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Massachusetts Host-Microbiome Center

2 Orders Completed
Boston, Massachusetts, US

About Massachusetts Host-Microbiome Center

Divison of: Harvard University

The Massachusetts Host-Microbiome Center core facilities provide support to groups around the world who are studying effects of the microbiota on the host. Core staff and equipment handles materials from in vitro systems, animal models and human studies. The core provides personnel, resources and equipment for... Show more »

The Massachusetts Host-Microbiome Center core facilities provide support to groups around the world who are studying effects of the microbiota on the host. Core staff and equipment handles materials from in vitro systems, animal models and human studies. The core provides personnel, resources and equipment for
(1) quantiative microbiology and microbiological assessment of complex samples
(2) maintenance of mice under germfree (gnotobiotic) or specifically-colonized conditions
(3) CLAMS metabolic caging units, including capacity to operate under germfree or defined-colonization conditions
(3) Technical sequencing for 16S rRNA gene analyses (phylotyping)
(4) Bacterial whole genome sequencing
(5) Short chain fatty acid (SCFA) and other microbial metabolite analyses in primary gut samples or culture supernatants
(6) CLIA-level (clinical laboratory) testing for clinical microbiology, Clostridium difficile detection (antigen, PCR and cell-culture based assays), fecal calprotectin, and screening of human or animal samples for multi-drug resistant organisms (MDROs).

The core maintains gnotobiotic/germ free isolators for housing of mice under germfree conditions, and biohazard levels 1 and 2 for specifically-associated mice. In-house bred germfree mice are also available to investigators for experiments.

In addition, the core maintains an extensive repository of commensal isolates and BL-2 pathogens for use in specific-associations as well as for in vitro studies. Experienced microbiologists routinely cultures primary samples from humans and/or animals to study complex samples using culture and/or sequencing-based methods. Equipment in the core includes a large 2-person Coy anaerobic hood, specialized incubators for culture of microaerophilic organisms, and equipment for biochemical and molecular typing of primary samples.

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Certifications & Qualifications

CLIA/CAP

Our Services (17)


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Clinical Microbiology

Price on request

CLIA (clinical laboratory) testing services to support Microbiome Trials

The Center's CLIA Unit offers the following clinical laboratory tests:

  • Stool Culture for enteric pathogens: Salmonella, Shigella, Campylobacter, Vibrio species; E. coli O157:H7
  • Clostridium difficile stool testing by rapid antigen and by PCR... Show more »

CLIA (clinical laboratory) testing services to support Microbiome Trials

The Center's CLIA Unit offers the following clinical laboratory tests:

  • Stool Culture for enteric pathogens: Salmonella, Shigella, Campylobacter, Vibrio species; E. coli O157:H7
  • Clostridium difficile stool testing by rapid antigen and by PCR (Cepheid GeneXpert)
  • Fecal Helicobacter pylori antigen testing
  • Fecal screening for multi-drug resistant organisms (MDROs), specifically CRE and ESBL+ species
  • Fecal Calprotectin testing
  • Screening for Methicillin Resistant Staphylococcus aureus (MRSA) by nasal swab
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Germ Free Animal Models

Price on request
  • On-site breeding and availability of wild-type germfree stocks
  • Maintenance of germfree mice
  • On-site breeding and availability of wild-type germfree stocks
  • Maintenance of germfree mice
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Mouse

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Bacterial Culture

Price on request

Aerobic and anaerobic culture

Aerobic and anaerobic culture

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Microbial Identification and Strain Typing

Price on request
  • Microbial identification and analysis
  • Short Chain Fatty Acid (SCFA) profiles on intestinal contents or culture supernatants
    • Volatile and non-volatile panels
  • 16S rRNA gene phylotyping (technical sequencing by Illumina MiSeq)
  • Microbial identification and analysis
  • Short Chain Fatty Acid (SCFA) profiles on intestinal contents or culture supernatants
    • Volatile and non-volatile panels
  • 16S rRNA gene phylotyping (technical sequencing by Illumina MiSeq)
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Illumina MiSeq

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Animal Necropsy Services

Price on request

Animal necropsy/tissue harvest and processing for histology or microbiological assessment, etc.

Animal necropsy/tissue harvest and processing for histology or microbiological assessment, etc.

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Specific Microbe-Associated Animal Models

Price on request

With commensal or pathogenic species in hand, the Gnotobiotics aspect of the core provides the only germfree facility in the Longwood Medical Area where investigators can specifically-associate germfree mice, or maintain germfree controls, to evaluate metabolic, immunologic and other physiologic effects of microbial colonization of the host.

With commensal or pathogenic species in hand, the Gnotobiotics aspect of the core provides the only germfree facility in the Longwood Medical Area where investigators can specifically-associate germfree mice, or maintain germfree controls, to evaluate metabolic, immunologic and other physiologic effects of microbial colonization of the host.

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Animal Models of Disease

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Microbiology Assays

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Microbiology

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Animal Models and Studies

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Discovery Pathology

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Clinical Microbiology, Virology and Parasitology

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Gnotobiotic Animal Models

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Clinical Research

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Clinical Laboratory Services

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Cells and Tissues

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Biology

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