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menal

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Emmendingen, Baden-Württemberg, DE

About menal

Founded: 1992 Type: Privately Held Size: 11-50 employees

Since its establishment in 1992, the medical and natural sciences laboratory has been a family-run company.

Responsibility, trust and reliability are our top priorities. The success of our clients confirms the quality of our work every day.

We also attach great importance to the personal care of the projects from the very beginning. For our customers, we perform the analysis work according to the principle of the "glass laboratory": At all times, we guarantee our customers an insight into the data obtained.

With innovative approaches, we support our customers in analytical questions. A wide range of methods is available for routine analysis as well as special projects. At our location in Emmendingen near Freiburg im Breisgau we have 480 square meters of laboratory space available in the new company building since 2001.

Our Services (24)


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Clinical Biomarkers

Price on request
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ADME/DMPK Studies

Drug Metabolism and Pharmacokinetics
Price on request

Analysis for pharmacokinetic studies and GLP-compliant toxicokinetic studies.

Quantification using

  • HPLC liquid chromatography
  • LC / MS / MS - liquid chromatography coupled with tandem mass spectrometry
  • LBA ligand binding assays
  • ELISA - Enzyme Linked Immunosorbent Assay

Coagulation (3 methods and different assays available)


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PK/PD Data Analysis

Price on request

Analytics for toxicokinetic studies according to "Good laboratory practice"

Quantification using

  • HPLC liquid chromatography
  • LC / MS / MS - liquid chromatography coupled with tandem mass spectrometry
  • LBA ligand binding assays
  • ELISA - Enzyme Linked Immunosorbent Assay

Coagulation (3 methods and different assays available)

Since 2009 we work under the " menal GLP " in Emmendingen and are certified by the state authority according to § 19b Chemicals Act as a test facility for analytical tests on biological materials.


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Biomarker Analysis

Price on request

Analytics for biomarker studies

Quantification using

  • HPLC liquid chromatography
  • LC / MS / MS - liquid chromatography coupled with tandem mass spectrometry
  • LBA ligand binding assays
  • ELISA - Enzyme Linked Immunosorbent Assay

Coagulation (3 methods and different assays available)
Cell Culture Applications / Ex Vivo
Enzyme / receptor assays


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Mammalian Cell Culture

Price on request

Cell culture applications for discovery, preclinical and clinical studies

  • Handling of cells and cell lines in the sterile area
  • Cell based assays
  • Cell insulation from whole blood
  • Stimulation of immunocompetent cells with subsequent quantification of the mediators of the immune response (Pharmacodymanische Studien - Ex Vivo)


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Coagulation Profile

Price on request

Excerpt from our established and validated assays:

  • activated partial Thromboplastin Time (aPTT)
  • Ecarin clotting time (ECT)
  • Stago ECA II (Dabigatran)
  • Technoclone Technoclot DTI (Dabigatran)
  • Hyphen hemoclot (Dabigatran)
  • Thrombin time (TT)
  • direct thrombin inhibitor (DTI)
  • AT III (AT3)
  • Clotting Assay Protein C
  • Chromogenic assay protein C
  • Clotting Assay APC-R
  • Hemoclot Thrombin Inhibitor
  • Prothrombin time (PT-INR)
  • D-dimer
  • Prothrombin F 1/2
  • Thrombin Generation Assay (TGA)
  • Fibrionopeptides A (FPA)
  • Customized neutralizing antibody assay
  • Anti-IIa activity (anti-2a)
  • Anti Xa activity (anti 10a)
  • Heparin Clotting Assay (UFH and LMWH)
  • fibrinogen
  • Tissue Factor Pathway Inhibitor Free (TFPI)
  • Tissue Factor Pathway Inhibitor Total (TFPI)
  • Tissue Factor Pathway Inhibitor Activity (TFPI)

If your assay is not listed, we are looking forward to your request.
All samples can be quantified on coagulation inhibitors using LC / MS.
Validations can be performed according to legal guidelines, I / EMA / FDA or customer requirements.


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Protein Quantification

Price on request

Quantification by means of a ligand binding assay, enzyme-linked immuno-sorbant assay, or mass spectrometry

instrumental:

  • HPLC - DAD
    • liquid chromatography coupled with diode array detector (UV-Vis Absorbance Spectrum)
  • LC / ESI-MS-MS
    • Liquid Chromatography coupled with tandem mass spectrometry, electrospray ionization
  • LC / ESI - MS
    • liquid chromatography coupled with mass spectrometry, electrospray ionization
  • LC / DAD-MS
    • liquid chromatography coupled with diode array Deketor and mass spectrometry

photometry:

  • FRET, BRET, TRF, TR-FRET
  • UV / Vis absorption
  • Luminescence
  • Fluorescence
  • Ligand Binding Assays (LBA)
  • Enzyme Linked Immunosorbent Assay (ELSIA)
  • Radioimmunoassay (RIA)
  • Enzyme Immunoassay (EIA)
  • Hybridization assays (aptamers)

Our methods for quantification have been applied since 1992 in many different projects and studies. A kuzer excerpt:

  • Quantitative determination of a substance using LC / MS / MS as part of a pharmacokinetics study for a medium-sized German pharmaceutical company
  • Quantitative determination of mediators of the immune response (ELISA) in an Ex-Vivo study for a TOP 10 pharmaceutical company (GLP / GCP)
  • Quantitative determination of aptamers in a GLP-compliant tox study for a medium-sized pharmaceutical company


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Plasma Protein Binding

Price on request

Plasmaprotein binding studies in different species or isolated proteins

  • in dialysis (radioactive)
  • instrumentally by HPLC

Radioactive Approvals: C14, H3, S35, P32, J125, J131

Our know-how has been successfully applied in over 50 PPB studies in human and animal plasmas.


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Receptor Assays

Price on request

Enzyme and receptor assays

  • Enzyme activity determination
  • Receptor Binding Assays

Extract from our projects:

  • Determination of antagonists at muscarinic receptor subtypes as part of a routine screening
  • Determination of antagonists at the CGRP Repezor as part of a routine screening
  • Inhibition of trypsin and plasmin


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Enzyme Assays

Price on request

Enzyme and receptor assays

  • Enzyme activity determination
  • Receptor Binding Assays

Extract from our projects:

  • Determination of antagonists at muscarinic receptor subtypes as part of a routine screening
  • Determination of antagonists at the CGRP Repezor as part of a routine screening
  • Inhibition of trypsin and plasmin


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Clinical Hematology

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Biomarkers

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Biology

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Clinical Research

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Bioanalysis

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Antibody/Antigen Detection Based Testing

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Clinical Laboratory Services

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Protein Services

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Cells and Tissues

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Pharmacology & Toxicology

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In vitro ADME/DMPK Studies

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Biochemistry & Molecular Biology

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Clinical Chemistry

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Biochemical Assays

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