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MD Biosciences Preclinical Laboratory Services

28 Orders Completed
Oakdale, Minnesota, US

About MD Biosciences Preclinical Laboratory Services

Founded: 1991 Type: Privately Held Size: 51-200 employees Divison of: MD Biosciences

We are proud to announce our new location in Cambridge, MA

MD Biosciences Preclinical Laboratory Services is a niche preclinical research group working with biopharmacuetical and medical device companies. Our core therapeutic areas are oncology, inflammation, CNS, pain and cardiovascular with an emphasis on the interplay between these systems. We place a great deal of importance on the scientific rationale of each individual study to ensure that it meets the goals of the R&D program. We are willing to invest in custom study design, development and validation with our sponsors to achieve clinically relevant data at the preclinical stages. We feel that this will help reduce the failure rate in clincial stages and the burden upon the industry. We employ a highly talented group of scientists consisting of PhD, MSc and Bachelor degrees. Each scientist is specialized and highly skilled in their area of expertise. Our group has all been trained in various techniques including microsurgical procedures, injection methods, model and method development as well as imaging and histological techniques. **Selected Publications** - Castel, D., Willentz, E., Doron, O., Brenner, O. and Meilin, S. (2014), Characterization of a porcine model of post-operative pain. *European Journal of Pain*, 18: 496–505. doi: 10.1002/j.1532-2149.2013.00399.x - Meilin, S., Machicao, F., & Elmlinger, M. (2014). Treatment with Actovegin improves spatial learning and memory in rats following transient forebrain ischaemia. *Journal of Cellular and Molecular Medicine* (8), 1623–1630. doi:10.1111/jcmm.12297

Certifications & Qualifications

AAALAC

Our Services (186)


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White Blood Cell Count Differential

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Editorial and Writing Services

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DNA Extraction and Purification

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RT-PCR

Reverse transcription polymerase chain reaction
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Western Blot

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Biostatistical Analysis

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Offering comprehensive biostatistical consulting services including analysis and review from study design to study readouts to optimize research needs.


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Neurochemistry Animal Models

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Drug Development

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Hair Growth Animal Models

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Imaging Flow Cytometry

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Flow Cytometry Experimental Design

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Flow Cytometry Data Acquisition

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Flow Cytometry Data Analysis

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Fluorescence Activated Cell Sorting (FACS)

Fluorescence Activated Cell Sorting
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Cell Cycle Analysis

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Custom CNS Animal Models

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Neurodegenerative diseases like Parkinson's as well as neuro-inflammatory diseases such as multiple sclerosis (MS), with additional capabilities in stroke and cerebral ischemia. Offering customizable study options upon request.

MPTP-induced Parkinson's disease model PLP-induced Experimental Autoimmune Encephalomyelitis (EAE) Spinal Cord Homogenate-induced EAE

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Chronic Constriction Injury Animal Models

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the left sciatic nerve is ligated causing inflammation and swelling, and ultimately peripheral pain.

sprague dawley rat c57/B16 mouse

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Cell-Based Screening Methods

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Cell Signaling Assays

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Cell Death Assays

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Colony Formation Assays

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Cell Adhesion Assays

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BrdU Assay

Bromodeoxyuridine Assay
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Cell Migration Assays

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Cell Co-Cultivation

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Extracellular Vesicle Analysis

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Electrophysiology

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Dantec KEYPOINT Focus tool utilized to measure electrophysiological action potentials. Capabilities in the assessment of muscle, motor and sensory action potential in rodent models of peripheral nerve injury to measure nerve regeneration, degeneration and protection in response to various treatments. Can apply to non-rodent species and pig models.


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Custom Animal Models

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Forced Swim Test

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A behavioral test used on rats to assess responses to threat of drowning


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Exploratory Animal Studies

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Elevated Plus Maze Animal Anxiety Test

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A test measuring anxiety in laboratory animals that usually uses rodents as a screening test


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Cylinder Test

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Asymmetry analysis assesses behavioral deficits in rats after stroke or brain injury.


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Dose Range Finding (DRF) Studies

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Quantitative Western Blot Analysis

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PCR Primer Design

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PCR Product Purification

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Porcine Models

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Large animal models offer high translatability from preclinical research to clinical trials. We offer pig models in neuropathic pain, post-operative pain, wound healing and other dermatology studies and pig nerve block.


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Pulmonary Inflammation Animal Models

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MD Biosciences offers models to study the inflammatory components involved in lung inflammation and asthma including OVA-induced asthma, HDM-induced asthma, LPS-acute lung injury, and bleomycin-induced fibrosis.

OVA Asthma Mouse LPS Rat LPS Bleomycin-induced Scleroderma/Systemic Sclerosis

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Peritonitis Animal Models

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Prothrombin Time Test

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Partial Thromboplastin Time Test

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Periodic Acid-Schiff (PAS) Staining

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Preclinical Histology

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Primary Cell Isolation

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Primary Biopsy Culture

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Primary Cell Lines

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Porcine Dermis

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Plastic Methyl Methacrylate Embedding

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Paraffin Sectioning

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Paraffin Embedding

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Plasma Bioanalysis

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In vivo Drug Efficacy Testing

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in vitro, in vivo and ex vivo modeling services for efficacy determinations, PK/PD assessments, mechanism of action studies, compound screening, biomarker analysis and more!

Rheumatoid Arthritis Collagen antibody-induced arthritis Renal Cancer Oncology CNS/Neurology Experimental autoimmune encephalomyelitis (EAE) Multiple sclerosis (MS) Pain Neuropathy Parkinson's disease (PD) Neurodegenerative diseases Psoriasis Dermatitis Inflammation Inflammatory Bowel Disease Cystic fibrosis Fibrotic Disease Pulmonary fibrosis Asthma Colitis Acute Kidney Injury Metabolism and Endocrinology Diabetes Obesity Sepsis Mouse Pig Rat Show 28 more tags Show less

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Preclinical Study Design

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In vivo Pharmacology Studies

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MD Biosciences features a wide range of validated in vivo models of human disease to support preclinical drug efficacy tests, and we provide customizable disease-specific models in order to fit each study's needs.


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ADME/DMPK Studies

Drug Metabolism and Pharmacokinetics
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Animal Model in vivo Analyses

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Variety of preclinical animal models for pharmacology, efficacy and mechanism of action studies in addition to biomarker analysis

Mouse IMQ Rat IMQ Il-23-induced Psoriasis DSS- induced colitis Fluorescein Isothiocynate Dermatitis DNCB Induced Contact Dermatitis Oxazalone Delayed Type Hypertrophy Passive Cutaneous Anaphylaxis OVA Asthma Allergy Lipoplysaccharide Lung Fibrosis-Belomycin Collagen antibody induced rheumatoid arthritis Collagen-induced rheumatoid arthritis Myelin Oligodentrocyte Glycoprotein Proteolipid Protein Myelin Basic Protein Middle Cerebral Artery Occlusion (MCAo) Four Vessel Occlusion (4VO) Non-Obese Diabetic (NOD) Steptozotocin (STZ) Dextran Sodium Sulfate (DSS) Unilateral Kidney Injury (AKI) bilateral AKI Sepsis Acute Kidney Injury (AKI) Diet-induced obesity Chronic Constrictive Injury (CCI) Spinal Nerve Ligation (SNL) Cuff Crush pig neuropathic pain Streptozotocin (STZ) tail flick visceral Capsaicin Complete Fruend Adjuvant (CFA) Carageenan Collagen-induced arthritis Monosodium Iodoacetate (MIA) Poly Arthritic Mono Arthritic Brennen pig POP model Nerve Block Incision Excision Burn Pig Rat Mouse SEB-induced T-cell Anergy HDM House dust mite induced asthma Bleomycin-induced Scleroderma/Systemic Sclerosis Non-Alcoholic Steatohepatitis (NASH) Non-alcoholic steatohepatitis Renal Fibrosis Fibrosis Show 58 more tags Show less

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High Throughput Screening (HTS)

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Biomarker Analysis

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Variety of methods across all major platforms for biomarker identification, development, analysis, qualification, validation and downstream application

qPCR qPCR Assay Real time qPCR IHC immunohistochemistry Dual-stain Immunohistochemistry Triple-stain Immunohistochemistry Immunofluorescence Flow cytometry ELISA ELISA Protein Analysis ELISA-based assay Cell-based assays multiplex Western blot quantitative western blot western blot Western blotting western blot normalization western blot optimization Immunoassays Immunophenotyping Immunogenicity Studies Fresh Tissue Frozen Tissue FFPE tissue Whole organs Tumor tissue Human tissue Mouse Rat Pig Dog Cat Human Non-human primates (NHP) Clinical chemistry Epigenetics Show 37 more tags Show less

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Biomarker Discovery

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Our capabilities include support for projects at every stage in the development pipeline, from the initial biomarker identification, qualification and validation through to downstream clinical applications. Some services include identification of druggable targets, characterization of indicators of disease severity or stratification of patient populations.

ELISA Protein Analysis Western blotting Multiplexed Protein Analysis Flow cytometry Serology Real time qPCR Multiplexed mRNA analysis Multiplexed miRNA analysis Tissue Extraction assay development Urinalysis Hematology Clinical chemistry Show 13 more tags Show less

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Animal Behavior Studies

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Animal Model Housing and Maintenance

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Demyelination Animal Models

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experimental autoimmune encephalomyelitis (EAE) and MS, EAE has been used as a model for the study of human demyelinating disease.


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Autoimmune Disease Animal Models

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Cellular Immunity Non-specific Immunity Humoral Immunity Allergy Th17 activation T cell inhibition Cytokine Release T cell stimulation Macrophage (Inhibition) Macrophage (stimulation) proliferation Show 11 more tags Show less

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Combination Therapy Efficacy Testing in Mice

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ELISA

Enzyme-linked immunosorbent assay
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plate-based assay technique designed for detecting and quantifying substances such as peptides, proteins, antibodies and hormones


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Acute Inflammatory Pain Animal Models

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offers commonly used models of acute inflammatory pain such as CFA and carrageenan - that can be extended - to evaluate a more chronic inflammatory pain state. We can help you study the release of Cytokines and their role in the initiation and maintenance of the inflammatory response along with prostaglandin

CFA Carrageenan

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Visceral Pain Animal Models

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Used in nociceptive pain models

von frey Motor Function Biomarker analysis IHC PK

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Osteoarthritis Animal Models

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Monosodium iodoacetate (MIA) induced osteoarthritis in rats. Cartilage damage and degradation leads to a chronic neuronal damage with neuropathic characteristics.

joint pain weight bearing Thermal Hyperalgesia mechanical Allodynia paw edema Rotorod Open field joint compression histology Show 9 more tags Show less

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Psoriasis Animal Models

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Imiquimod and IL23-induced psoriasis, FITC or DNCB-induced dermatitis, oxazolone-induced delayed-type hypersensitivity, and passive cutaneous anaphylaxis are our validated model offerings. Models are supported by a range of read-outs including protein and mRNA, histology and flow cytometry.

Imiquimod-induced psoriasis

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Atopic Dermatitis Animal Models

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FITC Induced Contact Dermatitis DNCB Induced Contact Dermatitis

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Custom Pain Animal Models

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Animal Nociception/Pain Tests

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MD Biosciences offers a wide range of pre-clinical pain models for nociception that can be customized according to sponsors criteria. Validated models include tail flick, visceral and capsaicin.

tail flick visceral Capsaicin

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Ischemia Animal Models

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Focal ischemia (MCAo) models are commonly used to mimic the human stroke situation, however the global ischemia model (4VO) would be highly relevant in clinical conditions such as cardiac arrest.

MCAo

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In vitro Diabetes Models

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The non-obese diabetic (NOD) mouse model develops spontaneous autoimmune diabetes, which shares similarities with type 1 diabetes. The STZ-induced diabetic model involves an autoimmune process that results in the destruction of Langerhans islets.

NOD STZ unilateral AKI bilateral AKI DIO rat DIO mouse Show 6 more tags Show less

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Inflammation Assays

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Anaphylaxis Animal Models

PCA Animal Model
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Passive Cutaneous Anaphylaxis (PCA) is an immediate dermal response to an allergan-IgE interaction. It is based on a passively transferred anaphylactic reaction from antiserum. Assessments include dry extravasation (mm), absorbancy, PK blood analysis and biomarker analysis.


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Delayed-Type Hypersensitivity (DTH) Animal Models

Delayed Type Hypersensitivity Animal Models
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Delayed Type Hypersensitivity (DTH) model evaluates the cell-mediated immune response to repeated exposure of skin to oxazolone. This results in a DTH reaction involving CD4+, CD8+ T cells and macrophages, resulting in local skin inflammation characterized by an increased thickness of the skin.


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Contact Dermatitis Animal Models

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FITC & DNCB-induced Contact Dermatitis Models. These models share many of the features of human contact dermatitis, both sensitization and challenge occurs epicutaneously.

FITC Induced Contact Dermatitis DNCB Induced Contact Dermatitis

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In vivo Psoriasis Assay

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IMQ-Induced Psoriasis Assay

This rapid model of psoriasis-like inflammation involves the IL-17/IL-23 axis. Imiquimod is a potent TLR7/8 ligand and potent immune modulator. Application of imiquimod on the back and ear of mice induces a psoriasis-like inflammation.

Rat IMQ Mouse IMQ

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Lung Inflammation Animal Models

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Following induction by the intranasal administration of LPS, leukocytes (mainly neutrophils) are recruited to the lung. Using this model, it is possible to measure and characterize the cellular profile of recruited leukocytes to the lung airways as well as the levels of pro-inflammatory cytokines.

LPS LPS

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Colitis Animal Models

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Acute DSS-induced colitis in mice and rats
Chronic DSS-induced colitis in mice
TNBS-induced colitis in mice and rats

Mouse Rat

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Rheumatoid Arthritis Animal Models

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Collagen induced arthritis (CIA) and adjuvant induced arthritis (AIA) are two commonly used models for this purpose. At MD Biosciences we offer our clients the novel and rapid collagen antibody-induced arthritis (CAIA) model as well.

Collagen-induced arthritis Collagen antibody induced rheumatoid arthritis

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Global Ischemia 4VO Animal Model

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The Global Ischemia model involves permanent occlusion of vertebral arteries and transient occlusion of carotid arteries. The 4VO model can be used to evaluate not only lack of blood flow to brain as found in cardiac arrest and coronary bypass surgery, but also neurodegeneration, dementia and oxygen stress.

Rat permanent 4VO Rat transient 4VO

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Sepsis Animal Models

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LPS is used to induce sepsis in mice, setting off an immune response activating immune cells that excrete cytokines.

Mouse LPS Sepsis induced by LPS

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Focal Cerebral Ischemia Animal Models

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The focal cerebral ischemic model is commonly used to assess ischemic injury in the brain, evaluate stroke or neurodegeneration as a result of oxygen stress.

Mouse transient MCAo Rat transient MCAo Rat permanent MACo

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Postoperative Pain Animal Models

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Validated POP and Brennan models using pigs and mice. Pigs demonstrate notable resemblance to human anatomy & physiology. This includes analogous dermal epidermal thickness, dermal papillary bodies and abundant subdermal adipose tissue to humans. Functionally, pig and human are similar in epidermal turnover time, type of keratinous proteins and lipid composition of the stratum corneum.

Rat Brennan model pig POP model

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Asthma Animal Models

Price on request

The murine OVA-induced asthma model is a widely used model that results in the characteristic features of asthma allowing the study and assessment of novel treatments.
he House Dust Mite (HDM) murine model of allergic asthma is used to assess therapies with potential indications in airway inflammation and/or pulmonary inflammation driven primarily by repeated exposure to allergens. Model includes Th2- associated cytokine response, eosinophilic infiltration into the lungs, airway hyper responsiveness (AHR) and epithelial tissue remodeling.

OVA HDM LPS

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Nociceptive Pain Animal Models

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MD Biosciences offers a wide range of pre-clinical pain models for nociception that can be customized according to sponsors criteria.

tail flick visceral Capsaicin

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Nerve Block Animal Models

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The rapid preclinical model of sciatic nerve block enables researchers to directly access and dose to the sciatic nerve and allows the screening of new nerve blocking agents or drugs designed to reverse the local analgesia. The capability can be applied to other models such as the SNL and CCI models.

Rat pig model

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Neuropathic Pain Animal Models

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Models in both the rodent as well as the pig bringing much needed translational value from preclinical studies to the human situation.

nerve injury chemotherapy STZ diabetic pig neuropathic pain

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Chemotherapy-Induced Peripheral Neuropathy Animal Models

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We conduct preclinical neuropathy models induced with Vincristine or Taxol to mimic the peripheral neuropathy that often results from chemotherapy treatments.

Rat taxol Rat vincristine

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Acute Kidney Failure Models

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MD Biosciences has validated ischemia-induced renal injury models (unilateral and bilateral) and has familiarity with a variety of other methods should Sponsors have interest in performing validation work on a cost-share basis.

LPS Rat LPS Mouse LPS Unilateral Kidney Injury Bilateral Acute Kidney Injury Sepsis Acute Kidney Injury (AKI) Show 6 more tags Show less

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Parkinsons Disease Animal Models

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We offer the classic 1-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP)- and 6-hydroxydopamine (6-OHDA)-induced neurotoxin models and genetic models of the disease.


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Spinal Cord Injury Models

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MDB offers a validated neurite outgrowth assay provides an in vitro method to examine the potential effects of exogenous compounds on neuronal activity and development, providing valuable information on the potential of therapeutic compounds to either enhance or inhibit neuritogenesis.

neurite outgrowth

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In vivo Phenotypic Screening

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LPS-Induced Inflammation Animal Models

Lipopolysaccharide-Induced Inflammation Animal Models
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The LPS lung inflammation model is an acute lung inflammation model where researchers can observe the pulmonary response following exposure to bacteria. Using this model, it is possible to measure and characterize the cellular profile of recruited leukocytes to the lung airways as well as the levels of pro-inflammatory cytokines.

F4/80 microglia cells GFAP

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Wound Healing Animal Models

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MD Biosciences offers various models of wound healing in both rodents and pigs. While rodent models provide data for earlier research stages, pig models are ideally suited for wound healing efficacy studies.

mouse incisional wound rat incisional wound rodent burn wound pig incisional wound pig excisional wound pig burn wound Show 6 more tags Show less

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Custom Cell-Based Assay Development

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PBMC human primary cells immortalized cell lines murine Rat ex vivo primary cells Custom Assays Show 7 more tags Show less

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Obesity Animal Models

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We conduct metabolic and inflammation research, with diet-induced rat and mouse models, and including the following assessments: feed intake, body weight, insulin levels, glucose tolerance, blood pressure, feed preparing, and biomarkers.

DIO mouse DIO rat Diet-induced obesity

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Metabolic Animal Models

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Metabolic disease services include models for diabetes, renal, obesity and inflammatory bowel disease. Multiple induction methods may be available for each disease. Diabetes models may be induced with streptozotocin, the use of db/db or NOD mice. Inflammatory Bowel Disease (IBD) may be induced with TNBS or DSS.

obesity diabetes IBD

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Clinical Laboratory Services

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MD Biosciences is proud to offer comprehensive diagnostic services for sample analysis and assay development performed to CLIA and GLP regulatory compliance. We provide a wide range of services for specialized diagnostic testing, clinical trial testing, GLP and GMP assessments of compounds/biologics and more! Our goal is to facilitate the advancement of diagnostic capabilities and improve analytical methods through application of rigorous biomarker-based strategies.

ELISA Protein Analysis Western blotting Multiplexed Protein Analysis Flow cytometry Serology real-time PCR Multiplexed mRNA analysis Multiplexed miRNA analysis Tissue Extraction assay development Urinalysis Hematology Clinical chemistry Show 13 more tags Show less

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Animal Learning, Memory, and Behavior Tests

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Immunology Animal Models

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Cellular Immunity Non-specific Immunity Humoral Immunity Allergy

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Safety Pharmacology

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Drug Discovery & Development

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Cells and Tissues

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RNA Services

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Bioanalysis

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Bioanaylsis for all sample types across all major methodologies.


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Protein Quantification

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Nephrology Animal Models

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Immune Cell Assays

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Protein Services

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Functional Human Tissue Assays

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Animal Cognition & Behavior Tests

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Respiratory Disease Animal Models

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Ovalbumin-induced allergic asthma is a widely used model to reproduce the airway eosinophilia, pulmonary inflammation and elevated IgE levels found during asthma.

The House Dust Mite (HDM) model demonstrates significant relevance for investigating the molecular mechanisms of allergic asthma pathogenesis.
LPS lung inflammation models are widely used to study host-response patterns in the pulmonary compartment.
Bleomycin induced lung injury model in mice is used for studying idiopathic pulmonary fibrosis (IPF).

OVA Asthma Allergy Lipoplysaccharide Lung LPS Fibrosis-Belomycin

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Clinical Chemistry

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Cell-Based Assays

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Screening and mechanism of action studies using primary or immortalized cell lines. Our scientists development experience crosses a broad range of study targets. Customizing each study for sponsor relevance including chosen cell system, stimulant time point(s), and read-outs.

PBMC human primary cells immortalized cell lines ex vivo primary cells Custom Assays

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CNS/Neurology Animal Models

Price on request

Offering validated models for neurodegenerative diseases including Parkinson's and neuro-inflammatory diseases such as multiple sclerosis (MS) with additional capabilities in stroke and cerebral ischemia. Our laboratories are also proud to be known as a center of excellence in the study of neuropathic, chronic and acute pain, offering multiple validated models and relevant pain read-outs. Our pain services are extended with unique pig translational models complementing our rodent studies and offering confidence as compounds move to IND and clinical stages of their development.

Myelin Oligodentrocyte Glycoprotein Proteolipid Protein PLP Myelin Basic Protein Middle Cerebral Artery Occlusion (MCAo) Four Vessel Occlusion (4VO) Show 6 more tags Show less

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In vitro Disease Models

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Dermatology Animal Models

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Dermal research with a host of preclinical and translational models. Imiquimod and IL23-induced psoriasis, FITC or DNCB-induced dermatitis, oxazolone-induced delayed-type hypersensitivity, as well as passive cutaneous anaphylaxis form the stable of our validated model offerings. Models are supported by a range of read-outs including protein and mRNA, histology and flow cytometry

IL-17 IL-23 Imiquimod-induced psoriasis

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In vivo Studies

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Bone/Cartilage Animal Models

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Functional & Cell Type Specific Assays

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Biomarkers

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Our highly-experienced team of biomarker experts applies systematic, scientifically-rigorous approaches to the discovery and development of biomarker candidates to provide solutions to complex translational questions.


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Animal Physiology Analyses

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Pharmacology & Toxicology

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Hit Identification

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Inflammation Animal Models

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We offer validated models of many inflammatory diseases including skin (IL-23 psoriasis, dermatitis, delayed type hyper-sensitivity, anaphylaxis), gastro-intestinal (TNBS or DSS induced IBD), respiratory (acute lung injury, asthma, fibrosis), joint (rheumatoid arthritis) and sepsis (LPS induced)


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Nucleic Acid Services

Price on request

Nucleic acid extractions from multiple sample types (fresh, frozen & FFPE tissues, liquid biopsies, disaggregated tumor samples, etc)

Applied Biosystems QuantStudio DX Cobas systems (4800 or 6800/8800, b 221, s 201, or u 411) Nucleic acid extraction Tissue Extraction Genomic DNA extraction DNA methylation DNA quantification Multiplexed miRNA analysis Multiplexed mRNA analysis PCR qPCR Assay Real time qPCR RT-qPCR miRNA mRNA DNA siRNA Show 17 more tags Show less

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Biochemistry & Molecular Biology

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Gastroenterology Animal Models

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Specialized Cell-Based Assays

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Drug Discovery

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Comprehensive Metabolic Panel

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Glucose Testing

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Genotyping and Gene Expression Assays

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Genotyping Services


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DNA Services

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DNA Services


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Multiplex Gene Expression Analysis

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Clinical Endocrinology Tests

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Allergy Animal Models

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Alanine Aminotransferase (ALT) Measurement

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Assay Development

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Assays include human primary cells, immortalized cell lines, murine and rat primary cells, ex vivo primary cells and custom assays.


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Diabetes Animal Models

Price on request

The non-obese diabetic (NOD) mouse model develops spontaneous autoimmune diabetes, similar to type 1 diabetes. The STZ-induced diabetic model involves an autoimmune process that results in the destruction of Langerhans islets. Multiple assessments available, and models available are rat, mouse and pig.


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Oncology Animal Models

Price on request

Various cancer models and specializes in murine solid tumors for both subcutaneous and orthotopic models, with an emphasis on disease progression, biomarkers and immunophenotyping. Other models include metastatic, xenographic and syngeneic.


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Bioanalytical Assays

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Bioanaylsis for all sample types across all major methodologies.

HPLC LC/MS/MS GC-MS

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Immunoassays

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Analgesic Animal Models

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A commonly used model to test the effect of new analgesic drugs in post-operative (incisional) pain is the Brennan model. This model can provide good answers to systemic drugs it is less suitable for testing local treatments such as implants, patches, medical devices and creams.

Rat Brennan model pig POP model

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T Cell Activation and Proliferation Assays

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Urinalysis

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Clinical urine tests are various tests of urine for diagnostic purposes offered by our clinical services.


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MicroRNA (miRNA) Quantification

Quantitative PCR microRNA quantitation
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Cell-Based Compound Screening

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Human Immune Cell Assays

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Animal Surgery

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RNA Extraction and Purification

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RNA extraction from a wide variety of sample formats


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In vivo PK/PD Studies

Price on request

A large animal model of neuropathic and nociceptive pain for preclinical evaluation of analgesic or neuro-protective therapies. The sciatica model was developed in the pig, providing more clinically relevant data at the preclinical stages. The model is suitable for evaluating both efficacy and PK/PD in the same animal and can be used for systemic, local and cell therapies as well as slow release drugs and devices.


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IBS/IBD Animal Models

Irritable Bowel Syndrome/Disease Animal Models
Price on request

DSS and TNBS-induced; custom protocols available upon request, as are derivative model validations

Inflammatory Bowel Disease Crohn's disease Ulcerative colitis Colitis DSS- induced colitis TNBS- induced colitis Dextran Sulfate Sodium- induced colitis Trinitrobenzenesulfonic acid- induced colitis Rat Mouse Gastroenterology Microbiology Inflammation Show 13 more tags Show less

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Pharmacology

Price on request

Within our laboratory services, our pharmacology services include specialized diagnostic testing, clinical trial testing, GLP and GMP assessments of compounds/biologics and more! Our goal is to facilitate the advancement of diagnostic capabilities and improve analytical methods through application of rigorous biomarker-based strategies.


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Immunophenotyping

Price on request
Request a quote for more information about this service.

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Cytometry

Price on request

Cytometry Services


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Flow Cytometry

Price on request

Multiparametric (16+ color) on the BD LSR Fortessa instrument

Inflammation Oncology Immunology Immuno-Oncology Autoimmune disease CNS/Neurology Cardiovascular Liver Disease Non-Alcoholic Steatohepatitis (NASH) Non-alcoholic fatty liver disease (NAFLD) BD LSRFortessa Miltenyi MacsQuant Flow cytometry Immunophenotyping immunology antibody validation Mouse Rat Pig Human Dog Cat Non-human primates (NHP) Show 23 more tags Show less

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Experimental Autoimmune Encephalomyelitis (EAE) Animal Models

Price on request

Variety of highly-validated EAE models with multiple induction methods, customizable protocols and advanced analytical readout capabilities

Multiple sclerosis (MS) Demyelinating diseases MOG- induced Experimental Autoimmune Encephalomyelitis (EAE) MBP-induced Experimental Autoimmune Encephalomyelitis (EAE) PLP-induced Experimental Autoimmune Encephalomyelitis (EAE) Myelin Oligodentrocyte Glycoprotein-Induced EAE Myelin Basic Protein-induced EAE Proteolipid Protein-induced EAE Spinal Cord Homogenate-induced EAE SCH-induced EAE Mouse Rat CNS/Neurology Inflammation Immunology Show 15 more tags Show less

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Ex Vivo Models and Assays

Price on request

Ex Vivo Models and Assays Services


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Cell Signaling Analyses

Price on request

Cell Signaling Analyses Services


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Cell Viability & Proliferation Assays

Price on request

Cell Viability & Proliferation Assays Services


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Cell Invasion & Migration Assays

Price on request

Cell Invasion & Migration Assays Services


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Mammalian Cell Culture

Price on request

Mammalian Cell Culture Services


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Animal Anxiety and Depression Tests

Price on request

Animal Anxiety and Depression Tests Services


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Animal Motor Function Tests

Price on request

Animal Motor Function Tests Services


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Protein Expression Visualization

Price on request

Protein Expression Visualization Services


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Mammalian Models

Price on request

Mammalian Models Services


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Model Organisms

Price on request

Model Organisms Services


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Clinical Hematology

Price on request

Clinical Hematology Services


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Common Histochemical Stains

Price on request

Common Histochemical Stains Services


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Histological Staining

Price on request

Histological Staining Services


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Clinical and Anatomic Pathology

Price on request

Clinical and Anatomic Pathology Services


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Primary Cell Culture

Price on request

Primary Cell Culture Services


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Cell and Tissue Culture

Price on request

Cell and Tissue Culture Services


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Human Primary Cells

Price on request

Human Primary Cells Services


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Tissue Sectioning

Price on request

Tissue Sectioning Services


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Tissue Embedding

Price on request

Tissue Embedding Services


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Tissue Processing

Price on request

Tissue Processing Services


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Human Whole Blood & PBMCs

Price on request

Human Whole Blood & PBMCs Services


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Biostatistics & Bioinformatics

Price on request

Biostatistics & Bioinformatics Services


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Statistical Analysis

Price on request

Statistical Analysis Services


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Data Analysis

Price on request

Data Analysis Services


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Data Services

Price on request

Data Services


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  • Positive review for Colitis Animal Models:

    June 2019

    "MD Biosciences is an experienced lab with considerable knowledge and expertise. I found them very easy to work with. Communication was outstanding and I was very pleased by the quality of the work from protocol construction through in life study execution to the final report. I would absolutely use their services again."

  • Positive review for Biomarker Analysis:

    December 2018

    "MD Biosciences worked with our small sample volumes. They provided comprehensive results in a clear and practical format. Highly recommended!"

MD Biosciences Preclinical Laboratory Services has not received any endorsements.