Global metabolomics will be performed using state-of-the-art high resolution mass spectrometry (HRMS) coupled to ultra-high pressure liquid chromatography (UHPLC) on serum, plasma, urine, tissue, cells, stool and other samples.
The targeted metabolomics offerings include acylcarnitines, amino acids and organic acids in cellular extracts, plasma or tissue using mass spectrometry.
New assays will be developed based on:
The targeted metabolomics will employ MS with selected reaction monitoring (SRM) using either a direct infusion approach or after chromatographic separation (UHPLC or GC).
Biomarker identification will be performed with accurate mass and fine mass resolution, tandem MS (MS/MS) provided by Core 3 and existing metabolomic databases (Metlin, ChemSpider, pubChem). Through constant collaboration, SECIM will continually grow the library of known metabolites.
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