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Maratech NMR Solutions

4 Orders Completed
Acton, Massachusetts, US

About Maratech NMR Solutions

Established in 2014, Maratech NMR solutions is a Boston based company founded by scientists with over 20 years of cutting edge experience in the pharmaceutical industry. Our experience spans neuroscience, inflammation, oncology and infectious disease. We partner with clients and enable unmet needs through state of the art NMR solution state methods.

We provide high quality NMR data that enables our clients to move their drug discovery research forward.
By using advanced deconvolution methodologies, we are able to work on the most complex of scientific problems.
Our modern methods and cutting edge technology allows for the lowest sample concentrations and fastest turnaround times in the industry.
The advantage is a faster turnaround time at an economical cost to our clients.

NMR: Proteins/Peptides/RNA/DNA

Resonance assignments
Binding analysis
Complete NMR-based 3D structure determination
SAR

Fragment and Small Molecule Screening

Ligand-observe methods (STD/waterlogsy NMR)
Target observe methods (HSQC/HMQC)
Competition assays
Screening of external libraries

Small Molecule

Structural determination
Stability analysis
Metabolite ID

Publications

"Mycofactocin-associated mycobacterial dehydrogenases with non-exchangeable NAD cofactors”. Nature Scientific Reports, 2017.

“N-Arylation of a hindered indoline as a route to 2-(2-methyl-1-(4-oxo-3,4-dihydrophthalazin-1-yl)-1H-indol-3- yl)acetic acid derivatives.” Tetrahedron Lett. 2011, 52, 6317-6320.

"An Improved Method for Determining Enantiomeric Excess by 13C-NMR in Chiral Liquid Crystal Media.” Chirality, 2010, 9:838-43.

"Total synthesis of enantiopure phalarine via a stereospecific Pictet-Spengler reaction: traceless transfer of chirality from L-tryptophan.” J Am Chem Soc 132(24):8506-12 (2010).

“The Synthesis and Biological Evaluation of Quinolyl-piperazinyl Piperidines as Potent Serotonin 5-HT(1A) Antagonists”. J Med Chem 53(10):4066-84 (2010).

“3,4-Dihydropyrimido(1,2-a)indol-10(2H)-ones as Potent Non-Peptidic Inhibitors of Caspase-3”. Bioorganic & Medicinal Chemistry, 2009, 17: 7755-7768.

“First scale-up synthesis of WAY-262398, a novel, dual-acting SSRI/5HT1a antagonist.” Organic Process Research and Development 2008, 12 (3), pp 545–546.

“Method for Stereochemical Identification of Small Molecules using Chiral Liquid Crystals, NMR, and Modeling.” American Pharma. Review 2007; 11:427-434.

“Enantiomeric separation and determination of absolute stereochemistry of asymmetric molecules in drug discovery - Building chiral technology toolboxes.” Chirality 19(9), 658 – 682, 2007.

“Stereochemical Identification of R and S Ibuprofen Using NMR and Modeling.” Chirality 2006; 19:741-50.

“Simultaneous Determination of 1H-1H and 1H-13C Residual Dipolar Couplings In A Chiral Liquid Crystal Solvent Using A Natural Abundance HSQC Experiment” MRC 2005; 43:512-519.

“Synthesis, characterization and solution structure of tethered oligonucleotides containing an internal 3'-phosphoglycolate, 5'-phosphate gapped lesion”. Nucl. Acids Res. 2002 30: 5497-5508.

“ Flexibility and Curvature of Duplex DNA Containing Mismatches Sites As a function of Temperature” Biochemistry 2000 39, 153-160.

“Damage Increases the Flexibility of Duplex DNA” Nuc. Acid. Res. 1999 27, 1854-1858.

Our Services (17)


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NMR

Nuclear magnetic resonance spectroscopy
Price on request

Specialize in Biophysics Methodologies
Screening, Ligand Binding, Solution Structures
Protein and Nucleic Acid Targets
19F, 1H, 13C, 15N NMR 
Located in the greater Boston/Cambridge area

NMR: Proteins/Peptides/RNA/DNA

Resonance assignments
Binding analysis
Binding site ID
Complete NMR-based 3D structure determination
SAR
Small Molecule Screening

Ligand-observe methods (STD/waterLOGSY/CPMG)
Target observe methods (2D HSQC/HMQC)

Competition assays
Binding constant determination (Kd)
Screening of external libraries
Deconvolution Technology

Bayesian Based Time Domain Method

NMR Services maratech NMR solutions:
NMR Instrumentation: 500, 600 and two 800 MHz spectrometers

with cryogenically cooled probes on the 600 and 800s.

4x more sensitive = 16x in time
Lower cost due to less materials needed

NMR Drug Discovery 1D, 2D and 3D NMR Agilent Bruker RNA, DNA and Protein Immuno-Oncology Oncology CNS/Neurology Inflammation Show 10 more tags Show less

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SAR Analysis

Price on request
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Fragment Screening

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Structure Determination

Price on request
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Metabolite Identification

Price on request
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Spectroscopy

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Categorical Structure Activity Relationship Modeling

Price on request

Categorical structure activity relationship modeling Services


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Hit Identification

Price on request

Hit Identification Services


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Drug Discovery

Price on request

Drug Discovery Services


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Drug Discovery & Development

Price on request

Drug Discovery & Development Services


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Imaging & Spectroscopy

Price on request
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DNA Services

Price on request

DNA Services


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Nucleic Acid Services

Price on request

Nucleic Acid Services


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Biochemistry & Molecular Biology

Price on request

Biochemistry & Molecular Biology Services


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Analytical Chemistry Services

Price on request

Analytical Chemistry Services


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Metabolomics

Price on request

Metabolomics Services


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Omics

Price on request

Omics Services


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BM

Bill Marathias

President and CEO
BM

Bill Marathias

President and CEO

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  • Positive review for NMR:

    June 2020

    "Yes, I would definitely work with Maratech NMR Solutions again. They maintained excellent open communication through my entire request and replied to my questions very promptly. They performed 1H and 13C on 17 compounds for me. At the end they sent me PDFs of all 34 spectra along with all the raw data."

Maratech NMR Solutions has not received any endorsements.