PDF Created with Sketch. Metrion - Axol Stem Cell Meeting_iPSC-derived atrial cardiomyocytes - 2018.pdf

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FileType/PDF Created with Sketch. Metrion - Milnes hERG dynamic drug protocol_Sophion User Meeting_2018.pdf

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FileType/PDF Created with Sketch. Metrion-Venomtech Kv1.3 toxin poster_RSC ion channel symposium_Feb 2020.pdf

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