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Medicines Discovery Catapult

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Alderley Edge, GB

About Medicines Discovery Catapult

Medicines Discovery Catapult (MDC) is enabling the community to reshape medicines discovery in the UK. It is ambitious, and it is achievable.​


We do this by championing innovative life science technology and new approaches, supporting UK innovators to succeed. ​

We are helping to industrialise and drive the adoption of new techniques and technologies.​

We are driven by helping our community make their mark on the industry and patients.

Our Services (194)


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Drug Delivery Systems

Price on request

We can help you understand your lead molecule or delivery technology by applying in vivo imaging to measure the biodistribution of labelled molecules (small molecules, antibodies and ADCs, nanomedicines) in real-time. This can assess the impact of different delivery methods on biodistribution and biological effects.


We can also apply mass spectrometry imaging and multiphoton imaging to measure the distribution of unlabelled molecules (and drug metabolites) in tissue sections.


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Funding Opportunity Identification

Price on request

We work with our community on identifying grants and other funding sources to accelerate their projects​.


Our experienced bids team have a wealth of grant expertise and work with our collaborators to give them the best chance of success​.


We share in the success of our collaborators and ensure the benefits are felt by the wider community.


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Drug Discovery Consulting

Price on request

We can help you navigate the drug discovery landscape. 


Our team have over 80 years combined experience across big pharma, SMEs, start-ups, spinouts - across different organisational and drug discovery stages 


The team can help you reach the stage where you have a drug ready to go to clinical trials, or the stage where you become an attractive acquisition target.



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Drug Mechanism of Action Studies

Mechanism of Action Studies
Price on request

We can help you understand your lead molecule or delivery technology by applying in vivo imaging to measure the biodistribution of labelled molecules (small molecules, antibodies and ADCs, nanomedicines) in real-time. This can assess the impact of different delivery methods on biodistribution and biological effects.


We can also apply mass spectrometry imaging and multiphoton imaging to measure the distribution of unlabelled molecules (and drug metabolites) in tissue sections.


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Drug Target Validation

Price on request

We can help you build a platform of evidence linking your drug molecule to modulation of its target protein and downstream biological effect, in relevant in vitro and in vivo assay systems.


Key technologies include:

  • Advanced microscopy
  • Mass spectrometry and mass spectrometry imaging
  • Transcriptomics and biomarker signatures
  • Preclinical Imaging

Together with a suite of molecular and cell biology methods.


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Drug Target Identification

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Drug Development

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Drug Discovery & Development

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Clinical Data Analysis

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Tumor Tissue

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Human Bone Marrow

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Fresh Human Tissue

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Frozen Human Tissue

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Human Biospecimens

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Data Analysis

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Data Services

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Drug Repositioning

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Biostatistics & Bioinformatics

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Bioinformatics Consulting

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Bioinformatics Data Analysis

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Bioinformatics

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Use data to understand and predict the increased effectiveness of bioinformatics. 

We apply best-practice bioinformatics services to test hypothesis or exploring large data sets, even working with you to develop new methods if needed. Our broad bioinformatics expertise across a range of research groups means we are likely to be familiar with your research topic and the best methods to analyse your data. Supporting your projects with our expertise in:

  • Discovering & Connecting Data - make the best drug discovery decisions, with data analysis discovering & connecting bioinformatics data assets & secure sharing.
  • Build New Algorithms - using our bioinformatics skills, extensive proprietary databases and market understanding, we can build algorithms to validate & drive adoption of your drug discovery.
  • AI & Machine Learning Approach - use our AI and machine learning resources to predict & detect patterns in your bioinformatics, including DNA sequencing, protein classification & gene expressions.


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Chemoinformatics

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Informatics

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Discovering and connecting data to build new algorithms, AI and machine learning approaches. 

Our deep expertise in scientific data analysis, information extraction, natural language processing, and machine learning enables the community to access our established expertise.

Using our informatics skills, extensive proprietary databases and algorithms, and market understanding, we can help validate and drive adoption of new data-driven approaches for:

  • Scientific data analysis
  • Information extraction
  • Natural language processing
  • Machine learning


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Cell Line Derived Xenograft (CDX) Models

Cell Line Derived Xenograft Models
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Uterine Xenograft

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Ultrasound Tomography

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Trichrome Staining

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Tissue Microarray Consulting

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Tissue Microarrays

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Tissue Cross Reactivity Studies

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Thyroid Xenograft

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Thyroid Patient Derived Xenograft (PDX)

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Target Gene Expression Analysis

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Stomach Patient Derived Xenograft (PDX)

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Stomach Xenograft

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Sprague Dawley Rat Model

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Pharmaco-Imaging

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Skin Xenograft

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Single Cell Isolation

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SCID Mouse Model

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SCID/BG Mouse Model

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Sarcoma Xenograft

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Sarcoma Patient Derived Xenograft (PDX)

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RNAscope Assay

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RNA Profiling

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qRT-PCR

Quantitative reverse transcription polymerase chain reaction
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qPCR

Quantitative PCR
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Quantitative Histology

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qPCR Data Analysis

Quantitative PCR Data Analysis
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Aptamer-Based Proximity Ligation Assay

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Nanoproteomic Proximity Ligation Assay

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Proteomics

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Prostate Xenograft

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Phosphatidylinositol 3-Kinase (PI3K) Assays

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Pharmacodynamic Biomarkers Discovery

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Pancreas Xenograft

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Pancreas Patient Derived Xenograft (PDX)

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Ovary Patient Derived Xenograft (PDX)

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Ovarian Xenograft

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Osteosarcoma Xenograft

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Oncology Animal Models

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NOD.SCID Mouse Model

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NOD-SCID Mouse Model

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Nano Mass Spectrometry Methods

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Nano-Imaging

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Multiple Myeloma Xenograft

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Organoids

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Multiomics

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MTT and MTS Assays

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Monocarboxylate Transporter Assays

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Microscopy Image Analysis

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Microscopy Consulting

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Microscopy

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Microelectrode Array (MEA) Data Analysis

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Organ-on-a-Chip

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3D organoid & organ-on-a-chip technology is helping to humanise our approach to drug discovery - with more sophisticated models of human organ systems.

Get in touch to test drugs in industry-validated models to increase your chance of clinical success and to gain access to:

  • Expert Support - get guidance for the most appropriate models to test your hypotheses & test candidate drugs in validated models of human relevance.
  • Partner & Commercial Expertise - we can offer partnership opportunities, including funding, resources & services to help with drug discovery & organ-on-a-chip research.
  • Innovative Technologies - use models alongside our technologies to generate data that will enable you to select, optimise or withdraw drugs at earlier stages of drug discovery.


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Bioanalytical Assay Development and Optimization

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Metastatic Carcinoma Patient Derived Xenograft (PDX)

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Metabolomics

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Metabolite Quantification

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Metabolite Profiling

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Metabolite Identification

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Xenograft Development

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Human Tumor Xenograft Models

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Xenograft Models

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Melanoma Xenograft

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Melanoma Patient Derived Xenograft (PDX)

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Magnetic Resonance Imaging (MRI) Research

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Magnetic Resonance Imaging (MRI) Image Processing

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Medical Imaging Services

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Non-Quantitative Mass Spectrometry Based Proteomics

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Mass Spectrometry-Based Proteomics

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Breast Xenograft

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Machine Learning and AI Solutions

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Lymphoma Xenograft

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Lymphoma Patient Derived Xenograft (PDX)

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Lung Small Cell Xenograft

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Lung Patient Derived Xenograft (PDX)

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Lung Non-small Cell Xenograft

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Luminescence Imaging

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Luciferase Assays

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Liver Xenograft

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Liver Cancer Patient Derived Xenograft (PDX)

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Liquid Biopsy

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Lipid Profiling

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Leukemia Xenograft

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Leukemia Patient Derived Xenograft (PDX)

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Kidney Xenograft

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Kidney Patient Derived Xenograft (PDX)

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In vivo Studies

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In vivo PK/PD Studies

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In vivo ADME/DMPK Studies

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In vivo Pharmacology Studies

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In vitro Skin Models

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In vitro Neurodegeneration Models

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In vitro Neural Models

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In vitro Hepatotoxicity Testing

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Biochemical Compound Screening

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In vitro Drug Efficacy Testing

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In vitro Cardiovascular Models

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In vitro Diagnostic Development

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In situ Proximity Ligation Assay

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Infectious Disease Animal Models

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ICP-MS

Inductively Coupled Plasma Mass Spectrometry
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Animal Immunology Assays

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Immunology Animal Models

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Nude Mouse Model

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Immunodeficient Animal Models

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Histopathology Consulting

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Preclinical Histology

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Histology and Pathology Services

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High Resolution Mass Spectrometry

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Cutting-Edge Mass Spectrometry Technology

To you achieve your goals, we have invested in cutting edge, direct-from-sample mass spectrometry technologies that enable us to rapidly measure biological ‘signatures’ from scarce molecular samples and look for spatial changes in drug and metabolite distribution. In addition, to provide the highest possible resolution, we have established the more traditional MS methods that use liquid chromatography to reduce the complexity of biological samples for analysis.

We have the following Mass Spectrometry Technology:

  • ESI & DESI - we have standard and nanoESI sources for direct infusion MS experiments and for use with UPLC and nanoHPLC front-ends.
  • REIMS - analyse phospholipids directly from samples, with iKnife technology for real-time characterisation of human tissue during electrosurgery. 
  • AMI-MS - use an automated platform for contactless ionisation & droplet formation to analyse up to 100,000 individual samples per day. 


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Hepatoma Xenograft

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Head and Neck Patient Derived Xenograft (PDX)

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Special Slide Staining

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SK-OV-3 Subcutaneous Xenograft

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Glucose Uptake Assays

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Glioma Xenograft

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Gastric Xenograft

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Gastric Patient Derived Xenograft (PDX)

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Gallbladder Patient Derived Xenograft (PDX)

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MicroRNA (miRNA) Expression Profiling

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RNA Expression Profiling

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Protein Expression Profiling

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Esophageal Patient Derived Xenograft (PDX)

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Endometrium Patient Derived Xenograft (PDX)

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Endometrial Xenograft

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ELISA

Enzyme-linked immunosorbent assay
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In vivo Cardiotoxicity Screening

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In vivo Toxicity Testing

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In vivo Hematoxicity Testing

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In vivo Hepatotoxicity Testing

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Digital PCR

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Digital Pathology Services

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Cytotoxicity Assays

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Cytokine Release Assay

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Tomography Services

Computed tomography services
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Colorectal Xenograft

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Colorectal Patient Derived Xenograft (PDX)

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Colon Xenograft

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Colon Patient Derived Xenograft (PDX)

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Chemotaxis Assays

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Cervical Patient Derived Xenograft (PDX)

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Cell Viability Assays

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Cell Proliferation Assays

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Cell Line Characterization

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2D Cell Culture

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3D Cell Culture Models

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Cell Culture Consulting

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Custom Cell-Based Assay Development

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Caco-2 Cell Permeability Assay

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Caco-2 Cell Lines

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Cachexia Animal Models

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Brain Xenograft

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Breast Patient Derived Xenograft (PDX)

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Mouse Models

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Brain Tumor Models

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Brain Patient Derived Xenograft (PDX)

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Bladder Patient Derived Xenograft (PDX)

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Biomarker Study Design

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Biomarker Analysis

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Biomarkers

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Identifying Biomarkers Characteristics for Disease and Responses to Drugs

Improve your understanding of drugs, disease and drug-target interactions within patients with a partner who can offer you technology and resources for biomarkers.

We can help you translate drugs from pre-clinical to a clinical setting, identifying drug dosages for patient benefit, select patients and treatment decisions, with our expert team on hand to give you scientific and commercial support. 

Our biomarkers service provides you access to:

  • Cutting Edge Expertise - get access to cutting-edge expertise, with a fresh bold approach focused on patient outcomes.
  • Partner & Commercial Expertise - we can offer partnership opportunities, including funding, resources & services to help with drug discovery.
  • Extensive Proprietary Databases - using our medicine discovery skills, extensive proprietary databases & algorithms, we can help validate new data-driven approaches. 


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Biomarker Discovery

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Animal in vivo Imaging

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Drug Development Consulting

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Animal Model in vivo Analyses

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Transgenic Animal Model Development

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Anatomic Pathology

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Adrenal Gland Patient Derived Xenograft (PDX)

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Assay Development Consulting

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Assay Development

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3D Cell-Based Assays

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Mass Spectrometry

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Human Tissue Procurement

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Electron Microscopy

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DB

Dan Bond

Digital and Content Lead
SF

Seema Fakira

Marketing Campaigns Manager
IH

Imran Haq

BDM
HH

Helen Hind

Samples & Data Lead
JM

Juliana Maynard

Lead Scientist

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