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MD Biosciences Preclinical Laboratory Services

Oakdale, Minnesota, US

MD Biosciences Preclinical Laboratory Services is a niche preclinical research group working with biopharmacuetical and medical device companies. Our core therapeutic areas are oncology, inflammation, CNS, pain and cardiovascular with an emphasis on the interplay between these systems.

We place a great deal of importance on the scientific rationale of each individual study to ensure that it meets the goals of the R&D program. We are willing to invest in custom study design, development and validation with our sponsors to achieve clinically relevant data at the preclinical stages. We feel that this will help reduce the failure rate in clincial stages and the burden upon the industry.

We employ a highly talented group of scientists consisting of PhD, MSc and Bachelor degrees. Each scientist is specialized and highly skilled in their area of expertise. Our group has all been trained in various techniques... Show more »

MD Biosciences Preclinical Laboratory Services is a niche preclinical research group working with biopharmacuetical and medical device companies. Our core therapeutic areas are oncology, inflammation, CNS, pain and cardiovascular with an emphasis on the interplay between these systems.

We place a great deal of importance on the scientific rationale of each individual study to ensure that it meets the goals of the R&D program. We are willing to invest in custom study design, development and validation with our sponsors to achieve clinically relevant data at the preclinical stages. We feel that this will help reduce the failure rate in clincial stages and the burden upon the industry.

We employ a highly talented group of scientists consisting of PhD, MSc and Bachelor degrees. Each scientist is specialized and highly skilled in their area of expertise. Our group has all been trained in various techniques including microsurgical procedures, injection methods, model and method development as well as imaging and histological techniques.

Selected Publications

  • Castel, D., Willentz, E., Doron, O., Brenner, O. and Meilin, S. (2014), Characterization of a porcine model of post-operative pain. European Journal of Pain, 18: 496–505. doi: 10.1002/j.1532-2149.2013.00399.x
  • Meilin, S., Machicao, F., & Elmlinger, M. (2014). Treatment with Actovegin improves spatial learning and memory in rats following transient forebrain ischaemia. Journal of Cellular and Molecular Medicine (8), 1623–1630. doi:10.1111/jcmm.12297
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Pulmonary Hypertension Animal Models
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osmotic minipump
multiplex cytokine profiling
multi-site histologic analysis
16S rRNA Sequencing
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Preclinical Efficacy Studies
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Brown Rat (Rattus norvegicus)
Porcine
murine
Cancer
Diabetes Type 1
Diabetes Type 2
Rheumatoid Arthritis
Fibrosis
Obesity
Sepsis
Diabetes
neurodegenerative diseases
neuropathy
multiple sclerosis
Experimental Autoimmune Encephalomyelitis (EAE)
colitis
dermatitis
psoriasis
inflammatory Bowel Disease
Wound Care
inflammation
Cystic Fibrosis
Asthma
Parkinsons Disease
Pain
Metabolic disorders
pulmonary fibrosis
Acute Kidney Injury
CNS/neurology
Collagen Induced Arthritis
Collagen Antibody-Induced Arthritis
Adjuvant-Induced Arthritis
Renca Renal Cancer
Preclinical Study Design
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In vivo Pharmacology Studies
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ADME/DMPK Studies
Drug Metabolism and Pharmacokinetics
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Animal Model in vivo Analyses
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Drug Potency and Efficacy Testing
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High Throughput Screening (HTS)
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Drug Development
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Biomarker Research – Tissue Based
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Biomarker Discovery
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Flow cytometry
assay development
Western blotting
ELISA Protein Analysis
Multiplexed Protein Analysis
Serology
Real time qPCR
Multiplexed mRNA analysis
Multiplexed miRNA analysis
Tissue Extraction
Urinalysis
Hematology
Clinical chemistry
Animal Behavior Studies
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Animal Model Housing and Maintenance
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Demyelination Animal Models
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Autoimmune Disease Animal Models
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proliferation
Cellular Immunity
Non-specific Immunity
Humoral Immunity
Allergy/Hypersensitivity
Th17 activation
T cell inhibition
Cytokine Release
T cell stimulation
Macrophage (Inhibition)
Macrophage (stimulation)
In vivo Drug Efficacy Testing
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Combination Therapy Efficacy Testing in Mice
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Troponin Assay
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ELISA
Enzyme-linked immunosorbent assay
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Acute Inflammatory Pain Animal Models
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CFA
Carrageenan
Visceral Pain Animal Models
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IHC
Biomarker analysis
PK
von frey
Motor Function
Osteoarthritis Animal Models
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histology
Open field
Rotorod
joint pain
weight bearing
Thermal Hyperalgesia
mechanical Allodynia
paw edema
joint compression
Psoriasis Animal Models
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Imiquimod-induced psoriasis
Atopic Dermatitis Animal Models
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FITC Induced Contact Dermatitis
DNCB Induced Contact Dermatitis
Custom Pain Animal Models
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Animal Nociception Tests
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tail flick
visceral
Capsaicin
Ischemia Animal Models
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MCAo
4Vo
Migraine Animal Models
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In vitro Diabetes Models
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NOD
STZ
unilateral AKI
bilateral AKI
DIO rat
DIO mouse
Inflammation Assays
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Anaphylaxis Animal Models
PCA Animal Model
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Delayed-Type Hypersensitivity (DTH) Animal Models
Delayed Type Hypersensitivity Animal Models
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Contact Dermatitis Animal Models
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FITC Induced Contact Dermatitis
DNCB Induced Contact Dermatitis
IMQ-Induced Psoriasis Assay
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Rat IMQ
Mouse IMQ
Lung Inflammation Animal Models
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LPS
LPS
Colitis Animal Models
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Acute DSS-induced colitis in mice and rats
Chronic DSS-induced colitis in mice
TNBS-induced colitis in mice and rats

Acute DSS-induced colitis in mice and rats
Chronic DSS-induced colitis in mice
TNBS-induced colitis in mice and rats

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Mouse
Rat
Rheumatoid Arthritis Animal Models
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Collagen-induced arthritis
Collagen antibody induced rheumatoid arthritis
Global Ischemia 4VO Animal Model
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Rat permanent 4VO
Rat transient 4VO
Sepsis Animal Models
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Sepsis induced by LPS
Mouse LPS
Focal Cerebral Ischemia Animal Models
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Mouse transient MCAo
Rat transient MCAo
Rat permanent MACo
Postoperative Pain Animal Models
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Rat Brennan model
pig POP model
Asthma Animal Models
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OVA
HDM
LPS
EAE Animal Model
Experimental Autoimmune Encephalomyelitis Animal Model
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Nociceptive Pain Animal Models
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tail flick
visceral
Capsaicin
Nerve Block Animal Models
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rat model
pig model
Neuropathic Pain Animal Models
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nerve injury
chemotherapy
STZ diabetic
pig neuropathic pain
Myocardial Ischemia Reperfusion Injury Animal Models
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ligation induced acute cardiac infarction
Coil-induced acute cardiac infarction
multi-focal myocardial infarction
balloon-induced acute cardiac reperfusion
Induction of vascular disease
Chemotherapy-Induced Peripheral Neuropathy Animal Models
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Rat taxol
Rat vincristine
Acute Kidney Failure Models
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LPS
Mouse LPS
Rat LPS
Parkinsons Disease Animal Models
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acute MPTP
60HDA
Spinal Cord Injury Models
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neurite outgrowth
In vivo Phenotypic Screening
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LPS-Induced Inflammation Animal Models
Lipopolysaccharide-Induced Inflammation Animal Models
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F4/80 microglia cells
GFAP
Wound Healing Animal Models
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mouse incisional wound
rat incisional wound
rodent burn wound
pig incisional wound
pig excisional wound
pig burn wound
Custom Cell-Based Assays
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Custom Assays
PBMC
human primary cells
immortalized cell lines
murine
rat
ex vivo primary cells
Obesity Animal Models
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DIO rat
DIO mouse
Metabolic Animal Models
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obesity
diabetes
acute kidney injury
IBD
Clinical Laboratory Services
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Flow cytometry
assay development
real-time PCR
Western blotting
ELISA Protein Analysis
Multiplexed Protein Analysis
Serology
Multiplexed mRNA analysis
Multiplexed miRNA analysis
Tissue Extraction
Urinalysis
Hematology
Clinical chemistry
Cardiovascular Animal Models
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Animal Learning, Memory, and Behavior Tests
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Immunology Animal Models
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Cellular Immunity
Non-specific Immunity
Humoral Immunity
Allergy/Hypersensitivity
Safety Pharmacology & Efficacy Testing
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Drug Discovery & Development
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Cells and Tissues
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Infectious Disease Animal Models
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RNA
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Bioanalysis
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Protein Quantification
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Nephrology Animal Models
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Immune Cell Assays
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Protein Services
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Functional Human Tissue Assays
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Animal Cognition & Behavior Tests
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Respiratory Disease Animal Models
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Animal Models of Disease
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Clinical Chemistry
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Cell-Based Assays
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CNS/Neurology Animal Models
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In vivo PK/PD Studies
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In vitro Disease Models
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Dermatology Animal Models
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In vivo Assays
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RNA Sequencing
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Bone/Cartilage Animal Models
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Functional & Cell Type Specific Assays
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Biomarkers
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Biology
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Animal Physiology Analyses
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Pharmacology & Toxicology
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Hit Identification
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Inflammation Animal Models
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Nucleic Acid Services
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Animal Models and Studies
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Pain/Neuropathy Animal Models
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Biochemistry & Molecular Biology
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Gastroenterology Animal Models
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Specialized Cell-Based Assays
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Drug Discovery
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