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Maratech NMR Solutions

2 Orders Completed
Acton, Massachusetts, US

About Maratech NMR Solutions

Founded in 2014, Maratech NMR solutions is a Boston based company founded by scientists with over 20 years of cutting edge experience in the... Show more »

Founded in 2014, Maratech NMR solutions is a Boston based company founded by scientists with over 20 years of cutting edge experience in the pharmaceutical industry. Our experience spans neuroscience, inflammation, oncology and infectious disease. We partner with clients and enable unmet needs through state of the art NMR solution state methods.

We provide high quality NMR data that enables our clients to move their drug discovery research forward.
By using advanced deconvolution methodologies, we are able to work on the most complex of scientific problems.
Our modern methods and cutting edge technology allows for the lowest sample concentrations and fastest turnaround times in the industry.
The advantage is a faster turnaround time at an economical cost to our clients.

NMR: Proteins/Peptides/RNA/DNA

Resonance assignments
Binding analysis
Complete NMR-based 3D structure determination
SAR

Fragment and Small Molecule Screening

Ligand-observe methods (STD/waterlogsy NMR)
Target observe methods (HSQC/HMQC)
Competition assays
Screening of external libraries

Small Molecule

Structural determination
Stability analysis
Metabolite ID

Publications

"Mycofactocin-associated mycobacterial dehydrogenases with non-exchangeable NAD cofactors”. Nature Scientific Reports, 2017.

“N-Arylation of a hindered indoline as a route to 2-(2-methyl-1-(4-oxo-3,4-dihydrophthalazin-1-yl)-1H-indol-3- yl)acetic acid derivatives.” Tetrahedron Lett. 2011, 52, 6317-6320.

"An Improved Method for Determining Enantiomeric Excess by 13C-NMR in Chiral Liquid Crystal Media.” Chirality, 2010, 9:838-43.

"Total synthesis of enantiopure phalarine via a stereospecific Pictet-Spengler reaction: traceless transfer of chirality from L-tryptophan.” J Am Chem Soc 132(24):8506-12 (2010).

“The Synthesis and Biological Evaluation of Quinolyl-piperazinyl Piperidines as Potent Serotonin 5-HT(1A) Antagonists”. J Med Chem 53(10):4066-84 (2010).

“3,4-Dihydropyrimido(1,2-a)indol-10(2H)-ones as Potent Non-Peptidic Inhibitors of Caspase-3”. Bioorganic & Medicinal Chemistry, 2009, 17: 7755-7768.

“First scale-up synthesis of WAY-262398, a novel, dual-acting SSRI/5HT1a antagonist.” Organic Process Research and Development 2008, 12 (3), pp 545–546.

“Method for Stereochemical Identification of Small Molecules using Chiral Liquid Crystals, NMR, and Modeling.” American Pharma. Review 2007; 11:427-434.

“Enantiomeric separation and determination of absolute stereochemistry of asymmetric molecules in drug discovery - Building chiral technology toolboxes.” Chirality 19(9), 658 – 682, 2007.

“Stereochemical Identification of R and S Ibuprofen Using NMR and Modeling.” Chirality 2006; 19:741-50.

“Simultaneous Determination of 1H-1H and 1H-13C Residual Dipolar Couplings In A Chiral Liquid Crystal Solvent Using A Natural Abundance HSQC Experiment” MRC 2005; 43:512-519.

“Synthesis, characterization and solution structure of tethered oligonucleotides containing an internal 3'-phosphoglycolate, 5'-phosphate gapped lesion”. Nucl. Acids Res. 2002 30: 5497-5508.

“ Flexibility and Curvature of Duplex DNA Containing Mismatches Sites As a function of Temperature” Biochemistry 2000 39, 153-160.

“Damage Increases the Flexibility of Duplex DNA” Nuc. Acid. Res. 1999 27, 1854-1858.

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Our Services (17)


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NMR

Nuclear magnetic resonance spectroscopy
Price on request

• Specialize in Biophysics Methodologies
• Screening, Ligand Binding, Solution Structures
• Protein and Nucleic Acid Targets
• NMR 
• Located in the greater Boston/Cambridge area

NMR: Proteins/Peptides/RNA/DNA

• Resonance... Show more »

• Specialize in Biophysics Methodologies
• Screening, Ligand Binding, Solution Structures
• Protein and Nucleic Acid Targets
• NMR 
• Located in the greater Boston/Cambridge area

NMR: Proteins/Peptides/RNA/DNA

• Resonance assignments
• Binding analysis
• Binding site ID
• Complete NMR-based 3D structure determination
• SAR
• Small Molecule Screening

• Ligand-observe methods (STD/waterLOGSY/CPMG)
• Target observe methods (2D HSQC/HMQC)
• Competition assays
• Binding constant determination (Kd)
• Screening of external libraries
• Deconvolution Technology
•Bayesian Based Time Domain Method

NMR Services maratech NMR solutions:
•NMR Instrumentation: 500, 600 and two 800 MHz spectrometers

with cryogenically cooled probes on the 600 and 800s.

• 4x more sensitive = 16x in time
• Lower cost due to less materials needed

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NMR Oncology CNS/Neurology Immuno-Oncology Inflammation 1D, 2D and 3D NMR Drug Discovery RNA, DNA and Protein Agilent Bruker Show 10 more tags Show less

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SAR Analysis

Price on request
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Fragment Screening

Price on request
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Structure Determination

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Metabolite Identification

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Spectroscopy

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Categorical Structure Activity Relationship Modeling

Price on request

Categorical structure activity relationship modeling Services

Categorical structure activity relationship modeling Services

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Hit Identification

Price on request

Hit Identification Services

Hit Identification Services

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Drug Discovery

Price on request

Drug Discovery Services

Drug Discovery Services

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Drug Discovery & Development

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Drug Discovery & Development Services

Drug Discovery & Development Services

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Imaging & Spectroscopy

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DNA Services

Price on request

DNA Services

DNA Services

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Nucleic Acid Services

Price on request

Nucleic Acid Services

Nucleic Acid Services

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Biochemistry & Molecular Biology

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Biochemistry & Molecular Biology Services

Biochemistry & Molecular Biology Services

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Analytical Chemistry Services

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Analytical Chemistry Services

Analytical Chemistry Services

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Metabolomics

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Metabolomics Services

Metabolomics Services

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Omics

Price on request

Omics Services

Omics Services

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Bill Marathias

President and CEO
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Bill Marathias

President and CEO

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