Default

Metabolon, Inc.

Research Triangle Park, NC, US

Metabolon is the world’s leading health technology company advancing metabolomics for precision medicine and every area of life sciences research. Our Precision Metabolomics™ is a powerful technology for assessing health and is delivering biomarker discoveries, innovative diagnostic tests, and ground-breaking partnerships in genomics and population health initiatives.

Almost every factor impacting the phenotype – from genetics and the microbiome to disease and lifestyle – exerts its influence by altering metabolite levels. By producing the most accurate, comprehensive picture of the metabolome, we help answer some of biology’s most challenging questions.

Metabolon is evolving precision medicine beyond genomics by applying our metabolomics-based technology to clinical uses. We provide a snapshot of an individual’s current state of health to promote wellness and improve diagnosis, treatment and monitoring of... Show more »

Metabolon is the world’s leading health technology company advancing metabolomics for precision medicine and every area of life sciences research. Our Precision Metabolomics™ is a powerful technology for assessing health and is delivering biomarker discoveries, innovative diagnostic tests, and ground-breaking partnerships in genomics and population health initiatives.

Almost every factor impacting the phenotype – from genetics and the microbiome to disease and lifestyle – exerts its influence by altering metabolite levels. By producing the most accurate, comprehensive picture of the metabolome, we help answer some of biology’s most challenging questions.

Metabolon is evolving precision medicine beyond genomics by applying our metabolomics-based technology to clinical uses. We provide a snapshot of an individual’s current state of health to promote wellness and improve diagnosis, treatment and monitoring of diseases.

Our technology and expertise also accelerate research and product development across the pharmaceutical, biotechnology, consumer products, agriculture and nutrition industries, as well as academic and government organizations. We offer scalable, customizable metabolomics solutions across the research continuum from discovery to clinical trials.

Metabolon was founded in 2000 and has over 200 employees, including nearly 40 PhDs from diverse backgrounds in data science, molecular biology and biochemistry, and an experienced staff of statistics, bioinformatics, medical, chemistry, and software development experts.

In addition, the staff at Metabolon has written and contributed to over 1,000 peer-reviewed journal publications, including numerous articles in Cell, Nature and Science.

Recent Publications

  • Clark-Matott, J., et al. Metabolomic analysis of exercise effects in the POLG mitochondrial DNA
    mutator mouse brain. Neurobiol Aging, 2015. 36 (11):2972-83.
  • Hall, J. A. Nutritional interventions that slow the age-associated decline in renal function in a
    canine geriatric model for elderly humans. The Journal of Nutrition, Health & Aging, 2015.
  • Solini, A., et al. Prediction of Declining Renal Function and Albuminuria in Patients with Type 2
    Diabetes by Metabolomics. J Clin Endocrinol Metab, 2015.jc20153345.
  • Pappa, V., et al. Lipid metabolites of the phospholipase A2 pathway and inflammatory cytokines
    are associated with brain volume in paediatric cerebral malaria. Malar J, 2015. 14 (1):513.
  • Le, H., et al. Characterization of intrinsic variability in time-series metabolomic data of cultured
    mammalian cells. Biotechnol Bioeng, 2015. 112 (11):2276-83.
  • Chattopadhyay, N., et al. KRAS Genotype Correlates with Proteasome Inhibitor Ixazomib Activity
    in Preclinical In Vivo Models of Colon and Non-Small Cell Lung Cancer: Potential Role of Tumor
    Metabolism. PLoS ONE, 2015. 10 (12):e0144825.
  • Herranz, D., et al. Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T
    cell acute lymphoblastic leukemia. Nat Med, 2015. 21 (10):1182-9.
  • Herranz, D., et al. Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in T
    cell acute lymphoblastic leukemia. Nat Med, 2015. 21 (10):1182-9.
  • Sankaranarayanan, K. Gut Microbiome Diversity among Cheyenne and Arapaho Individuals from
    Western Oklahoma. Current Biology, 2015. 21 (25)
  • Cassol, E., et al. Altered Monoamine and Acylcarnitine Metabolites in HIV-Positive and HIVNegative
    Subjects With Depression. J Acquir Immune Defic Syndr, 2015. 69 (1):18-28.
  • Diboun, I., et al. Metabolomics of dates (Phoenix dactylifera) reveals a highly dynamic ripening
    process accounting for major variation in fruit composition. BMC Plant Biol, 2015. 15 (1):291.
  • Wang, W., et al. Comparative Metabolomic Profiling Reveals That Dysregulated Glycolysis
    Stemming from Lack of Salvage NAD+ Biosynthesis Impairs Reproductive Development in
    Caenorhabditis elegans. J Biol Chem, 2015. 290 (43):26163-79.
  • Laguna, T. A., et al. Metabolomics analysis identifies novel plasma biomarkers of cystic fibrosis
    pulmonary exacerbation. Pediatr Pulmonol, 2015.
  • Pallister, T., et al. Food Preference Patterns in a UK Twin Cohort. Twin Res Hum Genet, 2015.1-
  • Jones, D. P. Sequencing the exposome: A call to action. Toxicol Rep, 2016. 3:29-45.
  • Ba, Q. Cumulative metabolic effects of low-dose benzo(a)pyrene exposure on human cells.
    Toxicology Research, 2015.
« Show less

Metabolon, Inc. has not listed any services.

Targeted Metabolomics
Price on request

Targeted assays and panels focus on a specific metabolite or metabolites and can be used to track biomarkers and improve biological understanding in both clinical and preclinical research. They are an excellent tool for rapidly and accurately establishing pharmacodynamics, translational studies, gauging efficacy and safety in... Show more »

Targeted assays and panels focus on a specific metabolite or metabolites and can be used to track biomarkers and improve biological understanding in both clinical and preclinical research. They are an excellent tool for rapidly and accurately establishing pharmacodynamics, translational studies, gauging efficacy and safety in clinical trials and for post-market surveillance studies. The role of biomarkers is also expanding to inform new indications and targets, patient segmentation and novel mechanisms of action.

Metabolon’s targeted metabolite assays provide precise measurements of metabolites in a wide variety of sample matrices. Metabolites can be valuable biomarkers because they are sensitive to specific enzyme inhibitors and signaling pathways (e.g. kinase inhibitors) and are associated with many diseases such as metabolic disorders and cancer.

LC-MS/MS-based assays offer unique advantages over legacy assay platforms such as ELISA or IHC. Assays can be customized based on your needs and developed for research use only (RUO) or validated under Good Clinical Practice (GCP) and Clinical Laboratory Improvement Amendments (CLIA).

Select from an ever-expanding, diverse menu of more than 150 pre-developed assays (qualified and /or validated) involving more than 250 metabolites for research or clinical trial use, including a fatty acid panel, short-chain fatty acid (SCFA) panel, bile acid panel and amino acid panel, such as:

-Fatty Acid Metabolism Panel: measures the major fatty acids of importance to human and animal metabolism, including saturated, mono-unsaturated omega-3, omega-6, trans and plasmalogen-derived fatty acids.
-Short-Chain Fatty Acid (SCFA) Panel: measures short-chain fatty acids in a variety of biological matrices. Quantitative measurements of SCFA can help elucidate the importance of the gut microbiome on human health.
-Bile Acid Panel: measures the major primary and secondary bile acids, as well as their glycine and taurine derivatives.
-Cholesterol Metabolism Panel: measures cholesterol, as well as intermediates in cholesterol synthesis and oxidation, phytosterols, and metabolic products of cholesterol to provide a comprehensive snapshot of sterol synthesis, absorption and excretion.
-Stratum Corneum Panel: measures more than 350 individual lipid metabolites found in stratum corneum, including free fatty acids, cholesterol sulfate, ceramides, dihydroceramides and phytoceramides.
-Sebum Lipid Panel: measures over 900 individual lipid species from multiple lipid classes, including wax esters and squalene. The fatty acids comprising the complex lipid classes are largely unique to skin metabolism and include odd and branched-chain fatty acids and a high concentration of the unusual sapienic acid (16:1n10) and its metabolites.
-accuGFR™ Panel: provides an estimate of the Glomerular Filtration Rate (GFR) that is more precise than current standard-of-care eGFR methods based on creatinine of cystatin C (MDRD or CKD-EPI), and it is independent of creatinine or cystatin C.
-7 alpha-hydroxy-4-cholesten-3-one (C4) Panel: measurement in peripheral blood provides an assessment of the rate of bile acid synthesis in the liver.
-Metal Ion Panel: provides precise measurements of biologically important macro- and micro-nutrient metals, such as zinc, chromium, magnesium and iron, in plasma, serum or urine.
-Amino Acid Panel: measures the major free amino acids in biofluids. Quantitative profiling of amino acids can be used to study a wide variety of genetic disorders and acquired conditions that influence the amino acid metabolism. Monitoring the amino acid profile is also a useful tool in bioprocessing applications.
-Custom Assays: provides precise measurement of metabolites in a wide variety of matrices. Metabolites can be valuable biomarkers, because they are sensitive to specific enzyme inhibitors and signaling pathways and are associated with many diseases.

« Show less
Metabolomics
Price on request

Metabolomics is a revolutionary technology for obtaining a comprehensive picture of the metabolome and mapping metabolites to their key biochemical pathways. It helps answer a wide variety of research questions and gives crucial insight into the function of genes, the basis of disease, and how treatments work. It can also identify... Show more »

Metabolomics is a revolutionary technology for obtaining a comprehensive picture of the metabolome and mapping metabolites to their key biochemical pathways. It helps answer a wide variety of research questions and gives crucial insight into the function of genes, the basis of disease, and how treatments work. It can also identify associated biomarkers, making it an attractive tool for investigators across multiple applications.

Many laboratories have metabolite profiling or analytical chemistry capabilities, but none have the technology and workflow that allow Metabolon to produce the most comprehensive, high-quality and accurate metabolomics data available. Our unique bioinformatics infrastructure and data interpretation experience transform that data into knowledge that you can immediately put into action.

Metabolon offers a range of metabolomics service offerings that support and advance research at every stage. Whether you want to survey the entire metabolome, only complex lipids, or just a few key pathways or metabolites, our team of experts will work with you to clearly define your goals and develop a customized plan to meet them.

Metabolomics applications for the drug discovery and preclinical phases are many.

  • Discovery through Target Selection
    • Novel biomarkers
    • Disease characterization
    • Target discovery
    • Mechanism of action
  • Lead through Candidate Selection
    • Lead optimization
    • Early toxicology & secondary effects
    • Candidate selection
  • Preclinical
    • Efficacy & PD biomarkers
    • Translatability
    • Drug off-target effect characterization
« Show less
Lipidomics
Price on request

Lipidomics is a more focused form of metabolomics that surveys complex lipids. Our Complex Lipid Panel is the only lipidomics method able to provide absolute quantitation, molecular species concentration and complete fatty acid composition of each covered lipid class. This unique method covers more than 1100 molecular species... Show more »

Lipidomics is a more focused form of metabolomics that surveys complex lipids. Our Complex Lipid Panel is the only lipidomics method able to provide absolute quantitation, molecular species concentration and complete fatty acid composition of each covered lipid class. This unique method covers more than 1100 molecular species across 16 lipid classes, including principle phospholipid sphingolipid and neutral lipid classes.

« Show less
Biomarker Discovery
Price on request

Metabolomics applications for the drug discovery and preclinical phases are many.

  • Discovery through Target Selection
    • Novel biomarkers
    • Disease characterization
    • Target discovery
    • Mechanism of action
  • Lead through Candidate Selection
    • Lead optimization
    • Early toxicology & secondary effects
      -... Show more »

Metabolomics applications for the drug discovery and preclinical phases are many.

  • Discovery through Target Selection
    • Novel biomarkers
    • Disease characterization
    • Target discovery
    • Mechanism of action
  • Lead through Candidate Selection
    • Lead optimization
    • Early toxicology & secondary effects
    • Candidate selection
  • Preclinical
    • Efficacy & PD biomarkers
    • Translatability
    • Drug off-target effect characterization
« Show less
Clinical Biomarkers
Price on request
Request a quote for more information about this service.
Biomarker Analytical Validation
Price on request
Request a quote for more information about this service.
Toxicology
Price on request
Request a quote for more information about this service.
Asymmetric Dimethylarginine (ADMA) Testing
Price on request
Request a quote for more information about this service.
Contract Services Directory
Price on request
Request a quote for more information about this service.
Pharmacodynamic Biomarkers Discovery
Price on request

Metabolomics applications for the drug discovery and preclinical phases are many.

  • Discovery through Target Selection
    • Novel biomarkers
    • Disease characterization
    • Target discovery
    • Mechanism of action
  • Lead through Candidate Selection
    • Lead optimization
    • Early toxicology & secondary effects
      -... Show more »

Metabolomics applications for the drug discovery and preclinical phases are many.

  • Discovery through Target Selection
    • Novel biomarkers
    • Disease characterization
    • Target discovery
    • Mechanism of action
  • Lead through Candidate Selection
    • Lead optimization
    • Early toxicology & secondary effects
    • Candidate selection
  • Preclinical
    • Efficacy & PD biomarkers
    • Translatability
    • Drug off-target effect characterization
« Show less
Pharmacology & Toxicology
Price on request
Request a quote for more information about this service.
Bioanalysis
Price on request
Request a quote for more information about this service.
Clinical Research
Price on request
Request a quote for more information about this service.
Microbial Fermentation and Bioprocessing
Price on request
Request a quote for more information about this service.
Clinical Laboratory Services
Price on request
Request a quote for more information about this service.
Clinical Chemistry
Price on request
Request a quote for more information about this service.
Antibody/Antigen Detection Based Testing
Price on request
Request a quote for more information about this service.
Biomarkers
Price on request
Request a quote for more information about this service.
Omics
Price on request
Request a quote for more information about this service.
Biology
Price on request
Request a quote for more information about this service.
Microbiology, Virology, and Parasitology
Price on request
Request a quote for more information about this service.
Ask A Question Find what you're looking for? If not, you can ask this lab a question:

Metabolon, Inc. has not received any ratings.

Be the first to endorse Metabolon, Inc.

Endorse this lab