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Metis Laboratories

Valley Stream, NY, US

METIS Labs specializes in custom in vitro and in vivo preclinical assays and research studies. One main focus is radiotracers for high sensitivity functional assays, radioligand binding assays, receptor occupancy, in vitro & ex vivo autoradiography, QWBA, and ADME studies. METIS provides custom radiolabeling and radiosynthesis of clients' molecules.

We also provide non-radioactive custom cell culture-based assays and rodent surgical models. Supporting this is preclinical imaging including digital microscopy (histology, immunostaining), digital autoradiography, optical imaging, and micro-PET and micro-SPECT imaging.

We help move clients' compositions through drug discovery, lead optimization, off-target effects, biodistriubtion and efficacy studies.

Metis Laboratories has not listed any services.

Radiolabeling Services
Price on request

METIS Labs can provide you custom radiolabeling and custom radiosynthesis of your small molecules, peptides, and proteins. METIS Labs’ will confidentially advise you on the appropriate labeling technique. High specific activity and retention of the molecular structure is essential for the success of radiometric assays such... Show more »

METIS Labs can provide you custom radiolabeling and custom radiosynthesis of your small molecules, peptides, and proteins. METIS Labs’ will confidentially advise you on the appropriate labeling technique. High specific activity and retention of the molecular structure is essential for the success of radiometric assays such as:

• Receptor Ligand Binding
• in vitro Autoradiography
• ex vivo Autoradiography
• in vivo receptor occupancy

Analysis of products is performed using methods including LC-MS, HPLC-Radiochemical Flow, HPLC-UV, TLC Radioscan and NMR.

Custom synthesis is an important part of our business. Often we subsidize the cost of custom synthesis for potentially new catalog products. Many of our exclusive products in our radiochemical catalog have been derived from custom syntheses. Built upon years of experience in a top pharmaceutical company our organic chemists provide world class expertise and integrated solutions to accelerate your drug development programs.

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Radiotracers
Price on request

METIS Labs specializes in custom in vitro and in vivo preclinical assays and research projects. One main focus is radiotracers for high sensitivity functional assays, radioligand binding assays, receptor occupancy, in vitro & ex vivo autoradiography, QWBA, and ADME studies.

METIS Labs specializes in custom in vitro and in vivo preclinical assays and research projects. One main focus is radiotracers for high sensitivity functional assays, radioligand binding assays, receptor occupancy, in vitro & ex vivo autoradiography, QWBA, and ADME studies.

« Show less
Digital autoradiography
Price on request

For autoradiography, we apply a phosphor screen apposed to a radioactive tissue section to give an image of the radiolabeled probe with our Fuji phosphorimagers, or radioactive disintegrations are detected in real-time with our BetaIMAGERs™. The radiolabeled probe can be applied to the tissue either in vitro or in... Show more »

For autoradiography, we apply a phosphor screen apposed to a radioactive tissue section to give an image of the radiolabeled probe with our Fuji phosphorimagers, or radioactive disintegrations are detected in real-time with our BetaIMAGERs™. The radiolabeled probe can be applied to the tissue either in vitro or in vivo.

Autoradiography can be used to determine in tissue sections:

  • Anatomical distribution of binding sites of a radiolabeled drug (receptor distribution)
  • Receptor occupancy of a competing unlabeled drug given either in vitro or ex vivo
  • [35S]-GTPγS binding to reveal distribution and functional activation of GPCR receptors
  • QWBA biodistribution among the organs of a laboratory animal
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Radioactive Cell Culture
Price on request
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Small Animal SPECT Scan
Small Animal Single Photon Emission Computed Tomography Scan
Price on request
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Digital Microscopy
Price on request
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