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Maxygen LLC

Sunnyvale, California, US

Maxygen uses directed evolution technologies for custom client programs to optimize biological products and processes in any sector of biotechnology. With over two decades of experience with this platform, we can facilitate the identification of novel and highly functional biosuperior proteins. Through a collaborative design process involving the client, Maxygen scientists identify functional sequence diversity to be recombined. We then generate combinatorial libraries of genes expressing candidate proteins using a process that mimics natural homologous DNA recombination. A tiered screening approach results in the identification of proteins conforming to the user-defined target product profile. Recursive rounds of evolution harness the power of combining beneficial changes to achieve significant improvements.

The original Maxygen was formed in 1997, went public in 1999, and was dissolved in 2013. During this time,... Show more »

Maxygen uses directed evolution technologies for custom client programs to optimize biological products and processes in any sector of biotechnology. With over two decades of experience with this platform, we can facilitate the identification of novel and highly functional biosuperior proteins. Through a collaborative design process involving the client, Maxygen scientists identify functional sequence diversity to be recombined. We then generate combinatorial libraries of genes expressing candidate proteins using a process that mimics natural homologous DNA recombination. A tiered screening approach results in the identification of proteins conforming to the user-defined target product profile. Recursive rounds of evolution harness the power of combining beneficial changes to achieve significant improvements.

The original Maxygen was formed in 1997, went public in 1999, and was dissolved in 2013. During this time, Maxygen scientists, following the lead of Dr. Pim Stemmer (1957-2013), demonstrated the value of the MolecularBreeding™ directed evolution technology to dramatically improve the function of genes and proteins. This technology was applied to agricultural products, enzymes, protein pharmaceuticals, and vaccines. Maxygen spun off several companies, including Avidia, Codexis, and Verdia, while other startups, such as Altravax, obtained exclusive licenses to the technology for specific fields.

In February 2017, former employees, investors, and other specialists in directed evolution and molecular engineering relaunched Maxygen. Their goal is to offer the best directed evolution approaches to any sector of biotechnology where improvements in function are required. This includes enzymes for various purposes (e.g., gene editing, in vitro RNA synthesis, next-generation sequencing, enzymatic synthesis of small molecules, and others), growth factors (e.g., for ex vivo cell culture), gene therapy vector and viral functions (e.g., infectivity, tropism, production levels), and vaccines (intrinsic immunogenicity, overcoming polymorphism).

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Protein Engineering/Directed Evolution
Price on request

Maxygen provides molecular breeding directed evolution services to the biotech industry. We can work with any sector of biotechnology where improvements in protein function are required. This includes enzymes for various purposes (e.g., chemical transformations, gene editing, in vitro RNA synthesis, next-generation sequencing,... Show more »

Maxygen provides molecular breeding directed evolution services to the biotech industry. We can work with any sector of biotechnology where improvements in protein function are required. This includes enzymes for various purposes (e.g., chemical transformations, gene editing, in vitro RNA synthesis, next-generation sequencing, enzymatic synthesis of small molecules, and others), growth factors (e.g., for ex vivo cell culture), gene therapy vector and viral functions (e.g., infectivity, tropism, production levels), and vaccines (intrinsic immunogenicity, overcoming polymorphism).

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Biology
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Biochemistry & Molecular Biology
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Protein Services
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Protein Production
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Recombinant Protein Expression
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Protein Expression in Mammalian Cells
Mammalian cell based recombinant protein production
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Protein Expression Optimization
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Project Management
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